Incidental Mutation 'R2871:Armc2'
ID 266597
Institutional Source Beutler Lab
Gene Symbol Armc2
Ensembl Gene ENSMUSG00000071324
Gene Name armadillo repeat containing 2
Synonyms 2610018I05Rik
MMRRC Submission 040459-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R2871 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 41790986-41894438 bp(-) (GRCm39)
Type of Mutation critical splice donor site (1 bp from exon)
DNA Base Change (assembly) C to T at 41842696 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000125412 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095729] [ENSMUST00000095729] [ENSMUST00000160262] [ENSMUST00000160262] [ENSMUST00000161927]
AlphaFold Q3URY6
Predicted Effect probably null
Transcript: ENSMUST00000095729
SMART Domains Protein: ENSMUSP00000093397
Gene: ENSMUSG00000071324

DomainStartEndE-ValueType
low complexity region 58 73 N/A INTRINSIC
low complexity region 222 237 N/A INTRINSIC
low complexity region 272 281 N/A INTRINSIC
low complexity region 324 336 N/A INTRINSIC
ARM 355 393 7.53e1 SMART
ARM 400 453 3.69e1 SMART
ARM 454 496 8.23e1 SMART
Blast:ARM 497 540 1e-16 BLAST
Blast:ARM 542 603 1e-6 BLAST
Blast:ARM 603 649 7e-20 BLAST
Blast:ARM 653 692 3e-8 BLAST
ARM 693 733 4.41e1 SMART
ARM 734 777 2.7e-1 SMART
Predicted Effect probably null
Transcript: ENSMUST00000095729
SMART Domains Protein: ENSMUSP00000093397
Gene: ENSMUSG00000071324

DomainStartEndE-ValueType
low complexity region 58 73 N/A INTRINSIC
low complexity region 222 237 N/A INTRINSIC
low complexity region 272 281 N/A INTRINSIC
low complexity region 324 336 N/A INTRINSIC
ARM 355 393 7.53e1 SMART
ARM 400 453 3.69e1 SMART
ARM 454 496 8.23e1 SMART
Blast:ARM 497 540 1e-16 BLAST
Blast:ARM 542 603 1e-6 BLAST
Blast:ARM 603 649 7e-20 BLAST
Blast:ARM 653 692 3e-8 BLAST
ARM 693 733 4.41e1 SMART
ARM 734 777 2.7e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000105503
Predicted Effect probably null
Transcript: ENSMUST00000160262
SMART Domains Protein: ENSMUSP00000125412
Gene: ENSMUSG00000071324

DomainStartEndE-ValueType
low complexity region 58 73 N/A INTRINSIC
low complexity region 222 237 N/A INTRINSIC
low complexity region 272 281 N/A INTRINSIC
low complexity region 324 336 N/A INTRINSIC
ARM 355 393 7.53e1 SMART
ARM 400 453 3.69e1 SMART
ARM 454 496 8.23e1 SMART
Blast:ARM 497 540 1e-16 BLAST
Blast:ARM 542 603 1e-6 BLAST
Blast:ARM 603 649 7e-20 BLAST
Blast:ARM 653 692 3e-8 BLAST
ARM 693 733 4.41e1 SMART
ARM 734 777 2.7e-1 SMART
Predicted Effect probably null
Transcript: ENSMUST00000160262
SMART Domains Protein: ENSMUSP00000125412
Gene: ENSMUSG00000071324

DomainStartEndE-ValueType
low complexity region 58 73 N/A INTRINSIC
low complexity region 222 237 N/A INTRINSIC
low complexity region 272 281 N/A INTRINSIC
low complexity region 324 336 N/A INTRINSIC
ARM 355 393 7.53e1 SMART
ARM 400 453 3.69e1 SMART
ARM 454 496 8.23e1 SMART
Blast:ARM 497 540 1e-16 BLAST
Blast:ARM 542 603 1e-6 BLAST
Blast:ARM 603 649 7e-20 BLAST
Blast:ARM 653 692 3e-8 BLAST
ARM 693 733 4.41e1 SMART
