Incidental Mutation 'R2870:Arhgef10'
| ID |
266517 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgef10
|
| Ensembl Gene |
ENSMUSG00000071176 |
| Gene Name |
Rho guanine nucleotide exchange factor (GEF) 10 |
| Synonyms |
6430549H08Rik |
| MMRRC Submission |
040458-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R2870 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
14911663-15001085 bp(+) (GRCm38) |
| Type of Mutation |
critical splice donor site (2 bp from exon) |
| DNA Base Change (assembly) |
T to C
at 14975093 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125526
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000084207]
[ENSMUST00000110800]
[ENSMUST00000163062]
|
| AlphaFold |
Q8C033 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000084207
|
| SMART Domains |
Protein: ENSMUSP00000081225
Gene: ENSMUSG00000071176
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
73 |
82 |
N/A |
INTRINSIC |
|
low complexity region
|
155 |
165 |
N/A |
INTRINSIC |
|
low complexity region
|
236 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
247 |
265 |
N/A |
INTRINSIC |
|
coiled coil region
|
308 |
335 |
N/A |
INTRINSIC |
|
RhoGEF
|
401 |
583 |
9.79e-58 |
SMART |
|
Blast:PH
|
617 |
829 |
6e-47 |
BLAST |
|
low complexity region
|
1256 |
1272 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000110800
|
| SMART Domains |
Protein: ENSMUSP00000106424
Gene: ENSMUSG00000071176
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
73 |
82 |
N/A |
INTRINSIC |
|
low complexity region
|
155 |
165 |
N/A |
INTRINSIC |
|
low complexity region
|
236 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
247 |
265 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
291 |
N/A |
INTRINSIC |
|
RhoGEF
|
362 |
544 |
9.79e-58 |
SMART |
|
Blast:PH
|
578 |
790 |
8e-47 |
BLAST |
|
low complexity region
|
1217 |
1233 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000163062
|
| SMART Domains |
Protein: ENSMUSP00000125526
Gene: ENSMUSG00000071176
| Domain | Start | End | E-Value | Type |
|---|
|
RhoGEF
|
73 |
255 |
9.79e-58 |
SMART |
|
Blast:PH
|
289 |
501 |
2e-47 |
BLAST |
|
low complexity region
|
899 |
915 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.9484 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930444G20Rik |
A |
T |
10: 22,067,379 (GRCm38) |
I234N |
probably benign |
Het |
| Actrt3 |
A |
G |
3: 30,599,698 (GRCm38) |
V51A |
probably damaging |
Het |
| Adgb |
C |
T |
10: 10,431,281 (GRCm38) |
|
probably null |
Het |
| AI481877 |
A |
C |
4: 59,093,850 (GRCm38) |
L226R |
probably damaging |
Het |
| Als2 |
A |
G |
1: 59,211,137 (GRCm38) |
S483P |
probably damaging |
Het |
| Ankrd10 |
C |
T |
8: 11,615,682 (GRCm38) |
R306H |
probably damaging |
Het |
| Armc2 |
C |
T |
10: 41,966,700 (GRCm38) |
|
probably null |
Het |
| Atp12a |
A |
G |
14: 56,386,950 (GRCm38) |
R952G |
possibly damaging |
Het |
| Atp6v1g1 |
A |
G |
4: 63,550,021 (GRCm38) |
Y87C |
probably benign |
Het |
| C030034I22Rik |
T |
A |
17: 69,418,111 (GRCm38) |
|
noncoding transcript |
Het |
| Cacna2d1 |
G |
A |
5: 16,312,568 (GRCm38) |
C404Y |
probably damaging |
Het |
| Ccdc163 |
T |
C |
4: 116,741,861 (GRCm38) |
|
silent |
Het |
| Ccdc59 |
A |
T |
10: 105,841,527 (GRCm38) |
K9M |
possibly damaging |
Het |
| Cd6 |
A |
G |
19: 10,794,626 (GRCm38) |
I307T |
possibly damaging |
Het |
| Clasrp |
C |
A |
7: 19,585,240 (GRCm38) |
