Incidental Mutation 'R3419:Gsto1'
ID 266991
Institutional Source Beutler Lab
Gene Symbol Gsto1
Ensembl Gene ENSMUSG00000025068
Gene Name glutathione S-transferase omega 1
Synonyms GSTX, p28
MMRRC Submission 040637-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3419 (G1)
Quality Score 225
Status Not validated
Chromosome 19
Chromosomal Location 47843412-47853229 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 47846344 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 64 (F64L)
Ref Sequence ENSEMBL: ENSMUSP00000026050 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026050]
AlphaFold O09131
Predicted Effect noncoding transcript
Transcript: ENSMUST00000026048
Predicted Effect probably benign
Transcript: ENSMUST00000026050
AA Change: F64L

PolyPhen 2 Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000026050
Gene: ENSMUSG00000025068
AA Change: F64L

DomainStartEndE-ValueType
Pfam:GST_N 22 95 1.6e-15 PFAM
Pfam:GST_N_3 26 101 9e-24 PFAM
Pfam:GST_N_2 31 96 2.2e-16 PFAM
Pfam:GST_C_2 89 204 5.1e-10 PFAM
Pfam:GST_C 106 209 1.3e-10 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130157
Meta Mutation Damage Score 0.0734 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.0%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the omega class of glutathione S-transferase (GST) proteins. GSTs are involved in the metabolism of xenobiotics and carcinogens. There is evidence that the encoded protein is involved in the biotransformation of arsenic. [provided by RefSeq, Dec 2015]
PHENOTYPE: Mice homozygous for a mutant allele do not display abnormal arsenate metabolism following acute arsenate exposure. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
5530400C23Rik A G 6: 133,271,082 (GRCm39) Q42R probably benign Het
Ankrd26 A G 6: 118,512,068 (GRCm39) L518P probably damaging Het
Armc9 T C 1: 86,122,060 (GRCm39) L395P probably damaging Het
Baz1a T C 12: 54,993,684 (GRCm39) K181E probably benign Het
Bend3 T C 10: 43,385,978 (GRCm39) S124P probably damaging Het
Cdh5 C T 8: 104,856,002 (GRCm39) R312C probably damaging Het
Col6a3 T C 1: 90,731,813 (GRCm39) D873G probably benign Het
Dmbx1 G C 4: 115,777,873 (GRCm39) R64G probably benign Het
Dpy19l2 T C 9: 24,492,501 (GRCm39) E699G probably damaging Het
Dync2i1 C T 12: 116,188,597 (GRCm39) V666I probably benign Het
Eef2k T A 7: 120,485,093 (GRCm39) M320K probably damaging Het
Exoc5 A T 14: 49,260,735 (GRCm39) N377K probably damaging Het
Fam20c A T 5: 138,743,623 (GRCm39) N220Y probably damaging Het
Fchsd2 T A 7: 100,927,867 (GRCm39) probably null Het
Flrt2 A G 12: 95,747,378 (GRCm39) Y572C probably damaging Het
Gm17093 A G 14: 44,759,047 (GRCm39) I190V unknown Het
Gucy1a1 A G 3: 82,013,440 (GRCm39) S401P probably damaging Het
Hoxd10 A G 2: 74,522,921 (GRCm39) K200E probably benign Het
Kcnj13 T C 1: 87,314,641 (GRCm39) T194A probably benign Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Lacc1 T G 14: 77,272,321 (GRCm39) E158D probably benign Het
