Incidental Mutation 'R3508:Adgrl3'
ID |
267460 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Adgrl3
|
Ensembl Gene |
ENSMUSG00000037605 |
Gene Name |
adhesion G protein-coupled receptor L3 |
Synonyms |
lectomedin 3, D130075K09Rik, 5430402I23Rik, Lphn3, LEC3 |
MMRRC Submission |
040664-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R3508 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
5 |
Chromosomal Location |
81167985-81972980 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
C to A
at 81872103 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Asparagine to Lysine
at position 932
(N932K)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000113208
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000036068]
[ENSMUST00000072521]
[ENSMUST00000117253]
[ENSMUST00000117407]
[ENSMUST00000117985]
[ENSMUST00000118034]
[ENSMUST00000120673]
[ENSMUST00000118078]
[ENSMUST00000118442]
[ENSMUST00000119385]
[ENSMUST00000119788]
[ENSMUST00000120128]
[ENSMUST00000120144]
[ENSMUST00000120292]
[ENSMUST00000120445]
[ENSMUST00000121641]
[ENSMUST00000121707]
[ENSMUST00000122037]
[ENSMUST00000122356]
[ENSMUST00000132375]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000036068
AA Change: N1000K
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000045342 Gene: ENSMUSG00000037605 AA Change: N1000K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
6.6e-27 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
1.1e-7 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
2.2e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
4.4e-72 |
PFAM |
Pfam:Latrophilin
|
1206 |
1276 |
2.4e-30 |
PFAM |
Pfam:Latrophilin
|
1272 |
1543 |
3.2e-113 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000072521
AA Change: N1000K
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000072336 Gene: ENSMUSG00000037605 AA Change: N1000K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
5.9e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
4.3e-8 |
PFAM |
Pfam:GAIN
|
630 |
856 |
1.2e-58 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
2.5e-73 |
PFAM |
Pfam:Latrophilin
|
1207 |
1274 |
4e-34 |
PFAM |
Pfam:Latrophilin
|
1272 |
1543 |
5e-89 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000117253
AA Change: N932K
PolyPhen 2
Score 0.930 (Sensitivity: 0.81; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000112470 Gene: ENSMUSG00000037605 AA Change: N932K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
5e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1265 |
7.5e-55 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000117407
AA Change: N1000K
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000112388 Gene: ENSMUSG00000037605 AA Change: N1000K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
2.4e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
6e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
2.6e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
7.7e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1321 |
1.8e-61 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000117985
AA Change: N932K
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000113950 Gene: ENSMUSG00000037605 AA Change: N932K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1.3e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