|
probably benign |
Het |
| Csmd2 |
T |
C |
4: 128,557,718 (GRCm38) |
F113S |
unknown |
Het |
| Csmd3 |
C |
T |
15: 47,857,924 (GRCm38) |
G1437D |
probably damaging |
Het |
| Cyp4a14 |
C |
A |
4: 115,487,301 (GRCm38) |
G456W |
probably damaging |
Het |
| Cyp4a30b |
A |
G |
4: 115,458,362 (GRCm38) |
H260R |
possibly damaging |
Het |
| Dcp1b |
C |
T |
6: 119,214,774 (GRCm38) |
S217L |
probably benign |
Het |
| Dhx57 |
A |
T |
17: 80,251,376 (GRCm38) |
D1051E |
probably benign |
Het |
| Dmp1 |
A |
G |
5: 104,212,108 (GRCm38) |
S217G |
probably benign |
Het |
| Eif4enif1 |
C |
T |
11: 3,242,586 (GRCm38) |
P805S |
probably damaging |
Het |
| Eral1 |
A |
G |
11: 78,076,278 (GRCm38) |
I164T |
possibly damaging |
Het |
| Esr1 |
G |
A |
10: 4,997,890 (GRCm38) |
R481H |
probably damaging |
Het |
| Fam19a2 |
A |
T |
10: 123,704,365 (GRCm38) |
H42L |
possibly damaging |
Het |
| Fan1 |
A |
G |
7: 64,363,190 (GRCm38) |
I668T |
probably benign |
Het |
| Gbp11 |
C |
T |
5: 105,331,000 (GRCm38) |
D191N |
probably benign |
Het |
| Gm21759 |
T |
A |
5: 8,180,863 (GRCm38) |
|
probably benign |
Het |
| Gm5454 |
C |
A |
13: 103,357,523 (GRCm38) |
|
noncoding transcript |
Het |
| Gm9874 |
A |
T |
17: 30,485,789 (GRCm38) |
|
probably benign |
Het |
| Gria2 |
G |
A |
3: 80,702,492 (GRCm38) |
T670I |
probably damaging |
Het |
| Gria4 |
T |
A |
9: 4,503,614 (GRCm38) |
N334I |
probably damaging |
Het |
| Grm5 |
T |
C |
7: 87,602,722 (GRCm38) |
V60A |
possibly damaging |
Het |
| Ift172 |
C |
T |
5: 31,257,861 (GRCm38) |
V1335I |
probably benign |
Het |
| Ino80d |
C |
T |
1: 63,061,039 (GRCm38) |
|
probably null |
Het |
| Kif1c |
A |
G |
11: 70,724,081 (GRCm38) |
E567G |
probably damaging |
Het |
| Krt31 |
T |
G |
11: 100,047,873 (GRCm38) |
N298T |
possibly damaging |
Het |
| Mapk7 |
C |
A |
11: 61,490,212 (GRCm38) |
|
probably benign |
Het |
| March8 |
C |
T |
6: 116,401,145 (GRCm38) |
|
probably benign |
Het |
| Matr3 |
T |
A |
18: 35,572,296 (GRCm38) |
S91R |
probably benign |
Het |
| Mdm1 |
A |
G |
10: 118,150,942 (GRCm38) |
T267A |
probably benign |
Het |
| Mlxip |
A |
G |
5: 123,452,667 (GRCm38) |
M878V |
probably benign |
Het |
| Mtm1 |
T |
C |
X: 71,296,362 (GRCm38) |
|
probably benign |
Homo |
| Mtor |
T |
A |
4: 148,540,030 (GRCm38) |
M2089K |
probably benign |
Het |
| Mylk2 |
A |
G |
2: 152,919,348 (GRCm38) |
K457R |
probably damaging |
Het |
| Nell1 |
A |
T |
7: 50,249,657 (GRCm38) |
|
probably benign |
Het |
| Nomo1 |
C |
A |
7: 46,046,937 (GRCm38) |
T293N |
probably damaging |
Het |
| Odf3l2 |
G |
A |
10: 79,645,653 (GRCm38) |
T14I |
probably benign |
Het |
| Olfr1080 |
T |
C |
2: 86,553,584 (GRCm38) |
D180G |
possibly damaging |
Het |
| Olfr1510 |
T |
G |
14: 52,410,861 (GRCm38) |
T4P |
probably benign |
Het |
| Olfr801 |
A |
T |
10: 129,669,759 (GRCm38) |
C253* |
probably null |
Het |
| Ostc |
T |
C |
3: 130,703,508 (GRCm38) |
N80S |
probably damaging |
Het |
| Otud4 |
T |
A |
8: 79,661,073 (GRCm38) |
N300K |
possibly damaging |
Het |
| Otx1 |
A |
G |
11: 21,998,681 (GRCm38) |
|
probably benign |
Het |
| Palmd |
T |
C |
3: 116,923,751 (GRCm38) |
R366G |
possibly damaging |
Het |
| Pcdhb20 |
A |
T |
18: 37,505,780 (GRCm38) |
Q453L |
possibly damaging |
Het |
| Pcdhga9 |
T |
A |
18: 37,737,471 (GRCm38) |
Y118N |
possibly damaging |
Het |
| Pes1 |
C |
A |
11: 3,976,834 (GRCm38) |
T372K |
probably benign |
Het |
| Plcl1 |
