Incidental Mutation 'R2870:St5'
ID 266516
Institutional Source Beutler Lab
Gene Symbol St5
Ensembl Gene ENSMUSG00000031024
Gene Name suppression of tumorigenicity 5
Synonyms 2610305K15Rik, 2010004M01Rik
MMRRC Submission 040458-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.414) question?
Stock # R2870 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 109523911-109703605 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to T at 109557430 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Asparagine at position 38 (Y38N)
Ref Sequence ENSEMBL: ENSMUSP00000078264 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077909] [ENSMUST00000079282] [ENSMUST00000084738] [ENSMUST00000168005] [ENSMUST00000207394] [ENSMUST00000207745] [ENSMUST00000208583]
AlphaFold Q924W7
Predicted Effect probably benign
Transcript: ENSMUST00000077909
AA Change: Y38N

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000077067
Gene: ENSMUSG00000031024
AA Change: Y38N

DomainStartEndE-ValueType
low complexity region 28 46 N/A INTRINSIC
low complexity region 197 213 N/A INTRINSIC
low complexity region 314 326 N/A INTRINSIC
low complexity region 327 348 N/A INTRINSIC
low complexity region 365 379 N/A INTRINSIC
low complexity region 407 426 N/A INTRINSIC
low complexity region 577 609 N/A INTRINSIC
low complexity region 624 638 N/A INTRINSIC
low complexity region 645 656 N/A INTRINSIC
uDENN 690 781 1.16e-30 SMART
DENN 788 972 7.84e-78 SMART
low complexity region 1007 1014 N/A INTRINSIC
dDENN 1019 1086 3.12e-22 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000079282
AA Change: Y38N

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000078264
Gene: ENSMUSG00000031024
AA Change: Y38N

DomainStartEndE-ValueType
low complexity region 28 46 N/A INTRINSIC
low complexity region 197 213 N/A INTRINSIC
low complexity region 314 326 N/A INTRINSIC
low complexity region 327 348 N/A INTRINSIC
low complexity region 365 379 N/A INTRINSIC
low complexity region 407 426 N/A INTRINSIC
low complexity region 577 609 N/A INTRINSIC
low complexity region 624 638 N/A INTRINSIC
low complexity region 645 656 N/A INTRINSIC
uDENN 690 781 1.16e-30 SMART
DENN 788 972 7.84e-78 SMART
low complexity region 1007 1014 N/A INTRINSIC
dDENN 1019 1086 3.12e-22 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000084738
SMART Domains Protein: ENSMUSP00000081789
Gene: ENSMUSG00000031024

DomainStartEndE-ValueType
low complexity region 160 192 N/A INTRINSIC
low complexity region 207 221 N/A INTRINSIC
low complexity region 228 239 N/A INTRINSIC
uDENN 273 364 1.16e-30 SMART
DENN 371 555 7.84e-78 SMART
low complexity region 590 597 N/A INTRINSIC
dDENN 602 669 3.12e-22 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000168005
SMART Domains Protein: ENSMUSP00000130119
Gene: ENSMUSG00000031024

DomainStartEndE-ValueType
low complexity region 160 192 N/A INTRINSIC
low complexity region 207 221 N/A INTRINSIC
low complexity region 228 239 N/A INTRINSIC
uDENN 273 364 1.16e-30 SMART
DENN 371 555 7.84e-78 SMART
low complexity region 590 597 N/A INTRINSIC
dDENN 602 669 3.12e-22 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000207394
AA Change: Y38N

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000207745
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208557
Predicted Effect probably benign
Transcript: ENSMUST00000208583
AA Change: Y38N

