Incidental Mutation 'R3411:Or5b101'
ID 267744
Institutional Source Beutler Lab
Gene Symbol Or5b101
Ensembl Gene ENSMUSG00000094755
Gene Name olfactory receptor family 5 subfamily B member 101
Synonyms Olfr1453, GA_x6K02T2RE5P-3357666-3356743, MOR202-6
MMRRC Submission 040629-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.074) question?
Stock # R3411 (G1)
Quality Score 225
Status Validated
Chromosome 19
Chromosomal Location 13004768-13005691 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to C at 13005411 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Alanine to Glycine at position 94 (A94G)
Ref Sequence ENSEMBL: ENSMUSP00000085071 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087773]
AlphaFold Q8VFX0
Predicted Effect probably benign
Transcript: ENSMUST00000087773
AA Change: A94G

PolyPhen 2 Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000085071
Gene: ENSMUSG00000094755
AA Change: A94G

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 6.6e-50 PFAM
Pfam:7tm_1 39 288 2.6e-20 PFAM
Meta Mutation Damage Score 0.0929 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.9%
  • 20x: 93.6%
Validation Efficiency 100% (62/62)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam4 A T 12: 81,466,596 (GRCm39) V675D possibly damaging Het
Adamts16 T C 13: 70,901,345 (GRCm39) T911A probably benign Het
Adgra1 T C 7: 139,427,619 (GRCm39) F62S possibly damaging Het
Adgra3 A G 5: 50,159,272 (GRCm39) V326A probably damaging Het
Aff1 T A 5: 103,902,572 (GRCm39) M1K probably null Het
AI429214 C T 8: 37,461,071 (GRCm39) S73L probably benign Het
Apc C A 18: 34,402,312 (GRCm39) probably benign Het
Apcs T C 1: 172,722,130 (GRCm39) Y72C probably damaging Het
Arid4a T C 12: 71,108,299 (GRCm39) probably benign Het
Armcx4 C A X: 133,591,774 (GRCm39) Q561K probably benign Het
Atp5po C T 16: 91,725,794 (GRCm39) R64H probably damaging Het
Bank1 G A 3: 135,953,534 (GRCm39) probably benign Het
Ccdc150 A G 1: 54,395,932 (GRCm39) D805G probably benign Het
Ccdc88a T A 11: 29,436,006 (GRCm39) C10S probably damaging Het
Dnah1 A T 14: 30,991,774 (GRCm39) M3076K possibly damaging Het
Dnpep A G 1: 75,293,270 (GRCm39) V33A probably damaging Het
Egfem1 C T 3: 29,637,170 (GRCm39) T202I probably damaging Het
Fam120b T A 17: 15,651,897 (GRCm39) probably benign Het
Frem1 T C 4: 82,881,416 (GRCm39) T1263A possibly damaging Het
Gm6802 C A 12: 19,540,621 (GRCm39) noncoding transcript Het
Golga2 C A 2: 32,192,954 (GRCm39) A424E probably damaging Het
Gpat2 G A 2: 127,270,211 (GRCm39) V75M probably damaging Het
Grik5 T C 7: 24,762,397 (GRCm39) D198G probably benign Het
Hcrtr2 A G 9: 76,140,290 (GRCm39) F333L probably benign Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Htr1b A C 9: 81,514,094 (GRCm39) V171G probably benign Het
Kalrn G T 16: 34,032,642 (GRCm39) D1117E probably benign Het
Kcp T C 6: 29,482,845 (GRCm39) N1408S possibly damaging Het
Klhl7 G T 5: 24,343,319 (GRCm39) V212L probably damaging Het
Klra17 T A 6: 129,851,809 (GRCm39) N21I probably damaging Het
Lrrc8d A T 5: 105,974,572 (GRCm39) noncoding transcript Het
Mast2 C G 4: 116,168,107 (GRCm39) E881Q possibly damaging Het
Mcm6 T C 1: 128,279,322 (GRCm39) T155A probably benign Het
Mslnl T C 17: 25,963,491 (GRCm39) F326L probably benign Het
Nlrp4c A G 7: 6,095,569 (GRCm39) K816E possibly damaging Het
Or10g1 T A 14: 52,647,818 (GRCm39) R170S possibly damaging Het
Or5p69 A T 7: 107,967,551 (GRCm39) I285F possibly damaging Het
Or8k3 T C 2: 86,058,986 (GRCm39) S110G probably benign Het
Otoa A G 7: 120,721,266 (GRCm39) Q427R probably damaging Het
Pcdhb6 A G 18: 37,468,945 (GRCm39) E622G probably damaging Het
Pdzd8 A G 19: 59,333,845 (GRCm39) Y59H probably damaging Het
Psmc3 A C 2: 90,886,263 (GRCm39) D159A probably damaging Het
Ripk4 T C 16: 97,545,157 (GRCm39) T497A probably benign Het
Rpn2 C A 2: 157,132,572 (GRCm39) A108E possibly damaging Het
Serpina3n A G 12: 104,377,536 (GRCm39) E263G possibly damaging Het
