Incidental Mutation 'R3424:Coro2b'
ID 267853
Institutional Source Beutler Lab
Gene Symbol Coro2b
Ensembl Gene ENSMUSG00000041729
Gene Name coronin, actin binding protein, 2B
Synonyms E130012P22Rik
MMRRC Submission 040642-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.091) question?
Stock # R3424 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 62326774-62444326 bp(-) (GRCm39)
Type of Mutation splice site (26 bp from exon)
DNA Base Change (assembly) A to T at 62336590 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000134079 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048043] [ENSMUST00000164246] [ENSMUST00000173171] [ENSMUST00000174439]
AlphaFold Q8BH44
Predicted Effect possibly damaging
Transcript: ENSMUST00000048043
AA Change: V228E

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000041826
Gene: ENSMUSG00000041729
AA Change: V228E

DomainStartEndE-ValueType
DUF1899 10 74 2.89e-31 SMART
WD40 73 116 8.75e-5 SMART
WD40 126 166 4.95e-4 SMART
WD40 169 208 1.33e-4 SMART
WD40 211 254 2.56e1 SMART
DUF1900 261 397 1.62e-84 SMART
coiled coil region 436 476 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000131981
SMART Domains Protein: ENSMUSP00000133481
Gene: ENSMUSG00000041729

DomainStartEndE-ValueType
DUF1900 3 97 6.37e-42 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151604
Predicted Effect possibly damaging
Transcript: ENSMUST00000164246
AA Change: V223E

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000128441
Gene: ENSMUSG00000041729
AA Change: V223E

DomainStartEndE-ValueType
DUF1899 5 69 2.89e-31 SMART
WD40 68 111 8.75e-5 SMART
WD40 121 161 4.95e-4 SMART
WD40 164 203 1.33e-4 SMART
WD40 206 249 2.56e1 SMART
DUF1900 256 317 5.33e-12 SMART
Predicted Effect probably null
Transcript: ENSMUST00000173171
SMART Domains Protein: ENSMUSP00000134709
Gene: ENSMUSG00000041729

DomainStartEndE-ValueType
DUF1899 16 80 2.89e-31 SMART
Pfam:WD40 87 121 1.7e-9 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000174439
SMART Domains Protein: ENSMUSP00000134079
Gene: ENSMUSG00000041729

