Incidental Mutation 'R3428:Vmn2r125'
| ID |
267950 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r125
|
| Ensembl Gene |
ENSMUSG00000096042 |
| Gene Name |
vomeronasal 2, receptor 125 |
| Synonyms |
Gm20782 |
| MMRRC Submission |
040646-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.078)
|
| Stock # |
R3428 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
156696567-156708037 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 156702436 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 74
(D74G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000094556
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096794]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000096794
AA Change: D74G
PolyPhen 2
Score 0.337 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000094556
Gene: ENSMUSG00000096042
AA Change: D74G
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
9 |
355 |
7e-32 |
PFAM |
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 94.9%
|
| Validation Efficiency |
100% (34/34) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam18 |
C |
A |
8: 25,157,620 (GRCm39) |
C110F |
probably damaging |
Het |
| Adamts14 |
C |
T |
10: 61,060,153 (GRCm39) |
E452K |
probably benign |
Het |
| Adrb3 |
T |
C |
8: 27,718,209 (GRCm39) |
D80G |
probably damaging |
Het |
| Alg5 |
T |
A |
3: 54,643,006 (GRCm39) |
M1K |
probably null |
Het |
| Ap1g1 |
A |
G |
8: 110,570,080 (GRCm39) |
E398G |
probably damaging |
Het |
| Arhgap17 |
A |
T |
7: 122,922,854 (GRCm39) |
L85Q |
probably damaging |
Het |
| Bbs9 |
T |
A |
9: 22,479,183 (GRCm39) |
|
probably benign |
Het |
| BC034090 |
T |
C |
1: 155,117,244 (GRCm39) |
I291M |
probably benign |
Het |
| Bicd1 |
T |
C |
6: 149,414,400 (GRCm39) |
L371P |
probably damaging |
Het |
| Cand2 |
A |
C |
6: 115,766,668 (GRCm39) |
R424S |
probably benign |
Het |
| Eng |
G |
T |
2: 32,547,545 (GRCm39) |
V29F |
probably damaging |
Het |
| Gm5828 |
T |
A |
1: 16,838,838 (GRCm39) |
|
noncoding transcript |
Het |
| Hspg2 |
T |
C |
4: 137,282,601 (GRCm39) |
L3447P |
probably damaging |
Het |
| Igtp |
G |
A |
11: 58,097,419 (GRCm39) |
V197I |
probably damaging |
Het |
| Kmt2a |
T |
A |
9: 44,759,416 (GRCm39) |
N844I |
probably benign |
Het |
| Lyzl4 |
T |
C |
9: 121,413,195 (GRCm39) |
I78V |
probably null |
Het |
| Mtg2 |
A |
G |
2: 179,726,065 (GRCm39) |
H225R |
possibly damaging |
Het |
| Or10a5 |
G |
A |
7: 106,635,923 (GRCm39) |
R187K |
probably benign |
Het |
| Pfpl |
T |
A |
19: 12,407,677 (GRCm39) |
S643T |
probably benign |
Het |
| Prelid1 |
T |
G |
13: 55,470,007 (GRCm39) |
V2G |
probably benign |
Het |
| Psma2 |
A |
T |
13: 14,791,362 (GRCm39) |
K2N |
probably benign |
Het |
| Sec24d |
C |
T |
3: 123,137,572 (GRCm39) |
|
probably benign |
Het |
| Setd1a |
G |
T |
7: 127,384,493 (GRCm39) |
|
probably benign |
Het |
| Slc20a1 |
A |
T |
2: 129,042,202 (GRCm39) |
N149I |
probably benign |
Het |
| Slc22a5 |
A |
G |
11: 53,760,152 (GRCm39) |
V388A |
probably benign |
Het |
| Tmem181a |
T |
A |
17: 6,346,061 (GRCm39) |
L185H |
probably damaging |
Het |
| Tns2 |
C |
T |
15: 102,017,369 (GRCm39) |
R281C |
probably damaging |
Het |
| Trav6-7-dv9 |
A |
G |
14: 53,947,788 (GRCm39) |
T97A |
probably benign |
Het |
| Trpv3 |
A |
T |
11: 73,176,767 (GRCm39) |
Y382F |
probably damaging |
Het |
| Ubr2 |
T |
C |
17: 47,279,365 (GRCm39) |
Y681C |
probably damaging |
Het |
| Unc80 |
G |
A |
1: 66,678,464 (GRCm39) |
V2082I |
probably benign |
Het |
| Yipf2 |
T |
C |
9: 21,500,941 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Vmn2r125 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,194 (GRCm39) |
missense |
probably benign |
|
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,333 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,332 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,521 (GRCm39) |
missense |
probably benign |
|
