Incidental Mutation 'R3424:Or10g9'
ID |
267852 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Or10g9
|
Ensembl Gene |
ENSMUSG00000059473 |
Gene Name |
olfactory receptor family 10 subfamily G member 9 |
Synonyms |
MOR223-1, Olfr979, GA_x6K02T2PVTD-33699706-33698771 |
MMRRC Submission |
040642-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.084)
|
Stock # |
R3424 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
9 |
Chromosomal Location |
39911502-39912546 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 39911830 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Glutamic Acid to Valine
at position 231
(E231V)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000148903
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080835]
[ENSMUST00000215523]
[ENSMUST00000216463]
|
AlphaFold |
Q8VH10 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000080835
AA Change: E231V
PolyPhen 2
Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
|
SMART Domains |
Protein: ENSMUSP00000079648 Gene: ENSMUSG00000059473 AA Change: E231V
Domain | Start | End | E-Value | Type |
Pfam:7tm_4
|
29 |
304 |
7.9e-58 |
PFAM |
Pfam:7tm_1
|
39 |
287 |
5.2e-22 |
PFAM |
|
Predicted Effect |
probably damaging
Transcript: ENSMUST00000215523
AA Change: E231V
PolyPhen 2
Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000216463
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.4%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 28 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
6030469F06Rik |
G |
T |
12: 31,234,632 (GRCm39) |
|
noncoding transcript |
Het |
Atp8b3 |
T |
C |
10: 80,372,181 (GRCm39) |
E16G |
probably benign |
Het |
BC016579 |
T |
A |
16: 45,449,846 (GRCm39) |
I191F |
probably damaging |
Het |
Cdh23 |
T |
G |
10: 60,212,660 (GRCm39) |
I1584L |
possibly damaging |
Het |
Cep250 |
G |
A |
2: 155,823,381 (GRCm39) |
D1011N |
probably benign |
Het |
Coro2b |
A |
T |
9: 62,336,590 (GRCm39) |
|
probably null |
Het |
Csf3r |
A |
G |
4: 125,937,549 (GRCm39) |
D811G |
probably damaging |
Het |
Dst |
T |
G |
1: 34,237,586 (GRCm39) |
|
probably benign |
Het |
Gabrr1 |
T |
C |
4: 33,158,058 (GRCm39) |
L227P |
probably damaging |
Het |
Galnt10 |
T |
C |
11: 57,536,539 (GRCm39) |
V52A |
probably benign |
Het |
Golga4 |
A |
C |
9: 118,363,715 (GRCm39) |
D229A |
probably benign |
Het |
Heatr5b |
G |
A |
17: 79,075,833 (GRCm39) |
T1495I |
possibly damaging |
Het |
Hoxd4 |
A |
G |
2: 74,557,657 (GRCm39) |
Y12C |
probably damaging |
Het |
Hps1 |
A |
T |
19: 42,748,952 (GRCm39) |
M522K |
possibly damaging |
Het |
Lrrc8e |
A |
T |
8: 4,284,611 (GRCm39) |
I279F |
probably damaging |
Het |
Mettl24 |
C |
T |
10: 40,559,637 (GRCm39) |
Q96* |
probably null |
Het |
Muc2 |
A |
G |
7: 141,279,595 (GRCm39) |
N193S |
probably damaging |
Het |
Mysm1 |
A |
G |
4: 94,853,558 (GRCm39) |
L347P |
probably benign |
Het |
Oxtr |
G |
T |
6: 112,454,191 (GRCm39) |
H24Q |
probably benign |
Het |
Paxip1 |
A |
G |
5: 27,980,671 (GRCm39) |
|
probably benign |
Het |
Pclo |
C |
T |
5: 14,730,432 (GRCm39) |
|
probably benign |
Het |
Ros1 |
C |
A |
10: 52,004,512 (GRCm39) |
|
probably null |
Het |
Slc18b1 |
T |
G |
10: 23,698,874 (GRCm39) |
M348R |
probably damaging |
Het |
Slco4c1 |