5.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.6e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1119 |
1.7e-72 |
PFAM |
Pfam:Latrophilin
|
1138 |
1512 |
6.8e-178 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000118034
AA Change: N932K
PolyPhen 2
Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000113534 Gene: ENSMUSG00000037605 AA Change: N932K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1.2e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
5.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.6e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
6.6e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1503 |
6.7e-178 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000120673
AA Change: N1000K
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000113482 Gene: ENSMUSG00000037605 AA Change: N1000K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
2.7e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
3.3e-8 |
PFAM |
Pfam:GAIN
|
630 |
856 |
6.4e-59 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
1.8e-73 |
PFAM |
Pfam:Latrophilin
|
1207 |
1580 |
1.4e-158 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000118078
AA Change: N932K
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
SMART Domains |
Protein: ENSMUSP00000112731 Gene: ENSMUSG00000037605 AA Change: N932K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
9.7e-27 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.3e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
4.8e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1201 |
2.6e-30 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000118442
AA Change: N1000K
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000113836 Gene: ENSMUSG00000037605 AA Change: N1000K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
4.7e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.3e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
1.4e-72 |
PFAM |
Pfam:Latrophilin
|
1206 |
1278 |
2.8e-30 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000119385
AA Change: N1000K
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000113243 Gene: ENSMUSG00000037605 AA Change: N1000K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
4.6e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.3e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
5.2e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1269 |
2.7e-30 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000119788
AA Change: N1000K
PolyPhen 2
Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000114067 Gene: ENSMUSG00000037605 AA Change: N1000K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
5.7e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
1.8e-72 |
PFAM |
Pfam:Latrophilin
|
1206 |
1279 |
3.6e-31 |
PFAM |
Pfam:Latrophilin
|
1273 |
1550 |
4.5e-113 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000120128
AA Change: N932K
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000113208 Gene: ENSMUSG00000037605 AA Change: N932K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