ARM 734 777 2.7e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000160367
Predicted Effect probably benign
Transcript: ENSMUST00000161927
SMART Domains Protein: ENSMUSP00000124049
Gene: ENSMUSG00000071324

DomainStartEndE-ValueType
low complexity region 58 75 N/A INTRINSIC
Meta Mutation Damage Score 0.9487 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.1%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b A G 11: 109,846,002 (GRCm39) C811R possibly damaging Het
Akap8l G A 17: 32,557,416 (GRCm39) T65I possibly damaging Het
Amdhd2 A G 17: 24,376,829 (GRCm39) probably benign Het
Arid4a T A 12: 71,069,034 (GRCm39) probably null Het
Atp6v1g1 A G 4: 63,468,258 (GRCm39) Y87C probably benign Het
C030034I22Rik T A 17: 69,725,106 (GRCm39) noncoding transcript Het
Ccnb1-ps C A 7: 41,755,499 (GRCm39) noncoding transcript Het
Cfap54 A T 10: 92,757,281 (GRCm39) F273I possibly damaging Het
Clasrp C A 7: 19,319,165 (GRCm39) probably benign Het
Csmd2 T C 4: 128,451,511 (GRCm39) F113S unknown Het
Cyp4a14 C A 4: 115,344,498 (GRCm39) G456W probably damaging Het
Cyp4a30b A G 4: 115,315,559 (GRCm39) H260R possibly damaging Het
Dennd2b A T 7: 109,156,637 (GRCm39) Y38N probably benign Het
Dhx57 A T 17: 80,558,805 (GRCm39) D1051E probably benign Het
Eif4enif1 C T 11: 3,192,586 (GRCm39) P805S probably damaging Het
Eml5 C T 12: 98,831,660 (GRCm39) D433N probably damaging Het
Fan1 A G 7: 64,012,938 (GRCm39) I668T probably benign Het
Frmpd4 A T X: 166,260,243 (GRCm39) D1166E probably benign Homo
Ftdc1 A T 16: 58,434,342 (GRCm39) I125K probably benign Het
Gm21759 T A 5: 8,230,863 (GRCm39) probably benign Het
Gm5454 C A 13: 103,494,031 (GRCm39) noncoding transcript Het
Gm9874 A T 17: 30,704,763 (GRCm39) probably benign Het
Gria2 G A 3: 80,609,799 (GRCm39) T670I probably damaging Het
Grid2ip C A 5: 143,343,684 (GRCm39) Q127K probably benign Het
Habp2 T A 19: 56,276,423 (GRCm39) probably benign Het
Hdhd2 T C 18: 77,042,702 (GRCm39) F44L probably damaging Het
Hmcn1 A T 1: 150,614,467 (GRCm39) V1313D possibly damaging Het
Ift172 C T 5: 31,415,205 (GRCm39) V1335I probably benign Het
Ighv2-2 G A 12: 113,552,118 (GRCm39) T40I possibly damaging Het
Kcnk10 T A 12: 98,401,072 (GRCm39) R520S probably benign Het
Kif1c A G 11: 70,614,907 (GRCm39) E567G probably damaging Het
Klf8 A T X: 152,165,678 (GRCm39) E82D probably damaging Homo
Kpna7 T C 5: 144,930,745 (GRCm39) T367A probably benign Het
Lpo A G 11: 87,707,350 (GRCm39) I221T possibly damaging Het
Lrrn3 T C 12: 41,502,722 (GRCm39) I532V probably benign Het
Mapk7 C A 11: 61,381,038 (GRCm39) probably benign Het
Matr3 T A 18: 35,705,349 (GRCm39) S91R probably benign Het
Mki67 G A 7: 135,309,878 (GRCm39) P191L probably benign Het
Mlxip A G 5: 123,590,730 (GRCm39) M878V probably benign Het
Mpp7 G A 18: 7,461,678 (GRCm39) P65L possibly damaging Het
Msh2 C A 17: 87,993,012 (GRCm39) Q314K possibly damaging Het
Mtm1 T C X: 70,339,968 (GRCm39) probably benign Homo
Mtor T A 4: 148,624,487 (GRCm39) M2089K probably benign Het
Myo9b G A 8: 71,786,981 (GRCm39) R721Q probably benign Het
