Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00990:Trip12'

26782

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trip12

Ensembl Gene

ENSMUSG00000026219

Gene Name

thyroid hormone receptor interactor 12

Synonyms

6720416K24Rik, 1110036I07Rik, Gtl6

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

IGL00990

Quality Score

Status

Chromosome

Chromosomal Location

84721189-84840516 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 84751884 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 1026 (N1026K)

Ref Sequence

ENSEMBL: ENSMUSP00000139563 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027421] [ENSMUST00000185909] [ENSMUST00000186465] [ENSMUST00000186648] [ENSMUST00000186894] [ENSMUST00000189670] [ENSMUST00000189841]

AlphaFold

G5E870

Predicted Effect

probably damaging
Transcript: ENSMUST00000027421
AA Change: N1059K

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000027421
Gene: ENSMUSG00000026219
AA Change: N1059K

Domain	Start	End	E-Value	Type
low complexity region	34	39	N/A	INTRINSIC
low complexity region	153	172	N/A	INTRINSIC
low complexity region	177	188	N/A	INTRINSIC
low complexity region	191	215	N/A	INTRINSIC
low complexity region	231	247	N/A	INTRINSIC
low complexity region	379	391	N/A	INTRINSIC
low complexity region	392	406	N/A	INTRINSIC
low complexity region	416	427	N/A	INTRINSIC
SCOP:d1ee4a_	446	660	5e-20	SMART
PDB:1WA5\|B	447	641	1e-5	PDB
Pfam:WWE	765	831	7.6e-22	PFAM
low complexity region	983	1006	N/A	INTRINSIC
low complexity region	1033	1047	N/A	INTRINSIC
low complexity region	1062	1073	N/A	INTRINSIC
low complexity region	1333	1344	N/A	INTRINSIC
low complexity region	1345	1362	N/A	INTRINSIC
Blast:HECTc	1363	1417	8e-8	BLAST
Blast:HECTc	1573	1629	2e-24	BLAST
HECTc	1636	2025	1.29e-177	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000185567

Predicted Effect

probably benign
Transcript: ENSMUST00000185909

SMART Domains

Protein: ENSMUSP00000139986
Gene: ENSMUSG00000026219

Domain	Start	End	E-Value	Type
low complexity region	195	214	N/A	INTRINSIC
low complexity region	219	230	N/A	INTRINSIC
low complexity region	233	257	N/A	INTRINSIC
low complexity region	273	289	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000186465
AA Change: N1059K

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000140224
Gene: ENSMUSG00000026219
AA Change: N1059K

Domain	Start	End	E-Value	Type
low complexity region	34	39	N/A	INTRINSIC
low complexity region	153	172	N/A	INTRINSIC
low complexity region	177	188	N/A	INTRINSIC
low complexity region	191	215	N/A	INTRINSIC
low complexity region	231	247	N/A	INTRINSIC
low complexity region	379	391	N/A	INTRINSIC
low complexity region	392	406	N/A	INTRINSIC
low complexity region	416	427	N/A	INTRINSIC
SCOP:d1ee4a_	446	660	5e-20	SMART
PDB:1WA5\|B	447	641	1e-5	PDB
Pfam:WWE	761	831	2.2e-22	PFAM
low complexity region	983	1006	N/A	INTRINSIC
low complexity region	1033	1047	N/A	INTRINSIC
low complexity region	1062	1073	N/A	INTRINSIC
low complexity region	1333	1344	N/A	INTRINSIC
low complexity region	1345	1362	N/A	INTRINSIC
Blast:HECTc	1363	1417	8e-8	BLAST
Blast:HECTc	1573	1629	2e-24	BLAST
HECTc	1636	2025	1.29e-177	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000186648
AA Change: N1026K

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000139563
Gene: ENSMUSG00000026219
AA Change: N1026K

Domain	Start	End	E-Value	Type
low complexity region	34	39	N/A	INTRINSIC
low complexity region	153	172	N/A	INTRINSIC
low complexity region	177	188	N/A	INTRINSIC
low complexity region	191	215	N/A	INTRINSIC
low complexity region	231	247	N/A	INTRINSIC
low complexity region	386	400	N/A	INTRINSIC
low complexity region	410	421	N/A	INTRINSIC
SCOP:d1ee4a_	440	654	5e-20	SMART
PDB:1WA5\|B	441	635	1e-5	PDB
low complexity region	950	973	N/A	INTRINSIC
low complexity region	1000	1014	N/A	INTRINSIC
low complexity region	1029	1040	N/A	INTRINSIC
low complexity region	1300	1311	N/A	INTRINSIC
low complexity region	1312	1329	N/A	INTRINSIC
Blast:HECTc	1330	1384	7e-8	BLAST
Blast:HECTc	1540	1596	2e-24	BLAST
HECTc	1603	1992	6.2e-180	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000186894

