Mutagenetix > Incidental Mutation

Incidental Mutation 'R3429:Zfp26'

268009

Institutional Source

Beutler Lab

Gene Symbol

Zfp26

Ensembl Gene

ENSMUSG00000063108

Gene Name

zinc finger protein 26

Synonyms

Zfp81-rs1, mkr-3, Zfp-26, KRAB15, 5033428C05Rik, Zfp70

MMRRC Submission

040647-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

R3429 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

20339745-20371458 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to G at 20352756 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000123960 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000159569] [ENSMUST00000162438]

AlphaFold

no structure available at present

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000075263

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000098970

Predicted Effect

probably benign
Transcript: ENSMUST00000159569

SMART Domains

Protein: ENSMUSP00000124075
Gene: ENSMUSG00000063108

Domain	Start	End	E-Value	Type
Blast:KRAB	40	93	3e-6	BLAST
KRAB	107	167	4.28e-32	SMART
ZnF_C2H2	289	311	3.34e-2	SMART
ZnF_C2H2	344	366	3.63e-3	SMART
ZnF_C2H2	372	394	4.54e-4	SMART
ZnF_C2H2	400	422	2.65e-5	SMART
ZnF_C2H2	428	450	1.12e-3	SMART
ZnF_C2H2	456	478	9.08e-4	SMART
ZnF_C2H2	484	506	7.9e-4	SMART
ZnF_C2H2	512	534	2.43e-4	SMART
ZnF_C2H2	540	562	1.36e-2	SMART
ZnF_C2H2	568	590	3.44e-4	SMART
ZnF_C2H2	596	618	6.52e-5	SMART
ZnF_C2H2	624	646	2.32e-1	SMART
ZnF_C2H2	652	674	9.22e-5	SMART
ZnF_C2H2	680	702	1.22e-4	SMART
ZnF_C2H2	708	730	4.87e-4	SMART
ZnF_C2H2	736	758	4.54e-4	SMART
ZnF_C2H2	764	786	3.44e-4	SMART
ZnF_C2H2	792	814	5.21e-4	SMART
ZnF_C2H2	820	842	3.44e-4	SMART
ZnF_C2H2	848	870	5.14e-3	SMART
ZnF_C2H2	876	898	2.79e-4	SMART
ZnF_C2H2	904	926	2.12e-4	SMART
ZnF_C2H2	932	954	9.56e1	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000160370