Six4 A G 12: 73,159,657 (GRCm39) F101S probably damaging Het
Slc16a4 G A 3: 107,208,188 (GRCm39) E233K probably benign Het
Smu1 T C 4: 40,752,008 (GRCm39) T183A probably benign Het
Sptb T G 12: 76,657,589 (GRCm39) K1311Q possibly damaging Het
Styxl1 T C 5: 135,794,618 (GRCm39) Y83C probably damaging Het
Sypl2 C T 3: 108,124,045 (GRCm39) V166I possibly damaging Het
Tal2 A G 4: 53,785,843 (GRCm39) N8S probably damaging Het
Tenm4 T C 7: 96,501,737 (GRCm39) Y1314H probably damaging Het
Ttn A C 2: 76,772,749 (GRCm39) N2415K possibly damaging Het
Usp53 T C 3: 122,743,507 (GRCm39) probably null Het
Vmn2r65 T C 7: 84,595,896 (GRCm39) I263V probably benign Het
Other mutations in Or5b101
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00914:Or5b101 APN 19 13,004,955 (GRCm39) missense probably damaging 0.98
IGL01137:Or5b101 APN 19 13,005,394 (GRCm39) missense possibly damaging 0.52
IGL01894:Or5b101 APN 19 13,005,649 (GRCm39) missense probably damaging 1.00
IGL02579:Or5b101 APN 19 13,004,892 (GRCm39) missense probably damaging 0.99
PIT4418001:Or5b101 UTSW 19 13,005,095 (GRCm39) nonsense probably null
R0099:Or5b101 UTSW 19 13,005,165 (GRCm39) missense probably damaging 1.00
R0211:Or5b101 UTSW 19 13,005,646 (GRCm39) missense possibly damaging 0.95
R0211:Or5b101 UTSW 19 13,005,646 (GRCm39) missense possibly damaging 0.95
R0395:Or5b101 UTSW 19 13,005,663 (GRCm39) missense probably damaging 1.00
R0453:Or5b101 UTSW 19 13,005,295 (GRCm39) missense probably damaging 0.97
R0847:Or5b101 UTSW 19 13,005,095 (GRCm39) nonsense probably null
R1227:Or5b101 UTSW 19 13,005,217 (GRCm39) missense probably benign
R1823:Or5b101 UTSW 19 13,005,181 (GRCm39) missense probably benign 0.06
R2509:Or5b101 UTSW 19 13,005,058 (GRCm39) missense probably damaging 1.00
R2899:Or5b101 UTSW 19 13,005,058 (GRCm39) missense probably damaging 1.00
R2964:Or5b101 UTSW 19 13,005,412 (GRCm39) missense probably benign 0.38
R2965:Or5b101 UTSW 19 13,005,412 (GRCm39) missense probably benign 0.38
R3157:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3158:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3409:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3410:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R3425:Or5b101 UTSW 19 13,005,411 (GRCm39) missense probably benign 0.03
R4018:Or5b101 UTSW 19 13,005,189 (GRCm39) missense probably benign
R4668:Or5b101 UTSW 19 13,005,445 (GRCm39) missense probably benign 0.00
R4805:Or5b101 UTSW 19 13,005,661 (GRCm39) missense probably benign 0.04
R5180:Or5b101 UTSW 19 13,004,776 (GRCm39) missense probably benign 0.01
R5391:Or5b101 UTSW 19 13,005,150 (GRCm39) missense probably damaging 1.00
R5557:Or5b101 UTSW 19 13,005,004 (GRCm39) missense probably benign 0.01
R5740:Or5b101 UTSW 19 13,004,926 (GRCm39) missense probably benign 0.24
R7472:Or5b101 UTSW 19 13,005,439 (GRCm39) missense probably benign
R7832:Or5b101 UTSW 19 13,005,360 (GRCm39) missense probably benign 0.02
R7970:Or5b101 UTSW 19 13,005,058 (GRCm39) missense probably damaging 1.00
R8044:Or5b101 UTSW 19 13,004,829 (GRCm39) missense probably damaging 1.00
R8229:Or5b101 UTSW 19 13,005,561 (GRCm39) missense possibly damaging 0.55
R8474:Or5b101 UTSW 19 13,005,357 (GRCm39) missense probably damaging 1.00
R8951:Or5b101 UTSW 19 13,004,827 (GRCm39) missense
R8957:Or5b101 UTSW 19 13,004,881 (GRCm39) missense probably benign 0.03
R9046:Or5b101 UTSW 19 13,005,115 (GRCm39) missense probably benign 0.01
R9059:Or5b101 UTSW 19 13,005,277 (GRCm39) missense probably damaging 1.00
R9131:Or5b101 UTSW 19 13,005,360 (GRCm39) missense probably benign 0.02
R9266:Or5b101 UTSW 19 13,005,648 (GRCm39) missense probably damaging 1.00
R9269:Or5b101 UTSW 19 13,004,994 (GRCm39) missense probably benign
Z1088:Or5b101 UTSW 19 13,005,391 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- TTCACAGAAGGAGAGACTTAATGC -3'
(R):5'- TCACCCTTATAGGAAATCTTGGGC -3'

Sequencing Primer
(F):5'- AGGAGAGACTTAATGCATCCATAG -3'
(R):5'- CCCTTATAGGAAATCTTGGGCTGATC -3'
Posted On 2015-02-18