Incidental Mutation 'R3617:Gad1-ps'
| ID |
268485 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Gad1-ps
|
| Ensembl Gene |
ENSMUSG00000090665 |
| Gene Name |
glutamate decarboxylase 1, pseudogene |
| Synonyms |
Gad-1ps |
| MMRRC Submission |
040674-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.231)
|
| Stock # |
R3617 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
99279906-99281681 bp(+) (GRCm39) |
| Type of Mutation |
exon |
| DNA Base Change (assembly) |
T to A
at 99281260 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000167243
|
| SMART Domains |
Protein: ENSMUSP00000133048
Gene: ENSMUSG00000090665
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pyridoxal_deC
|
1 |
368 |
4.3e-153 |
PFAM |
|
Pfam:Beta_elim_lyase
|
91 |
436 |
7.3e-8 |
PFAM |
|
Pfam:Aminotran_5
|
130 |
370 |
4.7e-7 |
PFAM |
|
| Meta Mutation Damage Score |
0.3591 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 97.1%
- 20x: 94.4%
|
| Validation Efficiency |
98% (41/42) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc9 |
A |
G |
6: 142,625,015 (GRCm39) |
V460A |
probably damaging |
Het |
| Aplf |
T |
C |
6: 87,648,865 (GRCm39) |
I25V |
possibly damaging |
Het |
| Ascc3 |
A |
G |
10: 50,494,281 (GRCm39) |
T239A |
probably benign |
Het |
| Bahd1 |
G |
A |
2: 118,753,004 (GRCm39) |
R757H |
probably damaging |
Het |
| Cbfa2t2 |
A |
T |
2: 154,278,904 (GRCm39) |
|
probably benign |
Het |
| Ccdc168 |
T |
C |
1: 44,100,114 (GRCm39) |
D328G |
probably benign |
Het |
| Cdkn1c |
C |
T |
7: 143,013,531 (GRCm39) |
|
probably benign |
Het |
| Cfap46 |
A |
G |
7: 139,219,515 (GRCm39) |
S1317P |
probably benign |
Het |
| Cntln |
C |
T |
4: 84,923,214 (GRCm39) |
Q560* |
probably null |
Het |
| Cntn2 |
G |
C |
1: 132,456,361 (GRCm39) |
A161G |
probably benign |
Het |
| Crybg1 |
A |
G |
10: 43,832,782 (GRCm39) |
I1991T |
possibly damaging |
Het |
| Cttnbp2 |
T |
C |
6: 18,414,189 (GRCm39) |
E952G |
probably damaging |
Het |
| Dhx36 |
T |
C |
3: 62,379,428 (GRCm39) |
T887A |
possibly damaging |
Het |
| Dhx36 |
A |
G |
3: 62,394,481 (GRCm39) |
F512L |
probably benign |
Het |
| Fthl17f |
A |
G |
X: 8,929,862 (GRCm39) |
T153A |
probably benign |
Het |
| Gba2 |
C |
T |
4: 43,573,803 (GRCm39) |
R163H |
probably damaging |
Het |
| Gm10717 |
A |
G |
9: 3,025,532 (GRCm39) |
Y39C |
probably benign |
Het |
| Gm17019 |
A |
T |
5: 15,081,081 (GRCm39) |
M120K |
possibly damaging |
Het |
| Helz2 |
C |
T |
2: 180,874,854 (GRCm39) |
R1880H |
probably damaging |
Het |
| Ifi204 |
T |
C |
1: 173,583,283 (GRCm39) |
I312V |
possibly damaging |
Het |
| Kncn |
T |
C |
4: 115,743,089 (GRCm39) |
F55L |
probably benign |
Het |
| Kndc1 |
G |
A |
7: 139,481,976 (GRCm39) |
|
probably benign |
Het |
| Nat8f3 |
C |
A |
6: 85,738,670 (GRCm39) |
A31S |
probably benign |
Het |
| Ndst4 |
T |
C |
3: 125,231,782 (GRCm39) |
I117T |
probably benign |
Het |
| Ndufa9 |
G |
T |
6: 126,826,071 (GRCm39) |
|
probably benign |
Het |
| Nup42 |
T |
C |
5: 24,387,325 (GRCm39) |
S372P |
probably benign |
Het |
| Pde6a |
A |
G |
18: 61,364,575 (GRCm39) |
|
probably benign |
Het |
| Pigw |
T |
C |
11: 84,769,133 (GRCm39) |
I65M |
probably damaging |
Het |
| Pip |
A |
G |
6: 41,828,871 (GRCm39) |
T139A |
probably benign |
Het |
| Rel |
A |
T |
11: 23,695,780 (GRCm39) |
D202E |
probably damaging |
Het |
| Rhot2 |
A |
G |
17: 26,059,955 (GRCm39) |
|
probably benign |
Het |
| Sh3rf3 |
G |
A |
10: 58,922,685 (GRCm39) |
R587Q |
possibly damaging |
Het |
| Sim1 |
T |
A |
10: 50,785,624 (GRCm39) |
M231K |
probably damaging |
Het |
| Slc12a9 |
G |
A |
5: 137,330,759 (GRCm39) |
T47M |
probably damaging |
Het |
| Slc4a4 |
A |
G |
5: 89,382,663 (GRCm39) |
D1036G |
probably benign |
Het |
| Tas2r143 |
