Incidental Mutation 'R3437:Tmem132e'
ID 267247
Institutional Source Beutler Lab
Gene Symbol Tmem132e
Ensembl Gene ENSMUSG00000020701
Gene Name transmembrane protein 132E
Synonyms LOC270893
MMRRC Submission 040655-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.517) question?
Stock # R3437 (G1)
Quality Score 216
Status Validated
Chromosome 11
Chromosomal Location 82279726-82337158 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 82335156 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 654 (Y654C)
Ref Sequence ENSEMBL: ENSMUSP00000090528 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054245] [ENSMUST00000092852]
AlphaFold Q6IEE6
Predicted Effect probably damaging
Transcript: ENSMUST00000054245
AA Change: Y746C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000052484
Gene: ENSMUSG00000020701
AA Change: Y746C

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Pfam:TMEM132D_N 45 176 1.1e-52 PFAM
low complexity region 202 216 N/A INTRINSIC
low complexity region 241 262 N/A INTRINSIC
low complexity region 318 328 N/A INTRINSIC
Pfam:TMEM132 451 797 1.7e-136 PFAM
low complexity region 827 837 N/A INTRINSIC
low complexity region 841 854 N/A INTRINSIC
Pfam:TMEM132D_C 867 944 2e-34 PFAM
low complexity region 967 998 N/A INTRINSIC
low complexity region 1016 1027 N/A INTRINSIC
low complexity region 1036 1043 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000092852
AA Change: Y654C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000090528
Gene: ENSMUSG00000020701
AA Change: Y654C

