Incidental Mutation 'IGL00929:Cdk18'
ID26655
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Cdk18
Ensembl Gene ENSMUSG00000026437
Gene Namecyclin-dependent kinase 18
SynonymsPctk3
Accession Numbers
Is this an essential gene? Possibly non essential (E-score: 0.418) question?
Stock #IGL00929
Quality Score
Status
Chromosome1
Chromosomal Location132112237-132139684 bp(-) (GRCm38)
Type of Mutationcritical splice donor site (2 bp from exon)
DNA Base Change (assembly) A to G at 132118519 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000107981 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027697] [ENSMUST00000112362] [ENSMUST00000185601]
Predicted Effect probably null
Transcript: ENSMUST00000027697
SMART Domains Protein: ENSMUSP00000027697
Gene: ENSMUSG00000026437

DomainStartEndE-ValueType
S_TKc 121 402 1.13e-95 SMART
Predicted Effect probably null
Transcript: ENSMUST00000112362
SMART Domains Protein: ENSMUSP00000107981
Gene: ENSMUSG00000026437

DomainStartEndE-ValueType
S_TKc 121 402 1.13e-95 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000185601
SMART Domains Protein: ENSMUSP00000140034
Gene: ENSMUSG00000026437

DomainStartEndE-ValueType
Blast:S_TKc 1 34 6e-15 BLAST
PDB:3MTL|A 1 34 2e-8 PDB
Predicted Effect noncoding transcript
Transcript: ENSMUST00000188387
Predicted Effect noncoding transcript
Transcript: ENSMUST00000189733
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 27 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acp1 A T 12: 30,904,900 H67Q probably damaging Het
Ankrd13b A G 11: 77,472,752 S247P probably damaging Het
Aqp4 C T 18: 15,393,599 G275E probably benign Het
Arhgef15 A T 11: 68,954,102 L223Q probably damaging Het
Asb13 A G 13: 3,649,427 Y209C probably damaging Het
Cntnap5a G A 1: 116,060,274 probably null Het
Cops6 A G 5: 138,161,386 M1V probably null Het
Dab2ip A T 2: 35,708,877 M137L possibly damaging Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Lemd1 A G 1: 132,256,709 D73G probably benign Het
Lpin1 G A 12: 16,573,699 S228L probably benign Het
Mtmr9 A G 14: 63,543,497 L48P probably damaging Het
Ncoa3 T A 2: 166,051,609 probably null Het
Ndc1 T A 4: 107,389,497 N372K probably benign Het
Ndufa2 A G 18: 36,744,175 probably benign Het
Nmt1 A T 11: 103,060,076 probably null Het
Olfr593 A T 7: 103,212,685 H264L probably damaging Het
Pcdhgb6 T C 18: 37,743,705 Y489H probably damaging Het
Rttn A T 18: 89,028,935 K907M probably damaging Het
Soga3 C A 10: 29,148,292 N401K probably damaging Het
Sos1 T C 17: 80,408,596 Y979C probably damaging Het
Spag6l C T 16: 16,767,013 A424T possibly damaging Het
Stt3b A T 9: 115,266,165 I266N probably damaging Het
Tet3 A G 6: 83,368,655 L1600P probably benign Het
Tiam1 T A 16: 89,794,739 I1358F probably damaging Het
Usp37 G T 1: 74,490,154 T122N probably benign Het
Vit T C 17: 78,579,401 S153P probably damaging Het
Other mutations in Cdk18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00519:Cdk18 APN 1 132115488 missense probably benign 0.36
R0184:Cdk18 UTSW 1 132118538 missense probably benign 0.00
R0606:Cdk18 UTSW 1 132117617 unclassified probably benign
R0624:Cdk18 UTSW 1 132118872 missense probably damaging 1.00
R1295:Cdk18 UTSW 1 132119960 unclassified probably benign
R1296:Cdk18 UTSW 1 132119960 unclassified probably benign
R1298:Cdk18 UTSW 1 132122451 start gained probably benign
R1611:Cdk18 UTSW 1 132122375 missense probably damaging 1.00
R1959:Cdk18 UTSW 1 132117821 missense possibly damaging 0.95
R2184:Cdk18 UTSW 1 132115952 missense probably damaging 1.00
R2279:Cdk18 UTSW 1 132115952 missense probably damaging 1.00
R2391:Cdk18 UTSW 1 132115474 missense probably benign
R4601:Cdk18 UTSW 1 132116919 missense possibly damaging 0.95
R5001:Cdk18 UTSW 1 132118849 critical splice donor site probably null
R5208:Cdk18 UTSW 1 132117480 critical splice donor site probably null
R5818:Cdk18 UTSW 1 132119098 critical splice donor site probably null
R6282:Cdk18 UTSW 1 132120020 missense probably damaging 1.00
R6546:Cdk18 UTSW 1 132122350 missense probably damaging 0.99
R6644:Cdk18 UTSW 1 132122069 nonsense probably null
R6892:Cdk18 UTSW 1 132122110 missense probably benign 0.01
R6965:Cdk18 UTSW 1 132117581 missense probably damaging 0.98
R7698:Cdk18 UTSW 1 132122378 missense probably damaging 1.00
Posted On2013-04-17