Incidental Mutation 'R3437:Mrgpra3'
ID |
267240 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Mrgpra3
|
Ensembl Gene |
ENSMUSG00000078698 |
Gene Name |
MAS-related GPR, member A3 |
Synonyms |
G protein-coupled receptor, MrgA3 |
MMRRC Submission |
040655-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.048)
|
Stock # |
R3437 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
47238698-47251120 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to C
at 47239314 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Leucine to Tryptophan
at position 204
(L204W)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000135437
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000176369]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000176369
AA Change: L204W
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
SMART Domains |
Protein: ENSMUSP00000135437 Gene: ENSMUSG00000078698 AA Change: L204W
Domain | Start | End | E-Value | Type |
low complexity region
|
14 |
31 |
N/A |
INTRINSIC |
Pfam:7TM_GPCR_Srx
|
48 |
234 |
6.3e-7 |
PFAM |
Pfam:7tm_1
|
57 |
286 |
2.7e-9 |
PFAM |
|
Meta Mutation Damage Score |
0.6467 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 94.6%
|
Validation Efficiency |
100% (42/42) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 43 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
A2m |
T |
G |
6: 121,616,253 (GRCm39) |
L127R |
probably null |
Het |
Ambp |
T |
C |
4: 63,067,721 (GRCm39) |
E163G |
probably benign |
Het |
Amy1 |
G |
A |
3: 113,349,658 (GRCm39) |
A504V |
probably damaging |
Het |
Angptl3 |
A |
T |
4: 98,921,540 (GRCm39) |
K219N |
probably benign |
Het |
Atp6v1g1 |
A |
G |
4: 63,468,255 (GRCm39) |
N86S |
probably benign |
Het |
Avl9 |
T |
C |
6: 56,713,612 (GRCm39) |
V290A |
probably benign |
Het |
Bad |
A |
G |
19: 6,919,799 (GRCm39) |
R37G |
probably benign |
Het |
Bicra |
T |
C |
7: 15,723,223 (GRCm39) |
D98G |
possibly damaging |
Het |
Cfap251 |
A |
G |
5: 123,392,435 (GRCm39) |
|
probably benign |
Het |
Col4a4 |
G |
A |
1: 82,474,889 (GRCm39) |
T650M |
unknown |
Het |
Cyp11b2 |
T |
C |
15: 74,727,298 (GRCm39) |
R128G |
probably benign |
Het |
Dst |
T |
C |
1: 34,229,303 (GRCm39) |
S1974P |
probably damaging |
Het |
Fabp1 |
T |
C |
6: 71,178,595 (GRCm39) |
L24P |
probably benign |
Het |
Flnb |
T |
C |
14: 7,942,057 (GRCm38) |
V2345A |
probably damaging |
Het |
Gmnc |
G |
T |
16: 26,779,217 (GRCm39) |
H221Q |
probably benign |
Het |
Homer1 |
T |
C |
13: 93,502,929 (GRCm39) |
|
probably benign |
Het |
Kit |
A |
G |
5: 75,806,565 (GRCm39) |
D690G |
probably damaging |
Het |
Lama2 |
C |
T |
10: 26,877,231 (GRCm39) |
E2652K |
probably benign |
Het |
Mc3r |
C |
T |
2: 172,091,588 (GRCm39) |
T270I |
probably benign |
Het |
Mroh1 |
C |
T |
15: 76,317,808 (GRCm39) |
T839I |
possibly damaging |
Het |
Naip2 |
T |
A |
13: 100,291,419 (GRCm39) |
H1173L |
probably benign |
Het |
Optc |
T |
C |
1: 133,825,617 (GRCm39) |
D303G |
probably damaging |
Het |
Or2n1d |
A |
G |
17: 38,646,323 (GRCm39) |
I92V |
probably damaging |
Het |
Or5af1 |
A |
T |
11: 58,722,150 (GRCm39) |
M57L |
probably damaging |
Het |
P4ha3 |
C |
T |
7: 99,934,831 (GRCm39) |
A31V |
possibly damaging |
Het |
Plch2 |
A |
G |
4: 155,075,470 (GRCm39) |
|
probably null |
Het |
Plpp2 |
A |
T |
10: 79,363,647 (GRCm39) |
|
probably null |
Het |
Polq |
A |
T |
16: 36,882,699 (GRCm39) |
N1342I |
probably damaging |
Het |
Pter |
T |
A |
2: 13,005,805 (GRCm39) |
L326H |
probably benign |
Het |
Pwwp2a |
C |
T |
11: 43,597,015 (GRCm39) |
Q452* |
probably null |
Het |
Slc8a2 |
T |
G |
7: 15,892,810 (GRCm39) |
V824G |
probably damaging |
Het |
Slfn2 |
A |
T |
11: 82,960,390 (GRCm39) |
H123L |
probably benign |
Het |
Tmem132e |
A |
G |
11: 82,335,156 (GRCm39) |
Y654C |
probably damaging |
