Incidental Mutation 'R3434:Or2ag13'
ID 266347
Institutional Source Beutler Lab
Gene Symbol Or2ag13
Ensembl Gene ENSMUSG00000108948
Gene Name olfactory receptor family 2 subfamily AG member 13
Synonyms Olfr695, GA_x6K02T2PBJ9-9092181-9091234, MOR283-6
MMRRC Submission 040652-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.121) question?
Stock # R3434 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 106312939-106315552 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 106472976 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 159 (Y159N)
Ref Sequence ENSEMBL: ENSMUSP00000150853 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060879] [ENSMUST00000213721] [ENSMUST00000216009]
AlphaFold Q8VFM3
Predicted Effect probably benign
Transcript: ENSMUST00000060879
AA Change: Y159N

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000050694
Gene: ENSMUSG00000109058
AA Change: Y159N

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 5.2e-46 PFAM
Pfam:7TM_GPCR_Srsx 35 296 1.8e-6 PFAM
Pfam:7tm_1 41 290 2.1e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213721
AA Change: Y159N

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Predicted Effect probably benign
Transcript: ENSMUST00000216009
AA Change: Y159N

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217164
Predicted Effect noncoding transcript
Transcript: ENSMUST00000217204
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.3%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca17 G A 17: 24,508,511 (GRCm39) A1008V probably damaging Het
Adora3 A G 3: 105,812,231 (GRCm39) K39R probably benign Het
Ankib1 A G 5: 3,742,760 (GRCm39) V1085A probably damaging Het
Atp7a G A X: 105,138,463 (GRCm39) R563K probably benign Het
Azin1 T C 15: 38,493,820 (GRCm39) I268V probably benign Het
Carm1 T C 9: 21,480,769 (GRCm39) F81S probably damaging Het
Ccnjl A G 11: 43,470,688 (GRCm39) Y152C probably damaging Het
Chrna3 T A 9: 54,931,610 (GRCm39) I61F possibly damaging Het
Clca3a2 G A 3: 144,514,522 (GRCm39) probably benign Het
Clstn2 T A 9: 97,336,768 (GRCm39) D903V probably benign Het
Dpysl3 C T 18: 43,494,126 (GRCm39) V70I probably benign Het
Drg2 A T 11: 60,352,218 (GRCm39) K180* probably null Het
Dync2h1 A C 9: 7,011,236 (GRCm39) H3659Q probably benign Het
Dysf A T 6: 84,047,870 (GRCm39) Y349F probably benign Het
Epb41l4b T C 4: 57,040,865 (GRCm39) N533D probably benign Het
Fam47e T A 5: 92,733,221 (GRCm39) V152D probably damaging Het
Fasn G A 11: 120,713,599 (GRCm39) A24V probably damaging Het
Fhl4 T C 10: 84,934,308 (GRCm39) T158A probably benign Het
Fnbp1l C T 3: 122,339,955 (GRCm39) R499Q probably damaging Het
Hdlbp A T 1: 93,355,883 (GRCm39) M358K probably benign Het
Ift74 A G 4: 94,510,089 (GRCm39) probably null Het
Lhx4 A G 1: 155,578,147 (GRCm39) Y332H probably damaging Het
Mast2 A T 4: 116,165,292 (GRCm39) S1314T probably benign Het
Mast4 A G 13: 102,923,887 (GRCm39) I508T probably damaging Het
Mdn1 T C 4: 32,733,726 (GRCm39) probably null Het
Mrps23 A G 11: 88,100,940 (GRCm39) K44E probably damaging Het
Mslnl G A 17: 25,961,908 (GRCm39) V128M probably damaging Het
Mup6 G T 4: 60,004,116 (GRCm39) probably null Het
Notch3 A T 17: 32,377,592 (GRCm39) D161E possibly damaging Het