SMART Domains

Protein: ENSMUSP00000140267
Gene: ENSMUSG00000026219

Domain	Start	End	E-Value	Type
low complexity region	34	39	N/A	INTRINSIC
low complexity region	153	172	N/A	INTRINSIC
low complexity region	177	188	N/A	INTRINSIC
low complexity region	191	215	N/A	INTRINSIC
low complexity region	231	247	N/A	INTRINSIC
low complexity region	379	391	N/A	INTRINSIC
low complexity region	392	406	N/A	INTRINSIC
low complexity region	416	427	N/A	INTRINSIC
SCOP:d1ee4a_	446	660	3e-20	SMART
PDB:1WA5\|B	447	641	7e-6	PDB
Blast:ARM	476	516	6e-6	BLAST
WWE	764	839	6.9e-25	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000189670

SMART Domains

Protein: ENSMUSP00000140789
Gene: ENSMUSG00000026219

Domain	Start	End	E-Value	Type
low complexity region	138	149	N/A	INTRINSIC
low complexity region	150	167	N/A	INTRINSIC
Blast:HECTc	168	222	5e-8	BLAST
Blast:HECTc	378	434	1e-24	BLAST
HECTc	441	830	6.2e-180	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000189841

SMART Domains

Protein: ENSMUSP00000140879
Gene: ENSMUSG00000026219

Domain	Start	End	E-Value	Type
low complexity region	1	24	N/A	INTRINSIC
low complexity region	51	63	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000190125