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000161248

Predicted Effect

probably benign
Transcript: ENSMUST00000162438

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000180846

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 96.9%
20x: 93.7%

Validation Efficiency

98% (65/66)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains one KRAB domain and eighteen C2H2-type zinc fingers. This gene is a candidate gene for autism and variable cognitive impairment in the 16q24.3 microdeletion syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2011]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	T	A	6: 121,613,249 (GRCm39)	M1K	probably null	Het
Afap1l2	C	A	19: 56,904,238 (GRCm39)	R683L	probably damaging	Het
Ankfy1	C	T	11: 72,602,980 (GRCm39)		probably benign	Het
Aoc1	A	T	6: 48,883,010 (GRCm39)	E295D	probably benign	Het
Asah1	C	T	8: 41,804,925 (GRCm39)		probably benign	Het
B4galnt4	T	C	7: 140,650,752 (GRCm39)	L842P	probably damaging	Het
Bhmt	T	C	13: 93,763,855 (GRCm39)	E62G	probably damaging	Het
Btbd10	T	A	7: 112,951,016 (GRCm39)	R25*	probably null	Het
Cdh5	T	A	8: 104,857,600 (GRCm39)	I342N	possibly damaging	Het
Clca3a2	T	A	3: 144,512,088 (GRCm39)	E109D	probably benign	Het
Cntrl	T	C	2: 35,035,112 (GRCm39)	L913S	probably damaging	Het
Col12a1	T	A	9: 79,587,593 (GRCm39)	T1183S	probably benign	Het
Col6a6	A	T	9: 105,655,166 (GRCm39)	Y852N	probably damaging	Het
Cpeb2	T	C	5: 43,438,573 (GRCm39)		probably null	Het
Cyp2c66	T	A	19: 39,151,892 (GRCm39)	N202K	probably damaging	Het
Dchs1	A	G	7: 105,405,711 (GRCm39)	V2391A	possibly damaging	Het
Dgat2	A	G	7: 98,806,300 (GRCm39)	V299A	probably benign	Het
Dnah6	G	A	6: 73,098,797 (GRCm39)	S2034L	possibly damaging	Het
Eps8l2	G	A	7: 140,937,832 (GRCm39)		probably null	Het
Fgg	T	A	3: 82,920,090 (GRCm39)	F290I	probably damaging	Het
Filip1	A	T	9: 79,760,952 (GRCm39)	M194K	probably damaging	Het
Foxl2	T	C	9: 98,838,035 (GRCm39)	F108L	probably damaging	Het
Fut1	T	C	7: 45,268,798 (GRCm39)	F196L	probably damaging	Het
Gm10323	A	C	13: 67,002,888 (GRCm39)	W17G	probably damaging	Het
Gstz1	T	A	12: 87,210,470 (GRCm39)		probably null	Het
Hacd1	T	C	2: 14,049,586 (GRCm39)		probably benign	Het
Hmcn2	T	A	2: 31,299,156 (GRCm39)	L2834Q	possibly damaging	Het
Hs3st3a1	C	T	11: 64,327,148 (GRCm39)	R86W	probably benign	Het
Krtap1-4	G	C	11: 99,474,020 (GRCm39)		probably benign	Het
Lmntd2	A	G	7: 140,793,910 (GRCm39)	V21A	probably benign	Het
Lonp1	T	A	17: 56,925,337 (GRCm39)	D485V	probably damaging	Het
Mia2	A	G	12: 59,236,427 (GRCm39)	T1346A	possibly damaging	Het
Mpp2	T	C	11: 101,976,141 (GRCm39)	T6A	probably benign	Het
Mycbp2	A	T	14: 103,466,866 (GRCm39)	V1299E	probably damaging	Het
Myo1d	C	T	11: 80,573,236 (GRCm39)	G197E	probably damaging	Het
Nfib	T	C	4: 82,416,532 (GRCm39)	I168V	possibly damaging	Het
Or2ak5	T	A	11: 58,611,097 (GRCm39)	Y259F	probably damaging	Het
Or2b7	A	T	13: 21,739,975 (GRCm39)	C72*	probably null	Het
Or2y1e	C	T	11: 49,218,868 (GRCm39)	A210V	probably benign	Het
Or4c121	T	A	2: 89,023,617 (GRCm39)	I254L	probably benign	Het
Or4c29	C	T	2: 88,739,810 (GRCm39)	R309Q	probably benign	Het
Parp3	A	T	9: 106,351,922 (GRCm39)	I150K	probably damaging	Het
Pnp	A	G	14: 51,185,443 (GRCm39)	D49G	probably benign	Het
Prkcq	T	C	2: 11,251,781 (GRCm39)	I206T	probably damaging	Het
Rif1	GCCACCA	GCCA	2: 52,000,336 (GRCm39)		probably benign	Het
Rlf	A	G	4: 121,007,729 (GRCm39)	L417P	probably benign	Het
Scn7a	AT	ATT	2: 66,531,239 (GRCm39)		probably null	Het
Sgce	T	A	6: 4,730,008 (GRCm39)	D72V	probably benign	Het
Sh3d21	A	G	4: 126,056,625 (GRCm39)	S66P	probably benign	Het
Sost	C	G	11: 101,854,865 (GRCm39)	G148A	probably damaging	Het
Sybu	T	C	15: 44,609,854 (GRCm39)	E138G	probably damaging	Het
Tas1r2	A	G	4: 139,396,886 (GRCm39)	T742A	probably damaging	Het
Tet3	A	G	6: 83,380,401 (GRCm39)	V589A	probably damaging	Het
Tnxb	C	A	17: 34,891,605 (GRCm39)	C649*	probably null	Het
Tnxb	A	G	17: 34,922,561 (GRCm39)	Y2458C	probably damaging	Het
Tsku	T	C	7: 98,001,746 (GRCm39)	N195S	probably damaging	Het
Vmn1r215	T	A	13: 23,260,378 (GRCm39)	N139K	probably damaging	Het
Zfp106	T	C	2: 120,357,544 (GRCm39)	H1117R	probably benign	Het
Zfp764l1	T	C	7: 126,990,914 (GRCm39)	T358A	possibly damaging	Het
Zfp804b	T	A	5: 7,230,625 (GRCm39)		probably benign	Het
Zfr	T	C	15: 12,153,006 (GRCm39)	S546P	probably benign	Het

