Incidental Mutation 'R3438:Oas1e'
ID 267275
Institutional Source Beutler Lab
Gene Symbol Oas1e
Ensembl Gene ENSMUSG00000066867
Gene Name 2'-5' oligoadenylate synthetase 1E
Synonyms 2'-5' oligoadenylate synthetase-like 7
MMRRC Submission 040656-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R3438 (G1)
Quality Score 225
Status Validated
Chromosome 5
Chromosomal Location 120924377-120933595 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 120933475 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 30 (E30G)
Ref Sequence ENSEMBL: ENSMUSP00000144442 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100785] [ENSMUST00000117193] [ENSMUST00000200786] [ENSMUST00000201172]
AlphaFold A0A0J9YV76
Predicted Effect probably benign
Transcript: ENSMUST00000100785
AA Change: E30G

PolyPhen 2 Score 0.073 (Sensitivity: 0.93; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000098348
Gene: ENSMUSG00000066867
AA Change: E30G

DomainStartEndE-ValueType
Pfam:OAS1_C 168 353 4.3e-74 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000117193
SMART Domains Protein: ENSMUSP00000112584
Gene: ENSMUSG00000001166

DomainStartEndE-ValueType
Pfam:OAS1_C 168 354 1.4e-76 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000200786
AA Change: E30G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000144442
Gene: ENSMUSG00000066867
AA Change: E30G

DomainStartEndE-ValueType
PDB:1PX5|B 4 60 4e-14 PDB
low complexity region 82 100 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000201006
Predicted Effect probably damaging
Transcript: ENSMUST00000201172
AA Change: E30G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000144529
Gene: ENSMUSG00000066867
AA Change: E30G

DomainStartEndE-ValueType
Pfam:OAS1_C 168 353 2.7e-71 PFAM
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.4%
Validation Efficiency 97% (37/38)
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017G19Rik A G 3: 40,575,673 (GRCm39) noncoding transcript Het
A2ml1 C T 6: 128,557,349 (GRCm39) A115T probably benign Het
Ampd3 T C 7: 110,402,433 (GRCm39) I479T probably damaging Het
Aoah G A 13: 21,101,242 (GRCm39) R254K probably benign Het
Appbp2 T C 11: 85,088,966 (GRCm39) E358G probably damaging Het
Col6a5 A G 9: 105,752,991 (GRCm39) S2294P possibly damaging Het
Cux1 T C 5: 136,340,414 (GRCm39) E632G probably damaging Het
Cyp7a1 T C 4: 6,272,769 (GRCm39) N148S probably damaging Het
Dgkz A T 2: 91,764,395 (GRCm39) probably benign Het
Dlgap1 A T 17: 70,823,356 (GRCm39) S114C probably damaging Het
Dmtn T A 14: 70,850,156 (GRCm39) I263F probably damaging Het
Gigyf2 C A 1: 87,368,302 (GRCm39) H1029N probably damaging Het
Gm10770 T A 2: 150,021,469 (GRCm39) probably null Het
Gnb1l A G 16: 18,371,117 (GRCm39) T203A probably benign Het
Kng2 T C 16: 22,830,821 (GRCm39) I163V probably benign Het
Lamc1 T C 1: 153,102,161 (GRCm39) D1479G probably benign Het
Larp7-ps A C 4: 92,079,919 (GRCm39) V23G possibly damaging Het
Lhx4 T A 1: 155,578,230 (GRCm39) D304V probably benign Het
Mybl1 G T 1: 9,757,870 (GRCm39) T143K probably damaging Het
Notch3 C T 17: 32,372,564 (GRCm39) C630Y probably damaging Het
Or4c114 T C 2: 88,904,707 (GRCm39) I243V probably benign Het
Or8b55 T G 9: 38,727,512 (GRCm39) F238V probably damaging Het
Or9e1 G T 11: 58,732,698 (GRCm39) G253* probably null Het
Otoa A G 7: 120,759,566 (GRCm39) E1056G possibly damaging Het
Plin4 A G 17: 56,414,193 (GRCm39) V144A probably benign Het
Sec16b T C 1: 157,384,328 (GRCm39) probably benign Het
Stk31 A G 6: 49,414,455 (GRCm39) S485G probably benign Het
Tanc2 C T 11: 105,748,401 (GRCm39) P511L probably damaging Het
Utrn T C 10: 12,357,062 (GRCm39) D309G probably damaging Het
Vpreb3 C T 10: 75,779,056 (GRCm39) probably benign Het
Vsx2 A T 12: 84,616,985 (GRCm39) Q90L probably damaging Het
Other mutations in Oas1e
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00583:Oas1e APN 5 120,932,337 (GRCm39) missense probably damaging 1.00
IGL02072:Oas1e APN 5 120,929,846 (GRCm39) critical splice donor site probably null
IGL02652:Oas1e APN 5 120,933,470 (GRCm39) missense probably damaging 0.99
R0049:Oas1e UTSW 5 120,933,395 (GRCm39) missense probably benign 0.01
R0242:Oas1e UTSW 5 120,929,839 (GRCm39) splice site probably benign
R0325:Oas1e UTSW 5 120,933,460 (GRCm39) missense probably damaging 1.00
R1528:Oas1e UTSW 5 120,926,054 (GRCm39) missense probably damaging 1.00
R3790:Oas1e UTSW 5 120,933,475 (GRCm39) missense probably damaging 1.00
R3963:Oas1e UTSW 5 120,932,205 (GRCm39) missense probably damaging 1.00
R4811:Oas1e UTSW 5 120,933,448 (GRCm39) missense probably damaging 0.98
R5095:Oas1e UTSW 5 120,932,329 (GRCm39) nonsense probably null
R5327:Oas1e UTSW 5 120,930,006 (GRCm39) missense probably damaging 1.00
R5860:Oas1e UTSW 5 120,930,015 (GRCm39) missense probably benign 0.13
R5909:Oas1e UTSW 5 120,926,972 (GRCm39) missense probably damaging 0.98
R6503:Oas1e UTSW 5 120,926,042 (GRCm39) missense probably benign 0.39
R7167:Oas1e UTSW 5 120,933,487 (GRCm39) missense probably benign 0.35
R7515:Oas1e UTSW 5 120,929,951 (GRCm39) missense probably damaging 1.00
R7563:Oas1e UTSW 5 120,927,021 (GRCm39) missense probably benign 0.00
R8114:Oas1e UTSW 5 120,924,708 (GRCm39) missense unknown
R8133:Oas1e UTSW 5 120,926,060 (GRCm39) missense probably benign 0.00
R8351:Oas1e UTSW 5 120,925,008 (GRCm39) splice site probably null
R8710:Oas1e UTSW 5 120,930,027 (GRCm39) nonsense probably null
R9667:Oas1e UTSW 5 120,932,347 (GRCm39) missense probably benign 0.28
RF020:Oas1e UTSW 5 120,932,383 (GRCm39) missense possibly damaging 0.58
Predicted Primers PCR Primer
(F):5'- TCTACATGAGGACACTGGGC -3'
(R):5'- AGAGGTCTGATCTGCATAGCCC -3'

Sequencing Primer
(F):5'- GCACAGAGCAGGTAGGTAACTCAC -3'
(R):5'- ATCTGCATAGCCCCGCCC -3'
Posted On 2015-02-18