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
low complexity region 226 236 N/A INTRINSIC
low complexity region 471 489 N/A INTRINSIC
low complexity region 735 745 N/A INTRINSIC
low complexity region 749 762 N/A INTRINSIC
transmembrane domain 798 820 N/A INTRINSIC
low complexity region 875 906 N/A INTRINSIC
low complexity region 924 935 N/A INTRINSIC
low complexity region 944 951 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000202598
Meta Mutation Damage Score 0.6213 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.6%
Validation Efficiency 100% (42/42)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T G 6: 121,616,253 (GRCm39) L127R probably null Het
Ambp T C 4: 63,067,721 (GRCm39) E163G probably benign Het
Amy1 G A 3: 113,349,658 (GRCm39) A504V probably damaging Het
Angptl3 A T 4: 98,921,540 (GRCm39) K219N probably benign Het
Atp6v1g1 A G 4: 63,468,255 (GRCm39) N86S probably benign Het
Avl9 T C 6: 56,713,612 (GRCm39) V290A probably benign Het
Bad A G 19: 6,919,799 (GRCm39) R37G probably benign Het
Bicra T C 7: 15,723,223 (GRCm39) D98G possibly damaging Het
Cfap251 A G 5: 123,392,435 (GRCm39) probably benign Het
Col4a4 G A 1: 82,474,889 (GRCm39) T650M unknown Het
Cyp11b2 T C 15: 74,727,298 (GRCm39) R128G probably benign Het
Dst T C 1: 34,229,303 (GRCm39) S1974P probably damaging Het
Fabp1 T C 6: 71,178,595 (GRCm39) L24P probably benign Het
Flnb T C 14: 7,942,057 (GRCm38) V2345A probably damaging Het
Gmnc G T 16: 26,779,217 (GRCm39) H221Q probably benign Het
Homer1 T C 13: 93,502,929 (GRCm39) probably benign Het
Kit A G 5: 75,806,565 (GRCm39) D690G probably damaging Het
Lama2 C T 10: 26,877,231 (GRCm39) E2652K probably benign Het
Mc3r C T 2: 172,091,588 (GRCm39) T270I probably benign Het
Mrgpra3 A C 7: 47,239,314 (GRCm39) L204W probably damaging Het
Mroh1 C T 15: 76,317,808 (GRCm39) T839I possibly damaging Het
Naip2 T A 13: 100,291,419 (GRCm39) H1173L probably benign Het
Optc T C 1: 133,825,617 (GRCm39) D303G probably damaging Het
Or2n1d A G 17: 38,646,323 (GRCm39) I92V probably damaging Het
Or5af1 A T 11: 58,722,150 (GRCm39) M57L probably damaging Het
P4ha3 C T 7: 99,934,831 (GRCm39) A31V possibly damaging Het
Plch2 A G 4: 155,075,470 (GRCm39) probably null Het
Plpp2 A T 10: 79,363,647 (GRCm39) probably null Het
Polq A T 16: 36,882,699 (GRCm39) N1342I probably damaging Het
Pter T A 2: 13,005,805 (GRCm39) L326H probably benign Het
Pwwp2a C T 11: 43,597,015 (GRCm39) Q452* probably null Het
Slc8a2 T G 7: 15,892,810 (GRCm39) V824G probably damaging Het
Slfn2 A T 11: 82,960,390 (GRCm39) H123L probably benign Het
Trim14 C T 4: 46,523,739 (GRCm39) V100I possibly damaging Het
Tro G A X: 149,429,252 (GRCm39) probably benign Het
Uspl1 T A 5: 149,151,507 (GRCm39) probably benign Het
Uty A G Y: 1,158,336 (GRCm39) I522T probably benign Het
Vmn1r120 A C 7: 20,787,582 (GRCm39) L43W probably damaging Het
Vmn2r16 A T 5: 109,478,362 (GRCm39) D39V probably damaging Het
Washc4 T A 10: 83,405,866 (GRCm39) I454N probably benign Het
Wnt16 T C 6: 22,298,133 (GRCm39) V333A probably damaging Het
Ylpm1 T C 12: 85,096,644 (GRCm39) probably null Het
Zfy1 A T Y: 726,357 (GRCm39) D469E possibly damaging Het
Other mutations in Tmem132e
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01576:Tmem132e APN 11 82,329,200 (GRCm39) missense probably damaging 1.00
IGL01586:Tmem132e APN 11 82,325,495 (GRCm39) missense probably damaging 1.00
IGL01729:Tmem132e APN 11 82,325,942 (GRCm39) missense possibly damaging 0.89
IGL02592:Tmem132e APN 11 82,325,462 (GRCm39) missense probably damaging 1.00
R0029:Tmem132e UTSW 11 82,335,587 (GRCm39) missense probably damaging 1.00
R0501:Tmem132e UTSW 11 82,325,894 (GRCm39) missense possibly damaging 0.90
R0612:Tmem132e UTSW 11 82,334,198 (GRCm39) missense probably damaging 1.00
R0613:Tmem132e UTSW 11 82,329,164 (GRCm39) missense probably damaging 1.00
R1311:Tmem132e UTSW 11 82,335,122 (GRCm39) missense probably damaging 1.00
R1430:Tmem132e UTSW 11 82,329,122 (GRCm39) missense probably damaging 1.00
R1607:Tmem132e UTSW 11 82,328,196 (GRCm39) missense probably benign 0.39
R1710:Tmem132e UTSW 11 82,334,343 (GRCm39) missense probably damaging 1.00
R1913:Tmem132e UTSW 11 82,334,243 (GRCm39) missense probably damaging 1.00
R1951:Tmem132e UTSW 11 82,335,908 (GRCm39) missense possibly damaging 0.84
R2018:Tmem132e UTSW 11 82,335,989 (GRCm39) missense probably benign 0.26
R2051:Tmem132e UTSW 11 82,331,264 (GRCm39) missense probably damaging 1.00
R2076:Tmem132e UTSW 11 82,325,894 (GRCm39) missense possibly damaging 0.90
R2100:Tmem132e UTSW 11 82,335,357 (GRCm39) missense probably damaging 1.00
R2325:Tmem132e UTSW 11 82,325,341 (GRCm39) missense probably damaging 1.00
R2924:Tmem132e UTSW 11 82,335,149 (GRCm39) missense probably damaging 1.00
R3436:Tmem132e UTSW 11 82,335,156 (GRCm39) missense probably damaging 1.00
R4594:Tmem132e UTSW 11 82,325,894 (GRCm39) missense possibly damaging 0.83
R4704:Tmem132e UTSW 11 82,334,357 (GRCm39) missense probably damaging 0.97
R4754:Tmem132e UTSW 11 82,335,677 (GRCm39) nonsense probably null
R4764:Tmem132e UTSW 11 82,325,338 (GRCm39) missense probably damaging 0.99
R5245:Tmem132e UTSW 11 82,333,464 (GRCm39) missense probably damaging 0.96
R5720:Tmem132e UTSW 11 82,333,276 (GRCm39) splice site probably null
R5793:Tmem132e UTSW 11 82,335,684 (GRCm39) missense probably damaging 1.00
R5984:Tmem132e UTSW 11 82,335,923 (GRCm39) missense probably damaging 1.00
R6980:Tmem132e UTSW 11 82,329,212 (GRCm39) critical splice donor site probably null
R7052:Tmem132e UTSW 11 82,328,189 (GRCm39) missense probably damaging 0.99
R7637:Tmem132e UTSW 11 82,325,342 (GRCm39) missense probably damaging 1.00
R7918:Tmem132e UTSW 11 82,336,116 (GRCm39) missense probably damaging 1.00
R8262:Tmem132e UTSW 11 82,325,666 (GRCm39) missense probably benign 0.33
R8772:Tmem132e UTSW 11 82,325,137 (GRCm39) missense probably damaging 0.99
R9248:Tmem132e UTSW 11 82,335,308 (GRCm39) missense probably damaging 1.00
Z1177:Tmem132e UTSW 11 82,335,930 (GRCm39) missense probably damaging 0.97
Z1177:Tmem132e UTSW 11 82,326,004 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGAGTCTCAGCTAGCACCTAG -3'
(R):5'- GAGTAGTAGCCAGCACACTCTTG -3'

Sequencing Primer
(F):5'- GCACCTAGCATTTCCAGTGTAAGG -3'
(R):5'- GCACACTCTTGCGCTTGG -3'
Posted On 2015-02-18