Incidental Mutation 'R2924:Mrgpra1'
| ID |
266201 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mrgpra1
|
| Ensembl Gene |
ENSMUSG00000050650 |
| Gene Name |
MAS-related GPR, member A1 |
| Synonyms |
MrgA1 |
| MMRRC Submission |
040509-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.066)
|
| Stock # |
R2924 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
46984623-47003988 bp(-) (GRCm39) |
| Type of Mutation |
splice site (5 bp from exon) |
| DNA Base Change (assembly) |
G to A
at 46984618 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000129978
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000098438]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000098438
|
| SMART Domains |
Protein: ENSMUSP00000129978
Gene: ENSMUSG00000050650
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
14 |
27 |
N/A |
INTRINSIC |
|
low complexity region
|
36 |
49 |
N/A |
INTRINSIC |
|
Pfam:7tm_1
|
57 |
225 |
2.1e-8 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.5%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 33 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Bcl9 |
A |
G |
3: 97,117,069 (GRCm39) |
S542P |
probably benign |
Het |
| Cass4 |
A |
G |
2: 172,268,592 (GRCm39) |
R225G |
possibly damaging |
Het |
| Ddx50 |
A |
T |
10: 62,463,373 (GRCm39) |
V440E |
probably damaging |
Het |
| Dmrtc2 |
G |
A |
7: 24,571,941 (GRCm39) |
C12Y |
probably damaging |
Het |
| Dock6 |
A |
T |
9: 21,720,926 (GRCm39) |
I1693N |
probably damaging |
Het |
| Fuom |
T |
C |
7: 139,679,862 (GRCm39) |
T110A |
probably benign |
Het |
| Gli2 |
C |
T |
1: 118,764,089 (GRCm39) |
R1354H |
probably benign |
Het |
| Gm5478 |
A |
T |
15: 101,552,229 (GRCm39) |
|
probably null |
Het |
| Hsp90aa1 |
T |
A |
12: 110,662,114 (GRCm39) |
M1L |
possibly damaging |
Het |
| Hsp90aa1 |
C |
A |
12: 110,662,115 (GRCm39) |
|
probably null |
Het |
| Il2rb |
T |
C |
15: 78,376,049 (GRCm39) |
M1V |
probably null |
Het |
| Ints6l |
A |
G |
X: 55,550,196 (GRCm39) |
E483G |
probably benign |
Het |
| Kalrn |
C |
T |
16: 33,810,180 (GRCm39) |
D2525N |
possibly damaging |
Het |
| Kcnd3 |
C |
T |
3: 105,566,082 (GRCm39) |
A421V |
probably damaging |
Het |
| Man2b2 |
A |
G |
5: 36,981,446 (GRCm39) |
F224L |
probably benign |
Het |
| Mtbp |
G |
A |
15: 55,483,210 (GRCm39) |
R429Q |
probably benign |
Het |
| Ncapg2 |
C |
A |
12: 116,402,349 (GRCm39) |
T727K |
probably benign |
Het |
| Nsf |
C |
T |
11: 103,821,578 (GRCm39) |
E26K |
possibly damaging |
Het |
| Nup214 |
A |
G |
2: 31,888,015 (GRCm39) |
K15E |
probably damaging |
Het |
| Or1e34 |
A |
G |
11: 73,778,337 (GRCm39) |
I287T |
probably damaging |
Het |
| Oxr1 |
T |
C |
15: 41,689,353 (GRCm39) |
Y526H |
probably benign |
Het |
| Plec |
A |
G |
15: 76,062,452 (GRCm39) |
F2563S |
probably damaging |
Het |
| Prex2 |
A |
G |
1: 11,168,711 (GRCm39) |
T236A |
probably damaging |
Het |
| Rbbp5 |
G |
C |
1: 132,420,401 (GRCm39) |
|
probably null |
Het |
| Slc24a2 |
A |
G |
4: 86,929,961 (GRCm39) |
S512P |
probably benign |
Het |
| Srd5a1 |
A |
G |
13: 69,734,834 (GRCm39) |
S191P |
probably damaging |
Het |
| Syt3 |
T |
A |
7: 44,045,222 (GRCm39) |
V518E |
probably damaging |
Het |
| Tmem132e |
T |
C |
11: 82,335,149 (GRCm39) |
S652P |
probably damaging |
Het |
| Uba6 |
A |
T |
5: 86,307,130 (GRCm39) |
V102D |
probably damaging |
Het |
| Unc13a |
A |
G |
8: 72,097,596 (GRCm39) |
V1158A |
possibly damaging |
Het |
| Upk3a |
A |
G |
15: 84,902,350 (GRCm39) |
Y59C |
probably benign |
Het |
| Zc3hav1 |
T |
C |
6: 38,331,045 (GRCm39) |
Y38C |
probably damaging |
Het |
| Zfp119a |
C |
A |
17: 56,175,343 (GRCm39) |
D51Y |
possibly damaging |
Het |
|
| Other mutations in Mrgpra1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00903:Mrgpra1
|
APN |
7 |
46,985,326 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01317:Mrgpra1
|
APN |
7 |
46,985,372 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01718:Mrgpra1
|
APN |
7 |
46,985,675 (GRCm39) |
splice site |
probably null |
|
|
IGL02252:Mrgpra1
|
APN |
7 |
46,984,912 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03301:Mrgpra1
|
APN |
7 |
46,985,164 (GRCm39) |
missense |
probably benign |
|
|
R0012:Mrgpra1
|
UTSW |
7 |
46,985,218 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1019:Mrgpra1
|
UTSW |
7 |
46,984,833 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2224:Mrgpra1
|
UTSW |
7 |
46,984,854 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R2520:Mrgpra1
|
UTSW |
7 |
46,985,020 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R3038:Mrgpra1
|
UTSW |
7 |
46,984,744 (GRCm39) |
nonsense |
probably null |
|
|
R3900:Mrgpra1
|
UTSW |
7 |
46,985,275 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
R4692:Mrgpra1
|
UTSW |
7 |
46,985,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4783:Mrgpra1
|
UTSW |
7 |
46,985,218 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4784:Mrgpra1
|
UTSW |
7 |
46,985,218 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4785:Mrgpra1
|
UTSW |
7 |
46,985,218 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4981:Mrgpra1
|
UTSW |
7 |
46,984,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5031:Mrgpra1
|
UTSW |
7 |
46,984,985 (GRCm39) |
nonsense |
probably null |
|
|
R6760:Mrgpra1
|
UTSW |
7 |
46,984,789 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7305:Mrgpra1
|
UTSW |
7 |
46,985,203 (GRCm39) |
missense |
probably benign |
0.38 |
|
R7348:Mrgpra1
|
UTSW |
7 |
46,985,157 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7837:Mrgpra1
|
UTSW |
7 |
46,985,076 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8158:Mrgpra1
|
UTSW |
7 |
46,985,204 (GRCm39) |
nonsense |
probably null |
|
|
R8856:Mrgpra1
|
UTSW |
7 |
46,985,583 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9100:Mrgpra1
|
UTSW |
7 |
46,984,732 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9694:Mrgpra1
|
UTSW |
7 |
46,985,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0012:Mrgpra1
|
UTSW |
7 |
46,985,623 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
|
| Posted On |
2015-02-05 |
Incidental Mutation