Incidental Mutation 'R3431:Gm4924'
ID 268120
Institutional Source Beutler Lab
Gene Symbol Gm4924
Ensembl Gene ENSMUSG00000073427
Gene Name predicted gene 4924
Synonyms mIF1
MMRRC Submission 040649-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.174) question?
Stock # R3431 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 82190087-82215477 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 82214864 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 887 (Y887*)
Ref Sequence ENSEMBL: ENSMUSP00000147402 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165906] [ENSMUST00000210025] [ENSMUST00000210381] [ENSMUST00000211099]
AlphaFold A0A1B0GR71
Predicted Effect probably null
Transcript: ENSMUST00000165906
AA Change: Y146*
SMART Domains Protein: ENSMUSP00000131819
Gene: ENSMUSG00000073427
AA Change: Y146*

DomainStartEndE-ValueType
ZnF_C2H2 34 56 2.4e-3 SMART
ZnF_C2H2 62 84 8.94e-3 SMART
ZnF_C2H2 90 112 9.58e-3 SMART
ZnF_C2H2 146 168 9.08e-4 SMART
ZnF_C2H2 174 196 6.78e-3 SMART
ZnF_C2H2 202 224 8.81e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000210025
Predicted Effect probably null
Transcript: ENSMUST00000210381
AA Change: Y887*
Predicted Effect probably benign
Transcript: ENSMUST00000211078
Predicted Effect probably benign
Transcript: ENSMUST00000211099
Meta Mutation Damage Score 0.9716 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.4%
  • 20x: 95.6%
Validation Efficiency 100% (41/41)
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acox3 A G 5: 35,746,560 (GRCm39) H140R possibly damaging Het
Adamts3 A G 5: 89,855,312 (GRCm39) probably benign Het
Apob T G 12: 8,060,778 (GRCm39) F3054V probably damaging Het
Bahd1 G A 2: 118,753,004 (GRCm39) R757H probably damaging Het
Calcb A T 7: 114,319,064 (GRCm39) R30W probably damaging Het
Cbl T C 9: 44,062,743 (GRCm39) *914W probably null Het
Chd4 A G 6: 125,097,523 (GRCm39) probably benign Het
Clec4a2 A T 6: 123,116,370 (GRCm39) probably null Het
Crb2 T A 2: 37,682,229 (GRCm39) V870E probably benign Het
Cyp2c39 A G 19: 39,525,306 (GRCm39) E203G probably damaging Het
Dhrs7 A T 12: 72,711,501 (GRCm39) L12Q probably damaging Het
Dnah5 A G 15: 28,295,413 (GRCm39) Y1382C probably benign Het
Efs C T 14: 55,157,681 (GRCm39) R117Q probably damaging Het
Evl T C 12: 108,614,567 (GRCm39) probably benign Het
Fbxo16 T C 14: 65,531,233 (GRCm39) F46L probably damaging Het
Fsip2 A G 2: 82,822,354 (GRCm39) E6029G possibly damaging Het
Gm20775 A T Y: 10,641,956 (GRCm39) noncoding transcript Het
H60c G T 10: 3,210,382 (GRCm39) R56S possibly damaging Het
Hbq1a T G 11: 32,250,715 (GRCm39) S133A probably benign Het
Hhipl1 A G 12: 108,277,948 (GRCm39) E92G probably damaging Het
Knl1 A T 2: 118,892,843 (GRCm39) E46D probably damaging Het
Mcm2 G A 6: 88,869,990 (GRCm39) R60C probably damaging Het
Mfsd13a C T 19: 46,360,431 (GRCm39) R328C probably damaging Het
Mmp21 T C 7: 133,280,479 (GRCm39) T164A probably benign Het
Mthfd2 T C 6: 83,288,330 (GRCm39) R142G probably benign Het
Mup4 T G 4: 59,959,192 (GRCm39) probably null Het
Npas3 A T 12: 54,115,832 (GRCm39) Q900L probably damaging Het
Nr1h3 T C 2: 91,022,205 (GRCm39) D141G probably damaging Het
Rap2a G T 14: 120,741,170 (GRCm39) A158S possibly damaging Het
Rttn A G 18: 89,113,695 (GRCm39) T1705A probably benign Het
Ryr3 A T 2: 112,486,876 (GRCm39) V3834E probably damaging Het
Taf5 A C 19: 47,064,272 (GRCm39) K405T probably damaging Het
Tbc1d19 T C 5: 54,005,548 (GRCm39) probably benign Het
Tmem232 A T 17: 65,572,297 (GRCm39) probably null Het
Tssk4 A G 14: 55,889,152 (GRCm39) N226S probably damaging Het
Tulp4 C A 17: 6,257,239 (GRCm39) S311R probably benign Het
Uggt1 C A 1: 36,249,140 (GRCm39) E267* probably null Het
Usp34 T C 11: 23,320,466 (GRCm39) I917T possibly damaging Het
Other mutations in Gm4924
AlleleSourceChrCoordTypePredicted EffectPPH Score
R5566:Gm4924 UTSW 10 82,214,475 (GRCm39) missense possibly damaging 0.46
R6170:Gm4924 UTSW 10 82,213,065 (GRCm39) nonsense probably null
R6258:Gm4924 UTSW 10 82,213,307 (GRCm39) intron probably benign
R6539:Gm4924 UTSW 10 82,214,358 (GRCm39) intron probably benign
R6861:Gm4924 UTSW 10 82,214,948 (GRCm39) nonsense probably null
R7077:Gm4924 UTSW 10 82,215,057 (GRCm39) missense unknown
R7128:Gm4924 UTSW 10 82,214,533 (GRCm39) missense unknown
R7166:Gm4924 UTSW 10 82,214,035 (GRCm39) missense unknown
R7186:Gm4924 UTSW 10 82,214,778 (GRCm39) missense unknown
R7731:Gm4924 UTSW 10 82,213,361 (GRCm39) missense unknown
R8525:Gm4924 UTSW 10 82,213,701 (GRCm39) intron probably benign
R8555:Gm4924 UTSW 10 82,213,224 (GRCm39) intron probably benign
R9084:Gm4924 UTSW 10 82,213,953 (GRCm39) missense unknown
R9113:Gm4924 UTSW 10 82,214,113 (GRCm39) missense unknown
R9124:Gm4924 UTSW 10 82,214,875 (GRCm39) missense unknown
R9428:Gm4924 UTSW 10 82,213,490 (GRCm39) missense unknown
R9708:Gm4924 UTSW 10 82,214,992 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TCATGAAAGAAGTCACACTGGAGA -3'
(R):5'- TGAATGCTGTCATGCTTCTGAA -3'

Sequencing Primer
(F):5'- TCACACTGGAGAGAAACCTTATG -3'
(R):5'- AGGTTACTTTTGCACGCAAAGGC -3'
Posted On 2015-02-18