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]
PHENOTYPE: Mice homozygous for a targeted allele exhibit complete embryonic lethality during organogenesis associated with embryonic growth retardation and abnormal placenta development. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 150 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6430531B16Rik	A	C	7: 139,978,103	V60G	probably damaging	Het
Adcy8	C	A	15: 64,822,313	V372L	probably benign	Het
Bod1l	T	C	5: 41,828,865	D458G	probably benign	Het
C87414	T	A	5: 93,636,477	Q376L	probably damaging	Het
Cacna1c	G	T	6: 118,613,295	H1416N	probably damaging	Het
Cacna2d1	T	C	5: 15,935,069	I19T	probably benign	Het
Cadps	T	A	14: 12,715,374	T153S	possibly damaging	Het
Cd200r1	A	T	16: 44,794,309	D317V	possibly damaging	Het
Dcaf5	C	T	12: 80,338,832	R840H	probably benign	Het
Dnhd1	A	C	7: 105,721,688	H4725P	possibly damaging	Het
Echdc3	C	A	2: 6,195,727	L149F	probably benign	Het
Efhb	T	G	17: 53,462,621	Q220P	possibly damaging	Het
Efr3b	A	T	12: 3,975,411	Y18*	probably null	Het
Eri1	T	C	8: 35,482,682	K41R	possibly damaging	Het
Eri1	C	A	8: 35,482,646	G53V	probably benign	Het
Gm10212	A	G	19: 11,569,560		noncoding transcript	Het
Gm11168	T	G	9: 3,005,124	F201C	probably damaging	Het
Gm14412	A	C	2: 177,315,686	S139A	probably benign	Het
Gm21411	C	T	4: 146,892,610	S69N	possibly damaging	Het
Gm21671	A	C	5: 25,954,224	W41G	probably benign	Het
Gm21738	A	G	14: 19,418,885	C16R	probably benign	Het
Gm21967	T	A	13: 119,609,535		probably benign	Het
Gm4952	A	T	19: 12,623,623	D69V	probably damaging	Het
Gm5591	T	G	7: 38,520,414	K345T	probably benign	Het
Gm7647	T	C	5: 94,962,980	S7P	probably benign	Het
Gm9733	C	T	3: 15,332,145		probably null	Het
Gm9758	G	A	5: 14,913,508		probably benign	Het
Gtse1	C	A	15: 85,868,817	Q378K	possibly damaging	Het
Haus3	T	C	5: 34,166,346	K307E	probably benign	Het
Hjurp	A	G	1: 88,270,269	L96S	probably benign	Het
Ifi205	T	A	1: 174,027,333		probably benign	Het
Ighg1	A	G	12: 113,329,184	V255A	unknown	Het
Ighv14-4	T	A	12: 114,176,632	M49L	probably benign	Het
Jak1	A	C	4: 101,171,357	L508R	probably damaging	Het
Kif18a	A	G	2: 109,334,422	Q821R	probably benign	Het
Kif21b	T	C	1: 136,152,342	S539P	possibly damaging	Het
Klhdc2	T	C	12: 69,307,213	V266A	probably benign	Het
Lonp2	G	T	8: 86,641,533		probably benign	Het
Mpdz	C	T	4: 81,303,584		probably benign	Het
Mroh2a	G	A	1: 88,230,746	E172K	probably damaging	Het
Mroh2a	G	T	1: 88,244,970	M823I	probably benign	Het
Mroh2a	G	A	1: 88,234,120	G309D	possibly damaging	Het
Mtif3	C	A	5: 146,959,104	G58*	probably null	Het
Muc4	T	G	16: 32,753,863	N1246K	probably benign	Het
Muc4	G	T	16: 32,753,848	K1241N	probably benign	Het
Muc4	G	A	16: 32,753,849	G1242R	probably benign	Het
Muc4	C	T	16: 32,755,805		probably benign	Het
Muc4	C	T	16: 32,753,823	P1233L	probably benign	Het
Muc4	C	A	16: 32,753,955	T1277K	possibly damaging	Het
Muc4	A	G	16: 32,754,071	R1316G	probably benign	Het
Muc4	A	T	16: 32,753,886	E1254V	probably benign	Het
Muc4	C	T	16: 32,752,569	P816S	probably benign	Het
Muc6	C	T	7: 141,638,890	A1957T	possibly damaging	Het
Naca	T	A	10: 128,043,800		probably benign	Het
Nars2	A	T	7: 97,002,790		probably benign	Het
Odf3l1	T	C	9: 56,849,057	E225G	probably benign	Het
Olfr1445	G	T	19: 12,883,901	V7L	probably benign	Het
Olfr342	A	C	2: 36,527,993	I194L	probably benign	Het
Olfr549	G	T	7: 102,554,891	L202F	probably damaging	Het
Olfr812	T	C	10: 129,842,473	T190A	probably damaging	Het
Pcdh7	G	A	5: 57,720,464	E454K	possibly damaging	Het
Pip5kl1	C	A	2: 32,583,347	A332D	probably benign	Het
Pisd	A	T	5: 32,739,358	S280T	probably benign	Het
Pramel5	A	G	4: 144,273,979	L9P	probably damaging	Het
Prkd3	G	T	17: 78,954,523	N787K	probably benign	Het
Prkdc	A	T	16: 15,702,115	H1139L	probably benign	Het
R3hdm1	A	G	1: 128,162,196		probably benign	Het
Rbfox2	T	C	15: 77,102,936	N206D	probably damaging	Het
Rlf	T	C	4: 121,148,339	E1258G	possibly damaging	Het
Rpl8	T	C	15: 76,905,042		probably benign	Het
Senp5	A	C	16: 31,990,274	V27G	probably benign	Het
Serpina1b	T	A	12: 103,728,266	K406N	probably damaging	Het
Sfi1	G	A	11: 3,134,337	A975V	probably benign	Het
