Incidental Mutation 'R3620:Or4k38'
ID 268583
Institutional Source Beutler Lab
Gene Symbol Or4k38
Ensembl Gene ENSMUSG00000096554
Gene Name olfactory receptor family 4 subfamily K member 38
Synonyms MOR248-16, Olfr1557, MOR248-2, Olfr1282, GA_x6K02T2Q125-72387537-72386620
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R3620 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 111165504-111166421 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 111165689 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 245 (I245L)
Ref Sequence ENSEMBL: ENSMUSP00000097213 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099618] [ENSMUST00000208176]
AlphaFold Q7TQY5
Predicted Effect probably benign
Transcript: ENSMUST00000099618
AA Change: I245L

PolyPhen 2 Score 0.060 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000097213
Gene: ENSMUSG00000096554
AA Change: I245L

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 5.5e-47 PFAM
Pfam:7tm_1 41 287 2.6e-18 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000208176
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010I14Rik T C 17: 9,226,864 (GRCm39) M473T probably benign Het
Asxl1 C A 2: 153,199,075 (GRCm39) R76S probably damaging Het
Bhlhe41 C A 6: 145,808,733 (GRCm39) G360C possibly damaging Het
Ccdc88a T C 11: 29,380,227 (GRCm39) I201T probably benign Het
Ccng1 T C 11: 40,642,992 (GRCm39) T152A probably benign Het
Cep192 T C 18: 67,962,928 (GRCm39) V648A probably benign Het
Cldn16 T A 16: 26,296,302 (GRCm39) F93I possibly damaging Het
Csmd1 T C 8: 16,042,684 (GRCm39) S2350G probably benign Het
Enpp6 T C 8: 47,518,540 (GRCm39) W223R probably benign Het
Fah T C 7: 84,238,159 (GRCm39) probably null Het
Fat2 A T 11: 55,147,521 (GRCm39) V3907D probably damaging Het
Fsip2 C A 2: 82,810,602 (GRCm39) T2307K probably benign Het
Gcg T C 2: 62,307,279 (GRCm39) E94G probably damaging Het
Gramd1b C A 9: 40,366,842 (GRCm39) R42L probably benign Het
H2bc9 C A 13: 23,727,324 (GRCm39) V67L probably benign Het
Hdc T A 2: 126,458,187 (GRCm39) Y45F possibly damaging Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Igsf10 T G 3: 59,243,752 (GRCm39) D194A probably damaging Het
Jarid2 T A 13: 45,059,752 (GRCm39) N661K probably damaging Het
Lrpprc A T 17: 85,077,452 (GRCm39) C412S probably benign Het
Mga T A 2: 119,747,149 (GRCm39) D433E probably damaging Het
Myo15a A T 11: 60,369,468 (GRCm39) S743C possibly damaging Het
Myo15b T G 11: 115,762,013 (GRCm39) L1176R possibly damaging Het
Ndor1 T C 2: 25,138,047 (GRCm39) Q526R probably damaging Het
Nipbl A G 15: 8,362,508 (GRCm39) I1429T probably damaging Het
Or1d2 T A 11: 74,256,050 (GRCm39) L185Q probably damaging Het
Or4c126 T C 2: 89,824,196 (GRCm39) I153T probably damaging Het
Otogl T C 10: 107,710,232 (GRCm39) D619G probably damaging Het
Pa2g4 C G 10: 128,399,464 (GRCm39) E67Q probably damaging Het
Pnpla1 C T 17: 29,096,362 (GRCm39) A147V probably damaging Het
Prdm13 A G 4: 21,683,532 (GRCm39) Y143H unknown Het
Rad23a A G 8: 85,567,193 (GRCm39) M1T probably null Het
Rpl31-ps17 C T 12: 54,748,397 (GRCm39) noncoding transcript Het
Slc10a2 A T 8: 5,154,909 (GRCm39) I92N probably damaging Het
Slc24a4 T C 12: 102,185,222 (GRCm39) F111L probably damaging Het
Sox11 T C 12: 27,391,735 (GRCm39) T225A probably benign Het
Thbs1 T C 2: 117,951,640 (GRCm39) V820A probably benign Het
Unc45a G T 7: 79,983,799 (GRCm39) N332K possibly damaging Het
Vmn1r159 A C 7: 22,542,258 (GRCm39) I258S possibly damaging Het
Wdr31 A T 4: 62,375,701 (GRCm39) F251L possibly damaging Het
Wdr43 C T 17: 71,957,601 (GRCm39) T530M probably benign Het
Zfp445 C T 9: 122,681,833 (GRCm39) A703T probably benign Het
Other mutations in Or4k38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02677:Or4k38 APN 2 111,166,147 (GRCm39) missense probably damaging 1.00
R0798:Or4k38 UTSW 2 111,165,689 (GRCm39) missense probably benign 0.16
R0932:Or4k38 UTSW 2 111,165,543 (GRCm39) missense probably benign 0.00
R0972:Or4k38 UTSW 2 111,165,763 (GRCm39) missense probably benign 0.18
R1033:Or4k38 UTSW 2 111,166,147 (GRCm39) missense probably damaging 1.00
R1864:Or4k38 UTSW 2 111,166,052 (GRCm39) missense possibly damaging 0.95
R1879:Or4k38 UTSW 2 111,165,808 (GRCm39) missense possibly damaging 0.61
R2343:Or4k38 UTSW 2 111,166,045 (GRCm39) missense probably damaging 1.00
R2509:Or4k38 UTSW 2 111,166,076 (GRCm39) missense probably damaging 0.98
R5589:Or4k38 UTSW 2 111,165,850 (GRCm39) missense possibly damaging 0.46
R6487:Or4k38 UTSW 2 111,166,012 (GRCm39) missense probably benign 0.00
R6818:Or4k38 UTSW 2 111,165,659 (GRCm39) missense probably benign 0.22
R7153:Or4k38 UTSW 2 111,166,246 (GRCm39) missense probably damaging 1.00
R7480:Or4k38 UTSW 2 111,165,737 (GRCm39) missense probably benign 0.22
R7589:Or4k38 UTSW 2 111,165,719 (GRCm39) missense probably damaging 1.00
R8441:Or4k38 UTSW 2 111,166,131 (GRCm39) nonsense probably null
R8774:Or4k38 UTSW 2 111,166,318 (GRCm39) missense probably damaging 1.00
R8774-TAIL:Or4k38 UTSW 2 111,166,318 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- ATACCTACCTACCAATAGCTTTGAG -3'
(R):5'- TAGCCTGCATGAATACTGATACTCTG -3'

Sequencing Primer
(F):5'- TCAGAATTCACTTGTGACTTATGAG -3'
(R):5'- GGAAATCCTAATAAATGCTGACAGTG -3'
Posted On 2015-02-19