A |
T |
6: 42,377,997 (GRCm39) |
I276F |
probably benign |
Het |
| Tgfbr3 |
A |
T |
5: 107,288,485 (GRCm39) |
F392Y |
possibly damaging |
Het |
| Tmem266 |
T |
C |
9: 55,307,918 (GRCm39) |
V148A |
probably damaging |
Het |
| Ubiad1 |
A |
G |
4: 148,520,817 (GRCm39) |
I269T |
probably benign |
Het |
| Vwc2l |
A |
G |
1: 70,768,041 (GRCm39) |
|
probably null |
Het |
| Zbtb49 |
G |
A |
5: 38,357,975 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Gad1-ps |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00963:Gad1-ps
|
APN |
10 |
99,281,310 (GRCm39) |
exon |
noncoding transcript |
|
|
IGL01301:Gad1-ps
|
APN |
10 |
99,281,013 (GRCm39) |
exon |
noncoding transcript |
|
|
IGL01394:Gad1-ps
|
APN |
10 |
99,281,424 (GRCm39) |
exon |
noncoding transcript |
|
|
IGL02220:Gad1-ps
|
APN |
10 |
99,281,184 (GRCm39) |
exon |
noncoding transcript |
|
|
IGL02240:Gad1-ps
|
APN |
10 |
99,280,820 (GRCm39) |
exon |
noncoding transcript |
|
|
IGL03406:Gad1-ps
|
APN |
10 |
99,280,641 (GRCm39) |
exon |
noncoding transcript |
|
|
ANU18:Gad1-ps
|
UTSW |
10 |
99,281,013 (GRCm39) |
exon |
noncoding transcript |
|
|
R0305:Gad1-ps
|
UTSW |
10 |
99,280,665 (GRCm39) |
exon |
noncoding transcript |
|
|
R0446:Gad1-ps
|
UTSW |
10 |
99,281,383 (GRCm39) |
exon |
noncoding transcript |
|
|
R0538:Gad1-ps
|
UTSW |
10 |
99,280,854 (GRCm39) |
exon |
noncoding transcript |
|
|
R1511:Gad1-ps
|
UTSW |
10 |
99,281,331 (GRCm39) |
exon |
noncoding transcript |
|
|
R1734:Gad1-ps
|
UTSW |
10 |
99,281,637 (GRCm39) |
exon |
noncoding transcript |
|
|
R1745:Gad1-ps
|
UTSW |
10 |
99,281,386 (GRCm39) |
exon |
noncoding transcript |
|
|
R1886:Gad1-ps
|
UTSW |
10 |
99,281,444 (GRCm39) |
exon |
noncoding transcript |
|
|
R3111:Gad1-ps
|
UTSW |
10 |
99,280,383 (GRCm39) |
exon |
noncoding transcript |
|
|
R5042:Gad1-ps
|
UTSW |
10 |
99,281,516 (GRCm39) |
exon |
noncoding transcript |
|
|
R5223:Gad1-ps
|
UTSW |
10 |
99,281,009 (GRCm39) |
exon |
noncoding transcript |
|
|
R5234:Gad1-ps
|
UTSW |
10 |
99,281,188 (GRCm39) |
exon |
noncoding transcript |
|
|
R5275:Gad1-ps
|
UTSW |
10 |
99,280,751 (GRCm39) |
exon |
noncoding transcript |
|
|
R5295:Gad1-ps
|
UTSW |
10 |
99,280,751 (GRCm39) |
exon |
noncoding transcript |
|
|
R5334:Gad1-ps
|
UTSW |
10 |
99,281,009 (GRCm39) |
exon |
noncoding transcript |
|
|
R5335:Gad1-ps
|
UTSW |
10 |
99,281,009 (GRCm39) |
exon |
noncoding transcript |
|
|
R5336:Gad1-ps
|
UTSW |
10 |
99,281,009 (GRCm39) |
exon |
noncoding transcript |
|
|
R5337:Gad1-ps
|
UTSW |
10 |
99,281,009 (GRCm39) |
exon |
noncoding transcript |
|
|
R5396:Gad1-ps
|
UTSW |
10 |
99,281,009 (GRCm39) |
exon |
noncoding transcript |
|
|
R5397:Gad1-ps
|
UTSW |
10 |
99,281,009 (GRCm39) |
exon |
noncoding transcript |
|
|
R5399:Gad1-ps
|
UTSW |
10 |
99,281,009 (GRCm39) |
exon |
noncoding transcript |
|
|
R5428:Gad1-ps
|
UTSW |
10 |
99,281,009 (GRCm39) |
exon |
noncoding transcript |
|
|
R5429:Gad1-ps
|
UTSW |
10 |
99,281,009 (GRCm39) |
exon |
noncoding transcript |
|
|
R5431:Gad1-ps
|
UTSW |
10 |
99,281,009 (GRCm39) |
exon |
noncoding transcript |
|
|
R5661:Gad1-ps
|
UTSW |
10 |
99,280,901 (GRCm39) |
exon |
noncoding transcript |
|
|
R5667:Gad1-ps
|
UTSW |
10 |
99,280,395 (GRCm39) |
exon |
noncoding transcript |
|
|
R5671:Gad1-ps
|
UTSW |
10 |
99,280,395 (GRCm39) |
exon |
noncoding transcript |
|
|
R5885:Gad1-ps
|
UTSW |
10 |
99,281,009 (GRCm39) |
exon |
noncoding transcript |
|
|
R5886:Gad1-ps
|
UTSW |
10 |
99,281,009 (GRCm39) |
exon |
noncoding transcript |
|
|
| Predicted Primers |
PCR Primer
(F):5'- TGCTCATGTCCCAGAAGCAC -3'
(R):5'- ACATTTGTGTGCTCAGGCTC -3'
Sequencing Primer
(F):5'- AAAGGGCCGATTCAGTCACCTG -3'
(R):5'- TGTGCTCAGGCTCACCATCG -3'
|
| Posted On |
2015-02-19 |
Incidental Mutation