Incidental Mutation 'R3415:Zfp641'
ID 266786
Institutional Source Beutler Lab
Gene Symbol Zfp641
Ensembl Gene ENSMUSG00000022987
Gene Name zinc finger protein 641
Synonyms 9930016F01Rik
MMRRC Submission 040633-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3415 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 98183466-98194042 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 98188421 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 153 (D153G)
Ref Sequence ENSEMBL: ENSMUSP00000133212 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023722] [ENSMUST00000169721]
AlphaFold Q8BZ34
Predicted Effect probably benign
Transcript: ENSMUST00000023722
AA Change: D139G

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
SMART Domains Protein: ENSMUSP00000023722
Gene: ENSMUSG00000022987
AA Change: D139G

DomainStartEndE-ValueType
KRAB 91 142 2.16e-10 SMART
ZnF_C2H2 236 258 1.58e-3 SMART
ZnF_C2H2 264 286 1.67e-2 SMART
ZnF_C2H2 292 314 1.33e-1 SMART
ZnF_C2H2 342 364 8.94e-3 SMART
ZnF_C2H2 370 392 3.83e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000169721
AA Change: D153G

PolyPhen 2 Score 0.276 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000133212
Gene: ENSMUSG00000022987
AA Change: D153G

DomainStartEndE-ValueType
low complexity region 83 89 N/A INTRINSIC
KRAB 95 156 2.56e-21 SMART
ZnF_C2H2 250 272 1.58e-3 SMART
ZnF_C2H2 278 300 1.67e-2 SMART
ZnF_C2H2 306 328 1.33e-1 SMART
ZnF_C2H2 356 378 8.94e-3 SMART
ZnF_C2H2 384 406 3.83e-2 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.7%
  • 10x: 97.5%
  • 20x: 95.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ccdc39 C G 3: 33,868,646 (GRCm39) L813F probably benign Het
Cdh13 A T 8: 119,401,946 (GRCm39) D116V probably benign Het
Cep170 G T 1: 176,583,610 (GRCm39) P923Q probably damaging Het
Chga A G 12: 102,529,043 (GRCm39) E340G probably benign Het
Cmip T A 8: 118,076,116 (GRCm39) probably null Het
Cnga4 A G 7: 105,056,325 (GRCm39) Y309C probably damaging Het
Crocc G A 4: 140,773,758 (GRCm39) T103I possibly damaging Het
Dph6 C T 2: 114,348,768 (GRCm39) V267I probably benign Het
Ero1a T C 14: 45,525,323 (GRCm39) T401A possibly damaging Het
Exoc6b C G 6: 84,867,547 (GRCm39) L288F possibly damaging Het
Ifi203 G A 1: 173,756,326 (GRCm39) R486* probably null Het
Igsf9b G A 9: 27,220,774 (GRCm39) V47I possibly damaging Het
Klhl42 G A 6: 147,009,378 (GRCm39) V406M probably damaging Het
Lims2 A T 18: 32,077,208 (GRCm39) Y58F probably damaging Het
Lrp12 A G 15: 39,741,678 (GRCm39) F365L probably damaging Het
Lrrc37 A T 11: 103,505,435 (GRCm39) S2178T possibly damaging Het
Mark4 T C 7: 19,185,650 (GRCm39) D28G probably benign Het
Mfsd13a C T 19: 46,360,431 (GRCm39) R328C probably damaging Het
Mmp1a A T 9: 7,464,869 (GRCm39) K34N possibly damaging Het
Or4k2 T A 14: 50,424,069 (GRCm39) T202S possibly damaging Het
P2rx5 G T 11: 73,051,486 (GRCm39) V22L possibly damaging Het
Pnma8a A G 7: 16,694,879 (GRCm39) R245G possibly damaging Het
Prpsap1 T C 11: 116,369,410 (GRCm39) S179G probably benign Het
Specc1 A G 11: 62,009,245 (GRCm39) T334A probably benign Het
Tas2r124 A T 6: 132,732,601 (GRCm39) R303S probably benign Het
Tm7sf2 A G 19: 6,113,629 (GRCm39) Y301H probably damaging Het
Unc13c G T 9: 73,839,868 (GRCm39) H328N probably benign Het
Zp3 A G 5: 136,014,514 (GRCm39) T278A probably benign Het
Zscan2 T A 7: 80,525,150 (GRCm39) S290R probably damaging Het
Other mutations in Zfp641
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01639:Zfp641 APN 15 98,189,066 (GRCm39) missense possibly damaging 0.85
IGL03092:Zfp641 APN 15 98,188,397 (GRCm39) missense probably damaging 1.00
IGL03191:Zfp641 APN 15 98,186,568 (GRCm39) missense probably damaging 0.98
R0079:Zfp641 UTSW 15 98,186,970 (GRCm39) missense probably benign 0.28
R0243:Zfp641 UTSW 15 98,187,008 (GRCm39) missense possibly damaging 0.82
R0487:Zfp641 UTSW 15 98,187,060 (GRCm39) missense probably benign
R2092:Zfp641 UTSW 15 98,191,593 (GRCm39) missense probably benign
R4834:Zfp641 UTSW 15 98,191,585 (GRCm39) missense probably damaging 1.00
R4851:Zfp641 UTSW 15 98,186,598 (GRCm39) missense probably damaging 0.99
R5776:Zfp641 UTSW 15 98,186,891 (GRCm39) missense probably damaging 1.00
R6057:Zfp641 UTSW 15 98,190,816 (GRCm39) missense probably benign 0.00
R6896:Zfp641 UTSW 15 98,191,684 (GRCm39) start codon destroyed probably benign 0.06
R6958:Zfp641 UTSW 15 98,190,832 (GRCm39) missense possibly damaging 0.46
R6969:Zfp641 UTSW 15 98,188,448 (GRCm39) missense possibly damaging 0.46
R8117:Zfp641 UTSW 15 98,186,856 (GRCm39) missense probably damaging 1.00
R8314:Zfp641 UTSW 15 98,188,464 (GRCm39) missense probably damaging 0.97
R9130:Zfp641 UTSW 15 98,186,732 (GRCm39) missense probably benign 0.12
Z1177:Zfp641 UTSW 15 98,186,416 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGCTGCTCCTGGGTGTTAAC -3'
(R):5'- TCCCAATGAGGAATCTAGGAAGC -3'

Sequencing Primer
(F):5'- ATACAAGTTCTCACGGGTATGGGC -3'
(R):5'- AGGAATCTAGGAAGCAGTTTTGTCC -3'
Posted On 2015-02-18