Incidental Mutation 'R3429:Or4c29'
ID 267982
Institutional Source Beutler Lab
Gene Symbol Or4c29
Ensembl Gene ENSMUSG00000075113
Gene Name olfactory receptor family 4 subfamily C member 29
Synonyms Olfr1209, MOR230-7, GA_x6K02T2Q125-50386882-50385950
MMRRC Submission 040647-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R3429 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 88739803-88740735 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 88739810 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Glutamine at position 309 (R309Q)
Ref Sequence ENSEMBL: ENSMUSP00000150607 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099809] [ENSMUST00000213136]
AlphaFold Q3SXJ3
Predicted Effect probably benign
Transcript: ENSMUST00000099809
AA Change: R309Q

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000097397
Gene: ENSMUSG00000075113
AA Change: R309Q

DomainStartEndE-ValueType
Pfam:7tm_4 29 303 2.2e-48 PFAM
Pfam:7TM_GPCR_Srsx 32 300 1.3e-5 PFAM
Pfam:7tm_1 39 285 7.6e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213136
AA Change: R309Q

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213240
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.7%
Validation Efficiency 98% (65/66)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T A 6: 121,613,249 (GRCm39) M1K probably null Het
Afap1l2 C A 19: 56,904,238 (GRCm39) R683L probably damaging Het
Ankfy1 C T 11: 72,602,980 (GRCm39) probably benign Het
Aoc1 A T 6: 48,883,010 (GRCm39) E295D probably benign Het
Asah1 C T 8: 41,804,925 (GRCm39) probably benign Het
B4galnt4 T C 7: 140,650,752 (GRCm39) L842P probably damaging Het
Bhmt T C 13: 93,763,855 (GRCm39) E62G probably damaging Het
Btbd10 T A 7: 112,951,016 (GRCm39) R25* probably null Het
Cdh5 T A 8: 104,857,600 (GRCm39) I342N possibly damaging Het
Clca3a2 T A 3: 144,512,088 (GRCm39) E109D probably benign Het
Cntrl T C 2: 35,035,112 (GRCm39) L913S probably damaging Het
Col12a1 T A 9: 79,587,593 (GRCm39) T1183S probably benign Het
Col6a6 A T 9: 105,655,166 (GRCm39) Y852N probably damaging Het
Cpeb2 T C 5: 43,438,573 (GRCm39) probably null Het
Cyp2c66 T A 19: 39,151,892 (GRCm39) N202K probably damaging Het
Dchs1 A G 7: 105,405,711 (GRCm39) V2391A possibly damaging Het
Dgat2 A G 7: 98,806,300 (GRCm39) V299A probably benign Het
Dnah6 G A 6: 73,098,797 (GRCm39) S2034L possibly damaging Het
Eps8l2 G A 7: 140,937,832 (GRCm39) probably null Het
Fgg T A 3: 82,920,090 (GRCm39) F290I probably damaging Het
Filip1 A T 9: 79,760,952 (GRCm39) M194K probably damaging Het
Foxl2 T C 9: 98,838,035 (GRCm39) F108L probably damaging Het
Fut1 T C 7: 45,268,798 (GRCm39) F196L probably damaging Het
Gm10323 A C 13: 67,002,888 (GRCm39) W17G probably damaging Het
Gstz1 T A 12: 87,210,470 (GRCm39) probably null Het
Hacd1 T C 2: 14,049,586 (GRCm39) probably benign Het
Hmcn2 T A 2: 31,299,156 (GRCm39) L2834Q possibly damaging Het
Hs3st3a1 C T 11: 64,327,148 (GRCm39) R86W probably benign Het
Krtap1-4 G C 11: 99,474,020 (GRCm39) probably benign Het
Lmntd2 A G 7: 140,793,910 (GRCm39) V21A probably benign Het
Lonp1 T A 17: 56,925,337 (GRCm39) D485V probably damaging Het
Mia2 A G 12: 59,236,427 (GRCm39) T1346A possibly damaging Het