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,678 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,261 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00990:Vmn2r125
|
APN |
4 |
156,703,195 (GRCm39) |
missense |
probably benign |
0.35 |
|
IGL01018:Vmn2r125
|
APN |
4 |
156,703,333 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01018:Vmn2r125
|
APN |
4 |
156,703,332 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL01018:Vmn2r125
|
APN |
4 |
156,703,521 (GRCm39) |
missense |
probably benign |
|
|
IGL01018:Vmn2r125
|
APN |
4 |
156,703,195 (GRCm39) |
missense |
probably benign |
0.35 |
|
IGL01018:Vmn2r125
|
APN |
4 |
156,703,194 (GRCm39) |
missense |
probably benign |
|
|
IGL01018:Vmn2r125
|
APN |
4 |
156,703,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01018:Vmn2r125
|
APN |
4 |
156,702,907 (GRCm39) |
splice site |
probably benign |
|
|
IGL02644:Vmn2r125
|
APN |
4 |
156,703,294 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03144:Vmn2r125
|
APN |
4 |
156,702,314 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
BB013:Vmn2r125
|
UTSW |
4 |
156,702,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
FR4342:Vmn2r125
|
UTSW |
4 |
156,703,260 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0408:Vmn2r125
|
UTSW |
4 |
156,703,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0785:Vmn2r125
|
UTSW |
4 |
156,703,396 (GRCm39) |
missense |
probably benign |
|
|
R1185:Vmn2r125
|
UTSW |
4 |
156,703,396 (GRCm39) |
missense |
probably benign |
|
|
R1185:Vmn2r125
|
UTSW |
4 |
156,703,396 (GRCm39) |
missense |
probably benign |
|
|
R1530:Vmn2r125
|
UTSW |
4 |
156,703,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1698:Vmn2r125
|
UTSW |
4 |
156,703,333 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1780:Vmn2r125
|
UTSW |
4 |
156,703,668 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1977:Vmn2r125
|
UTSW |
4 |
156,707,162 (GRCm39) |
splice site |
probably null |
|
|
R2917:Vmn2r125
|
UTSW |
4 |
156,703,564 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3712:Vmn2r125
|
UTSW |
4 |
156,702,419 (GRCm39) |
nonsense |
probably null |
|
|
R4274:Vmn2r125
|
UTSW |
4 |
156,702,382 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4575:Vmn2r125
|
UTSW |
4 |
156,702,272 (GRCm39) |
missense |
probably null |
0.30 |
|
R4707:Vmn2r125
|
UTSW |
4 |
156,702,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5229:Vmn2r125
|
UTSW |
4 |
156,703,333 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5504:Vmn2r125
|
UTSW |
4 |
156,703,456 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R5587:Vmn2r125
|
UTSW |
4 |
156,702,433 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5987:Vmn2r125
|
UTSW |
4 |
156,702,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6037:Vmn2r125
|
UTSW |
4 |
156,703,396 (GRCm39) |
missense |
probably benign |
|
|
R6183:Vmn2r125
|
UTSW |
4 |
156,702,364 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6456:Vmn2r125
|
UTSW |
4 |
156,703,357 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7342:Vmn2r125
|
UTSW |
4 |
156,703,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7926:Vmn2r125
|
UTSW |
4 |
156,702,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8113:Vmn2r125
|
UTSW |
4 |
156,703,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8191:Vmn2r125
|
UTSW |
4 |
156,703,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8272:Vmn2r125
|
UTSW |
4 |
156,702,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8962:Vmn2r125
|
UTSW |
4 |
156,703,186 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R9187:Vmn2r125
|
UTSW |
4 |
156,703,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTTCTGATGAGATCAACAAGAATCC -3'
(R):5'- CTGTATGTACCGTACATCTATGAACTG -3'
Sequencing Primer
(F):5'- ACAAGAATCCTTATCTTTTACCCAAC -3'
(R):5'- GTGTGTGTGTGTGTGTAGCAGC -3'
|
| Posted On |
2015-02-18 |
Incidental Mutation