Incidental Mutation 'R3415:Zfp641'
ID |
266786 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Zfp641
|
Ensembl Gene |
ENSMUSG00000022987 |
Gene Name |
zinc finger protein 641 |
Synonyms |
9930016F01Rik |
MMRRC Submission |
040633-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R3415 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
15 |
Chromosomal Location |
98183466-98194042 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 98188421 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Aspartic acid to Glycine
at position 153
(D153G)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000133212
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000023722]
[ENSMUST00000169721]
|
AlphaFold |
Q8BZ34 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000023722
AA Change: D139G
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
SMART Domains |
Protein: ENSMUSP00000023722 Gene: ENSMUSG00000022987 AA Change: D139G
Domain | Start | End | E-Value | Type |
KRAB
|
91 |
142 |
2.16e-10 |
SMART |
ZnF_C2H2
|
236 |
258 |
1.58e-3 |
SMART |
ZnF_C2H2
|
264 |
286 |
1.67e-2 |
SMART |
ZnF_C2H2
|
292 |
314 |
1.33e-1 |
SMART |
ZnF_C2H2
|
342 |
364 |
8.94e-3 |
SMART |
ZnF_C2H2
|
370 |
392 |
3.83e-2 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000169721
AA Change: D153G
PolyPhen 2
Score 0.276 (Sensitivity: 0.91; Specificity: 0.88)
|
SMART Domains |
Protein: ENSMUSP00000133212 Gene: ENSMUSG00000022987 AA Change: D153G
Domain | Start | End | E-Value | Type |
low complexity region
|
83 |
89 |
N/A |
INTRINSIC |
KRAB
|
95 |
156 |
2.56e-21 |
SMART |
ZnF_C2H2
|
250 |
272 |
1.58e-3 |
SMART |
ZnF_C2H2
|
278 |
300 |
1.67e-2 |
SMART |
ZnF_C2H2
|
306 |
328 |
1.33e-1 |
SMART |
ZnF_C2H2
|
356 |
378 |
8.94e-3 |
SMART |
ZnF_C2H2
|
384 |
406 |
3.83e-2 |
SMART |
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.5%
- 20x: 95.8%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 29 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Ccdc39 |
C |
G |
3: 33,868,646 (GRCm39) |
L813F |
probably benign |
Het |
Cdh13 |
A |
T |
8: 119,401,946 (GRCm39) |
D116V |
probably benign |
Het |
Cep170 |
G |
T |
1: 176,583,610 (GRCm39) |
P923Q |
probably damaging |
Het |
Chga |
A |
G |
12: 102,529,043 (GRCm39) |
E340G |
probably benign |
Het |
Cmip |
T |
A |
8: 118,076,116 (GRCm39) |
|
probably null |
Het |
Cnga4 |
A |
G |
7: 105,056,325 (GRCm39) |
Y309C |
probably damaging |
Het |
Crocc |
G |
A |
4: 140,773,758 (GRCm39) |
T103I |
possibly damaging |
Het |
Dph6 |
C |
T |
2: 114,348,768 (GRCm39) |
V267I |
probably benign |
Het |
Ero1a |
T |
C |
14: 45,525,323 (GRCm39) |
T401A |
possibly damaging |
Het |
Exoc6b |
C |
G |
6: 84,867,547 (GRCm39) |
L288F |
possibly damaging |
Het |
Ifi203 |
G |
A |
1: 173,756,326 (GRCm39) |
R486* |
probably null |
Het |
Igsf9b |
G |
A |
9: 27,220,774 (GRCm39) |
V47I |
possibly damaging |
Het |
Klhl42 |
G |
A |
6: 147,009,378 (GRCm39) |
V406M |
probably damaging |
Het |
Lims2 |
A |
T |
18: 32,077,208 (GRCm39) |
Y58F |