9.8e-27 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.4e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.2e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1119 |
1.3e-72 |
PFAM |
Pfam:Latrophilin
|
1138 |
1210 |
2.6e-30 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000120144
AA Change: N932K
PolyPhen 2
Score 0.962 (Sensitivity: 0.78; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000113619 Gene: ENSMUSG00000037605 AA Change: N932K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.3e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
5.1e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1253 |
8.4e-62 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000120292
AA Change: N932K
PolyPhen 2
Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
|
SMART Domains |
Protein: ENSMUSP00000112548 Gene: ENSMUSG00000037605 AA Change: N932K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
4.5e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.3e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1119 |
1.3e-72 |
PFAM |
Pfam:Latrophilin
|
1138 |
1262 |
8.5e-62 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000120445
AA Change: N1000K
PolyPhen 2
Score 0.967 (Sensitivity: 0.77; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000113249 Gene: ENSMUSG00000037605 AA Change: N1000K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
2.2e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
2.8e-8 |
PFAM |
Pfam:GAIN
|
630 |
856 |
5.1e-59 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1187 |
1.4e-73 |
PFAM |
Pfam:Latrophilin
|
1207 |
1328 |
8e-64 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000121641
AA Change: N1000K
PolyPhen 2
Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000113694 Gene: ENSMUSG00000037605 AA Change: N1000K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
5.8e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
7e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1571 |
7.3e-178 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000121707
AA Change: N1000K
PolyPhen 2
Score 0.981 (Sensitivity: 0.75; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000112823 Gene: ENSMUSG00000037605 AA Change: N1000K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
1.3e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
5.6e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
1.7e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
6.8e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1267 |
6.4e-30 |
PFAM |
Pfam:Latrophilin
|
1263 |
1534 |
8.7e-113 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000122037
AA Change: N932K
PolyPhen 2
Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000113374 Gene: ENSMUSG00000037605 AA Change: N932K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
43 |
123 |
1.2e-26 |
PFAM |
OLF
|
137 |
393 |
2.71e-170 |
SMART |
low complexity region
|
426 |
448 |
N/A |
INTRINSIC |
Pfam:HRM
|
495 |
553 |
5.3e-8 |
PFAM |
Pfam:DUF3497
|
559 |
789 |
1.5e-84 |
PFAM |
GPS
|
814 |
866 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
874 |
1110 |
6.3e-73 |
PFAM |
Pfam:Latrophilin
|
1129 |
1199 |
4.4e-30 |
PFAM |
Pfam:Latrophilin
|
1194 |
1460 |
1.3e-112 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000201055
