Incidental Mutation 'IGL00938:Olfr427'
ID26665
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr427
Ensembl Gene ENSMUSG00000059371
Gene Nameolfactory receptor 427
SynonymsMOR105-7, MOR105-9, GA_x6K02T2P20D-21075927-21074980
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.070) question?
Stock #IGL00938
Quality Score
Status
Chromosome1
Chromosomal Location174096891-174103224 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 174100367 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Threonine at position 303 (M303T)
Ref Sequence ENSEMBL: ENSMUSP00000149570 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080831] [ENSMUST00000213832]
Predicted Effect probably benign
Transcript: ENSMUST00000080831
AA Change: M303T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000079644
Gene: ENSMUSG00000059371
AA Change: M303T

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 1.2e-58 PFAM
Pfam:7tm_1 41 289 3.7e-16 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201135
Predicted Effect probably benign
Transcript: ENSMUST00000213832
AA Change: M303T

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 23 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamtsl1 A G 4: 86,342,278 I909V possibly damaging Het
Alkal2 C A 12: 30,887,090 H101N probably damaging Het
Camk2g C T 14: 20,737,330 G500S probably damaging Het
Col4a1 G A 8: 11,236,456 probably benign Het
Fry T A 5: 150,370,180 V446E probably damaging Het
Gpc2 C A 5: 138,278,907 R86L probably benign Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Krt16 A T 11: 100,248,717 C58* probably null Het
Ltbp2 T C 12: 84,831,799 R309G probably benign Het
Mapkapk5 T C 5: 121,537,103 probably benign Het
Mpdz G A 4: 81,292,512 A1665V probably damaging Het
Mpp7 T C 18: 7,353,297 T470A probably benign Het
Mypn T A 10: 63,192,423 D287V probably damaging Het
Nup160 T C 2: 90,732,827 L1312P probably damaging Het
Olfr1250 C T 2: 89,657,076 V122M probably damaging Het
Poln C A 5: 34,129,224 C200F probably damaging Het
Pparg A G 6: 115,463,139 I225V probably benign Het
Pspn T C 17: 56,999,629 E100G probably benign Het
Slc12a8 G A 16: 33,540,897 V50I probably damaging Het
Suz12 A G 11: 80,007,569 probably benign Het
Ubiad1 A G 4: 148,436,357 F270S probably benign Het
Vmn1r185 T C 7: 26,611,691 I130V probably benign Het
Vmn1r210 A T 13: 22,827,368 C249* probably null Het
Other mutations in Olfr427
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01804:Olfr427 APN 1 174099835 missense probably damaging 1.00
IGL02573:Olfr427 APN 1 174100130 missense possibly damaging 0.94
IGL02736:Olfr427 APN 1 174099647 missense probably damaging 0.99
R0012:Olfr427 UTSW 1 174100207 missense probably damaging 1.00
R0437:Olfr427 UTSW 1 174100399 missense probably benign 0.04
R0688:Olfr427 UTSW 1 174100064 missense probably damaging 1.00
R1473:Olfr427 UTSW 1 174099749 missense probably damaging 1.00
R1754:Olfr427 UTSW 1 174100033 missense probably benign 0.24
R5453:Olfr427 UTSW 1 174099467 missense probably benign
R5776:Olfr427 UTSW 1 174099773 missense probably damaging 1.00
R6700:Olfr427 UTSW 1 174099839 missense probably damaging 1.00
R7472:Olfr427 UTSW 1 174099733 missense probably damaging 1.00
R7683:Olfr427 UTSW 1 174099476 missense probably benign 0.01
Posted On2013-04-17