A |
T |
1: 96,768,976 (GRCm39) |
S295R |
probably benign |
Het |
Tmeff2 |
A |
G |
1: 51,018,776 (GRCm39) |
|
probably benign |
Het |
Tspan31 |
T |
A |
10: 126,904,371 (GRCm39) |
Q141L |
probably benign |
Het |
Virma |
G |
T |
4: 11,513,177 (GRCm39) |
E344* |
probably null |
Het |
Zbtb17 |
G |
T |
4: 141,192,299 (GRCm39) |
G415C |
probably damaging |
Het |
|
Other mutations in Or10g9 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL02718:Or10g9
|
APN |
9 |
39,912,182 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02939:Or10g9
|
APN |
9 |
39,912,194 (GRCm39) |
missense |
probably benign |
0.26 |
IGL02991:Or10g9
|
UTSW |
9 |
39,911,698 (GRCm39) |
missense |
probably damaging |
1.00 |
R1388:Or10g9
|
UTSW |
9 |
39,911,948 (GRCm39) |
missense |
probably damaging |
0.99 |
R1572:Or10g9
|
UTSW |
9 |
39,912,490 (GRCm39) |
missense |
probably benign |
0.35 |
R2089:Or10g9
|
UTSW |
9 |
39,912,500 (GRCm39) |
missense |
probably benign |
0.01 |
R2091:Or10g9
|
UTSW |
9 |
39,912,500 (GRCm39) |
missense |
probably benign |
0.01 |
R2091:Or10g9
|
UTSW |
9 |
39,912,500 (GRCm39) |
missense |
probably benign |
0.01 |
R2179:Or10g9
|
UTSW |
9 |
39,912,220 (GRCm39) |
missense |
probably benign |
0.44 |
R3964:Or10g9
|
UTSW |
9 |
39,911,767 (GRCm39) |
missense |
possibly damaging |
0.95 |
R3965:Or10g9
|
UTSW |
9 |
39,911,767 (GRCm39) |
missense |
possibly damaging |
0.95 |
R4111:Or10g9
|
UTSW |
9 |
39,912,194 (GRCm39) |
nonsense |
probably null |
|
R4537:Or10g9
|
UTSW |
9 |
39,911,616 (GRCm39) |
missense |
probably benign |
0.01 |
R4737:Or10g9
|
UTSW |
9 |
39,911,718 (GRCm39) |
missense |
probably damaging |
0.96 |
R4926:Or10g9
|
UTSW |
9 |
39,912,319 (GRCm39) |
splice site |
probably null |
|
R5303:Or10g9
|
UTSW |
9 |
39,911,884 (GRCm39) |
missense |
probably damaging |
1.00 |
R5587:Or10g9
|
UTSW |
9 |
39,911,917 (GRCm39) |
missense |
possibly damaging |
0.90 |
R6387:Or10g9
|
UTSW |
9 |
39,912,148 (GRCm39) |
missense |
probably damaging |
0.99 |
R6394:Or10g9
|
UTSW |
9 |
39,912,001 (GRCm39) |
missense |
probably benign |
0.04 |
R6765:Or10g9
|
UTSW |
9 |
39,912,493 (GRCm39) |
missense |
probably damaging |
1.00 |
R7312:Or10g9
|
UTSW |
9 |
39,912,106 (GRCm39) |
missense |
probably benign |
0.22 |
R7463:Or10g9
|
UTSW |
9 |
39,911,860 (GRCm39) |
missense |
probably benign |
0.07 |
R7486:Or10g9
|
UTSW |
9 |
39,912,181 (GRCm39) |
missense |
probably benign |
0.39 |
R7581:Or10g9
|
UTSW |
9 |
39,911,718 (GRCm39) |
missense |
probably damaging |
0.96 |
R8364:Or10g9
|
UTSW |
9 |
39,911,660 (GRCm39) |
missense |
probably benign |
0.22 |
R8414:Or10g9
|
UTSW |
9 |
39,912,241 (GRCm39) |
missense |
probably benign |
0.19 |
R9049:Or10g9
|
UTSW |
9 |
39,911,919 (GRCm39) |
missense |
possibly damaging |
0.56 |
R9567:Or10g9
|
UTSW |
9 |
39,912,367 (GRCm39) |
missense |
possibly damaging |
0.95 |
R9632:Or10g9
|
UTSW |
9 |
39,912,172 (GRCm39) |
missense |
probably damaging |
1.00 |
R9710:Or10g9
|
UTSW |
9 |
39,912,172 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Predicted Primers |
PCR Primer
(F):5'- TCAGGGTGTACACAACAGGG -3'
(R):5'- TGTCCAGACTACATTGACCTTC -3'
Sequencing Primer
(F):5'- GTTGAGTAGGGGTGTCAACAC -3'
(R):5'- CAACCAGATCCAGCATTATTTCTGTG -3'
|
Posted On |
2015-02-18 |