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000122356
AA Change: N1000K
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000113600 Gene: ENSMUSG00000037605 AA Change: N1000K
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
low complexity region
|
62 |
87 |
N/A |
INTRINSIC |
Pfam:Gal_Lectin
|
111 |
191 |
2.8e-26 |
PFAM |
OLF
|
205 |
461 |
2.71e-170 |
SMART |
low complexity region
|
494 |
516 |
N/A |
INTRINSIC |
Pfam:HRM
|
563 |
621 |
7e-8 |
PFAM |
Pfam:DUF3497
|
627 |
857 |
3.1e-84 |
PFAM |
GPS
|
882 |
934 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
942 |
1178 |
9.3e-73 |
PFAM |
Pfam:Latrophilin
|
1197 |
1267 |
9e-30 |
PFAM |
Pfam:Latrophilin
|
1262 |
1528 |
2.8e-112 |
PFAM |
|
Predicted Effect |
unknown
Transcript: ENSMUST00000124117
AA Change: N344K
|
SMART Domains |
Protein: ENSMUSP00000118882 Gene: ENSMUSG00000037605 AA Change: N344K
Domain | Start | End | E-Value | Type |
Pfam:GAIN
|
2 |
201 |
1.8e-51 |
PFAM |
GPS
|
227 |
279 |
3.72e-25 |
SMART |
Pfam:7tm_2
|
287 |
523 |
9.1e-75 |
PFAM |
Pfam:Latrophilin
|
543 |
610 |
7.2e-35 |
PFAM |
Pfam:Latrophilin
|
607 |
873 |
1.8e-89 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000153264
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000132375
|
SMART Domains |
Protein: ENSMUSP00000117211 Gene: ENSMUSG00000037605
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.0%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008] PHENOTYPE: Mice homozygous for a gene trap allele exhibit increased dopamine and serotonine levels in the dorsal striatum, hyperactivity, increased stereotypic behavior and enhanced hyperactivity in response to cocaine. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 62 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca8a |
A |
T |
11: 109,953,991 (GRCm39) |
F816L |
probably benign |
Het |
Apol8 |
T |
C |
15: 77,633,643 (GRCm39) |
E311G |
probably damaging |
Het |
Atad2b |
G |
A |
12: 5,000,595 (GRCm39) |
|
probably null |
Het |
Carmil1 |
A |
G |
13: 24,203,659 (GRCm39) |
|
probably benign |
Het |
Cdc20b |
T |
C |
13: 113,217,576 (GRCm39) |
S332P |
possibly damaging |
Het |
Cep162 |
A |
G |
9: 87,114,030 (GRCm39) |
|
probably null |
Het |
Cfap54 |
T |
A |
10: 92,721,286 (GRCm39) |
S2482C |
unknown |
Het |
Cnpy1 |
T |
C |
5: 28,412,365 (GRCm39) |
E107G |
probably damaging |
Het |
Crtac1 |
C |
T |
19: 42,293,180 (GRCm39) |
V310I |
probably benign |
Het |
Csmd3 |
CCTTTGCGCTT |
CCTT |
15: 47,604,632 (GRCm39) |
|
probably null |
Het |
Elmo1 |
T |
C |
13: 20,789,402 (GRCm39) |
I706T |
probably damaging |
Het |
F12 |
T |
C |
13: 55,568,872 (GRCm39) |
T297A |
probably benign |
Het |
Fanci |
A |
G |
7: 79,083,220 (GRCm39) |
I736V |
probably benign |
Het |
Fbn1 |
T |
C |
2: 125,148,247 (GRCm39) |
N2667S |
probably benign |
Het |
Flt4 |
T |
C |
11: 49,524,941 (GRCm39) |
S596P |
probably damaging |
Het |
Fndc1 |
G |
A |
17: 7,983,940 (GRCm39) |
R1329* |
probably null |
Het |
Gjd4 |
G |
T |
18: 9,280,811 (GRCm39) |
S89* |
probably null |
Het |
H2-M10.1 |
T |
G |
17: 36,636,506 (GRCm39) |
R99S |
possibly damaging |
Het |
Homer3 |
T |
A |
8: 70,744,005 (GRCm39) |
V243D |
probably benign |
Het |
Hspa14 |
A |
G |
2: 3,492,045 (GRCm39) |
S437P |