A |
T |
1: 55,697,150 (GRCm38) |
D550V |
probably benign |
Het |
| Plekhg5 |
T |
A |
4: 152,107,503 (GRCm38) |
C433S |
probably benign |
Het |
| Plin2 |
A |
G |
4: 86,668,678 (GRCm38) |
M1T |
probably null |
Het |
| Pold1 |
C |
T |
7: 44,543,347 (GRCm38) |
|
silent |
Het |
| Ppp1r7 |
T |
A |
1: 93,357,863 (GRCm38) |
|
probably null |
Het |
| Psmb8 |
T |
C |
17: 34,200,170 (GRCm38) |
I146T |
probably damaging |
Het |
| Pzp |
A |
T |
6: 128,485,556 (GRCm38) |
|
probably null |
Het |
| Rel |
T |
C |
11: 23,761,129 (GRCm38) |
I13V |
probably benign |
Het |
| Reln |
C |
T |
5: 22,049,791 (GRCm38) |
V527I |
possibly damaging |
Het |
| Retnla |
A |
G |
16: 48,843,612 (GRCm38) |
R90G |
probably benign |
Het |
| Slc39a8 |
T |
A |
3: 135,886,793 (GRCm38) |
|
probably null |
Het |
| Slc5a8 |
A |
G |
10: 88,904,963 (GRCm38) |
I247V |
probably benign |
Het |
| Son |
A |
G |
16: 91,664,317 (GRCm38) |
|
probably null |
Het |
| Spcs2 |
T |
C |
7: 99,839,761 (GRCm38) |
D240G |
probably damaging |
Het |
| St5 |
A |
T |
7: 109,557,430 (GRCm38) |
Y38N |
probably benign |
Het |
| Stx3 |
A |
T |
19: 11,789,574 (GRCm38) |
V91D |
probably damaging |
Het |
| Taf6l |
A |
G |
19: 8,778,628 (GRCm38) |
|
probably benign |
Het |
| Tbc1d8 |
A |
G |
1: 39,405,317 (GRCm38) |
F187S |
probably damaging |
Het |
| Thbs1 |
C |
G |
2: 118,119,378 (GRCm38) |
N611K |
probably damaging |
Het |
| Tipin |
A |
C |
9: 64,304,327 (GRCm38) |
S232R |
probably benign |
Het |
| Tmem132b |
A |
G |
5: 125,638,268 (GRCm38) |
D347G |
probably benign |
Het |
| Tmem161a |
C |
T |
8: 70,178,915 (GRCm38) |
|
probably benign |
Het |
| Vmn2r68 |
A |
C |
7: 85,233,626 (GRCm38) |
M306R |
probably benign |
Het |
| Vwa7 |
G |
A |
17: 35,021,242 (GRCm38) |
M395I |
probably damaging |
Het |
| Ybx3 |
G |
A |
6: 131,370,413 (GRCm38) |
A253V |
probably damaging |
Het |
| Zfp53 |
A |
T |
17: 21,508,078 (GRCm38) |
E124D |
probably benign |
Het |
| Zzz3 |
T |
A |
3: 152,446,844 (GRCm38) |
|
silent |
Het |
|
| Other mutations in Arhgef10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00766:Arhgef10
|
APN |
8 |
14,975,006 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00823:Arhgef10
|
APN |
8 |
14,940,378 (GRCm38) |
unclassified |
probably benign |
|
|
IGL01012:Arhgef10
|
APN |
8 |
14,979,977 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01311:Arhgef10
|
APN |
8 |
14,991,054 (GRCm38) |
splice site |
probably null |
|
|
IGL01596:Arhgef10
|
APN |
8 |
14,999,468 (GRCm38) |
nonsense |
probably null |
|
|
IGL01888:Arhgef10
|
APN |
8 |
14,962,577 (GRCm38) |
nonsense |
probably null |
|
|
IGL01938:Arhgef10
|
APN |
8 |
14,991,062 (GRCm38) |
missense |
probably benign |
0.09 |
|
IGL02151:Arhgef10
|
APN |
8 |
14,928,889 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
IGL02274:Arhgef10
|
APN |
8 |
14,947,205 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02369:Arhgef10
|
APN |
8 |
14,997,551 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02411:Arhgef10
|
APN |
8 |
14,954,819 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02500:Arhgef10
|
APN |
8 |
14,961,238 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02597:Arhgef10
|
APN |
8 |
14,930,198 (GRCm38) |
missense |
probably benign |
0.27 |
|
IGL02602:Arhgef10
|
APN |
8 |
14,930,198 (GRCm38) |
missense |
probably benign |
0.27 |
|
IGL02743:Arhgef10
|
APN |
8 |
14,930,198 (GRCm38) |
missense |