Sfi1	T	C	11: 3,143,689		probably benign	Het
Sfi1	C	T	11: 3,135,671	A853T	probably damaging	Het
Shc1	T	C	3: 89,424,229	S154P	probably damaging	Het
Skint5	A	G	4: 113,542,873		probably null	Het
Slc17a8	T	C	10: 89,576,530	D531G	probably benign	Het
Slc4a10	A	C	2: 62,286,940	T718P	probably damaging	Het
Slc7a11	C	T	3: 50,379,069	R411Q	probably damaging	Het
Slitrk3	A	G	3: 73,050,081	F453L	probably damaging	Het
Slk	A	C	19: 47,580,252	Q20P	probably damaging	Het
Smg5	T	C	3: 88,343,038		probably null	Het
Sp110	G	A	1: 85,586,281	R252C	possibly damaging	Het
Sp140	C	T	1: 85,626,165	R242C	possibly damaging	Het
Sp140	G	A	1: 85,626,133	R231K	probably benign	Het
Speer4b	G	A	5: 27,501,274	P30S	probably damaging	Het
Stim1	T	A	7: 102,426,747	H395Q	probably damaging	Het
Sult2a1	T	C	7: 13,804,036	I187M	probably benign	Het
Thap1	C	T	8: 26,160,882	P37L	possibly damaging	Het
Thap1	G	A	8: 26,162,731	D189N	probably benign	Het
Thrap3	C	T	4: 126,165,395		probably benign	Het
Tmem132d	C	T	5: 127,784,832	V742I	possibly damaging	Het
Tmprss9	A	G	10: 80,892,292	D572G	possibly damaging	Het
Tmtc1	T	G	6: 148,443,944	T86P	probably benign	Het
Ttll5	T	A	12: 85,876,589	V280E	probably damaging	Het
Ubn2	T	A	6: 38,482,605	D592E	possibly damaging	Het
Ubr1	T	G	2: 120,930,872	H608P	probably damaging	Het
Ugt1a6b	A	T	1: 88,215,178		probably null	Het
Vmn1r77	C	A	7: 12,041,768	S89Y	probably benign	Het
Vmn1r77	A	C	7: 12,041,476	I60L	probably benign	Het
Vmn2r114	A	T	17: 23,291,238	L756Q	probably damaging	Het
Vmn2r114	G	T	17: 23,290,983	S841Y	probably benign	Het
Vmn2r114	G	A	17: 23,290,965	A847V	probably benign	Het
Vmn2r115	G	A	17: 23,359,779	G742D	probably damaging	Het
Vmn2r115	C	T	17: 23,346,264	S375F	probably benign	Het
Vmn2r115	G	T	17: 23,348,034	G507*	probably null	Het
Vmn2r115	T	A	17: 23,359,824	L757Q	probably damaging	Het
Vmn2r115	A	G	17: 23,356,960	M511V	probably benign	Het
Vmn2r115	C	T	17: 23,346,371	Q411*	probably null	Het
Vmn2r115	A	G	17: 23,346,372	Q411R	probably benign	Het
Vmn2r115	C	T	17: 23,359,397	P615S	probably damaging	Het
Vmn2r115	A	G	17: 23,346,161	N341D	probably benign	Het
Vmn2r115	A	T	17: 23,346,206	M356L	possibly damaging	Het
Vmn2r115	G	T	17: 23,359,349	A599S	probably benign	Het
Vmn2r115	C	T	17: 23,346,176	P346S	probably benign	Het
Vmn2r115	G	A	17: 23,346,278	E380K	probably benign	Het
Vmn2r115	A	C	17: 23,346,339	N400T	probably damaging	Het
Vmn2r116	C	T	17: 23,397,727	P540S	probably damaging	Het
Vmn2r116	C	T	17: 23,387,236	S374F	probably benign	Het
Vmn2r117	C	T	17: 23,477,840	A198T	probably damaging	Het
Vmn2r117	A	C	17: 23,479,546	S18A	probably benign	Het
Vmn2r117	T	G	17: 23,475,429	K481N	probably damaging	Het
Vmn2r121	T	G	X: 124,127,802	K840N	probably benign	Het
Vmn2r121	T	A	X: 124,127,783	N847Y	possibly damaging	Het
Vmn2r121	C	T	X: 124,133,716	E73K	probably benign	Het
Vmn2r125	A	C	4: 156,350,900	Q191P	probably benign	Het
Vmn2r125	C	A	4: 156,350,899	Q191K	probably benign	Het
Vmn2r125	T	C	4: 156,350,966	V213A	probably benign	Het
Vmn2r125	T	C	4: 156,351,383	M352T	probably benign	Het
Vmn2r125	C	T	4: 156,351,038	T237I	probably benign	Het
Vmn2r125	A	T	4: 156,351,037	T237S	probably benign	Het
Vmn2r125	T	A	4: 156,351,226	L300M	probably benign	Het
Vmn2r88	A	G	14: 51,413,125	I98M	probably benign	Het
Vmn2r88	T	C	14: 51,413,060	F77L	probably benign	Het
Vmn2r88	T	C	14: 51,413,256	I142T	probably benign	Het
Vmn2r88	C	T	14: 51,416,802	P539L	possibly damaging	Het
Vmn2r89	A	C	14: 51,455,971	Q259H	probably benign	Het
Vmn2r89	T	G	14: 51,457,493	L477V	probably benign	Het
Vmn2r-ps159	T	C	4: 156,334,263		noncoding transcript	Het
Vmn2r-ps159	C	A	4: 156,338,435		noncoding transcript	Het
Vmn2r-ps159	G	T	4: 156,338,460		noncoding transcript	Het
Vmn2r-ps159	T	G	4: 156,334,562		noncoding transcript	Het
Vmn2r-ps159	T	G	4: 156,338,484		noncoding transcript	Het
Vmn2r-ps159	G	T	4: 156,334,397		noncoding transcript	Het
Vmn2r-ps159	A	T	4: 156,338,146		noncoding transcript	Het
Zfp180	G	A	7: 24,104,416	C85Y	possibly damaging	Het
Zfp180	C	T	7: 24,104,830	R225C	probably benign	Het
Zfp180	G	A	7: 24,104,995	V280M	possibly damaging	Het
Zfp982	G	A	4: 147,512,369	C61Y	probably benign	Het