probably damaging |
Het |
Inpp1 |
A |
T |
1: 52,838,550 (GRCm39) |
I33N |
probably damaging |
Het |
Ipo5 |
T |
A |
14: 121,176,956 (GRCm39) |
Y714N |
probably damaging |
Het |
Kif27 |
T |
C |
13: 58,461,026 (GRCm39) |
E898G |
possibly damaging |
Het |
Klhdc7b |
T |
A |
15: 89,271,095 (GRCm39) |
M1K |
probably null |
Het |
Krt87 |
A |
G |
15: 101,386,039 (GRCm39) |
Y241H |
probably benign |
Het |
Mfsd4b1 |
A |
G |
10: 39,878,715 (GRCm39) |
I394T |
probably benign |
Het |
Micall1 |
A |
G |
15: 79,006,965 (GRCm39) |
D264G |
probably damaging |
Het |
Mms22l |
T |
G |
4: 24,586,224 (GRCm39) |
D905E |
probably benign |
Het |
Musk |
A |
G |
4: 58,327,347 (GRCm39) |
D217G |
probably damaging |
Het |
Napb |
T |
C |
2: 148,540,880 (GRCm39) |
T236A |
probably benign |
Het |
Nbn |
T |
A |
4: 15,962,387 (GRCm39) |
D38E |
probably damaging |
Het |
Ncaph |
T |
C |
2: 126,969,113 (GRCm39) |
N87D |
probably benign |
Het |
Or4a78 |
A |
G |
2: 89,497,816 (GRCm39) |
V138A |
probably benign |
Het |
Pcdhb13 |
T |
A |
18: 37,576,204 (GRCm39) |
V194E |
probably damaging |
Het |
Pck1 |
T |
C |
2: 173,000,177 (GRCm39) |
V536A |
possibly damaging |
Het |
Pld5 |
C |
T |
1: 175,821,603 (GRCm39) |
G188S |
probably damaging |
Het |
Plekha8 |
T |
C |
6: 54,590,179 (GRCm39) |
V48A |
probably damaging |
Het |
Pnkd |
A |
G |
1: 74,389,793 (GRCm39) |
T306A |
probably benign |
Het |
Ppm1k |
T |
C |
6: 57,491,975 (GRCm39) |
E279G |
probably damaging |
Het |
Ppm1l |
G |
T |
3: 69,456,813 (GRCm39) |
K243N |
possibly damaging |
Het |
Ppp1r13b |
T |
C |
12: 111,838,801 (GRCm39) |
T26A |
probably damaging |
Het |
Rtel1 |
T |
C |
2: 180,964,202 (GRCm39) |
V67A |
probably benign |
Het |
Rxfp4 |
T |
C |
3: 88,559,899 (GRCm39) |
E184G |
probably damaging |
Het |
Scp2d1 |
A |
G |
2: 144,665,918 (GRCm39) |
I86V |
probably benign |
Het |
Sec16a |
G |
T |
2: 26,315,862 (GRCm39) |
P1718Q |
probably damaging |
Het |
Sgcg |
T |
A |
14: 61,459,195 (GRCm39) |
T245S |
probably benign |
Het |
Slc18a2 |
A |
G |
19: 59,261,989 (GRCm39) |
T215A |
probably benign |
Het |
Sorcs1 |
G |
A |
19: 50,213,613 (GRCm39) |
R705C |
probably damaging |
Het |
Sox17 |
G |
T |
1: 4,562,378 (GRCm39) |
P146Q |
probably damaging |
Het |
Spata31d1e |
A |
T |
13: 59,890,319 (GRCm39) |
Y500* |
probably null |
Het |
Stimate |
C |
T |
14: 30,594,537 (GRCm39) |
L217F |
probably damaging |
Het |
Sybu |
T |
A |
15: 44,536,478 (GRCm39) |
E616V |
probably damaging |
Het |
Tk2 |
C |
T |
8: 104,957,825 (GRCm39) |
V174I |
probably benign |
Het |
Tmc5 |
G |
A |
7: 118,244,618 (GRCm39) |
V499I |
probably benign |
Het |
Tonsl |
T |
C |
15: 76,523,956 (GRCm39) |
T15A |
probably benign |
Het |
Ttll12 |
A |
G |
15: 83,464,831 (GRCm39) |
I448T |
probably damaging |
Het |
Ttn |
A |
G |
2: 76,584,101 (GRCm39) |
S22336P |
probably damaging |
Het |
Ubap1 |
C |
A |
4: 41,379,163 (GRCm39) |
H126N |
probably damaging |
Het |
Upf1 |
C |
T |
8: 70,791,110 (GRCm39) |
R544H |
probably damaging |
Het |
Vmn2r84 |
T |
C |
10: 130,226,777 (GRCm39) |
N354D |
probably damaging |
Het |
Vpreb3 |
A |
C |
10: 75,785,037 (GRCm39) |
H45P |
probably benign |
Het |
Zc3h13 |
T |
A |
14: 75,546,380 (GRCm39) |
Y160* |
probably null |
Het |
|