probably benign |
0.27 |
|
IGL02744:Arhgef10
|
APN |
8 |
14,930,198 (GRCm38) |
missense |
probably benign |
0.27 |
|
IGL03113:Arhgef10
|
APN |
8 |
14,954,505 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03248:Arhgef10
|
APN |
8 |
14,928,847 (GRCm38) |
missense |
probably benign |
0.00 |
|
P0028:Arhgef10
|
UTSW |
8 |
14,928,925 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
P4748:Arhgef10
|
UTSW |
8 |
14,928,925 (GRCm38) |
missense |
possibly damaging |
0.79 |
|
R0049:Arhgef10
|
UTSW |
8 |
14,954,446 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0197:Arhgef10
|
UTSW |
8 |
14,962,636 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0479:Arhgef10
|
UTSW |
8 |
14,991,070 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0701:Arhgef10
|
UTSW |
8 |
14,962,636 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0966:Arhgef10
|
UTSW |
8 |
14,940,343 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1367:Arhgef10
|
UTSW |
8 |
14,940,225 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1572:Arhgef10
|
UTSW |
8 |
14,991,211 (GRCm38) |
missense |
possibly damaging |
0.53 |
|
R1631:Arhgef10
|
UTSW |
8 |
14,947,157 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1766:Arhgef10
|
UTSW |
8 |
14,979,836 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1920:Arhgef10
|
UTSW |
8 |
14,956,987 (GRCm38) |
splice site |
probably benign |
|
|
R2051:Arhgef10
|
UTSW |
8 |
14,945,320 (GRCm38) |
missense |
probably null |
1.00 |
|
R2088:Arhgef10
|
UTSW |
8 |
14,983,898 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R2118:Arhgef10
|
UTSW |
8 |
14,934,820 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2120:Arhgef10
|
UTSW |
8 |
14,934,820 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2121:Arhgef10
|
UTSW |
8 |
14,934,820 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2122:Arhgef10
|
UTSW |
8 |
14,934,820 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2124:Arhgef10
|
UTSW |
8 |
14,934,820 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2318:Arhgef10
|
UTSW |
8 |
14,928,855 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2870:Arhgef10
|
UTSW |
8 |
14,975,666 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2870:Arhgef10
|
UTSW |
8 |
14,975,666 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2870:Arhgef10
|
UTSW |
8 |
14,975,093 (GRCm38) |
critical splice donor site |
probably null |
|
|
R2872:Arhgef10
|
UTSW |
8 |
14,975,666 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2872:Arhgef10
|
UTSW |
8 |
14,975,666 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2872:Arhgef10
|
UTSW |
8 |
14,975,093 (GRCm38) |
critical splice donor site |
probably null |
|
|
R2872:Arhgef10
|
UTSW |
8 |
14,975,093 (GRCm38) |
critical splice donor site |
probably null |
|
|
R2874:Arhgef10
|
UTSW |
8 |
14,975,666 (GRCm38) |
missense |
probably benign |
0.01 |
|
R2874:Arhgef10
|
UTSW |
8 |
14,975,093 (GRCm38) |
critical splice donor site |
probably null |
|
|
R3522:Arhgef10
|
UTSW |
8 |
14,954,918 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4049:Arhgef10
|
UTSW |
8 |
14,979,998 (GRCm38) |
missense |
probably benign |
0.05 |
|
R4324:Arhgef10
|
UTSW |
8 |
14,940,335 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R4351:Arhgef10
|
UTSW |
8 |
14,991,145 (GRCm38) |
nonsense |
probably null |
|
|
R4384:Arhgef10
|
UTSW |
8 |
14,930,157 (GRCm38) |
nonsense |
probably null |