Mpp2 T C 11: 101,976,141 (GRCm39) T6A probably benign Het
Mycbp2 A T 14: 103,466,866 (GRCm39) V1299E probably damaging Het
Myo1d C T 11: 80,573,236 (GRCm39) G197E probably damaging Het
Nfib T C 4: 82,416,532 (GRCm39) I168V possibly damaging Het
Or2ak5 T A 11: 58,611,097 (GRCm39) Y259F probably damaging Het
Or2b7 A T 13: 21,739,975 (GRCm39) C72* probably null Het
Or2y1e C T 11: 49,218,868 (GRCm39) A210V probably benign Het
Or4c121 T A 2: 89,023,617 (GRCm39) I254L probably benign Het
Parp3 A T 9: 106,351,922 (GRCm39) I150K probably damaging Het
Pnp A G 14: 51,185,443 (GRCm39) D49G probably benign Het
Prkcq T C 2: 11,251,781 (GRCm39) I206T probably damaging Het
Rif1 GCCACCA GCCA 2: 52,000,336 (GRCm39) probably benign Het
Rlf A G 4: 121,007,729 (GRCm39) L417P probably benign Het
Scn7a AT ATT 2: 66,531,239 (GRCm39) probably null Het
Sgce T A 6: 4,730,008 (GRCm39) D72V probably benign Het
Sh3d21 A G 4: 126,056,625 (GRCm39) S66P probably benign Het
Sost C G 11: 101,854,865 (GRCm39) G148A probably damaging Het
Sybu T C 15: 44,609,854 (GRCm39) E138G probably damaging Het
Tas1r2 A G 4: 139,396,886 (GRCm39) T742A probably damaging Het
Tet3 A G 6: 83,380,401 (GRCm39) V589A probably damaging Het
Tnxb C A 17: 34,891,605 (GRCm39) C649* probably null Het
Tnxb A G 17: 34,922,561 (GRCm39) Y2458C probably damaging Het
Tsku T C 7: 98,001,746 (GRCm39) N195S probably damaging Het
Vmn1r215 T A 13: 23,260,378 (GRCm39) N139K probably damaging Het
Zfp106 T C 2: 120,357,544 (GRCm39) H1117R probably benign Het
Zfp26 A G 9: 20,352,756 (GRCm39) probably benign Het
Zfp764l1 T C 7: 126,990,914 (GRCm39) T358A possibly damaging Het
Zfp804b T A 5: 7,230,625 (GRCm39) probably benign Het
Zfr T C 15: 12,153,006 (GRCm39) S546P probably benign Het
Other mutations in Or4c29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03103:Or4c29 APN 2 88,740,522 (GRCm39) missense probably benign 0.18
R0179:Or4c29 UTSW 2 88,740,237 (GRCm39) missense possibly damaging 0.62
R0245:Or4c29 UTSW 2 88,740,219 (GRCm39) missense possibly damaging 0.72
R0737:Or4c29 UTSW 2 88,740,617 (GRCm39) missense probably damaging 1.00
R2168:Or4c29 UTSW 2 88,740,522 (GRCm39) missense probably damaging 0.99
R2311:Or4c29 UTSW 2 88,739,813 (GRCm39) missense probably benign 0.00
R3430:Or4c29 UTSW 2 88,739,810 (GRCm39) missense probably benign
R3876:Or4c29 UTSW 2 88,739,952 (GRCm39) missense possibly damaging 0.96
R5717:Or4c29 UTSW 2 88,740,366 (GRCm39) missense possibly damaging 0.57
R6029:Or4c29 UTSW 2 88,740,380 (GRCm39) missense probably damaging 1.00
R6154:Or4c29 UTSW 2 88,740,734 (GRCm39) start codon destroyed probably null 1.00
R7188:Or4c29 UTSW 2 88,740,203 (GRCm39) missense probably damaging 1.00
R7197:Or4c29 UTSW 2 88,740,708 (GRCm39) missense probably benign 0.01
R7744:Or4c29 UTSW 2 88,740,003 (GRCm39) missense possibly damaging 0.45
R8913:Or4c29 UTSW 2 88,739,991 (GRCm39) missense probably benign 0.24
R9017:Or4c29 UTSW 2 88,739,951 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- ACAATGACAGCCACAATTGGTG -3'
(R):5'- GCATCTTTATATACACACGCCCTG -3'

Sequencing Primer
(F):5'- GAAGGGTCTTTGTACCTAATTGTAC -3'
(R):5'- GCCCTGCAACAACATTTCCTATGG -3'
Posted On 2015-02-18