Other mutations in Adgrl3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00391:Adgrl3
|
APN |
5 |
81,872,071 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL00596:Adgrl3
|
APN |
5 |
81,794,314 (GRCm39) |
missense |
probably benign |
0.01 |
IGL00766:Adgrl3
|
APN |
5 |
81,942,415 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00787:Adgrl3
|
APN |
5 |
81,841,401 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00917:Adgrl3
|
APN |
5 |
81,841,421 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL01155:Adgrl3
|
APN |
5 |
81,708,740 (GRCm39) |
missense |
probably benign |
0.39 |
IGL01348:Adgrl3
|
APN |
5 |
81,874,570 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01401:Adgrl3
|
APN |
5 |
81,836,516 (GRCm39) |
missense |
possibly damaging |
0.94 |
IGL01443:Adgrl3
|
APN |
5 |
81,613,134 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01532:Adgrl3
|
APN |
5 |
81,842,416 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01779:Adgrl3
|
APN |
5 |
81,535,717 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01920:Adgrl3
|
APN |
5 |
81,613,143 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02065:Adgrl3
|
APN |
5 |
81,660,064 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02365:Adgrl3
|
APN |
5 |
81,660,428 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02879:Adgrl3
|
APN |
5 |
81,659,966 (GRCm39) |
missense |
probably damaging |
1.00 |
R0010:Adgrl3
|
UTSW |
5 |
81,940,250 (GRCm39) |
missense |
possibly damaging |
0.58 |
R0077:Adgrl3
|
UTSW |
5 |
81,919,532 (GRCm39) |
splice site |
probably benign |
|
R0103:Adgrl3
|
UTSW |
5 |
81,940,194 (GRCm39) |
intron |
probably benign |
|
R0138:Adgrl3
|
UTSW |
5 |
81,841,454 (GRCm39) |
missense |
probably damaging |
1.00 |
R0149:Adgrl3
|
UTSW |
5 |
81,908,544 (GRCm39) |
missense |
probably damaging |
1.00 |
R0349:Adgrl3
|
UTSW |
5 |
81,919,491 (GRCm39) |
missense |
probably damaging |
1.00 |
R0361:Adgrl3
|
UTSW |
5 |
81,908,544 (GRCm39) |
missense |
probably damaging |
1.00 |
R0522:Adgrl3
|
UTSW |
5 |
81,874,648 (GRCm39) |
missense |
possibly damaging |
0.91 |
R0610:Adgrl3
|
UTSW |
5 |
81,841,563 (GRCm39) |
splice site |
probably benign |
|
R0658:Adgrl3
|
UTSW |
5 |
81,796,560 (GRCm39) |
missense |
probably benign |
0.18 |
R0671:Adgrl3
|
UTSW |
5 |
81,708,752 (GRCm39) |
missense |
probably benign |
0.45 |
R0679:Adgrl3
|
UTSW |
5 |
81,942,824 (GRCm39) |
missense |
probably damaging |
1.00 |
R1413:Adgrl3
|
UTSW |
5 |
81,841,366 (GRCm39) |
missense |
probably damaging |
1.00 |
R1444:Adgrl3
|
UTSW |
5 |
81,660,200 (GRCm39) |
missense |
probably damaging |
1.00 |
R1574:Adgrl3
|
UTSW |
5 |
81,935,296 (GRCm39) |
missense |
probably damaging |
1.00 |
R1574:Adgrl3
|
UTSW |
5 |
81,935,296 (GRCm39) |
missense |
probably damaging |
1.00 |
R1738:Adgrl3
|
UTSW |
5 |
81,535,826 (GRCm39) |
missense |
probably damaging |
0.99 |
R1744:Adgrl3
|
UTSW |
5 |
81,942,267 (GRCm39) |
missense |
probably damaging |
1.00 |
R1803:Adgrl3
|
UTSW |
5 |
81,919,464 (GRCm39) |
nonsense |
probably null |
|
R1891:Adgrl3
|
UTSW |
5 |
81,659,891 (GRCm39) |
missense |
probably damaging |
1.00 |
R1988:Adgrl3
|
UTSW |
5 |
81,836,414 (GRCm39) |
missense |
probably damaging |
1.00 |
R2126:Adgrl3
|
UTSW |
5 |
81,660,383 (GRCm39) |
missense |
probably damaging |