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208981
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene was identified by its ability to suppress the tumorigenicity of Hela cells in nude mice. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 87 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Actrt3 A G 3: 30,599,698 (GRCm38) V51A probably damaging Het
Adgb C T 10: 10,431,281 (GRCm38) probably null Het
Als2 A G 1: 59,211,137 (GRCm38) S483P probably damaging Het
Ankrd10 C T 8: 11,615,682 (GRCm38) R306H probably damaging Het
Arhgef10 A G 8: 14,975,666 (GRCm38) I459V probably benign Het
Arhgef10 T C 8: 14,975,093 (GRCm38) probably null Het
Armc2 C T 10: 41,966,700 (GRCm38) probably null Het
Atp12a A G 14: 56,386,950 (GRCm38) R952G possibly damaging Het
Atp6v1g1 A G 4: 63,550,021 (GRCm38) Y87C probably benign Het
C030034I22Rik T A 17: 69,418,111 (GRCm38) noncoding transcript Het
Cacna2d1 G A 5: 16,312,568 (GRCm38) C404Y probably damaging Het
Ccdc163 T C 4: 116,741,861 (GRCm38) silent Het
Ccdc59 A T 10: 105,841,527 (GRCm38) K9M possibly damaging Het
Cd6 A G 19: 10,794,626 (GRCm38) I307T possibly damaging Het
Cimap1d G A 10: 79,645,653 (GRCm38) T14I probably benign Het
Clasrp C A 7: 19,585,240 (GRCm38) probably benign Het
Csmd2 T C 4: 128,557,718 (GRCm38) F113S unknown Het
Csmd3 C T 15: 47,857,924 (GRCm38) G1437D probably damaging Het
Cyp4a14 C A 4: 115,487,301 (GRCm38) G456W probably damaging Het
Cyp4a30b A G 4: 115,458,362 (GRCm38) H260R possibly damaging Het
Dcp1b C T 6: 119,214,774 (GRCm38) S217L probably benign Het
Dhx57 A T 17: 80,251,376 (GRCm38) D1051E probably benign Het
Dmp1 A G 5: 104,212,108 (GRCm38) S217G probably benign Het
Eif4enif1 C T 11: 3,242,586 (GRCm38) P805S probably damaging Het
Eral1 A G 11: 78,076,278 (GRCm38) I164T possibly damaging Het
Esr1 G A 10: 4,997,890 (GRCm38) R481H probably damaging Het
Fan1 A G 7: 64,363,190 (GRCm38) I668T probably benign Het
Gbp11 C T 5: 105,331,000 (GRCm38) D191N probably benign Het
Gm21759 T A 5: 8,180,863 (GRCm38) probably benign Het
Gm5454 C A 13: 103,357,523 (GRCm38) noncoding transcript Het
Gm9874 A T 17: 30,485,789 (GRCm38) probably benign Het
Gria2 G A 3: 80,702,492 (GRCm38) T670I probably damaging Het
Gria4 T A 9: 4,503,614 (GRCm38) N334I probably damaging Het
Grm5 T C 7: 87,602,722 (GRCm38) V60A possibly damaging Het
Ift172 C T 5: 31,257,861 (GRCm38) V1335I probably benign Het
Ino80d C T 1: 63,061,039 (GRCm38) probably null Het
Kif1c A G 11: 70,724,081 (GRCm38) E567G probably damaging Het
Krt31 T G 11: 100,047,873 (GRCm38) N298T possibly damaging Het
Mapk7 C A 11: 61,490,212 (GRCm38) probably benign Het
Marchf8 C T 6: 116,401,145 (GRCm38) probably benign Het
Matr3 T A 18: 35,572,296 (GRCm38) S91R probably benign Het
Mdm1 A G 10: 118,150,942 (GRCm38) T267A probably benign Het
Mlxip A G 5: 123,452,667 (GRCm38) M878V probably benign Het
Mtm1 T C X: 71,296,362 (GRCm38) probably benign Homo
Mtor T A 4: 148,540,030 (GRCm38) M2089K probably benign Het
Mylk2 A G 2: 152,919,348 (GRCm38) K457R probably damaging Het
Nell1 A T 7: 50,249,657 (GRCm38) probably benign Het
Nomo1 C A 7: 46,046,937 (GRCm38) T293N probably damaging Het
Or10g1 T G 14: 52,410,861 (GRCm38) T4P probably benign Het
Or6c211 A T 10: 129,669,759 (GRCm38) C253* probably null Het
Or8k33 T C 2: 86,553,584 (GRCm38) D180G possibly damaging Het
Ostc T C 3: 130,703,508 (GRCm38) N80S probably damaging Het
Otud4 T A 8: 79,661,073 (GRCm38) N300K possibly damaging Het
