Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL00942:Slc16a14'

26670

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Slc16a14

Ensembl Gene

ENSMUSG00000026220

Gene Name

solute carrier family 16 (monocarboxylic acid transporters), member 14

Synonyms

1110004H10Rik

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.117) question?

Stock #

IGL00942

Quality Score

Status

Chromosome

Chromosomal Location

84905898-84935134 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 84922871 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 131 (T131I)

Ref Sequence

ENSEMBL: ENSMUSP00000027422 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027422]

AlphaFold

Q8K1C7

Predicted Effect

probably damaging
Transcript: ENSMUST00000027422
AA Change: T131I

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000027422
Gene: ENSMUSG00000026220
AA Change: T131I

Domain	Start	End	E-Value	Type
Pfam:MFS_1	42	427	6.7e-42	PFAM
Pfam:MFS_1	419	509	7.9e-10	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933416C03Rik	A	G	10: 116,113,436	S62P	possibly damaging	Het
Arap2	A	C	5: 62,698,389	L568*	probably null	Het
Arfgef2	G	A	2: 166,885,853	V1574M	probably damaging	Het
Arhgef12	C	T	9: 42,982,000	R969H	probably damaging	Het
Cacng1	A	T	11: 107,704,369	F127L	probably benign	Het
Cntnap5c	T	C	17: 57,769,598	V10A	probably benign	Het
Crtac1	T	G	19: 42,323,794	D160A	probably damaging	Het
Csmd3	C	T	15: 47,847,106		probably null	Het
Grin3a	A	G	4: 49,770,589	F728L	probably damaging	Het
Hecw1	C	T	13: 14,340,740		probably benign	Het
Hist1h3a	T	C	13: 23,761,938		probably benign	Het
Iyd	C	T	10: 3,554,070	C239F	probably damaging	Het
Madd	A	G	2: 91,170,578	V486A	probably damaging	Het
Map3k7	A	G	4: 32,019,539	D533G	probably damaging	Het
Matk	A	G	10: 81,258,294	D20G	probably benign	Het
Mphosph10	A	G	7: 64,389,755	S156P	probably benign	Het
Mtif2	G	A	11: 29,538,753	E356K	probably damaging	Het
Ndufb10	T	C	17: 24,724,184		probably null	Het
Nipal3	A	T	4: 135,468,593	L233Q	possibly damaging	Het
Olfr860	T	C	9: 19,846,259	Y120C	probably damaging	Het
Prss32	T	A	17: 23,859,160	C273*	probably null	Het
Prtg	T	C	9: 72,892,340	S807P	possibly damaging	Het
Ric3	T	G	7: 109,054,412	E157D	probably damaging	Het
Ric3	T	A	7: 109,054,413	E157V	probably damaging	Het
Slc1a2	A	T	2: 102,739,814	N137Y	probably damaging	Het
Slc25a27	T	C	17: 43,664,089	I94V	probably benign	Het
Slco1a1	G	A	6: 141,946,628	T4I	probably benign	Het
Slf1	A	T	13: 77,043,947	F923I	possibly damaging	Het
Ttll12	A	C	15: 83,582,448	V306G	possibly damaging	Het
Tulp2	G	A	7: 45,516,268	V97I	possibly damaging	Het
Vmn2r65	T	G	7: 84,943,553	Q482P	probably damaging	Het
Wdr24	T	A	17: 25,826,621	N443K	probably benign	Het

Other mutations in Slc16a14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01563:Slc16a14	APN	1	84912187	splice site	probably benign
R0315:Slc16a14	UTSW	1	84912496	missense	possibly damaging	0.46
R0380:Slc16a14	UTSW	1	84929530	missense	possibly damaging	0.72
R1469:Slc16a14	UTSW	1	84929461	missense	probably damaging	1.00
R1469:Slc16a14	UTSW	1	84929461	missense	probably damaging	1.00
R1837:Slc16a14	UTSW	1	84912399	missense	probably benign	0.02
R2149:Slc16a14	UTSW	1	84907399	missense	probably damaging	1.00
R2293:Slc16a14	UTSW	1	84912843	missense	probably benign
R3790:Slc16a14	UTSW	1	84929280	unclassified	probably benign
R4016:Slc16a14	UTSW	1	84912507	nonsense	probably null
R4596:Slc16a14	UTSW	1	84929357	missense	probably damaging	1.00
R4637:Slc16a14	UTSW	1	84907282	missense	possibly damaging	0.86
R4723:Slc16a14	UTSW	1	84913020	missense	probably damaging	1.00
R5137:Slc16a14	UTSW	1	84912597	missense	probably damaging	1.00
R5262:Slc16a14	UTSW	1	84912891	missense	probably benign	0.00
R5410:Slc16a14	UTSW	1	84907424	missense	probably damaging	0.98
R5927:Slc16a14	UTSW	1	84912267	missense	possibly damaging	0.91
R5968:Slc16a14	UTSW	1	84912505	missense	possibly damaging	0.70
R6052:Slc16a14	UTSW	1	84912709	missense	possibly damaging	0.75
R6264:Slc16a14	UTSW	1	84907409	missense	probably benign	0.30
R6290:Slc16a14	UTSW	1	84907385	missense	probably benign	0.10
R7383:Slc16a14	UTSW	1	84912571	missense	probably damaging	1.00
R7390:Slc16a14	UTSW	1	84929466	missense	probably benign	0.25
R7535:Slc16a14	UTSW	1	84913122	missense	probably damaging	1.00
R8326:Slc16a14	UTSW	1	84912345	missense	possibly damaging	0.94
R8669:Slc16a14	UTSW	1	84922884	missense	probably benign	0.00
R8784:Slc16a14	UTSW	1	84913063	missense	probably benign	0.01
R9409:Slc16a14	UTSW	1	84929395	nonsense	probably null

Posted On

2013-04-17