DomainStartEndE-ValueType
WD40 1 41 4.95e-4 SMART
WD40 44 83 1.33e-4 SMART
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.4%
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygous knockout reduces susceptibility to Doxorubicin-induced focal segmental glomerulosclerosis with lower levels of proteinuria and less renal glomerulus damage. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 28 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6030469F06Rik G T 12: 31,234,632 (GRCm39) noncoding transcript Het
Atp8b3 T C 10: 80,372,181 (GRCm39) E16G probably benign Het
BC016579 T A 16: 45,449,846 (GRCm39) I191F probably damaging Het
Cdh23 T G 10: 60,212,660 (GRCm39) I1584L possibly damaging Het
Cep250 G A 2: 155,823,381 (GRCm39) D1011N probably benign Het
Csf3r A G 4: 125,937,549 (GRCm39) D811G probably damaging Het
Dst T G 1: 34,237,586 (GRCm39) probably benign Het
Gabrr1 T C 4: 33,158,058 (GRCm39) L227P probably damaging Het
Galnt10 T C 11: 57,536,539 (GRCm39) V52A probably benign Het
Golga4 A C 9: 118,363,715 (GRCm39) D229A probably benign Het
Heatr5b G A 17: 79,075,833 (GRCm39) T1495I possibly damaging Het
Hoxd4 A G 2: 74,557,657 (GRCm39) Y12C probably damaging Het
Hps1 A T 19: 42,748,952 (GRCm39) M522K possibly damaging Het
Lrrc8e A T 8: 4,284,611 (GRCm39) I279F probably damaging Het
Mettl24 C T 10: 40,559,637 (GRCm39) Q96* probably null Het
Muc2 A G 7: 141,279,595 (GRCm39) N193S probably damaging Het
Mysm1 A G 4: 94,853,558 (GRCm39) L347P probably benign Het
Or10g9 T A 9: 39,911,830 (GRCm39) E231V probably damaging Het
Oxtr G T 6: 112,454,191 (GRCm39) H24Q probably benign Het
Paxip1 A G 5: 27,980,671 (GRCm39) probably benign Het
Pclo C T 5: 14,730,432 (GRCm39) probably benign Het
Ros1 C A 10: 52,004,512 (GRCm39) probably null Het
Slc18b1 T G 10: 23,698,874 (GRCm39) M348R probably damaging Het
Slco4c1 A T 1: 96,768,976 (GRCm39) S295R probably benign Het
Tmeff2 A G 1: 51,018,776 (GRCm39) probably benign Het
Tspan31 T A 10: 126,904,371 (GRCm39) Q141L probably benign Het
Virma G T 4: 11,513,177 (GRCm39) E344* probably null Het
Zbtb17 G T 4: 141,192,299 (GRCm39) G415C probably damaging Het
Other mutations in Coro2b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01772:Coro2b APN 9 62,333,090 (GRCm39) missense probably damaging 0.99
IGL01834:Coro2b APN 9 62,338,639 (GRCm39) missense possibly damaging 0.93
IGL03242:Coro2b APN 9 62,336,243 (GRCm39) nonsense probably null
PIT4151001:Coro2b UTSW 9 62,336,286 (GRCm39) missense probably damaging 1.00
R0422:Coro2b UTSW 9 62,335,259 (GRCm39) missense probably benign 0.00
R0835:Coro2b UTSW 9 62,333,119 (GRCm39) missense possibly damaging 0.68
R0944:Coro2b UTSW 9 62,335,263 (GRCm39) missense probably benign 0.08
R1115:Coro2b UTSW 9 62,338,609 (GRCm39) missense probably damaging 0.96
R1254:Coro2b UTSW 9 62,336,247 (GRCm39) missense probably damaging 0.98
R1422:Coro2b UTSW 9 62,336,229 (GRCm39) critical splice donor site probably null
R1532:Coro2b UTSW 9 62,396,705 (GRCm39) missense probably damaging 1.00
R1543:Coro2b UTSW 9 62,333,123 (GRCm39) missense probably benign 0.32
R3971:Coro2b UTSW 9 62,336,522 (GRCm39) missense possibly damaging 0.55
R3972:Coro2b UTSW 9 62,336,522 (GRCm39) missense possibly damaging 0.55
R4035:Coro2b UTSW 9 62,333,071 (GRCm39) unclassified probably benign
R4233:Coro2b UTSW 9 62,333,467 (GRCm39) missense possibly damaging 0.69
R4734:Coro2b UTSW 9 62,333,860 (GRCm39) missense probably benign 0.02
R4825:Coro2b UTSW 9 62,361,905 (GRCm39) missense probably benign 0.30
R5332:Coro2b UTSW 9 62,336,512 (GRCm39) missense probably damaging 0.97
R5702:Coro2b UTSW 9 62,333,859 (GRCm39) missense probably damaging 0.97
R6474:Coro2b UTSW 9 62,333,910 (GRCm39) missense probably benign 0.16
R6500:Coro2b UTSW 9 62,396,606 (GRCm39) missense probably benign 0.24
R6674:Coro2b UTSW 9 62,339,709 (GRCm39) missense probably damaging 1.00
R7102:Coro2b UTSW 9 62,328,667 (GRCm39) missense possibly damaging 0.81
R7347:Coro2b UTSW 9 62,396,654 (GRCm39) missense probably benign
R8199:Coro2b UTSW 9 62,336,302 (GRCm39) missense probably benign 0.00
R8447:Coro2b UTSW 9 62,333,842 (GRCm39) missense probably damaging 1.00
R8970:Coro2b UTSW 9 62,333,809 (GRCm39) unclassified probably benign
R9023:Coro2b UTSW 9 62,332,978 (GRCm39) missense
R9211:Coro2b UTSW 9 62,427,662 (GRCm39) missense probably benign 0.06
R9325:Coro2b UTSW 9 62,396,609 (GRCm39) missense probably benign
R9443:Coro2b UTSW 9 62,333,080 (GRCm39) missense probably benign 0.21
R9516:Coro2b UTSW 9 62,335,291 (GRCm39) nonsense probably null
R9653:Coro2b UTSW 9 62,335,259 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTGCAGACCCCTCCAGCAG -3'
(R):5'- ATTTTGCATGTGTTGGAGAAGGA -3'

Sequencing Primer
(F):5'- CAGAAACCTCAGGAGCTCAGATATAG -3'
(R):5'- CTCTTACAAAGACCCTGGTGATGG -3'
Posted On 2015-02-18