Mutagenetix > Incidental Mutation

Incidental Mutation 'R3437:Vmn1r120'

267239

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r120

Ensembl Gene

ENSMUSG00000093986

Gene Name

vomeronasal 1 receptor 120

Synonyms

Gm5730

MMRRC Submission

040655-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

R3437 (G1)

Quality Score

130

Status

Not validated

Chromosome

Chromosomal Location

20786792-20787709 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 20787582 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Tryptophan at position 43 (L43W)

Ref Sequence

ENSEMBL: ENSMUSP00000100837 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105202]

AlphaFold

K7N6J6

Predicted Effect

probably damaging
Transcript: ENSMUST00000105202
AA Change: L43W

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000100837
Gene: ENSMUSG00000093986
AA Change: L43W

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	297	2.3e-15	PFAM
Pfam:7tm_1	31	286	3.6e-6	PFAM
Pfam:V1R	41	296	6.4e-13	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.2%
20x: 94.6%

Validation Efficiency

100% (42/42)

Allele List at MGI

Other mutations in this stock

Total: 43 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	T	G	6: 121,616,253 (GRCm39)	L127R	probably null	Het
Ambp	T	C	4: 63,067,721 (GRCm39)	E163G	probably benign	Het
Amy1	G	A	3: 113,349,658 (GRCm39)	A504V	probably damaging	Het
Angptl3	A	T	4: 98,921,540 (GRCm39)	K219N	probably benign	Het
Atp6v1g1	A	G	4: 63,468,255 (GRCm39)	N86S	probably benign	Het
Avl9	T	C	6: 56,713,612 (GRCm39)	V290A	probably benign	Het
Bad	A	G	19: 6,919,799 (GRCm39)	R37G	probably benign	Het
Bicra	T	C	7: 15,723,223 (GRCm39)	D98G	possibly damaging	Het
Cfap251	A	G	5: 123,392,435 (GRCm39)		probably benign	Het
Col4a4	G	A	1: 82,474,889 (GRCm39)	T650M	unknown	Het
Cyp11b2	T	C	15: 74,727,298 (GRCm39)	R128G	probably benign	Het
Dst	T	C	1: 34,229,303 (GRCm39)	S1974P	probably damaging	Het
Fabp1	T	C	6: 71,178,595 (GRCm39)	L24P	probably benign	Het
Flnb	T	C	14: 7,942,057 (GRCm38)	V2345A	probably damaging	Het
Gmnc	G	T	16: 26,779,217 (GRCm39)	H221Q	probably benign	Het
Homer1	T	C	13: 93,502,929 (GRCm39)		probably benign	Het
Kit	A	G	5: 75,806,565 (GRCm39)	D690G	probably damaging	Het
Lama2	C	T	10: 26,877,231 (GRCm39)	E2652K	probably benign	Het
Mc3r	C	T	2: 172,091,588 (GRCm39)	T270I	probably benign	Het
Mrgpra3	A	C	7: 47,239,314 (GRCm39)	L204W	probably damaging	Het
Mroh1	C	T	15: 76,317,808 (GRCm39)	T839I	possibly damaging	Het
Naip2	T	A	13: 100,291,419 (GRCm39)	H1173L	probably benign	Het
Optc	T	C	1: 133,825,617 (GRCm39)	D303G	probably damaging	Het
Or2n1d	A	G	17: 38,646,323 (GRCm39)	I92V	probably damaging	Het
Or5af1	A	T	11: 58,722,150 (GRCm39)	M57L	probably damaging	Het
P4ha3	C	T	7: 99,934,831 (GRCm39)	A31V	possibly damaging	Het
Plch2	A	G	4: 155,075,470 (GRCm39)		probably null	Het
Plpp2	A	T	10: 79,363,647 (GRCm39)		probably null	Het
Polq	A	T	16: 36,882,699 (GRCm39)	N1342I	probably damaging	Het
Pter	T	A	2: 13,005,805 (GRCm39)	L326H	probably benign	Het
Pwwp2a	C	T	11: 43,597,015 (GRCm39)	Q452*	probably null	Het
Slc8a2	T	G	7: 15,892,810 (GRCm39)	V824G	probably damaging	Het
Slfn2	A	T	11: 82,960,390 (GRCm39)	H123L	probably benign	Het
Tmem132e	A	G	11: 82,335,156 (GRCm39)	Y654C	probably damaging	Het
Trim14	C	T	4: 46,523,739 (GRCm39)	V100I	possibly damaging	Het
Tro	G	A	X: 149,429,252 (GRCm39)		probably benign	Het
Uspl1	T	A	5: 149,151,507 (GRCm39)		probably benign	Het
Uty	A	G	Y: 1,158,336 (GRCm39)	I522T	probably benign	Het
Vmn2r16	A	T	5: 109,478,362 (GRCm39)	D39V	probably damaging	Het
Washc4	T	A	10: 83,405,866 (GRCm39)	I454N	probably benign	Het
Wnt16	T	C	6: 22,298,133 (GRCm39)	V333A	probably damaging	Het
Ylpm1	T	C	12: 85,096,644 (GRCm39)		probably null	Het
Zfy1	A	T	Y: 726,357 (GRCm39)	D469E	possibly damaging	Het

Other mutations in Vmn1r120

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00474:Vmn1r120	APN	7	20,786,935 (GRCm39)	missense	probably benign	0.00
IGL02533:Vmn1r120	APN	7	20,787,063 (GRCm39)	missense	probably damaging	1.00
IGL03261:Vmn1r120	APN	7	20,787,450 (GRCm39)	missense	probably damaging	1.00
R0539:Vmn1r120	UTSW	7	20,787,397 (GRCm39)	missense	probably damaging	0.99
R0973:Vmn1r120	UTSW	7	20,786,941 (GRCm39)	missense	probably damaging	1.00
R1831:Vmn1r120	UTSW	7	20,787,556 (GRCm39)	missense	probably benign
R2034:Vmn1r120	UTSW	7	20,786,883 (GRCm39)	missense	possibly damaging	0.56
R2149:Vmn1r120	UTSW	7	20,786,889 (GRCm39)	missense	probably damaging	0.98
R5449:Vmn1r120	UTSW	7	20,787,074 (GRCm39)	missense	possibly damaging	0.53
R5548:Vmn1r120	UTSW	7	20,787,482 (GRCm39)	missense	probably benign	0.01
R5730:Vmn1r120	UTSW	7	20,786,934 (GRCm39)	missense	possibly damaging	0.80
R6305:Vmn1r120	UTSW	7	20,787,531 (GRCm39)	missense	possibly damaging	0.95
R7348:Vmn1r120	UTSW	7	20,787,377 (GRCm39)	missense	probably damaging	1.00
R8435:Vmn1r120	UTSW	7	20,787,557 (GRCm39)	missense	probably benign	0.44
R8486:Vmn1r120	UTSW	7	20,787,027 (GRCm39)	missense	probably benign
R9613:Vmn1r120	UTSW	7	20,787,046 (GRCm39)	missense	probably benign	0.03

Predicted Primers

PCR Primer
(F):5'- ATGATGGATACTCAGGACACAGGTG -3'
(R):5'- CAGAAACCTGAGAAGAGTAGTGTTC -3'

Sequencing Primer
(F):5'- AAGTTTGTGTTTCTTGCCACCATG -3'
(R):5'- AGTGTTCTATCTAATCATCCAGGGTC -3'

Posted On

2015-02-18