Otx1 A G 11: 21,998,681 (GRCm38) probably benign Het
Palmd T C 3: 116,923,751 (GRCm38) R366G possibly damaging Het
Pcdhb20 A T 18: 37,505,780 (GRCm38) Q453L possibly damaging Het
Pcdhga9 T A 18: 37,737,471 (GRCm38) Y118N possibly damaging Het
Pes1 C A 11: 3,976,834 (GRCm38) T372K probably benign Het
Plcl1 A T 1: 55,697,150 (GRCm38) D550V probably benign Het
Plekhg5 T A 4: 152,107,503 (GRCm38) C433S probably benign Het
Plin2 A G 4: 86,668,678 (GRCm38) M1T probably null Het
Pold1 C T 7: 44,543,347 (GRCm38) silent Het
Ppp1r7 T A 1: 93,357,863 (GRCm38) probably null Het
Psmb8 T C 17: 34,200,170 (GRCm38) I146T probably damaging Het
Pzp A T 6: 128,485,556 (GRCm38) probably null Het
Rel T C 11: 23,761,129 (GRCm38) I13V probably benign Het
Reln C T 5: 22,049,791 (GRCm38) V527I possibly damaging Het
Retnla A G 16: 48,843,612 (GRCm38) R90G probably benign Het
Semp2l2b A T 10: 22,067,379 (GRCm38) I234N probably benign Het
Shoc1 A C 4: 59,093,850 (GRCm38) L226R probably damaging Het
Slc39a8 T A 3: 135,886,793 (GRCm38) probably null Het
Slc5a8 A G 10: 88,904,963 (GRCm38) I247V probably benign Het
Son A G 16: 91,664,317 (GRCm38) probably null Het
Spcs2 T C 7: 99,839,761 (GRCm38) D240G probably damaging Het
Stx3 A T 19: 11,789,574 (GRCm38) V91D probably damaging Het
Taf6l A G 19: 8,778,628 (GRCm38) probably benign Het
Tafa2 A T 10: 123,704,365 (GRCm38) H42L possibly damaging Het
Tbc1d8 A G 1: 39,405,317 (GRCm38) F187S probably damaging Het
Thbs1 C G 2: 118,119,378 (GRCm38) N611K probably damaging Het
Tipin A C 9: 64,304,327 (GRCm38) S232R probably benign Het
Tmem132b A G 5: 125,638,268 (GRCm38) D347G probably benign Het
Tmem161a C T 8: 70,178,915 (GRCm38) probably benign Het
Vmn2r68 A C 7: 85,233,626 (GRCm38) M306R probably benign Het
Vwa7 G A 17: 35,021,242 (GRCm38) M395I probably damaging Het
Ybx3 G A 6: 131,370,413 (GRCm38) A253V probably damaging Het
Zfp53 A T 17: 21,508,078 (GRCm38) E124D probably benign Het
Zzz3 T A 3: 152,446,844 (GRCm38) silent Het
Other mutations in St5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00493:St5 APN 7 109,527,708 (GRCm38) missense possibly damaging 0.71
IGL01132:St5 APN 7 109,570,005 (GRCm38) splice site probably null
IGL01288:St5 APN 7 109,539,822 (GRCm38) missense probably damaging 0.96
IGL01645:St5 APN 7 109,527,634 (GRCm38) nonsense probably null
IGL01714:St5 APN 7 109,570,062 (GRCm38) missense probably damaging 0.99
IGL02021:St5 APN 7 109,557,372 (GRCm38) missense probably damaging 1.00
IGL02302:St5 APN 7 109,525,331 (GRCm38) missense probably damaging 1.00
IGL02496:St5 APN 7 109,556,235 (GRCm38) missense possibly damaging 0.83
IGL02795:St5 APN 7 109,556,364 (GRCm38) missense probably damaging 1.00
Bucolic UTSW 7 109,525,548 (GRCm38) nonsense probably null
Halcyon UTSW 7 109,556,793 (GRCm38) nonsense probably null
FR4340:St5 UTSW 7 109,556,921 (GRCm38) unclassified probably benign
FR4737:St5 UTSW 7 109,556,921 (GRCm38) unclassified probably benign
PIT4466001:St5 UTSW 7 109,531,130 (GRCm38) missense probably damaging 1.00
PIT4469001:St5 UTSW 7 109,531,130 (GRCm38) missense probably damaging 1.00
PIT4472001:St5 UTSW 7 109,531,130 (GRCm38) missense probably damaging 1.00
R0024:St5 UTSW 7 109,524,659 (GRCm38) missense probably damaging 1.00
R0124:St5 UTSW 7 109,542,511 (GRCm38) missense possibly damaging 0.66
R0125:St5 UTSW 7 109,556,338 (GRCm38) missense probably benign 0.19
R0365:St5 UTSW 7 109,538,949 (GRCm38) missense probably damaging 1.00
R0491:St5 UTSW 7 109,557,204 (GRCm38) missense probably benign 0.45