1.00 |
R2136:Adgrl3
|
UTSW |
5 |
81,660,101 (GRCm39) |
missense |
probably damaging |
1.00 |
R2171:Adgrl3
|
UTSW |
5 |
81,660,362 (GRCm39) |
nonsense |
probably null |
|
R2891:Adgrl3
|
UTSW |
5 |
81,841,366 (GRCm39) |
missense |
probably damaging |
1.00 |
R3732:Adgrl3
|
UTSW |
5 |
81,942,793 (GRCm39) |
missense |
probably benign |
0.05 |
R3732:Adgrl3
|
UTSW |
5 |
81,942,793 (GRCm39) |
missense |
probably benign |
0.05 |
R3733:Adgrl3
|
UTSW |
5 |
81,942,793 (GRCm39) |
missense |
probably benign |
0.05 |
R3982:Adgrl3
|
UTSW |
5 |
81,842,373 (GRCm39) |
missense |
possibly damaging |
0.95 |
R4085:Adgrl3
|
UTSW |
5 |
81,660,391 (GRCm39) |
missense |
probably benign |
0.02 |
R4462:Adgrl3
|
UTSW |
5 |
81,836,357 (GRCm39) |
missense |
probably damaging |
1.00 |
R4725:Adgrl3
|
UTSW |
5 |
81,914,052 (GRCm39) |
missense |
possibly damaging |
0.67 |
R4726:Adgrl3
|
UTSW |
5 |
81,794,425 (GRCm39) |
missense |
possibly damaging |
0.61 |
R4781:Adgrl3
|
UTSW |
5 |
81,908,571 (GRCm39) |
missense |
probably damaging |
1.00 |
R4837:Adgrl3
|
UTSW |
5 |
81,914,081 (GRCm39) |
missense |
probably benign |
0.07 |
R4841:Adgrl3
|
UTSW |
5 |
81,942,118 (GRCm39) |
missense |
possibly damaging |
0.53 |
R4883:Adgrl3
|
UTSW |
5 |
81,837,493 (GRCm39) |
missense |
probably damaging |
1.00 |
R4921:Adgrl3
|
UTSW |
5 |
81,659,957 (GRCm39) |
missense |
probably damaging |
1.00 |
R4945:Adgrl3
|
UTSW |
5 |
81,659,895 (GRCm39) |
missense |
probably damaging |
1.00 |
R5055:Adgrl3
|
UTSW |
5 |
81,794,398 (GRCm39) |
missense |
possibly damaging |
0.48 |
R5313:Adgrl3
|
UTSW |
5 |
81,874,516 (GRCm39) |
missense |
probably damaging |
1.00 |
R5385:Adgrl3
|
UTSW |
5 |
81,874,648 (GRCm39) |
missense |
probably damaging |
1.00 |
R5447:Adgrl3
|
UTSW |
5 |
81,613,188 (GRCm39) |
intron |
probably benign |
|
R5482:Adgrl3
|
UTSW |
5 |
81,942,360 (GRCm39) |
missense |
probably damaging |
1.00 |
R5586:Adgrl3
|
UTSW |
5 |
81,871,994 (GRCm39) |
missense |
probably damaging |
0.99 |
R5637:Adgrl3
|
UTSW |
5 |
81,841,391 (GRCm39) |
missense |
probably damaging |
1.00 |
R5919:Adgrl3
|
UTSW |
5 |
81,794,417 (GRCm39) |
missense |
probably benign |
0.00 |
R6090:Adgrl3
|
UTSW |
5 |
81,660,173 (GRCm39) |
missense |
probably damaging |
1.00 |
R6093:Adgrl3
|
UTSW |
5 |
81,794,369 (GRCm39) |
missense |
probably benign |
0.42 |
R6107:Adgrl3
|
UTSW |
5 |
81,836,410 (GRCm39) |
missense |
probably damaging |
0.97 |
R6245:Adgrl3
|
UTSW |
5 |
81,836,403 (GRCm39) |
missense |
probably benign |
0.01 |
R6426:Adgrl3
|
UTSW |
5 |
81,874,717 (GRCm39) |
missense |
probably damaging |
1.00 |
R6440:Adgrl3
|
UTSW |
5 |
81,942,341 (GRCm39) |
nonsense |
probably null |
|
R6516:Adgrl3
|
UTSW |
5 |
81,613,119 (GRCm39) |
missense |
probably damaging |
1.00 |
R6527:Adgrl3
|
UTSW |
5 |
81,935,364 (GRCm39) |
missense |
probably damaging |
0.99 |
R6622:Adgrl3
|
UTSW |
5 |
81,942,606 (GRCm39) |
missense |
probably benign |
0.34 |
R6842:Adgrl3
|
UTSW |
5 |
81,888,927 (GRCm39) |
missense |
probably damaging |
1.00 |
R6902:Adgrl3
|
UTSW |
5 |
81,837,434 (GRCm39) |
missense |
probably damaging |
1.00 |
R6921:Adgrl3
|
UTSW |
5 |
81,796,560 (GRCm39) |
missense |
probably damaging |
0.99 |
R7201:Adgrl3
|
UTSW |
5 |
81,872,069 (GRCm39) |
missense |
probably damaging |
