Incidental Mutation 'R3196:Or7g25'
ID 267651
Institutional Source Beutler Lab
Gene Symbol Or7g25
Ensembl Gene ENSMUSG00000048391
Gene Name olfactory receptor family 7 subfamily G member 25
Synonyms GA_x6K02T2PVTD-12986331-12985390, Olfr843, MOR155-2
MMRRC Submission 040617-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.128) question?
Stock # R3196 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 19159653-19160759 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 19160495 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 67 (S67P)
Ref Sequence ENSEMBL: ENSMUSP00000151203 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061365] [ENSMUST00000214019] [ENSMUST00000214267]
AlphaFold Q7TRG4
Predicted Effect probably damaging
Transcript: ENSMUST00000061365
AA Change: S67P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000051027
Gene: ENSMUSG00000048391
AA Change: S67P

DomainStartEndE-ValueType
Pfam:7tm_4 31 307 2.4e-51 PFAM
Pfam:7tm_1 41 290 3.3e-24 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214019
AA Change: S67P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000214267
AA Change: S67P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9130401M01Rik A T 15: 57,892,132 (GRCm39) N158K probably benign Het
Acnat1 G C 4: 49,447,457 (GRCm39) P357A probably damaging Het
Akap6 T A 12: 53,119,240 (GRCm39) C1102* probably null Het
Amelx T C X: 167,964,826 (GRCm39) probably benign Het
Brap G A 5: 121,803,259 (GRCm39) V136I possibly damaging Het
Crygs C T 16: 22,624,301 (GRCm39) G102D possibly damaging Het
Csgalnact1 TGG TG 8: 68,913,737 (GRCm39) probably null Het
Csk A T 9: 57,537,556 (GRCm39) C119* probably null Het
Dcbld1 T C 10: 52,195,587 (GRCm39) L265P probably damaging Het
Desi1 T A 15: 81,887,976 (GRCm39) K31N probably damaging Het
Dpy19l2 C A 9: 24,607,285 (GRCm39) G59C probably damaging Het
Eif2b5 T C 16: 20,324,272 (GRCm39) V498A probably benign Het
Epdr1 A T 13: 19,778,815 (GRCm39) Y94N probably damaging Het
Fat1 T C 8: 45,404,905 (GRCm39) V552A probably benign Het
Focad A G 4: 88,325,588 (GRCm39) E151G possibly damaging Het
Frem1 A G 4: 82,932,351 (GRCm39) F117L probably damaging Het
Frem2 A T 3: 53,444,752 (GRCm39) Y2460N probably damaging Het
Gm3604 A T 13: 62,517,868 (GRCm39) C163* probably null Het
Gpalpp1 A C 14: 76,336,063 (GRCm39) probably null Het
Grid2ip A G 5: 143,373,933 (GRCm39) I858V probably damaging Het
Grin2b ATTGTTGT ATTGT 6: 135,709,453 (GRCm39) probably benign Het
Hps4 A G 5: 112,512,429 (GRCm39) T182A probably damaging Het
Impa1 A T 3: 10,394,075 (GRCm39) probably null Het
Kcnh3 T C 15: 99,131,862 (GRCm39) S606P probably damaging Het
Kif23 T A 9: 61,839,193 (GRCm39) R301* probably null Het
Kirrel1 C T 3: 86,996,458 (GRCm39) M380I probably null Het
Lcp2 G T 11: 34,040,670 (GRCm39) A529S probably benign Het
Lhx8 G A 3: 154,035,925 (GRCm39) A22V probably benign Het
Lin28a A T 4: 133,735,235 (GRCm39) S134T possibly damaging Het
Med27 T A 2: 29,236,882 (GRCm39) V9E possibly damaging Het
Mmp7 C A 9: 7,692,219 (GRCm39) S31R probably benign Het
Mtcl1 T G 17: 66,650,829 (GRCm39) E1545D probably benign Het
Muc16 A G 9: 18,409,126 (GRCm39) Y187H probably damaging Het
Myo3a G T 2: 22,404,679 (GRCm39) K678N possibly damaging Het
Nsmce1 T C 7: 125,085,645 (GRCm39) M15V probably benign Het
Nxpe3 A T 16: 55,670,078 (GRCm39) N342K probably damaging Het
Or8g2 T A 9: 39,821,756 (GRCm39) I219N probably damaging Het
Pcdhb9 A G 18: 37,534,663 (GRCm39) N219S probably benign Het
Pck2 T A 14: 55,781,449 (GRCm39) V190E probably damaging Het