Other mutations in Trip12

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00331:Trip12	APN	1	84730541	missense	probably damaging	1.00
IGL00430:Trip12	APN	1	84763861	missense	probably damaging	0.96
IGL00465:Trip12	APN	1	84763861	missense	probably damaging	0.96
IGL00819:Trip12	APN	1	84754272	missense	probably damaging	1.00
IGL00900:Trip12	APN	1	84724764	missense	possibly damaging	0.56
IGL01087:Trip12	APN	1	84757859	missense	probably damaging	0.99
IGL01400:Trip12	APN	1	84751978	missense	probably damaging	0.99
IGL01521:Trip12	APN	1	84766198	splice site	probably benign
IGL01619:Trip12	APN	1	84814910	missense	probably damaging	0.99
IGL01796:Trip12	APN	1	84728278	missense	probably benign	0.42
IGL01975:Trip12	APN	1	84814813	splice site	probably benign
IGL02190:Trip12	APN	1	84766070	missense	probably damaging	0.98
IGL02474:Trip12	APN	1	84794133	missense	probably benign
IGL02517:Trip12	APN	1	84743814	unclassified	probably benign
IGL02631:Trip12	APN	1	84766008	missense	possibly damaging	0.91
IGL02991:Trip12	APN	1	84738815	missense	probably damaging	1.00
IGL03161:Trip12	APN	1	84761132	unclassified	probably benign
IGL03388:Trip12	APN	1	84743186	missense	probably damaging	0.99
cardamom	UTSW	1	84749276	missense	probably damaging	0.99
pungent	UTSW	1	84793915	missense	possibly damaging	0.70
spices	UTSW	1	84793875	missense	probably benign	0.10
sulfuric	UTSW	1	84759050	missense	probably benign	0.19
Turmeric	UTSW	1	84754343	missense	probably benign	0.07
LCD18:Trip12	UTSW	1	84754482	unclassified	probably benign
R0090:Trip12	UTSW	1	84732136	splice site	probably benign
R0111:Trip12	UTSW	1	84759133	unclassified	probably benign
R0471:Trip12	UTSW	1	84726207	missense	probably damaging	1.00
R0486:Trip12	UTSW	1	84761084	nonsense	probably null
R0557:Trip12	UTSW	1	84724747	missense	probably damaging	1.00
R0570:Trip12	UTSW	1	84751548	missense	probably damaging	1.00
R0614:Trip12	UTSW	1	84757761	missense	probably damaging	1.00
R0627:Trip12	UTSW	1	84768597	missense	probably damaging	1.00
R0630:Trip12	UTSW	1	84793915	missense	possibly damaging	0.70
R0657:Trip12	UTSW	1	84759050	missense	probably benign	0.19
R0741:Trip12	UTSW	1	84745181	missense	probably benign	0.09
R0862:Trip12	UTSW	1	84744009	missense	probably damaging	0.99
R0864:Trip12	UTSW	1	84744009	missense	probably damaging	0.99
R1124:Trip12	UTSW	1	84737037	missense	probably damaging	1.00
R1252:Trip12	UTSW	1	84776350	nonsense	probably null
R1455:Trip12	UTSW	1	84759100	missense	probably benign	0.01
R1487:Trip12	UTSW	1	84768631	missense	probably damaging	1.00
R1702:Trip12	UTSW	1	84745063	missense	probably damaging	1.00
R1781:Trip12	UTSW	1	84730621	missense	probably benign	0.01
R1847:Trip12	UTSW	1	84749269	missense	probably damaging	1.00
R1854:Trip12	UTSW	1	84728145	missense	probably damaging	1.00
R1866:Trip12	UTSW	1	84745060	missense	probably damaging	1.00
R1926:Trip12	UTSW	1	84749291	missense	probably damaging	0.98
R1935:Trip12	UTSW	1	84794101	missense	possibly damaging	0.46
R1950:Trip12	UTSW	1	84760801	missense	probably damaging	1.00
