Incidental Mutation 'R3436:Slfn2'
ID 267199
Institutional Source Beutler Lab
Gene Symbol Slfn2
Ensembl Gene ENSMUSG00000072620
Gene Name schlafen 2
Synonyms Shlf2
MMRRC Submission 040654-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R3436 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 82955938-82961504 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 82960390 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Histidine to Leucine at position 123 (H123L)
Ref Sequence ENSEMBL: ENSMUSP00000035562 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038038]
AlphaFold Q9Z0I6
Predicted Effect probably benign
Transcript: ENSMUST00000038038
AA Change: H123L

PolyPhen 2 Score 0.045 (Sensitivity: 0.94; Specificity: 0.83)
SMART Domains Protein: ENSMUSP00000035562
Gene: ENSMUSG00000072620
AA Change: H123L

DomainStartEndE-ValueType
low complexity region 162 172 N/A INTRINSIC
Pfam:AlbA_2 231 365 4.5e-12 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214134
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.3%
Validation Efficiency 100% (40/40)
MGI Phenotype PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit increased susceptibility to bacterial and viral infections, reduced T cell numbers, decreased T cell proliferation, and increased apoptosis of activated T cells. [provided by MGI curators]
Allele List at MGI

All alleles(1) : Chemically induced(1)

Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ambp T C 4: 63,067,721 (GRCm39) E163G probably benign Het
Angptl3 A T 4: 98,921,540 (GRCm39) K219N probably benign Het
Atp6v1g1 A G 4: 63,468,255 (GRCm39) N86S probably benign Het
Cadps A T 14: 12,616,158 (GRCm38) probably null Het
Ccdc146 A G 5: 21,502,003 (GRCm39) S804P possibly damaging Het
Cdc20b T C 13: 113,215,233 (GRCm39) I267T probably damaging Het
Cdh8 A G 8: 100,127,350 (GRCm39) probably benign Het
Dse G T 10: 34,028,470 (GRCm39) N873K probably benign Het
Ehd1 G T 19: 6,327,044 (GRCm39) E14* probably null Het
F8 A G X: 74,311,030 (GRCm39) probably benign Het
Flnb T C 14: 7,942,057 (GRCm38) V2345A probably damaging Het
Fndc1 T C 17: 7,969,189 (GRCm39) K1559E probably damaging Het
Ighg1 T C 12: 113,293,180 (GRCm39) E170G probably damaging Het
Kmt2b G T 7: 30,276,117 (GRCm39) P1794Q probably damaging Het
Lama2 C T 10: 26,877,231 (GRCm39) E2652K probably benign Het
Med25 C A 7: 44,535,314 (GRCm39) R37L possibly damaging Het
Optc T C 1: 133,825,617 (GRCm39) D303G probably damaging Het
Or2n1d A G 17: 38,646,323 (GRCm39) I92V probably damaging Het
Or2n1e G A 17: 38,586,421 (GRCm39) G253D probably damaging Het
Or4c102 T A 2: 88,422,448 (GRCm39) F100Y probably damaging Het
Pkd1l2 T C 8: 117,767,478 (GRCm39) N1271D probably benign Het
Plpp2 A T 10: 79,363,647 (GRCm39) probably null Het
Polq A T 16: 36,882,699 (GRCm39) N1342I probably damaging Het
Prr16 A G 18: 51,436,195 (GRCm39) N225D probably benign Het
Pwwp2a C T 11: 43,597,015 (GRCm39) Q452* probably null Het
Sort1 T A 3: 108,245,123 (GRCm39) I325N probably damaging Het
Tmem132e A G 11: 82,335,156 (GRCm39) Y654C probably damaging Het
Tmprss11b A T 5: 86,815,443 (GRCm39) Y48* probably null Het
Tpp2 T C 1: 43,979,304 (GRCm39) I67T probably damaging Het
Trdn G A 10: 33,344,191 (GRCm39) probably null Het
Trim14 C T 4: 46,523,739 (GRCm39) V100I possibly damaging Het
Trim17 T C 11: 58,856,059 (GRCm39) C39R probably damaging Het
Trim52 C T 14: 106,344,741 (GRCm39) P133L possibly damaging Het
Unc13b T C 4: 43,097,028 (GRCm39) probably benign Het
Vmn2r94 G A 17: 18,478,650 (GRCm39) probably benign Het
Vsig4 A G X: 95,334,422 (GRCm39) V29A probably benign Het
Washc4 T A 10: 83,405,866 (GRCm39) I454N probably benign Het
Wnk3 T A X: 150,069,300 (GRCm39) F886I probably benign Het
Ylpm1 T C 12: 85,096,644 (GRCm39) probably null Het
Zfp507 A T 7: 35,487,195 (GRCm39) Y234N probably damaging Het
Other mutations in Slfn2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02141:Slfn2 APN 11 82,960,670 (GRCm39) missense probably benign 0.32
IGL02407:Slfn2 APN 11 82,960,402 (GRCm39) missense probably benign 0.00
IGL03303:Slfn2 APN 11 82,960,293 (GRCm39) missense possibly damaging 0.82
elektra UTSW 11 82,960,426 (GRCm39) missense probably damaging 1.00
elektra2 UTSW 11 82,960,390 (GRCm39) missense probably benign 0.05
R2270:Slfn2 UTSW 11 82,960,761 (GRCm39) missense probably damaging 0.99
R2392:Slfn2 UTSW 11 82,956,154 (GRCm39) missense possibly damaging 0.91
R3437:Slfn2 UTSW 11 82,960,390 (GRCm39) missense probably benign 0.05
R5849:Slfn2 UTSW 11 82,960,402 (GRCm39) missense probably benign 0.00
R7612:Slfn2 UTSW 11 82,961,089 (GRCm39) missense probably damaging 1.00
R7738:Slfn2 UTSW 11 82,960,799 (GRCm39) missense probably damaging 1.00
R8211:Slfn2 UTSW 11 82,960,585 (GRCm39) missense possibly damaging 0.50
R8465:Slfn2 UTSW 11 82,960,487 (GRCm39) missense probably damaging 1.00
R8986:Slfn2 UTSW 11 82,960,427 (GRCm39) missense possibly damaging 0.71
R8987:Slfn2 UTSW 11 82,960,363 (GRCm39) missense probably damaging 0.97
R9627:Slfn2 UTSW 11 82,960,367 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- TTCTCACCTCAGAAAACAGGAG -3'
(R):5'- TTCAGGGAAGGCTATGCTTG -3'

Sequencing Primer
(F):5'- GGAGAATGCAAACATCTCTCTAGCTG -3'
(R):5'- AACTCTGGTCTGACACAGGG -3'
Posted On 2015-02-18