Pde4b G A 4: 102,456,840 (GRCm39) A429T probably damaging Het
Phf1 T C 17: 27,153,429 (GRCm39) V54A probably damaging Het
Pla2r1 T C 2: 60,353,127 (GRCm39) E278G probably damaging Het
Ptges3 G T 10: 127,908,016 (GRCm39) R122L probably benign Het
Rnpepl1 C T 1: 92,844,881 (GRCm39) T391I probably damaging Het
Rps6kb1 G A 11: 86,397,633 (GRCm39) A404V probably benign Het
Rrm2b T C 15: 37,945,391 (GRCm39) probably null Het
Sh3rf1 C T 8: 61,679,321 (GRCm39) P121L probably benign Het
Skint9 T G 4: 112,248,148 (GRCm39) I199L probably benign Het
Slc9b2 G T 3: 135,042,290 (GRCm39) R523L probably benign Het
Slco1c1 T A 6: 141,477,174 (GRCm39) probably null Het
Stox2 T C 8: 47,645,865 (GRCm39) T532A probably damaging Het
Tbcel A G 9: 42,327,248 (GRCm39) L385P probably damaging Het
Tle5 A G 10: 81,401,474 (GRCm39) N181D probably benign Het
Tmem268 G A 4: 63,496,149 (GRCm39) probably null Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Top3a G A 11: 60,650,182 (GRCm39) T122M probably damaging Het
Trav7n-4 G A 14: 53,329,088 (GRCm39) V33I probably benign Het
Ttn T G 2: 76,539,551 (GRCm39) E26151D possibly damaging Het
Ttn C T 2: 76,687,228 (GRCm39) probably benign Het
Tyk2 A G 9: 21,035,328 (GRCm39) C195R possibly damaging Het
Ugt2b38 T C 5: 87,558,078 (GRCm39) K528E probably damaging Het
Usp28 T A 9: 48,937,125 (GRCm39) D483E probably benign Het
Vldlr A G 19: 27,220,554 (GRCm39) D598G probably damaging Het
Vmn1r51 T G 6: 90,106,498 (GRCm39) I138S probably damaging Het
Vps13b G A 15: 35,869,541 (GRCm39) A2682T probably damaging Het
Wac T A 18: 7,917,568 (GRCm39) V346E probably damaging Het
Zdbf2 T C 1: 63,347,579 (GRCm39) V1986A possibly damaging Het
Other mutations in Or7g25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02104:Or7g25 APN 9 19,160,166 (GRCm39) missense probably benign 0.21
IGL02338:Or7g25 APN 9 19,159,960 (GRCm39) missense probably damaging 0.98
IGL03197:Or7g25 APN 9 19,160,098 (GRCm39) missense probably benign 0.37
IGL03227:Or7g25 APN 9 19,160,518 (GRCm39) missense probably damaging 1.00
IGL03046:Or7g25 UTSW 9 19,160,441 (GRCm39) missense probably damaging 0.99
IGL03052:Or7g25 UTSW 9 19,159,938 (GRCm39) nonsense probably null
R0423:Or7g25 UTSW 9 19,160,248 (GRCm39) nonsense probably null
R1316:Or7g25 UTSW 9 19,160,035 (GRCm39) missense probably benign 0.06
R1759:Or7g25 UTSW 9 19,160,384 (GRCm39) missense probably benign 0.36
R1782:Or7g25 UTSW 9 19,159,877 (GRCm39) missense probably benign 0.04
R2517:Or7g25 UTSW 9 19,160,357 (GRCm39) missense probably benign 0.21
R3742:Or7g25 UTSW 9 19,159,979 (GRCm39) missense possibly damaging 0.91
R4191:Or7g25 UTSW 9 19,160,383 (GRCm39) missense probably benign 0.05
R4320:Or7g25 UTSW 9 19,160,052 (GRCm39) missense probably damaging 1.00
R4523:Or7g25 UTSW 9 19,160,525 (GRCm39) missense probably damaging 0.98
R4756:Or7g25 UTSW 9 19,160,153 (GRCm39) missense possibly damaging 0.56
R4908:Or7g25 UTSW 9 19,160,149 (GRCm39) missense probably benign 0.00
R5319:Or7g25 UTSW 9 19,160,329 (GRCm39) missense possibly damaging 0.60
R5554:Or7g25 UTSW 9 19,160,039 (GRCm39) missense probably benign 0.02
R6011:Or7g25 UTSW 9 19,159,807 (GRCm39) missense probably damaging 0.98
R7330:Or7g25 UTSW 9 19,160,567 (GRCm39) missense probably benign 0.01
R7862:Or7g25 UTSW 9 19,160,736 (GRCm39) start gained probably benign
R9544:Or7g25 UTSW 9 19,160,561 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ACGGTCATAGGCCATCACAG -3'
(R):5'- ATGTGACCCCAAAGAATTTGTG -3'

Sequencing Primer
(F):5'- GTCATAGGCCATCACAGCAAGTAG -3'
(R):5'- GTGACCCCAAAGAATTTGTGAAAAC -3'
Posted On 2015-02-18