probably damaging |
Het |
Lrp12 |
A |
G |
15: 39,741,678 (GRCm39) |
F365L |
probably damaging |
Het |
Lrrc37 |
A |
T |
11: 103,505,435 (GRCm39) |
S2178T |
possibly damaging |
Het |
Mark4 |
T |
C |
7: 19,185,650 (GRCm39) |
D28G |
probably benign |
Het |
Mfsd13a |
C |
T |
19: 46,360,431 (GRCm39) |
R328C |
probably damaging |
Het |
Mmp1a |
A |
T |
9: 7,464,869 (GRCm39) |
K34N |
possibly damaging |
Het |
Or4k2 |
T |
A |
14: 50,424,069 (GRCm39) |
T202S |
possibly damaging |
Het |
P2rx5 |
G |
T |
11: 73,051,486 (GRCm39) |
V22L |
possibly damaging |
Het |
Pnma8a |
A |
G |
7: 16,694,879 (GRCm39) |
R245G |
possibly damaging |
Het |
Prpsap1 |
T |
C |
11: 116,369,410 (GRCm39) |
S179G |
probably benign |
Het |
Specc1 |
A |
G |
11: 62,009,245 (GRCm39) |
T334A |
probably benign |
Het |
Tas2r124 |
A |
T |
6: 132,732,601 (GRCm39) |
R303S |
probably benign |
Het |
Tm7sf2 |
A |
G |
19: 6,113,629 (GRCm39) |
Y301H |
probably damaging |
Het |
Unc13c |
G |
T |
9: 73,839,868 (GRCm39) |
H328N |
probably benign |
Het |
Zp3 |
A |
G |
5: 136,014,514 (GRCm39) |
T278A |
probably benign |
Het |
Zscan2 |
T |
A |
7: 80,525,150 (GRCm39) |
S290R |
probably damaging |
Het |
|
Other mutations in Zfp641 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01639:Zfp641
|
APN |
15 |
98,189,066 (GRCm39) |
missense |
possibly damaging |
0.85 |
IGL03092:Zfp641
|
APN |
15 |
98,188,397 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03191:Zfp641
|
APN |
15 |
98,186,568 (GRCm39) |
missense |
probably damaging |
0.98 |
R0079:Zfp641
|
UTSW |
15 |
98,186,970 (GRCm39) |
missense |
probably benign |
0.28 |
R0243:Zfp641
|
UTSW |
15 |
98,187,008 (GRCm39) |
missense |
possibly damaging |
0.82 |
R0487:Zfp641
|
UTSW |
15 |
98,187,060 (GRCm39) |
missense |
probably benign |
|
R2092:Zfp641
|
UTSW |
15 |
98,191,593 (GRCm39) |
missense |
probably benign |
|
R4834:Zfp641
|
UTSW |
15 |
98,191,585 (GRCm39) |
missense |
probably damaging |
1.00 |
R4851:Zfp641
|
UTSW |
15 |
98,186,598 (GRCm39) |
missense |
probably damaging |
0.99 |
R5776:Zfp641
|
UTSW |
15 |
98,186,891 (GRCm39) |
missense |
probably damaging |
1.00 |
R6057:Zfp641
|
UTSW |
15 |
98,190,816 (GRCm39) |
missense |
probably benign |
0.00 |
R6896:Zfp641
|
UTSW |
15 |
98,191,684 (GRCm39) |
start codon destroyed |
probably benign |
0.06 |
R6958:Zfp641
|
UTSW |
15 |
98,190,832 (GRCm39) |
missense |
possibly damaging |
0.46 |
R6969:Zfp641
|
UTSW |
15 |
98,188,448 (GRCm39) |
missense |
possibly damaging |
0.46 |
R8117:Zfp641
|
UTSW |
15 |
98,186,856 (GRCm39) |
missense |
probably damaging |
1.00 |
R8314:Zfp641
|
UTSW |
15 |
98,188,464 (GRCm39) |
missense |
probably damaging |
0.97 |
R9130:Zfp641
|
UTSW |
15 |
98,186,732 (GRCm39) |
missense |
probably benign |
0.12 |
Z1177:Zfp641
|
UTSW |
15 |
98,186,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TGCTGCTCCTGGGTGTTAAC -3'
(R):5'- TCCCAATGAGGAATCTAGGAAGC -3'
Sequencing Primer
(F):5'- ATACAAGTTCTCACGGGTATGGGC -3'
(R):5'- AGGAATCTAGGAAGCAGTTTTGTCC -3'
|
Posted On |
2015-02-18 |