R0534:St5 UTSW 7 109,541,428 (GRCm38) missense probably damaging 1.00
R0662:St5 UTSW 7 109,557,426 (GRCm38) missense probably damaging 1.00
R0743:St5 UTSW 7 109,557,345 (GRCm38) missense probably damaging 1.00
R0772:St5 UTSW 7 109,542,320 (GRCm38) splice site probably null
R0774:St5 UTSW 7 109,542,320 (GRCm38) splice site probably null
R0787:St5 UTSW 7 109,525,620 (GRCm38) missense possibly damaging 0.94
R0884:St5 UTSW 7 109,557,345 (GRCm38) missense probably damaging 1.00
R1518:St5 UTSW 7 109,557,355 (GRCm38) missense probably damaging 1.00
R1908:St5 UTSW 7 109,525,326 (GRCm38) nonsense probably null
R1909:St5 UTSW 7 109,525,326 (GRCm38) nonsense probably null
R2232:St5 UTSW 7 109,557,207 (GRCm38) missense probably benign
R2358:St5 UTSW 7 109,556,446 (GRCm38) missense probably benign 0.01
R2847:St5 UTSW 7 109,525,337 (GRCm38) missense probably damaging 1.00
R2869:St5 UTSW 7 109,557,430 (GRCm38) missense probably benign 0.01
R2869:St5 UTSW 7 109,557,430 (GRCm38) missense probably benign 0.01
R2870:St5 UTSW 7 109,557,430 (GRCm38) missense probably benign 0.01
R2871:St5 UTSW 7 109,557,430 (GRCm38) missense probably benign 0.01
R2871:St5 UTSW 7 109,557,430 (GRCm38) missense probably benign 0.01
R2873:St5 UTSW 7 109,557,430 (GRCm38) missense probably benign 0.01
R2874:St5 UTSW 7 109,557,430 (GRCm38) missense probably benign 0.01
R4534:St5 UTSW 7 109,531,156 (GRCm38) missense probably damaging 1.00
R4536:St5 UTSW 7 109,531,156 (GRCm38) missense probably damaging 1.00
R4559:St5 UTSW 7 109,525,578 (GRCm38) missense probably damaging 1.00
R4798:St5 UTSW 7 109,557,033 (GRCm38) missense probably damaging 0.99
R4846:St5 UTSW 7 109,556,836 (GRCm38) nonsense probably null
R5110:St5 UTSW 7 109,542,490 (GRCm38) missense probably benign 0.02
R5181:St5 UTSW 7 109,556,790 (GRCm38) missense probably benign
R5268:St5 UTSW 7 109,557,312 (GRCm38) missense probably benign
R5403:St5 UTSW 7 109,556,905 (GRCm38) missense probably damaging 1.00
R5836:St5 UTSW 7 109,541,345 (GRCm38) missense possibly damaging 0.78
R5932:St5 UTSW 7 109,570,016 (GRCm38) missense probably damaging 1.00
R5937:St5 UTSW 7 109,557,271 (GRCm38) missense possibly damaging 0.86
R6180:St5 UTSW 7 109,556,888 (GRCm38) missense probably benign 0.11
R6741:St5 UTSW 7 109,545,097 (GRCm38) missense possibly damaging 0.95
R6781:St5 UTSW 7 109,525,304 (GRCm38) missense possibly damaging 0.83
R7086:St5 UTSW 7 109,525,574 (GRCm38) missense probably damaging 1.00
R7466:St5 UTSW 7 109,525,346 (GRCm38) missense probably damaging 1.00
R7644:St5 UTSW 7 109,556,793 (GRCm38) nonsense probably null
R8354:St5 UTSW 7 109,525,548 (GRCm38) nonsense probably null
R8745:St5 UTSW 7 109,557,072 (GRCm38) missense probably benign 0.02
R8859:St5 UTSW 7 109,524,656 (GRCm38) missense probably damaging 1.00
R9016:St5 UTSW 7 109,540,435 (GRCm38) missense possibly damaging 0.84
R9178:St5 UTSW 7 109,557,084 (GRCm38) missense probably benign 0.31
R9361:St5 UTSW 7 109,527,784 (GRCm38) missense probably damaging 1.00
R9564:St5 UTSW 7 109,526,329 (GRCm38) missense probably damaging 1.00
R9595:St5 UTSW 7 109,556,766 (GRCm38) missense probably damaging 0.96
RF062:St5 UTSW 7 109,556,946 (GRCm38) unclassified probably benign
X0067:St5 UTSW 7 109,556,240 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGAAGCTGGTAGCCTTGAGG -3'
(R):5'- GCTATTCTTTACTTGAGGACAGCC -3'

Sequencing Primer
(F):5'- CCTTGAGGGTACAAATGGGTG -3'
(R):5'- GTAGCCAGTGATGACCTTGAACTC -3'
Posted On 2015-02-18