Other mutations in Zfp26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00902:Zfp26	APN	9	20,350,844 (GRCm39)	missense	possibly damaging	0.68
IGL02273:Zfp26	APN	9	20,352,744 (GRCm39)	missense	probably damaging	0.96
FR4449:Zfp26	UTSW	9	20,349,842 (GRCm39)	missense	probably benign	0.01
FR4548:Zfp26	UTSW	9	20,349,842 (GRCm39)	missense	probably benign	0.01
FR4737:Zfp26	UTSW	9	20,349,842 (GRCm39)	missense	probably benign	0.01
FR4976:Zfp26	UTSW	9	20,349,842 (GRCm39)	missense	probably benign	0.01
LCD18:Zfp26	UTSW	9	20,349,842 (GRCm39)	missense	probably benign	0.01
R0157:Zfp26	UTSW	9	20,349,166 (GRCm39)	missense	probably benign	0.37
R1591:Zfp26	UTSW	9	20,348,921 (GRCm39)	missense	probably benign	0.01
R1818:Zfp26	UTSW	9	20,353,487 (GRCm39)	missense	probably benign	0.00
R1936:Zfp26	UTSW	9	20,348,849 (GRCm39)	missense	probably benign	0.04
R2081:Zfp26	UTSW	9	20,347,913 (GRCm39)	missense	probably benign	0.17
R2107:Zfp26	UTSW	9	20,353,533 (GRCm39)	missense	probably benign
R2240:Zfp26	UTSW	9	20,348,563 (GRCm39)	missense	probably damaging	1.00
R3785:Zfp26	UTSW	9	20,349,098 (GRCm39)	missense	probably damaging	1.00
R4050:Zfp26	UTSW	9	20,353,525 (GRCm39)	missense	probably benign
R4198:Zfp26	UTSW	9	20,348,012 (GRCm39)	missense	probably benign	0.17
R4200:Zfp26	UTSW	9	20,348,012 (GRCm39)	missense	probably benign	0.17
R4360:Zfp26	UTSW	9	20,349,869 (GRCm39)	missense	probably benign	0.35
R4505:Zfp26	UTSW	9	20,353,561 (GRCm39)	missense	probably benign	0.29
R5171:Zfp26	UTSW	9	20,356,203 (GRCm39)	missense	probably benign
R5412:Zfp26	UTSW	9	20,349,535 (GRCm39)	missense	possibly damaging	0.75
R5493:Zfp26	UTSW	9	20,355,615 (GRCm39)	missense	possibly damaging	0.66
R5576:Zfp26	UTSW	9	20,348,803 (GRCm39)	missense	possibly damaging	0.86
R5652:Zfp26	UTSW	9	20,349,137 (GRCm39)	nonsense	probably null
R6089:Zfp26	UTSW	9	20,348,989 (GRCm39)	missense	probably damaging	0.99
R6332:Zfp26	UTSW	9	20,348,582 (GRCm39)	missense	probably damaging	1.00
R7599:Zfp26	UTSW	9	20,349,129 (GRCm39)	missense	probably damaging	1.00
R7713:Zfp26	UTSW	9	20,352,630 (GRCm39)	missense	probably benign	0.08
R8460:Zfp26	UTSW	9	20,348,373 (GRCm39)	missense	probably damaging	1.00
R8679:Zfp26	UTSW	9	20,356,201 (GRCm39)	missense	possibly damaging	0.46
R8814:Zfp26	UTSW	9	20,349,730 (GRCm39)	missense	probably benign	0.01
R9130:Zfp26	UTSW	9	20,348,723 (GRCm39)	missense	probably damaging	1.00
R9351:Zfp26	UTSW	9	20,349,447 (GRCm39)	nonsense	probably null
R9432:Zfp26	UTSW	9	20,347,830 (GRCm39)	missense	probably damaging	1.00
R9587:Zfp26	UTSW	9	20,348,213 (GRCm39)	missense	probably damaging	1.00
R9719:Zfp26	UTSW	9	20,347,861 (GRCm39)	missense	possibly damaging	0.95
X0065:Zfp26	UTSW	9	20,348,187 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- TGAGCTGACACCATATTGTAGAAC -3'
(R):5'- GCTTGGGAATGTGCCACAAC -3'

Sequencing Primer
(F):5'- ggtagttctccagcatca -3'
(R):5'- CTTGGGAATGTGCCACAACATAGG -3'

Posted On

2015-02-18