Lyn A T 4: 3,746,833 (GRCm39) I204F probably damaging Het
Mapk6 T C 9: 75,305,039 (GRCm39) E126G probably damaging Het
Mbd6 C G 10: 127,122,372 (GRCm39) R152P probably null Het
Or2h1b A T 17: 37,462,242 (GRCm39) V53E probably damaging Het
Or52e15 A G 7: 104,645,727 (GRCm39) I128T probably damaging Het
Or8g17 C T 9: 38,930,372 (GRCm39) C155Y probably benign Het
P2ry1 T C 3: 60,911,133 (GRCm39) F91L probably damaging Het
Paqr3 A G 5: 97,247,559 (GRCm39) L183P probably damaging Het
Pcdh15 C A 10: 74,420,054 (GRCm39) D1166E probably benign Het
Pik3r1 T C 13: 101,828,723 (GRCm39) D25G probably benign Het
Poc5 A T 13: 96,540,925 (GRCm39) T365S possibly damaging Het
Polr3a A G 14: 24,517,103 (GRCm39) L716P probably damaging Het
Ppp1r3a A T 6: 14,719,413 (GRCm39) D500E probably benign Het
Ptcd3 A T 6: 71,860,470 (GRCm39) I579K possibly damaging Het
Rnf168 A G 16: 32,118,010 (GRCm39) N524D probably benign Het
Scn7a AT ATT 2: 66,531,239 (GRCm39) probably null Het
Sel1l A G 12: 91,776,776 (GRCm39) W689R probably damaging Het
Serpinb13 T C 1: 106,926,657 (GRCm39) S218P probably damaging Het
Serpini1 A G 3: 75,547,589 (GRCm39) Y367C probably damaging Het
Snrnp48 G A 13: 38,405,335 (GRCm39) D248N possibly damaging Het
St6galnac4 A G 2: 32,485,743 (GRCm39) T217A probably damaging Het
Tdrd1 T A 19: 56,819,663 (GRCm39) N54K possibly damaging Het
Tmem30c A G 16: 57,098,031 (GRCm39) V130A probably benign Het
Trpa1 T C 1: 14,944,605 (GRCm39) I1046M probably benign Het
Tulp2 T A 7: 45,168,176 (GRCm39) M196K possibly damaging Het
Unc5b G A 10: 60,614,593 (GRCm39) R235W probably damaging Het
Vmn1r175 A T 7: 23,508,075 (GRCm39) M184K probably damaging Het
Vmn2r2 A T 3: 64,024,320 (GRCm39) F754I probably benign Het
Vmn2r9 A C 5: 108,994,299 (GRCm39) M450R probably damaging Het
Other mutations in Gsto1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00570:Gsto1 APN 19 47,846,375 (GRCm39) missense probably benign 0.24
R0277:Gsto1 UTSW 19 47,846,416 (GRCm39) missense probably damaging 0.98
R1426:Gsto1 UTSW 19 47,846,381 (GRCm39) missense probably damaging 1.00
R1733:Gsto1 UTSW 19 47,843,674 (GRCm39) missense probably damaging 1.00
R3418:Gsto1 UTSW 19 47,846,344 (GRCm39) missense probably benign 0.01
R3710:Gsto1 UTSW 19 47,847,971 (GRCm39) critical splice donor site probably null
R4830:Gsto1 UTSW 19 47,852,830 (GRCm39) missense probably benign 0.01
R4953:Gsto1 UTSW 19 47,843,759 (GRCm39) missense probably damaging 1.00
R5567:Gsto1 UTSW 19 47,846,338 (GRCm39) missense probably damaging 1.00
R5570:Gsto1 UTSW 19 47,846,338 (GRCm39) missense probably damaging 1.00
R6448:Gsto1 UTSW 19 47,846,420 (GRCm39) missense probably benign 0.02
R7994:Gsto1 UTSW 19 47,847,899 (GRCm39) missense probably benign
R9029:Gsto1 UTSW 19 47,852,837 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TGTGGTCAGAACTCTCCTCC -3'
(R):5'- ATCACAAAGGCAGCGCTGAG -3'

Sequencing Primer
(F):5'- GAACTCTCCTCCTCCATCCAAGG -3'
(R):5'- CATACCTTAGAGAATGACTCAAGGG -3'
Posted On 2015-02-18