1.00 |
R7207:Adgrl3
|
UTSW |
5 |
81,457,874 (GRCm39) |
start codon destroyed |
probably null |
0.33 |
R7215:Adgrl3
|
UTSW |
5 |
81,841,397 (GRCm39) |
missense |
probably damaging |
1.00 |
R7376:Adgrl3
|
UTSW |
5 |
81,942,597 (GRCm39) |
missense |
probably damaging |
1.00 |
R7441:Adgrl3
|
UTSW |
5 |
81,871,987 (GRCm39) |
missense |
possibly damaging |
0.70 |
R7582:Adgrl3
|
UTSW |
5 |
81,841,523 (GRCm39) |
missense |
probably damaging |
0.99 |
R7682:Adgrl3
|
UTSW |
5 |
81,942,407 (GRCm39) |
missense |
probably damaging |
0.97 |
R7863:Adgrl3
|
UTSW |
5 |
81,660,596 (GRCm39) |
missense |
probably damaging |
1.00 |
R7877:Adgrl3
|
UTSW |
5 |
81,842,467 (GRCm39) |
missense |
probably benign |
0.30 |
R8051:Adgrl3
|
UTSW |
5 |
81,613,113 (GRCm39) |
missense |
probably damaging |
1.00 |
R8237:Adgrl3
|
UTSW |
5 |
81,935,408 (GRCm39) |
frame shift |
probably null |
|
R8390:Adgrl3
|
UTSW |
5 |
81,914,057 (GRCm39) |
missense |
probably damaging |
1.00 |
R8392:Adgrl3
|
UTSW |
5 |
81,794,397 (GRCm39) |
missense |
probably benign |
0.01 |
R8475:Adgrl3
|
UTSW |
5 |
81,871,976 (GRCm39) |
missense |
probably benign |
0.31 |
R8478:Adgrl3
|
UTSW |
5 |
81,942,348 (GRCm39) |
missense |
possibly damaging |
0.87 |
R8550:Adgrl3
|
UTSW |
5 |
81,942,599 (GRCm39) |
missense |
possibly damaging |
0.79 |
R8685:Adgrl3
|
UTSW |
5 |
81,874,708 (GRCm39) |
missense |
possibly damaging |
0.91 |
R8792:Adgrl3
|
UTSW |
5 |
81,836,522 (GRCm39) |
missense |
probably damaging |
0.99 |
R8851:Adgrl3
|
UTSW |
5 |
81,613,119 (GRCm39) |
missense |
probably damaging |
1.00 |
R8868:Adgrl3
|
UTSW |
5 |
81,794,451 (GRCm39) |
missense |
probably benign |
|
R8889:Adgrl3
|
UTSW |
5 |
81,874,516 (GRCm39) |
missense |
probably damaging |
1.00 |
R8892:Adgrl3
|
UTSW |
5 |
81,874,516 (GRCm39) |
missense |
probably damaging |
1.00 |
R8942:Adgrl3
|
UTSW |
5 |
81,796,568 (GRCm39) |
missense |
probably benign |
0.09 |
R9023:Adgrl3
|
UTSW |
5 |
81,613,065 (GRCm39) |
missense |
probably damaging |
0.99 |
R9089:Adgrl3
|
UTSW |
5 |
81,808,291 (GRCm39) |
missense |
possibly damaging |
0.77 |
R9100:Adgrl3
|
UTSW |
5 |
81,842,299 (GRCm39) |
missense |
possibly damaging |
0.85 |
R9104:Adgrl3
|
UTSW |
5 |
81,457,912 (GRCm39) |
missense |
probably benign |
0.00 |
R9172:Adgrl3
|
UTSW |
5 |
81,922,251 (GRCm39) |
missense |
probably benign |
0.01 |
R9284:Adgrl3
|
UTSW |
5 |
81,657,568 (GRCm39) |
splice site |
probably benign |
|
R9286:Adgrl3
|
UTSW |
5 |
81,794,413 (GRCm39) |
missense |
probably benign |
|
R9644:Adgrl3
|
UTSW |
5 |
81,872,036 (GRCm39) |
missense |
probably damaging |
0.99 |
R9689:Adgrl3
|
UTSW |
5 |
81,942,780 (GRCm39) |
missense |
probably damaging |
0.98 |
R9757:Adgrl3
|
UTSW |
5 |
81,613,086 (GRCm39) |
missense |
probably benign |
0.07 |
R9795:Adgrl3
|
UTSW |
5 |
81,837,421 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Adgrl3
|
UTSW |
5 |
81,660,005 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1088:Adgrl3
|
UTSW |
5 |
81,477,729 (GRCm39) |
missense |
probably benign |
0.33 |
|
Predicted Primers |
PCR Primer
(F):5'- GATGCAGTCCACGATCTTCTTC -3'
(R):5'- ATGTACACCCCATCTGTAAGATC -3'
Sequencing Primer
(F):5'- ACGATCTTCTTCTGGATGTGATCACG -3'
(R):5'- CACTGTTTCTTATTGGCAATGGAC -3'
|
Posted On |
2015-02-18 |