Incidental Mutation 'IGL00902:Olfr1015'
ID26831
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1015
Ensembl Gene ENSMUSG00000033850
Gene Nameolfactory receptor 1015
SynonymsGA_x6K02T2Q125-47264151-47265089, MOR213-3
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.150) question?
Stock #IGL00902
Quality Score
Status
Chromosome2
Chromosomal Location85782017-85787812 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 85786117 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Threonine at position 202 (M202T)
Ref Sequence ENSEMBL: ENSMUSP00000148957 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047870] [ENSMUST00000215945]
Predicted Effect probably benign
Transcript: ENSMUST00000047870
AA Change: M202T

PolyPhen 2 Score 0.213 (Sensitivity: 0.92; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000046301
Gene: ENSMUSG00000033850
AA Change: M202T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.5e-49 PFAM
Pfam:7tm_1 41 290 4.2e-19 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214726
Predicted Effect probably benign
Transcript: ENSMUST00000215945
AA Change: M202T

PolyPhen 2 Score 0.213 (Sensitivity: 0.92; Specificity: 0.88)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932438A13Rik G A 3: 37,041,345 G1001D probably damaging Het
Adamts7 T G 9: 90,188,794 probably null Het
Akap11 A G 14: 78,495,838 S1876P probably benign Het
Capn10 A G 1: 92,942,559 I256V probably benign Het
Catsperg2 T A 7: 29,701,143 H262L possibly damaging Het
Col22a1 C A 15: 71,964,659 G509V probably damaging Het
Dab2ip T C 2: 35,717,112 F523S probably damaging Het
Dbnl G T 11: 5,798,105 A313S probably benign Het
Ddo T C 10: 40,647,554 V180A probably damaging Het
Enox1 A G 14: 77,582,404 M200V possibly damaging Het
Fabp6 G A 11: 43,598,716 R33C probably damaging Het
Gm9104 T C 17: 45,466,014 probably benign Het
Gspt1 C T 16: 11,232,579 V303I probably damaging Het
Igf2r C T 17: 12,700,358 C1469Y probably damaging Het
Igflr1 T C 7: 30,567,275 S183P possibly damaging Het
Itga6 T C 2: 71,849,394 V1001A probably benign Het
Itih1 G A 14: 30,932,482 probably benign Het
Krt86 C T 15: 101,473,860 H104Y probably benign Het
Lrp5 T C 19: 3,600,774 N1220S probably damaging Het
March6 A G 15: 31,484,978 Y434H probably damaging Het
Mbd1 A G 18: 74,275,239 Y211C possibly damaging Het
Mpeg1 C A 19: 12,461,769 A197D probably damaging Het
Mroh2b T A 15: 4,915,222 L435Q probably damaging Het
Mss51 A C 14: 20,486,167 M160R probably damaging Het
Ndufs7 T G 10: 80,256,005 Y190* probably null Het
Olfr768 T A 10: 129,093,396 I193L probably benign Het
Pcdh17 A G 14: 84,446,849 E252G probably damaging Het
Ric1 T C 19: 29,567,231 V151A probably benign Het
Sgo2a A G 1: 58,016,099 T481A probably benign Het
Slc5a8 A G 10: 88,919,461 T477A probably benign Het
Smg5 G A 3: 88,353,085 V661I probably benign Het
Snx19 A T 9: 30,428,732 I389F possibly damaging Het
Spem1 A T 11: 69,821,817 I64N probably damaging Het
Ssfa2 G A 2: 79,660,478 R980Q probably damaging Het
Thada A T 17: 84,447,976 M262K probably damaging Het
Uox A G 3: 146,610,406 D32G possibly damaging Het
Usp42 A T 5: 143,719,874 probably benign Het
Usp43 G A 11: 67,891,419 P391L probably benign Het
Vmn2r56 T C 7: 12,715,499 S271G probably benign Het
Wdr64 T A 1: 175,728,825 C213S probably damaging Het
Zfp26 A T 9: 20,439,548 S194T possibly damaging Het
Other mutations in Olfr1015
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01716:Olfr1015 APN 2 85786143 missense probably damaging 0.97
IGL03196:Olfr1015 APN 2 85786021 missense possibly damaging 0.63
IGL03374:Olfr1015 APN 2 85785709 missense probably damaging 1.00
R0329:Olfr1015 UTSW 2 85785803 nonsense probably null
R0330:Olfr1015 UTSW 2 85785803 nonsense probably null
R0714:Olfr1015 UTSW 2 85786399 missense probably damaging 1.00
R0965:Olfr1015 UTSW 2 85786299 missense probably damaging 1.00
R1078:Olfr1015 UTSW 2 85786093 missense possibly damaging 0.53
R3826:Olfr1015 UTSW 2 85786215 nonsense probably null
R5031:Olfr1015 UTSW 2 85785718 nonsense probably null
R5239:Olfr1015 UTSW 2 85785658 missense probably damaging 1.00
R6120:Olfr1015 UTSW 2 85786341 missense probably damaging 1.00
R6177:Olfr1015 UTSW 2 85785660 missense probably damaging 0.99
R6726:Olfr1015 UTSW 2 85785562 missense possibly damaging 0.51
R6954:Olfr1015 UTSW 2 85786382 nonsense probably null
R7766:Olfr1015 UTSW 2 85785658 missense probably damaging 1.00
Z1176:Olfr1015 UTSW 2 85786120 missense probably damaging 1.00
Posted On2013-04-17