|Institutional Source||Beutler Lab|
|Gene Name||par-6 family cell polarity regulator beta|
|Essential gene?||Possibly non essential (E-score: 0.372)|
|Stock #||R3616 (G1)|
|Chromosomal Location||168081004-168101203 bp(+) (GRCm38)|
|Type of Mutation||splice site|
|DNA Base Change (assembly)||T to C at 168087339 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000052619 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000052125]|
|PDB Structure||Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6 [X-RAY DIFFRACTION]|
|Coding Region Coverage||
|Validation Efficiency||100% (29/29)|
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain, an OPR domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cytoplasmic protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. [provided by RefSeq, Jul 2008]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Pard6b||
(F):5'- AACTGATGCAGGGCTGTCAC -3'
(R):5'- GGAAACCGCCTTGTGGTAGTTG -3'
(F):5'- ATGCAGGGCTGTCACGTGAG -3'
(R):5'- GTCATCATTATTTATAGGCAGCAGG -3'