R1994:Trip12	UTSW	1	84749172	missense	probably damaging	1.00
R2014:Trip12	UTSW	1	84760866	nonsense	probably null
R2391:Trip12	UTSW	1	84814790	frame shift	probably null
R2423:Trip12	UTSW	1	84814790	frame shift	probably null
R2433:Trip12	UTSW	1	84743823	missense	possibly damaging	0.84
R2905:Trip12	UTSW	1	84754343	missense	probably benign	0.07
R3040:Trip12	UTSW	1	84742245	missense	probably benign	0.13
R3735:Trip12	UTSW	1	84814790	frame shift	probably null
R3907:Trip12	UTSW	1	84732106	missense	possibly damaging	0.53
R4394:Trip12	UTSW	1	84725741	missense	probably damaging	1.00
R4540:Trip12	UTSW	1	84749276	missense	probably damaging	0.99
R4859:Trip12	UTSW	1	84793810	missense	probably damaging	0.99
R5240:Trip12	UTSW	1	84794133	missense	probably benign
R5278:Trip12	UTSW	1	84762147	missense	probably damaging	1.00
R5377:Trip12	UTSW	1	84757431	missense	probably damaging	1.00
R5510:Trip12	UTSW	1	84768680	missense	probably damaging	1.00
R5542:Trip12	UTSW	1	84749344	missense	probably damaging	1.00
R5550:Trip12	UTSW	1	84761099	missense	probably damaging	0.99
R5886:Trip12	UTSW	1	84730458	intron	probably benign
R5893:Trip12	UTSW	1	84759163	unclassified	probably benign
R5914:Trip12	UTSW	1	84763458	missense	probably damaging	1.00
R5925:Trip12	UTSW	1	84749253	nonsense	probably null
R5985:Trip12	UTSW	1	84725771	missense	probably damaging	0.99
R6135:Trip12	UTSW	1	84760838	missense	probably benign	0.00
R6158:Trip12	UTSW	1	84761012	missense	possibly damaging	0.84
R6419:Trip12	UTSW	1	84793870	missense	probably damaging	1.00
R6816:Trip12	UTSW	1	84793714	missense	probably damaging	0.99
R7144:Trip12	UTSW	1	84793714	missense	probably damaging	0.99
R7194:Trip12	UTSW	1	84794222	missense	probably benign	0.07
R7355:Trip12	UTSW	1	84814883	missense	probably damaging	1.00
R7361:Trip12	UTSW	1	84750442	missense	probably damaging	0.98
R7588:Trip12	UTSW	1	84760883	missense	probably damaging	0.99
R7705:Trip12	UTSW	1	84777449	missense	probably damaging	1.00
R7818:Trip12	UTSW	1	84760806	missense	probably damaging	1.00
R7918:Trip12	UTSW	1	84745063	missense	probably damaging	0.98
R8127:Trip12	UTSW	1	84738742	missense	probably damaging	0.99
R8221:Trip12	UTSW	1	84766050	missense	possibly damaging	0.80
R8336:Trip12	UTSW	1	84766041	missense	probably benign	0.37
R8373:Trip12	UTSW	1	84795767	missense	probably damaging	0.98
R8719:Trip12	UTSW	1	84745069	missense	probably damaging	0.98
R8771:Trip12	UTSW	1	84743297	unclassified	probably benign
R8997:Trip12	UTSW	1	84793875	missense	probably benign	0.10
R9146:Trip12	UTSW	1	84794160	missense	possibly damaging	0.89
R9236:Trip12	UTSW	1	84725829	missense	probably damaging	1.00
R9338:Trip12	UTSW	1	84749298	missense	probably damaging	0.99
R9391:Trip12	UTSW	1	84795752	missense	probably benign	0.00
R9516:Trip12	UTSW	1	84757494	missense	probably damaging	1.00
X0023:Trip12	UTSW	1	84760787	missense	probably benign	0.12
X0065:Trip12	UTSW	1	84749163	missense	probably benign	0.21
Z1088:Trip12	UTSW	1	84766168	missense	probably damaging	1.00

Posted On

2013-04-17