Mutagenetix > Incidental Mutation

Incidental Mutation 'R3411:Or10g1'

267735

Institutional Source

Beutler Lab

Gene Symbol

Or10g1

Ensembl Gene

ENSMUSG00000063106

Gene Name

olfactory receptor family 10 subfamily G member 1

Synonyms

MOR223-6, GA_x6K02T2RJGY-583652-584608, Olfr1510

MMRRC Submission

040629-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R3411 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

52647346-52648384 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 52647818 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Serine at position 170 (R170S)

Ref Sequence

ENSEMBL: ENSMUSP00000150294 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079459] [ENSMUST00000215928]

AlphaFold

E9PZZ6

Predicted Effect

possibly damaging
Transcript: ENSMUST00000079459
AA Change: R170S

PolyPhen 2 Score 0.645 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000078424
Gene: ENSMUSG00000063106
AA Change: R170S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	8.1e-50	PFAM
Pfam:7tm_1	45	293	1.8e-20	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206257
AA Change: R170S

Predicted Effect

possibly damaging
Transcript: ENSMUST00000215928
AA Change: R170S

PolyPhen 2 Score 0.645 (Sensitivity: 0.87; Specificity: 0.91)

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 99.1%
3x: 98.4%
10x: 96.9%
20x: 93.6%

Validation Efficiency

100% (62/62)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adam4	A	T	12: 81,466,596 (GRCm39)	V675D	possibly damaging	Het
Adamts16	T	C	13: 70,901,345 (GRCm39)	T911A	probably benign	Het
Adgra1	T	C	7: 139,427,619 (GRCm39)	F62S	possibly damaging	Het
Adgra3	A	G	5: 50,159,272 (GRCm39)	V326A	probably damaging	Het
Aff1	T	A	5: 103,902,572 (GRCm39)	M1K	probably null	Het
AI429214	C	T	8: 37,461,071 (GRCm39)	S73L	probably benign	Het
Apc	C	A	18: 34,402,312 (GRCm39)		probably benign	Het
Apcs	T	C	1: 172,722,130 (GRCm39)	Y72C	probably damaging	Het
Arid4a	T	C	12: 71,108,299 (GRCm39)		probably benign	Het
Armcx4	C	A	X: 133,591,774 (GRCm39)	Q561K	probably benign	Het
Atp5po	C	T	16: 91,725,794 (GRCm39)	R64H	probably damaging	Het
Bank1	G	A	3: 135,953,534 (GRCm39)		probably benign	Het
Ccdc150	A	G	1: 54,395,932 (GRCm39)	D805G	probably benign	Het
Ccdc88a	T	A	11: 29,436,006 (GRCm39)	C10S	probably damaging	Het
Dnah1	A	T	14: 30,991,774 (GRCm39)	M3076K	possibly damaging	Het
Dnpep	A	G	1: 75,293,270 (GRCm39)	V33A	probably damaging	Het
Egfem1	C	T	3: 29,637,170 (GRCm39)	T202I	probably damaging	Het
Fam120b	T	A	17: 15,651,897 (GRCm39)		probably benign	Het
Frem1	T	C	4: 82,881,416 (GRCm39)	T1263A	possibly damaging	Het
Gm6802	C	A	12: 19,540,621 (GRCm39)		noncoding transcript	Het
Golga2	C	A	2: 32,192,954 (GRCm39)	A424E	probably damaging	Het
Gpat2	G	A	2: 127,270,211 (GRCm39)	V75M	probably damaging	Het
Grik5	T	C	7: 24,762,397 (GRCm39)	D198G	probably benign	Het
Hcrtr2	A	G	9: 76,140,290 (GRCm39)	F333L	probably benign	Het
Hjurp	GT	GTT	1: 88,194,246 (GRCm39)		probably null	Het
Htr1b	A	C	9: 81,514,094 (GRCm39)	V171G	probably benign	Het
Kalrn	G	T	16: 34,032,642 (GRCm39)	D1117E	probably benign	Het
Kcp	T	C	6: 29,482,845 (GRCm39)	N1408S	possibly damaging	Het
Klhl7	G	T	5: 24,343,319 (GRCm39)	V212L	probably damaging	Het
Klra17	T	A	6: 129,851,809 (GRCm39)	N21I	probably damaging	Het
Lrrc8d	A	T	5: 105,974,572 (GRCm39)		noncoding transcript	Het
Mast2	C	G	4: 116,168,107 (GRCm39)	E881Q	possibly damaging	Het
Mcm6	T	C	1: 128,279,322 (GRCm39)	T155A	probably benign	Het
Mslnl	T	C	17: 25,963,491 (GRCm39)	F326L	probably benign	Het
Nlrp4c	A	G	7: 6,095,569 (GRCm39)	K816E	possibly damaging	Het
Or5b101	G	C	19: 13,005,411 (GRCm39)	A94G	probably benign	Het
Or5p69	A	T	7: 107,967,551 (GRCm39)	I285F	possibly damaging	Het
Or8k3	T	C	2: 86,058,986 (GRCm39)	S110G	probably benign	Het
Otoa	A	G	7: 120,721,266 (GRCm39)	Q427R	probably damaging	Het
Pcdhb6	A	G	18: 37,468,945 (GRCm39)	E622G	probably damaging	Het
Pdzd8	A	G	19: 59,333,845 (GRCm39)	Y59H	probably damaging	Het
Psmc3	A	C	2: 90,886,263 (GRCm39)	D159A	probably damaging	Het
Ripk4	T	C	16: 97,545,157 (GRCm39)	T497A	probably benign	Het
Rpn2	C	A	2: 157,132,572 (GRCm39)	A108E	possibly damaging	Het
Serpina3n	A	G	12: 104,377,536 (GRCm39)	E263G	possibly damaging	Het
Six4	A	G	12: 73,159,657 (GRCm39)	F101S	probably damaging	Het
Slc16a4	G	A	3: 107,208,188 (GRCm39)	E233K	probably benign	Het
Smu1	T	C	4: 40,752,008 (GRCm39)	T183A	probably benign	Het
Sptb	T	G	12: 76,657,589 (GRCm39)	K1311Q	possibly damaging	Het
Styxl1	T	C	5: 135,794,618 (GRCm39)	Y83C	probably damaging	Het
Sypl2	C	T	3: 108,124,045 (GRCm39)	V166I	possibly damaging	Het
Tal2	A	G	4: 53,785,843 (GRCm39)	N8S	probably damaging	Het
Tenm4	T	C	7: 96,501,737 (GRCm39)	Y1314H	probably damaging	Het
Ttn	A	C	2: 76,772,749 (GRCm39)	N2415K	possibly damaging	Het
Usp53	T	C	3: 122,743,507 (GRCm39)		probably null	Het
Vmn2r65	T	C	7: 84,595,896 (GRCm39)	I263V	probably benign	Het