|
|
R4385:Arhgef10
|
UTSW |
8 |
14,930,157 (GRCm38) |
nonsense |
probably null |
|
|
R4685:Arhgef10
|
UTSW |
8 |
14,956,963 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5111:Arhgef10
|
UTSW |
8 |
14,932,408 (GRCm38) |
missense |
probably benign |
0.00 |
|
R5169:Arhgef10
|
UTSW |
8 |
14,930,051 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R5670:Arhgef10
|
UTSW |
8 |
14,954,774 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5945:Arhgef10
|
UTSW |
8 |
14,980,028 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6593:Arhgef10
|
UTSW |
8 |
14,962,564 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R6593:Arhgef10
|
UTSW |
8 |
14,962,522 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6734:Arhgef10
|
UTSW |
8 |
14,975,053 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6859:Arhgef10
|
UTSW |
8 |
14,975,005 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6890:Arhgef10
|
UTSW |
8 |
14,928,786 (GRCm38) |
missense |
probably benign |
0.27 |
|
R7068:Arhgef10
|
UTSW |
8 |
14,958,639 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7081:Arhgef10
|
UTSW |
8 |
14,997,547 (GRCm38) |
nonsense |
probably null |
|
|
R7157:Arhgef10
|
UTSW |
8 |
14,930,030 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7232:Arhgef10
|
UTSW |
8 |
14,940,323 (GRCm38) |
missense |
probably benign |
0.10 |
|
R7514:Arhgef10
|
UTSW |
8 |
14,975,956 (GRCm38) |
missense |
probably benign |
0.16 |
|
R7544:Arhgef10
|
UTSW |
8 |
14,979,854 (GRCm38) |
missense |
probably benign |
0.34 |
|
R7657:Arhgef10
|
UTSW |
8 |
14,979,893 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7736:Arhgef10
|
UTSW |
8 |
14,980,583 (GRCm38) |
nonsense |
probably null |
|
|
R7777:Arhgef10
|
UTSW |
8 |
14,945,373 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8000:Arhgef10
|
UTSW |
8 |
14,930,054 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8060:Arhgef10
|
UTSW |
8 |
14,954,446 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8441:Arhgef10
|
UTSW |
8 |
14,991,237 (GRCm38) |
splice site |
probably benign |
|
|
R8545:Arhgef10
|
UTSW |
8 |
14,975,931 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R8545:Arhgef10
|
UTSW |
8 |
14,928,868 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8702:Arhgef10
|
UTSW |
8 |
14,942,638 (GRCm38) |
missense |
probably benign |
|
|
R8846:Arhgef10
|
UTSW |
8 |
14,975,956 (GRCm38) |
missense |
probably benign |
0.16 |
|
R8854:Arhgef10
|
UTSW |
8 |
14,979,798 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R9076:Arhgef10
|
UTSW |
8 |
14,974,993 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9384:Arhgef10
|
UTSW |
8 |
14,991,067 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9479:Arhgef10
|
UTSW |
8 |
14,997,632 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9799:Arhgef10
|
UTSW |
8 |
14,940,268 (GRCm38) |
missense |
probably damaging |
0.99 |
|
X0024:Arhgef10
|
UTSW |
8 |
14,978,486 (GRCm38) |
missense |
probably benign |
0.01 |
|
X0027:Arhgef10
|
UTSW |
8 |
14,997,631 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
Z1088:Arhgef10
|
UTSW |
8 |
14,964,191 (GRCm38) |
missense |
probably benign |
0.01 |
|
| Predicted Primers |
PCR Primer
(F):5'- AATGTATTTCGGTGCCGCCC -3'
(R):5'- CTGGGGACTAATCACACAGAGAC -3'
Sequencing Primer
(F):5'- CCAGGCAGGGTACAGTAAGC -3'
(R):5'- GAGACATAAAATCCAAGCTCAAGTG -3'
|
| Posted On |
2015-02-18 |
Incidental Mutation