Incidental Mutation 'R3430:Or1e29'
ID 268082
Institutional Source Beutler Lab
Gene Symbol Or1e29
Ensembl Gene ENSMUSG00000070383
Gene Name olfactory receptor family 1 subfamily E member 29
Synonyms MOR135-6, GA_x6K02T2P1NL-3932085-3931147, Olfr389
MMRRC Submission 040648-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R3430 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 73667213-73671415 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 73667365 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 263 (S263T)
Ref Sequence ENSEMBL: ENSMUSP00000149734 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000122224] [ENSMUST00000124927] [ENSMUST00000215418]
AlphaFold Q7TRX7
Predicted Effect noncoding transcript
Transcript: ENSMUST00000118611
Predicted Effect probably damaging
Transcript: ENSMUST00000122224
AA Change: S263T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000113364
Gene: ENSMUSG00000070383
AA Change: S263T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.8e-56 PFAM
Pfam:7TM_GPCR_Srsx 35 305 4.2e-6 PFAM
Pfam:7tm_1 41 290 2e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000124927
AA Change: S263T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000115639
Gene: ENSMUSG00000070383
AA Change: S263T

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srsx 35 221 6.6e-7 PFAM
Pfam:7tm_1 41 224 3.5e-29 PFAM
Pfam:7tm_4 139 224 1.4e-20 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215418
AA Change: S263T