Or4a67 T C 2: 88,598,413 (GRCm39) D82G probably damaging Het
Or5w11 T C 2: 87,459,418 (GRCm39) F204L probably benign Het
P2rx4 T A 5: 122,863,133 (GRCm39) I202K probably damaging Het
Phykpl A G 11: 51,489,482 (GRCm39) T363A probably benign Het
Pitpnm1 G A 19: 4,162,234 (GRCm39) A1047T probably damaging Het
Ppat A G 5: 77,065,912 (GRCm39) I402T probably damaging Het
Rpgr A G X: 10,042,841 (GRCm39) S656P probably benign Het
Rsbn1l T C 5: 21,110,928 (GRCm39) probably benign Het
Sacs A G 14: 61,449,752 (GRCm39) K3933E probably damaging Het
Scn7a T C 2: 66,505,847 (GRCm39) I1681V probably benign Het
Sel1l3 T C 5: 53,274,432 (GRCm39) D1016G probably benign Het
Sf3a3 C A 4: 124,618,870 (GRCm39) T277N possibly damaging Het
Slc35a5 A G 16: 44,964,396 (GRCm39) I279T probably benign Het
Slc39a10 T C 1: 46,874,877 (GRCm39) T142A probably benign Het
Tle3 T A 9: 61,321,376 (GRCm39) probably null Het
Tmem117 T C 15: 94,992,573 (GRCm39) I411T probably damaging Het
Ttn T C 2: 76,698,721 (GRCm39) T5A possibly damaging Het
Tubgcp3 T C 8: 12,708,381 (GRCm39) probably null Het
Ush2a C T 1: 188,465,955 (GRCm39) P2841L probably damaging Het
Vmn1r209 A T 13: 22,990,267 (GRCm39) M141K probably benign Het
Vmn2r91 A T 17: 18,330,370 (GRCm39) probably benign Het
Other mutations in Or2ag13
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01010:Or2ag13 APN 7 106,473,460 (GRCm39) utr 5 prime probably benign
IGL02143:Or2ag13 APN 7 106,473,180 (GRCm39) missense probably benign 0.02
R0492:Or2ag13 UTSW 7 106,473,084 (GRCm39) missense probably damaging 1.00
R1816:Or2ag13 UTSW 7 106,472,695 (GRCm39) nonsense probably null
R1834:Or2ag13 UTSW 7 106,473,348 (GRCm39) missense probably damaging 1.00
R2011:Or2ag13 UTSW 7 106,472,634 (GRCm39) missense probably benign 0.03
R3842:Or2ag13 UTSW 7 106,473,302 (GRCm39) missense probably benign 0.07
R4405:Or2ag13 UTSW 7 106,472,580 (GRCm39) missense probably damaging 1.00
R4742:Or2ag13 UTSW 7 106,472,635 (GRCm39) missense probably damaging 0.99
R4815:Or2ag13 UTSW 7 106,473,444 (GRCm39) missense probably benign
R4851:Or2ag13 UTSW 7 106,473,221 (GRCm39) missense probably damaging 1.00
R4856:Or2ag13 UTSW 7 106,473,177 (GRCm39) missense probably damaging 1.00
R5663:Or2ag13 UTSW 7 106,472,877 (GRCm39) missense probably benign 0.43
R5783:Or2ag13 UTSW 7 106,472,541 (GRCm39) missense probably damaging 0.97
R6552:Or2ag13 UTSW 7 106,313,850 (GRCm39) small deletion probably benign
R6640:Or2ag13 UTSW 7 106,313,247 (GRCm39) missense probably damaging 1.00
R6798:Or2ag13 UTSW 7 106,313,402 (GRCm39) missense probably damaging 1.00
R7365:Or2ag13 UTSW 7 106,313,171 (GRCm39) missense probably benign 0.03
R7496:Or2ag13 UTSW 7 106,313,435 (GRCm39) missense probably benign 0.23
R7923:Or2ag13 UTSW 7 106,313,649 (GRCm39) nonsense probably null
R9012:Or2ag13 UTSW 7 106,313,115 (GRCm39) missense probably benign 0.10
R9572:Or2ag13 UTSW 7 106,313,546 (GRCm39) missense probably damaging 1.00
R9596:Or2ag13 UTSW 7 106,313,412 (GRCm39) missense probably benign 0.01
R9756:Or2ag13 UTSW 7 106,313,002 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGACAAGGGCTTTCTTCCTG -3'
(R):5'- TGTTCCTGGCACTGACACTG -3'

Sequencing Primer
(F):5'- CTCATTTGAGGGCATATGGAGCAC -3'
(R):5'- TGGGTGGTGCAGAAGACCTC -3'
Posted On 2015-02-18