Het |
Trim14 |
C |
T |
4: 46,523,739 (GRCm39) |
V100I |
possibly damaging |
Het |
Tro |
G |
A |
X: 149,429,252 (GRCm39) |
|
probably benign |
Het |
Uspl1 |
T |
A |
5: 149,151,507 (GRCm39) |
|
probably benign |
Het |
Uty |
A |
G |
Y: 1,158,336 (GRCm39) |
I522T |
probably benign |
Het |
Vmn1r120 |
A |
C |
7: 20,787,582 (GRCm39) |
L43W |
probably damaging |
Het |
Vmn2r16 |
A |
T |
5: 109,478,362 (GRCm39) |
D39V |
probably damaging |
Het |
Washc4 |
T |
A |
10: 83,405,866 (GRCm39) |
I454N |
probably benign |
Het |
Wnt16 |
T |
C |
6: 22,298,133 (GRCm39) |
V333A |
probably damaging |
Het |
Ylpm1 |
T |
C |
12: 85,096,644 (GRCm39) |
|
probably null |
Het |
Zfy1 |
A |
T |
Y: 726,357 (GRCm39) |
D469E |
possibly damaging |
Het |
|
Other mutations in Mrgpra3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00162:Mrgpra3
|
APN |
7 |
47,239,267 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02097:Mrgpra3
|
APN |
7 |
47,239,204 (GRCm39) |
missense |
possibly damaging |
0.94 |
IGL02101:Mrgpra3
|
APN |
7 |
47,239,300 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL03071:Mrgpra3
|
APN |
7 |
47,238,929 (GRCm39) |
utr 3 prime |
probably benign |
|
PIT4445001:Mrgpra3
|
UTSW |
7 |
47,239,908 (GRCm39) |
missense |
possibly damaging |
0.88 |
R0828:Mrgpra3
|
UTSW |
7 |
47,239,884 (GRCm39) |
missense |
probably benign |
0.12 |
R1118:Mrgpra3
|
UTSW |
7 |
47,239,039 (GRCm39) |
missense |
possibly damaging |
0.83 |
R1835:Mrgpra3
|
UTSW |
7 |
47,239,694 (GRCm39) |
nonsense |
probably null |
|
R2258:Mrgpra3
|
UTSW |
7 |
47,239,842 (GRCm39) |
missense |
probably benign |
0.35 |
R2393:Mrgpra3
|
UTSW |
7 |
47,239,365 (GRCm39) |
missense |
possibly damaging |
0.92 |
R3973:Mrgpra3
|
UTSW |
7 |
47,239,414 (GRCm39) |
missense |
probably benign |
0.22 |
R4273:Mrgpra3
|
UTSW |
7 |
47,239,180 (GRCm39) |
missense |
probably benign |
0.01 |
R4495:Mrgpra3
|
UTSW |
7 |
47,239,813 (GRCm39) |
missense |
probably benign |
0.00 |
R4768:Mrgpra3
|
UTSW |
7 |
47,239,476 (GRCm39) |
missense |
possibly damaging |
0.94 |
R4822:Mrgpra3
|
UTSW |
7 |
47,239,716 (GRCm39) |
missense |
possibly damaging |
0.69 |
R4967:Mrgpra3
|
UTSW |
7 |
47,239,267 (GRCm39) |
missense |
probably benign |
0.33 |
R5207:Mrgpra3
|
UTSW |
7 |
47,239,909 (GRCm39) |
missense |
probably benign |
0.06 |
R5569:Mrgpra3
|
UTSW |
7 |
47,239,759 (GRCm39) |
missense |
probably benign |
0.00 |
R5763:Mrgpra3
|
UTSW |
7 |
47,239,355 (GRCm39) |
nonsense |
probably null |
|
R6102:Mrgpra3
|
UTSW |
7 |
47,239,897 (GRCm39) |
missense |
possibly damaging |
0.92 |
R6612:Mrgpra3
|
UTSW |
7 |
47,239,783 (GRCm39) |
missense |
probably benign |
0.00 |
R6718:Mrgpra3
|
UTSW |
7 |
47,239,444 (GRCm39) |
missense |
probably benign |
0.25 |
R6859:Mrgpra3
|
UTSW |
7 |
47,239,781 (GRCm39) |
missense |
probably benign |
0.04 |
R7029:Mrgpra3
|
UTSW |
7 |
47,239,290 (GRCm39) |
missense |
probably benign |
0.00 |
R7034:Mrgpra3
|
UTSW |
7 |
47,239,838 (GRCm39) |
missense |
possibly damaging |
0.49 |
R7036:Mrgpra3
|
UTSW |
7 |
47,239,838 (GRCm39) |
missense |
possibly damaging |
0.49 |
R7097:Mrgpra3
|
UTSW |
7 |
47,239,389 (GRCm39) |
missense |
probably benign |
|
R7475:Mrgpra3
|
UTSW |
7 |
47,239,695 (GRCm39) |
missense |
probably damaging |
1.00 |
R8289:Mrgpra3
|
UTSW |
7 |
47,239,468 (GRCm39) |
missense |
possibly damaging |
0.76 |
R8315:Mrgpra3
|
UTSW |
7 |
47,251,051 (GRCm39) |
start codon destroyed |
probably null |
0.93 |
R9500:Mrgpra3
|
UTSW |
7 |
47,239,400 (GRCm39) |
nonsense |
probably null |
|
Z1177:Mrgpra3
|
UTSW |
7 |
47,251,049 (GRCm39) |
nonsense |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- CCAGGTGCAATCCAGAATAACAGG -3'
(R):5'- TGAGCATGCTCAGTGCCATC -3'
Sequencing Primer
(F):5'- TAACAGGAACCAGGTGATGCCC -3'
(R):5'- ATCTGGTATCACTGCCGCCG -3'
|
Posted On |
2015-02-18 |