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Meta Mutation Damage Score 0.3146 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.5%
Validation Efficiency 100% (67/67)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afap1l2 C A 19: 56,904,238 (GRCm39) R683L probably damaging Het
Ahnak A G 19: 8,984,322 (GRCm39) I1869V probably benign Het
Aoc1 A T 6: 48,883,010 (GRCm39) E295D probably benign Het
Arhgef19 T C 4: 140,984,111 (GRCm39) L777P probably benign Het
Atf7ip A G 6: 136,552,322 (GRCm39) probably benign Het
Bhmt T C 13: 93,763,855 (GRCm39) E62G probably damaging Het
Bpifa6 A G 2: 153,831,171 (GRCm39) I246V probably benign Het
Btbd10 T A 7: 112,951,016 (GRCm39) R25* probably null Het
Ccdc88a T A 11: 29,398,033 (GRCm39) D255E probably damaging Het
Chd7 T C 4: 8,844,517 (GRCm39) V1542A probably damaging Het
Cimip1 T C 2: 173,370,066 (GRCm39) Y114H possibly damaging Het
Col12a1 T A 9: 79,587,593 (GRCm39) T1183S probably benign Het
Col20a1 T A 2: 180,655,078 (GRCm39) L1145* probably null Het
Dchs1 A G 7: 105,405,711 (GRCm39) V2391A possibly damaging Het
Dgat2 A G 7: 98,806,300 (GRCm39) V299A probably benign Het
Dmxl2 T A 9: 54,384,745 (GRCm39) N94I possibly damaging Het
Dnah6 G A 6: 73,098,797 (GRCm39) S2034L possibly damaging Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Filip1 A T 9: 79,760,952 (GRCm39) M194K probably damaging Het
Fut1 T C 7: 45,268,798 (GRCm39) F196L probably damaging Het
Gm10323 A C 13: 67,002,888 (GRCm39) W17G probably damaging Het
Grin3a C A 4: 49,792,534 (GRCm39) V400L probably benign Het
Htr3a T C 9: 48,818,688 (GRCm39) N82S probably benign Het
Il23r A C 6: 67,429,458 (GRCm39) S295A probably benign Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Lama5 T C 2: 179,838,110 (GRCm39) K869E probably benign Het
Lce1d A T 3: 92,593,037 (GRCm39) probably benign Het
Lkaaear1 T C 2: 181,339,324 (GRCm39) D42G probably benign Het
Mapk8ip2 A G 15: 89,341,485 (GRCm39) E232G possibly damaging Het
Marf1 A G 16: 13,958,041 (GRCm39) probably benign Het
Mpeg1 A T 19: 12,440,492 (GRCm39) H650L probably benign Het
Nfib T C 4: 82,416,532 (GRCm39) I168V possibly damaging Het
Or2b7 A T 13: 21,739,975 (GRCm39) C72* probably null Het
Or4c29 C T 2: 88,739,810 (GRCm39) R309Q probably benign Het
Or4e5 A G 14: 52,727,882 (GRCm39) F180L possibly damaging Het
Or8b3b A T 9: 38,584,435 (GRCm39) F102I probably damaging Het
Otx2 T A 14: 48,896,254 (GRCm39) K260M probably damaging Het
P2ry12 C T 3: 59,125,448 (GRCm39) D76N probably damaging Het
Parp3 A T 9: 106,351,922 (GRCm39) I150K probably damaging Het
Prex2 T G 1: 11,220,078 (GRCm39) I683S possibly damaging Het
Prss34 A T 17: 25,518,078 (GRCm39) K86I probably benign Het
Ptpn20 T A 14: 33,336,485 (GRCm39) V108D possibly damaging Het
Rlf A G 4: 121,007,729 (GRCm39) L417P probably benign Het
Rsad2 T C 12: 26,506,418 (GRCm39) M1V probably null Het
S1pr5 A G 9: 21,156,378 (GRCm39) V16A probably benign Het
Scn7a AT ATT 2: 66,531,239 (GRCm39) probably null Het
Serpinb3b A T 1: 107,082,425 (GRCm39) S280T probably benign Het
Sh3d21 A G 4: 126,056,625 (GRCm39) S66P probably benign Het
Sh3yl1 T C 12: 31,009,841 (GRCm39) S253P probably benign Het
Smarca2 A G 19: 26,668,749 (GRCm39) E916G probably damaging Het
Sptbn1 A G 11: 30,169,686 (GRCm39) I14T possibly damaging Het
Supt16 A T 14: 52,412,816 (GRCm39) M559K probably benign Het
Tas1r2 A G 4: 139,396,886 (GRCm39) T742A probably damaging Het
Tbc1d5 T C 17: 51,107,156 (GRCm39) K467E probably damaging Het
Tet3 A G 6: 83,380,401 (GRCm39) V589A probably damaging Het
Tmem131 A G 1: 36,847,902 (GRCm39) probably benign Het
Tmtc3 A G 10: 100,283,437 (GRCm39) F706S probably benign Het
Tsku T C 7: 98,001,746 (GRCm39) N195S probably damaging Het
Vmn2r129 G T 4: 156,686,692 (GRCm39) noncoding transcript Het
Vmn2r85 T A 10: 130,254,758 (GRCm39) H642L probably damaging Het
Zfc3h1 A G 10: 115,246,428 (GRCm39) probably benign Het
Other mutations in Or1e29
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01458:Or1e29 APN 11 73,667,532 (GRCm39) missense probably benign 0.44
IGL01766:Or1e29 APN 11 73,667,901 (GRCm39) missense probably benign 0.41
IGL01771:Or1e29 APN 11 73,667,490 (GRCm39) missense probably damaging 1.00
IGL02535:Or1e29 APN 11 73,667,442 (GRCm39) missense probably benign 0.00
IGL02639:Or1e29 APN 11 73,667,371 (GRCm39) missense probably benign 0.21
IGL03060:Or1e29 APN 11 73,667,289 (GRCm39) missense probably damaging 1.00
IGL03075:Or1e29 APN 11 73,667,298 (GRCm39) missense probably damaging 1.00
R0081:Or1e29 UTSW 11 73,667,935 (GRCm39) missense possibly damaging 0.59
R0426:Or1e29 UTSW 11 73,667,263 (GRCm39) missense probably benign 0.13
R1140:Or1e29 UTSW 11 73,667,680 (GRCm39) missense probably benign
R1638:Or1e29 UTSW 11 73,667,974 (GRCm39) missense possibly damaging 0.95
R2001:Or1e29 UTSW 11 73,667,539 (GRCm39) missense probably benign
R2214:Or1e29 UTSW 11 73,667,655 (GRCm39) nonsense probably null
R3076:Or1e29 UTSW 11 73,667,466 (GRCm39) missense possibly damaging 0.93
R3077:Or1e29 UTSW 11 73,667,466 (GRCm39) missense possibly damaging 0.93
R3078:Or1e29 UTSW 11 73,667,466 (GRCm39) missense possibly damaging 0.93
R3081:Or1e29 UTSW 11 73,668,051 (GRCm39) missense probably damaging 1.00
R3731:Or1e29 UTSW 11 73,667,565 (GRCm39) missense probably benign 0.08
R4090:Or1e29 UTSW 11 73,667,667 (GRCm39) missense probably damaging 1.00
R4303:Or1e29 UTSW 11 73,667,664 (GRCm39) missense possibly damaging 0.78
R4516:Or1e29 UTSW 11 73,667,866 (GRCm39) missense probably benign 0.06
R4556:Or1e29 UTSW 11 73,667,307 (GRCm39) missense possibly damaging 0.65
R4557:Or1e29 UTSW 11 73,667,307 (GRCm39) missense possibly damaging 0.65
R4775:Or1e29 UTSW 11 73,667,377 (GRCm39) missense probably damaging 1.00
R4858:Or1e29 UTSW 11 73,667,372 (GRCm39) missense probably benign 0.44
R5015:Or1e29 UTSW 11 73,668,007 (GRCm39) missense probably benign 0.07
R5087:Or1e29 UTSW 11 73,668,084 (GRCm39) missense possibly damaging 0.75
R6599:Or1e29 UTSW 11 73,667,506 (GRCm39) missense probably benign
R6701:Or1e29 UTSW 11 73,667,296 (GRCm39) missense probably damaging 1.00
R6784:Or1e29 UTSW 11 73,667,676 (GRCm39) missense probably damaging 1.00
R6916:Or1e29 UTSW 11 73,667,895 (GRCm39) missense probably benign 0.00
R7066:Or1e29 UTSW 11 73,668,018 (GRCm39) missense probably damaging 0.99
R7226:Or1e29 UTSW 11 73,667,503 (GRCm39) missense possibly damaging 0.95
R7457:Or1e29 UTSW 11 73,667,652 (GRCm39) missense probably benign 0.06
R7486:Or1e29 UTSW 11 73,667,847 (GRCm39) missense probably damaging 1.00
R7990:Or1e29 UTSW 11 73,667,497 (GRCm39) missense probably benign 0.00
R8289:Or1e29 UTSW 11 73,667,839 (GRCm39) missense probably benign
R9131:Or1e29 UTSW 11 73,668,150 (GRCm39) start codon destroyed probably null 1.00
R9160:Or1e29 UTSW 11 73,667,881 (GRCm39) missense probably benign 0.01
R9239:Or1e29 UTSW 11 73,667,346 (GRCm39) missense probably benign 0.00
R9666:Or1e29 UTSW 11 73,667,976 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCTTGTAGGTCCTATGATGAGAG -3'
(R):5'- CTTCTGAAGTTGTCTTGCTCAG -3'

Sequencing Primer
(F):5'- GGTCCTATGATGAGAGACAATATCTG -3'
(R):5'- GCTCAGACACTTTTGTTAATGAGTTG -3'
Posted On 2015-02-18