Incidental Mutation 'R3420:Amn1'
ID 267010
Institutional Source Beutler Lab
Gene Symbol Amn1
Ensembl Gene ENSMUSG00000068250
Gene Name antagonist of mitotic exit network 1
Synonyms C730024G19Rik
MMRRC Submission 040638-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.087) question?
Stock # R3420 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 149059075-149090210 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 149070950 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 196 (L196*)
Ref Sequence ENSEMBL: ENSMUSP00000107160 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095319] [ENSMUST00000111535] [ENSMUST00000141346]
AlphaFold B8JKV0
Predicted Effect probably null
Transcript: ENSMUST00000095319
AA Change: L153*
SMART Domains Protein: ENSMUSP00000092957
Gene: ENSMUSG00000068250
AA Change: L153*

DomainStartEndE-ValueType
LRR 17 41 2.82e0 SMART
LRR 42 70 1.52e2 SMART
LRR 71 96 1.25e-1 SMART
LRR 97 122 3.89e-3 SMART
LRR 123 147 1.44e1 SMART
LRR 150 175 1.28e1 SMART
Blast:LRR 176 204 3e-10 BLAST
Predicted Effect probably null
Transcript: ENSMUST00000111535
AA Change: L196*
SMART Domains Protein: ENSMUSP00000107160
Gene: ENSMUSG00000068250
AA Change: L196*

DomainStartEndE-ValueType
LRR 60 84 2.82e0 SMART
LRR 85 113 1.52e2 SMART
LRR 114 139 1.25e-1 SMART
LRR 140 165 3.89e-3 SMART
LRR 166 190 1.44e1 SMART
LRR 193 218 1.28e1 SMART
Blast:LRR 219 247 4e-10 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127743
Predicted Effect noncoding transcript
Transcript: ENSMUST00000134181
Predicted Effect probably benign
Transcript: ENSMUST00000141346
SMART Domains Protein: ENSMUSP00000116060
Gene: ENSMUSG00000068250

DomainStartEndE-ValueType
LRR 17 41 2.82e0 SMART
LRR 42 70 1.52e2 SMART
LRR 71 96 1.25e-1 SMART
LRR 97 121 1.44e1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149149
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150610
Predicted Effect noncoding transcript
Transcript: ENSMUST00000152062
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203043
Predicted Effect probably benign
Transcript: ENSMUST00000156864
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204681
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Agbl3 A G 6: 34,770,900 (GRCm39) T132A probably benign Het
Ccdc73 A T 2: 104,782,292 (GRCm39) K216M probably null Het
Ccdc73 G A 2: 104,782,293 (GRCm39) probably null Het
Celsr2 A G 3: 108,321,732 (GRCm39) V360A probably benign Het
Ckap5 T A 2: 91,400,597 (GRCm39) W650R probably damaging Het
Cyp2b9 G A 7: 25,909,528 (GRCm39) G432E probably damaging Het
Dclre1b A G 3: 103,715,412 (GRCm39) Y29H probably damaging Het
Enthd1 T C 15: 80,444,225 (GRCm39) D110G probably damaging Het
Grin1 C T 2: 25,193,926 (GRCm39) G390D probably damaging Het
Hoxc6 T A 15: 102,919,327 (GRCm39) W188R probably damaging Het
Kcnip1 A G 11: 33,595,594 (GRCm39) V43A probably damaging Het
Kifap3 T A 1: 163,621,595 (GRCm39) I81N probably damaging Het
Klb G A 5: 65,529,485 (GRCm39) G338S probably damaging Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Nuak2 A G 1: 132,259,818 (GRCm39) D532G probably benign Het
Or8d1 A G 9: 38,766,621 (GRCm39) K88E possibly damaging Het
Prps2 G A X: 166,165,504 (GRCm39) probably null Het
Prss23 C A 7: 89,159,107 (GRCm39) V321L possibly damaging Het
Psmb2 T C 4: 126,571,630 (GRCm39) M28T probably damaging Het
Ric1 T C 19: 29,544,990 (GRCm39) I230T probably damaging Het
Slc25a17 C T 15: 81,244,901 (GRCm39) V11I probably benign Het
Slc5a4a T C 10: 76,012,407 (GRCm39) V359A probably benign Het
Slco1a5 A T 6: 142,213,964 (GRCm39) D52E possibly damaging Het
Tafa1 C A 6: 96,626,099 (GRCm39) D112E probably damaging Het
Tlr4 A G 4: 66,757,773 (GRCm39) I189V probably benign Het
Washc1 T C 17: 66,424,028 (GRCm39) S247P probably damaging Het
Zdhhc14 T A 17: 5,803,366 (GRCm39) *490R probably null Het
Zfp217 A G 2: 169,961,937 (GRCm39) F130S possibly damaging Het
Other mutations in Amn1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02391:Amn1 APN 6 149,070,944 (GRCm39) critical splice donor site probably null
PIT4453001:Amn1 UTSW 6 149,072,357 (GRCm39) missense probably benign 0.00
R0153:Amn1 UTSW 6 149,090,091 (GRCm39) utr 5 prime probably benign
R0494:Amn1 UTSW 6 149,086,634 (GRCm39) unclassified probably benign
R0557:Amn1 UTSW 6 149,072,503 (GRCm39) missense possibly damaging 0.50
R0717:Amn1 UTSW 6 149,084,970 (GRCm39) missense possibly damaging 0.88
R0736:Amn1 UTSW 6 149,084,970 (GRCm39) missense possibly damaging 0.88
R3421:Amn1 UTSW 6 149,070,950 (GRCm39) nonsense probably null
R4466:Amn1 UTSW 6 149,068,343 (GRCm39) splice site probably null
R4760:Amn1 UTSW 6 149,086,611 (GRCm39) missense probably benign
R5294:Amn1 UTSW 6 149,086,622 (GRCm39) unclassified probably benign
R5356:Amn1 UTSW 6 149,068,392 (GRCm39) missense possibly damaging 0.80
R5561:Amn1 UTSW 6 149,086,522 (GRCm39) missense probably damaging 0.98
R7501:Amn1 UTSW 6 149,086,529 (GRCm39) missense probably benign 0.19
R7564:Amn1 UTSW 6 149,086,529 (GRCm39) missense probably benign 0.19
R7643:Amn1 UTSW 6 149,086,529 (GRCm39) missense probably benign 0.19
R7645:Amn1 UTSW 6 149,086,529 (GRCm39) missense probably benign 0.19
R8097:Amn1 UTSW 6 149,070,853 (GRCm39) unclassified probably benign
R9390:Amn1 UTSW 6 149,084,983 (GRCm39) missense probably damaging 1.00
R9565:Amn1 UTSW 6 149,090,103 (GRCm39) start gained probably benign
X0064:Amn1 UTSW 6 149,072,533 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCGCAGCAGGTTATCTCAGG -3'
(R):5'- GCCCCTAACTCAGAACAATGTATTTG -3'

Sequencing Primer
(F):5'- AGCAGGTTATCTCAGGTTTGTTGTAC -3'
(R):5'- AGGGGCATTGAACTCACTCTTAG -3'
Posted On 2015-02-18