Nav1 A G 1: 135,388,495 (GRCm39) silent Het
Nell1 A T 7: 49,899,405 (GRCm39) probably benign Het
Nlrp4b C T 7: 10,444,170 (GRCm39) Q40* probably null Het
Nomo1 C A 7: 45,696,361 (GRCm39) T293N probably damaging Het
Notum A G 11: 120,551,022 (GRCm39) V48A probably benign Het
Npas3 C T 12: 54,114,796 (GRCm39) R542* probably null Het
Or10z1 T C 1: 174,078,092 (GRCm39) S134G probably benign Het
Or13a17 A G 7: 140,271,198 (GRCm39) I127V possibly damaging Het
Or13j1 C A 4: 43,706,458 (GRCm39) V37L probably benign Het
Or5t16 A T 2: 86,819,192 (GRCm39) C109* probably null Het
Ostc T C 3: 130,497,157 (GRCm39) N80S probably damaging Het
Palmd T C 3: 116,717,400 (GRCm39) R366G possibly damaging Het
Parp1 A G 1: 180,401,230 (GRCm39) D45G probably damaging Het
Pcdhga9 T A 18: 37,870,524 (GRCm39) Y118N possibly damaging Het
Pcnx3 A T 19: 5,733,774 (GRCm39) probably benign Het
Pes1 C A 11: 3,926,834 (GRCm39) T372K probably benign Het
Pkp4 C A 2: 59,138,500 (GRCm39) T250K probably benign Het
Plekhg5 T A 4: 152,191,960 (GRCm39) C433S probably benign Het
Plin2 A G 4: 86,586,915 (GRCm39) M1T probably null Het
Prdx4 A G X: 154,123,460 (GRCm39) V15A probably benign Homo
Psmb8 T C 17: 34,419,144 (GRCm39) I146T probably damaging Het
Psmd13 A T 7: 140,466,968 (GRCm39) T116S probably damaging Het
Rel T C 11: 23,711,129 (GRCm39) I13V probably benign Het
Reln C T 5: 22,254,789 (GRCm39) V527I possibly damaging Het
Rnf6 T C 5: 146,147,215 (GRCm39) Y601C probably benign Het
Rps6kc1 T C 1: 190,631,766 (GRCm39) I48M probably damaging Het
Shoc1 A C 4: 59,093,850 (GRCm39) L226R probably damaging Het
Slc39a8 T A 3: 135,592,554 (GRCm39) probably null Het
Son A G 16: 91,461,205 (GRCm39) probably null Het
Sppl2c C T 11: 104,078,141 (GRCm39) P314S probably benign Het
Tnni3k C T 3: 154,644,387 (GRCm39) probably null Het
Vmn2r68 A C 7: 84,882,834 (GRCm39) M306R probably benign Het
Vmn2r70 T A 7: 85,208,227 (GRCm39) Y750F probably damaging Het
Vwa7 G A 17: 35,240,218 (GRCm39) M395I probably damaging Het
Zfp53 A T 17: 21,728,340 (GRCm39) E124D probably benign Het
Zzz3 T A 3: 152,152,481 (GRCm39) silent Het
Other mutations in Armc2
AlleleSourceChrCoordTypePredicted EffectPPH Score
PIT4131001:Armc2 UTSW 10 41,823,883 (GRCm39) splice site probably benign
R0144:Armc2 UTSW 10 41,823,883 (GRCm39) splice site probably benign
R0427:Armc2 UTSW 10 41,876,406 (GRCm39) missense possibly damaging 0.87
R0540:Armc2 UTSW 10 41,798,691 (GRCm39) missense probably benign 0.11
R0561:Armc2 UTSW 10 41,869,188 (GRCm39) missense probably benign 0.02
R0607:Armc2 UTSW 10 41,798,691 (GRCm39) missense probably benign 0.11
R1099:Armc2 UTSW 10 41,793,183 (GRCm39) missense probably benign 0.39
R1130:Armc2 UTSW 10 41,887,830 (GRCm39) missense possibly damaging 0.85
R2116:Armc2 UTSW 10 41,839,663 (GRCm39) missense probably damaging 0.98
R2870:Armc2 UTSW 10 41,842,696 (GRCm39) critical splice donor site probably null
R2870:Armc2 UTSW 10 41,842,696 (GRCm39) critical splice donor site probably null
R2871:Armc2 UTSW 10 41,842,696 (GRCm39) critical splice donor site probably null
