Incidental Mutation 'R3428:Lyzl4'
ID 267963
Institutional Source Beutler Lab
Gene Symbol Lyzl4
Ensembl Gene ENSMUSG00000032530
Gene Name lysozyme-like 4
Synonyms 1810009N24Rik, LYC4
MMRRC Submission 040646-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # R3428 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 121406909-121471162 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 121413195 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 78 (I78V)
Ref Sequence ENSEMBL: ENSMUSP00000151031 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077706] [ENSMUST00000120918] [ENSMUST00000125075] [ENSMUST00000213757] [ENSMUST00000214592]
AlphaFold Q9D925
Predicted Effect probably null
Transcript: ENSMUST00000077706
AA Change: I78V

PolyPhen 2 Score 0.358 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000076887
Gene: ENSMUSG00000032530
AA Change: I78V

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
LYZ1 20 144 1.29e-36 SMART
Predicted Effect probably null
Transcript: ENSMUST00000120918
AA Change: I78V

PolyPhen 2 Score 0.358 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000113034
Gene: ENSMUSG00000032530
AA Change: I78V

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
LYZ1 20 144 1.29e-36 SMART
Predicted Effect probably null
Transcript: ENSMUST00000125075
AA Change: I78V

PolyPhen 2 Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000115284
Gene: ENSMUSG00000032530
AA Change: I78V

DomainStartEndE-ValueType
low complexity region 3 14 N/A INTRINSIC
LYZ1 20 91 6.48e-5 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000128080
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156364
Predicted Effect probably null
Transcript: ENSMUST00000213757
AA Change: I78V

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
Predicted Effect probably null
Transcript: ENSMUST00000214592
AA Change: I78V

PolyPhen 2 Score 0.964 (Sensitivity: 0.78; Specificity: 0.95)
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 94.9%
Validation Efficiency 100% (34/34)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL4 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam18 C A 8: 25,157,620 (GRCm39) C110F probably damaging Het
Adamts14 C T 10: 61,060,153 (GRCm39) E452K probably benign Het
Adrb3 T C 8: 27,718,209 (GRCm39) D80G probably damaging Het
Alg5 T A 3: 54,643,006 (GRCm39) M1K probably null Het
Ap1g1 A G 8: 110,570,080 (GRCm39) E398G probably damaging Het
Arhgap17 A T 7: 122,922,854 (GRCm39) L85Q probably damaging Het
Bbs9 T A 9: 22,479,183 (GRCm39) probably benign Het
BC034090 T C 1: 155,117,244 (GRCm39) I291M probably benign Het
Bicd1 T C 6: 149,414,400 (GRCm39) L371P probably damaging Het
Cand2 A C 6: 115,766,668 (GRCm39) R424S probably benign Het
Eng G T 2: 32,547,545 (GRCm39) V29F probably damaging Het
Gm5828 T A 1: 16,838,838 (GRCm39) noncoding transcript Het
Hspg2 T C 4: 137,282,601 (GRCm39) L3447P probably damaging Het
Igtp G A 11: 58,097,419 (GRCm39) V197I probably damaging Het
Kmt2a T A 9: 44,759,416 (GRCm39) N844I probably benign Het
Mtg2 A G 2: 179,726,065 (GRCm39) H225R possibly damaging Het
Or10a5 G A 7: 106,635,923 (GRCm39) R187K probably benign Het
Pfpl T A 19: 12,407,677 (GRCm39) S643T probably benign Het
Prelid1 T G 13: 55,470,007 (GRCm39) V2G probably benign Het
Psma2 A T 13: 14,791,362 (GRCm39) K2N probably benign Het
Sec24d C T 3: 123,137,572 (GRCm39) probably benign Het
Setd1a G T 7: 127,384,493 (GRCm39) probably benign Het
Slc20a1 A T 2: 129,042,202 (GRCm39) N149I probably benign Het
Slc22a5 A G 11: 53,760,152 (GRCm39) V388A probably benign Het
Tmem181a T A 17: 6,346,061 (GRCm39) L185H probably damaging Het
Tns2 C T 15: 102,017,369 (GRCm39) R281C probably damaging Het
Trav6-7-dv9 A G 14: 53,947,788 (GRCm39) T97A probably benign Het
Trpv3 A T 11: 73,176,767 (GRCm39) Y382F probably damaging Het
Ubr2 T C 17: 47,279,365 (GRCm39) Y681C probably damaging Het
Unc80 G A 1: 66,678,464 (GRCm39) V2082I probably benign Het
Vmn2r125 A G 4: 156,702,436 (GRCm39) D74G probably benign Het
Yipf2 T C 9: 21,500,941 (GRCm39) probably benign Het
Other mutations in Lyzl4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3237:Lyzl4 UTSW 9 121,413,233 (GRCm39) missense probably benign 0.18
R3916:Lyzl4 UTSW 9 121,412,101 (GRCm39) missense probably damaging 1.00
R3917:Lyzl4 UTSW 9 121,412,101 (GRCm39) missense probably damaging 1.00
R4868:Lyzl4 UTSW 9 121,412,075 (GRCm39) missense probably damaging 0.99
R5589:Lyzl4 UTSW 9 121,413,469 (GRCm39) missense probably damaging 1.00
R5945:Lyzl4 UTSW 9 121,413,529 (GRCm39) missense unknown
R6343:Lyzl4 UTSW 9 121,407,150 (GRCm39) missense possibly damaging 0.71
R6943:Lyzl4 UTSW 9 121,412,047 (GRCm39) nonsense probably null
R8071:Lyzl4 UTSW 9 121,407,160 (GRCm39) nonsense probably null
R9631:Lyzl4 UTSW 9 121,413,055 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- TGAAGGTCTGTAGGCTCCTG -3'
(R):5'- CTGTGAGTAGGACCCTTTCG -3'

Sequencing Primer
(F):5'- TCCTGTGCCCTGAAGGACTG -3'
(R):5'- CGGGCCATCTCTCTCTCAC -3'
Posted On 2015-02-18