Other mutations in Or10g1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01564:Or10g1	APN	14	52,648,299 (GRCm39)	missense	probably benign	0.04
IGL02097:Or10g1	APN	14	52,647,511 (GRCm39)	missense	probably benign
R0282:Or10g1	UTSW	14	52,647,720 (GRCm39)	missense	possibly damaging	0.94
R1449:Or10g1	UTSW	14	52,648,024 (GRCm39)	missense	probably damaging	1.00
R2113:Or10g1	UTSW	14	52,647,753 (GRCm39)	missense	probably damaging	1.00
R2870:Or10g1	UTSW	14	52,648,318 (GRCm39)	missense	probably benign
R2870:Or10g1	UTSW	14	52,648,318 (GRCm39)	missense	probably benign
R2872:Or10g1	UTSW	14	52,648,318 (GRCm39)	missense	probably benign
R2872:Or10g1	UTSW	14	52,648,318 (GRCm39)	missense	probably benign
R2873:Or10g1	UTSW	14	52,648,318 (GRCm39)	missense	probably benign
R3409:Or10g1	UTSW	14	52,647,818 (GRCm39)	missense	possibly damaging	0.64
R4480:Or10g1	UTSW	14	52,647,765 (GRCm39)	missense	probably damaging	1.00
R5292:Or10g1	UTSW	14	52,647,902 (GRCm39)	missense	possibly damaging	0.90
R5297:Or10g1	UTSW	14	52,647,675 (GRCm39)	missense	probably damaging	1.00
R5441:Or10g1	UTSW	14	52,647,414 (GRCm39)	missense	probably benign	0.02
R5749:Or10g1	UTSW	14	52,647,961 (GRCm39)	missense	probably damaging	1.00
R5872:Or10g1	UTSW	14	52,648,225 (GRCm39)	missense	probably damaging	1.00
R5941:Or10g1	UTSW	14	52,647,525 (GRCm39)	missense	probably benign	0.01
R7209:Or10g1	UTSW	14	52,647,550 (GRCm39)	missense	possibly damaging	0.80
R7379:Or10g1	UTSW	14	52,647,718 (GRCm39)	missense	probably benign	0.08
R7463:Or10g1	UTSW	14	52,648,168 (GRCm39)	missense	probably benign	0.00
R7692:Or10g1	UTSW	14	52,647,945 (GRCm39)	missense	probably damaging	1.00
R8894:Or10g1	UTSW	14	52,647,465 (GRCm39)	missense	probably damaging	1.00
R9286:Or10g1	UTSW	14	52,648,075 (GRCm39)	nonsense	probably null
R9394:Or10g1	UTSW	14	52,647,570 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GATGGCATGAACTATGTTGGC -3'
(R):5'- GCAAGGCTATCCCATTTGGTG -3'

Sequencing Primer
(F):5'- CTATGTTGGCATAGGAGAGCAGAATC -3'
(R):5'- GGTGGTTGTGCAGCTCAAC -3'

Posted On

2015-02-18