R2872:Armc2 UTSW 10 41,842,696 (GRCm39) critical splice donor site probably null
R2872:Armc2 UTSW 10 41,842,696 (GRCm39) critical splice donor site probably null
R2873:Armc2 UTSW 10 41,842,696 (GRCm39) critical splice donor site probably null
R3083:Armc2 UTSW 10 41,842,726 (GRCm39) missense probably damaging 1.00
R3771:Armc2 UTSW 10 41,798,223 (GRCm39) missense probably damaging 1.00
R3784:Armc2 UTSW 10 41,798,190 (GRCm39) missense probably benign 0.08
R3880:Armc2 UTSW 10 41,839,721 (GRCm39) missense possibly damaging 0.71
R4024:Armc2 UTSW 10 41,869,054 (GRCm39) missense probably benign
R4155:Armc2 UTSW 10 41,887,863 (GRCm39) missense probably damaging 0.96
R4370:Armc2 UTSW 10 41,793,196 (GRCm39) missense probably benign 0.13
R4378:Armc2 UTSW 10 41,869,078 (GRCm39) missense possibly damaging 0.66
R4896:Armc2 UTSW 10 41,799,790 (GRCm39) missense probably damaging 1.00
R5119:Armc2 UTSW 10 41,798,144 (GRCm39) missense probably damaging 1.00
R5159:Armc2 UTSW 10 41,884,711 (GRCm39) missense probably damaging 0.96
R5517:Armc2 UTSW 10 41,839,846 (GRCm39) missense probably benign 0.29
R5640:Armc2 UTSW 10 41,887,894 (GRCm39) missense possibly damaging 0.87
R5767:Armc2 UTSW 10 41,887,923 (GRCm39) missense probably benign 0.02
R5965:Armc2 UTSW 10 41,798,568 (GRCm39) missense possibly damaging 0.94
R6897:Armc2 UTSW 10 41,869,225 (GRCm39) critical splice acceptor site probably null
R7233:Armc2 UTSW 10 41,799,800 (GRCm39) missense probably damaging 1.00
R7829:Armc2 UTSW 10 41,802,856 (GRCm39) missense probably benign
R7832:Armc2 UTSW 10 41,842,792 (GRCm39) missense probably damaging 1.00
R7999:Armc2 UTSW 10 41,887,954 (GRCm39) missense possibly damaging 0.62
R8029:Armc2 UTSW 10 41,802,996 (GRCm39) missense probably damaging 1.00
R8030:Armc2 UTSW 10 41,842,738 (GRCm39) missense possibly damaging 0.73
R8033:Armc2 UTSW 10 41,884,680 (GRCm39) missense possibly damaging 0.87
R8191:Armc2 UTSW 10 41,839,747 (GRCm39) missense probably benign 0.29
R8304:Armc2 UTSW 10 41,823,935 (GRCm39) missense probably damaging 1.00
R8334:Armc2 UTSW 10 41,799,761 (GRCm39) missense probably damaging 1.00
R8370:Armc2 UTSW 10 41,799,833 (GRCm39) missense possibly damaging 0.96
R9142:Armc2 UTSW 10 41,851,404 (GRCm39) missense probably benign 0.00
R9227:Armc2 UTSW 10 41,823,935 (GRCm39) missense probably damaging 1.00
R9230:Armc2 UTSW 10 41,823,935 (GRCm39) missense probably damaging 1.00
R9320:Armc2 UTSW 10 41,839,774 (GRCm39) missense possibly damaging 0.85
R9708:Armc2 UTSW 10 41,839,744 (GRCm39) missense possibly damaging 0.87
R9743:Armc2 UTSW 10 41,798,598 (GRCm39) missense probably benign 0.25
R9746:Armc2 UTSW 10 41,800,457 (GRCm39) missense probably damaging 1.00
Z1176:Armc2 UTSW 10 41,839,652 (GRCm39) missense probably damaging 1.00
Z1176:Armc2 UTSW 10 41,803,040 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GTCATTAGGTCCCACCACATC -3'
(R):5'- CCTGAGTGTGGAGGTCTTCAAG -3'

Sequencing Primer
(F):5'- ACTGAGCTGGTCACAGTAGACTC -3'
(R):5'- AAGGTGCCAGGCCTTTATTTC -3'
Posted On 2015-02-18