Mutagenetix > Incidental Mutation

Incidental Mutation 'R3620:Vmn1r159'

268592

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r159

Ensembl Gene

ENSMUSG00000095931

Gene Name

vomeronasal 1 receptor 159

Synonyms

Gm16507

Accession Numbers

Essential gene?

Not available question?

Stock #

R3620 (G1)

Quality Score

Status

Not validated

Chromosome

Chromosomal Location

22542113-22543030 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 22542258 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Serine at position 258 (I258S)

Ref Sequence

ENSEMBL: ENSMUSP00000129692 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167871]

AlphaFold

K7N701

Predicted Effect

possibly damaging
Transcript: ENSMUST00000167871
AA Change: I258S

PolyPhen 2 Score 0.895 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000129692
Gene: ENSMUSG00000095931
AA Change: I258S

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	297	1.8e-16	PFAM
Pfam:7tm_1	31	288	7e-8	PFAM
Pfam:V1R	41	296	6.3e-16	PFAM

Coding Region Coverage

1x: 99.1%
3x: 98.6%
10x: 97.3%
20x: 95.4%

Validation Efficiency

100% (44/44)

Allele List at MGI

Other mutations in this stock

Total: 42 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700010I14Rik	T	C	17: 9,226,864 (GRCm39)	M473T	probably benign	Het
Asxl1	C	A	2: 153,199,075 (GRCm39)	R76S	probably damaging	Het
Bhlhe41	C	A	6: 145,808,733 (GRCm39)	G360C	possibly damaging	Het
Ccdc88a	T	C	11: 29,380,227 (GRCm39)	I201T	probably benign	Het
Ccng1	T	C	11: 40,642,992 (GRCm39)	T152A	probably benign	Het
Cep192	T	C	18: 67,962,928 (GRCm39)	V648A	probably benign	Het
Cldn16	T	A	16: 26,296,302 (GRCm39)	F93I	possibly damaging	Het
Csmd1	T	C	8: 16,042,684 (GRCm39)	S2350G	probably benign	Het
Enpp6	T	C	8: 47,518,540 (GRCm39)	W223R	probably benign	Het
Fah	T	C	7: 84,238,159 (GRCm39)		probably null	Het
Fat2	A	T	11: 55,147,521 (GRCm39)	V3907D	probably damaging	Het
Fsip2	C	A	2: 82,810,602 (GRCm39)	T2307K	probably benign	Het
Gcg	T	C	2: 62,307,279 (GRCm39)	E94G	probably damaging	Het
Gramd1b	C	A	9: 40,366,842 (GRCm39)	R42L	probably benign	Het
H2bc9	C	A	13: 23,727,324 (GRCm39)	V67L	probably benign	Het
Hdc	T	A	2: 126,458,187 (GRCm39)	Y45F	possibly damaging	Het
Hivep2	C	A	10: 14,004,713 (GRCm39)	T437K	probably benign	Het
Igsf10	T	G	3: 59,243,752 (GRCm39)	D194A	probably damaging	Het
Jarid2	T	A	13: 45,059,752 (GRCm39)	N661K	probably damaging	Het
Lrpprc	A	T	17: 85,077,452 (GRCm39)	C412S	probably benign	Het
Mga	T	A	2: 119,747,149 (GRCm39)	D433E	probably damaging	Het
Myo15a	A	T	11: 60,369,468 (GRCm39)	S743C	possibly damaging	Het
Myo15b	T	G	11: 115,762,013 (GRCm39)	L1176R	possibly damaging	Het
Ndor1	T	C	2: 25,138,047 (GRCm39)	Q526R	probably damaging	Het
Nipbl	A	G	15: 8,362,508 (GRCm39)	I1429T	probably damaging	Het
Or1d2	T	A	11: 74,256,050 (GRCm39)	L185Q	probably damaging	Het
Or4c126	T	C	2: 89,824,196 (GRCm39)	I153T	probably damaging	Het
Or4k38	T	A	2: 111,165,689 (GRCm39)	I245L	probably benign	Het
Otogl	T	C	10: 107,710,232 (GRCm39)	D619G	probably damaging	Het
Pa2g4	C	G	10: 128,399,464 (GRCm39)	E67Q	probably damaging	Het
Pnpla1	C	T	17: 29,096,362 (GRCm39)	A147V	probably damaging	Het
Prdm13	A	G	4: 21,683,532 (GRCm39)	Y143H	unknown	Het
Rad23a	A	G	8: 85,567,193 (GRCm39)	M1T	probably null	Het
Rpl31-ps17	C	T	12: 54,748,397 (GRCm39)		noncoding transcript	Het
Slc10a2	A	T	8: 5,154,909 (GRCm39)	I92N	probably damaging	Het
Slc24a4	T	C	12: 102,185,222 (GRCm39)	F111L	probably damaging	Het
Sox11	T	C	12: 27,391,735 (GRCm39)	T225A	probably benign	Het
Thbs1	T	C	2: 117,951,640 (GRCm39)	V820A	probably benign	Het
Unc45a	G	T	7: 79,983,799 (GRCm39)	N332K	possibly damaging	Het
Wdr31	A	T	4: 62,375,701 (GRCm39)	F251L	possibly damaging	Het
Wdr43	C	T	17: 71,957,601 (GRCm39)	T530M	probably benign	Het
Zfp445	C	T	9: 122,681,833 (GRCm39)	A703T	probably benign	Het

Other mutations in Vmn1r159

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
ANU23:Vmn1r159	UTSW	7	22,542,588 (GRCm39)	missense	probably damaging	0.99
R1183:Vmn1r159	UTSW	7	22,543,019 (GRCm39)	missense	probably null	0.80
R1522:Vmn1r159	UTSW	7	22,542,693 (GRCm39)	missense	probably damaging	0.98
R1700:Vmn1r159	UTSW	7	22,542,390 (GRCm39)	missense	probably damaging	1.00
R2570:Vmn1r159	UTSW	7	22,542,307 (GRCm39)	missense	probably benign	0.07
R4939:Vmn1r159	UTSW	7	22,542,316 (GRCm39)	missense	probably damaging	1.00
R4985:Vmn1r159	UTSW	7	22,542,959 (GRCm39)	missense	probably damaging	1.00
R6161:Vmn1r159	UTSW	7	22,542,612 (GRCm39)	missense	possibly damaging	0.63
R6365:Vmn1r159	UTSW	7	22,542,826 (GRCm39)	missense	probably damaging	1.00
R7033:Vmn1r159	UTSW	7	22,542,289 (GRCm39)	missense	probably damaging	1.00
R7633:Vmn1r159	UTSW	7	22,542,448 (GRCm39)	missense	probably damaging	1.00
R7817:Vmn1r159	UTSW	7	22,542,487 (GRCm39)	missense	possibly damaging	0.47
R7846:Vmn1r159	UTSW	7	22,542,696 (GRCm39)	missense	probably benign	0.01
R8008:Vmn1r159	UTSW	7	22,542,665 (GRCm39)	missense	possibly damaging	0.56
R8019:Vmn1r159	UTSW	7	22,542,248 (GRCm39)	missense	probably benign	0.01
R8222:Vmn1r159	UTSW	7	22,542,608 (GRCm39)	nonsense	probably null
R8291:Vmn1r159	UTSW	7	22,542,255 (GRCm39)	missense	possibly damaging	0.94
R8817:Vmn1r159	UTSW	7	22,542,559 (GRCm39)	missense	probably benign	0.04
R9170:Vmn1r159	UTSW	7	22,542,765 (GRCm39)	missense	probably damaging	1.00
R9242:Vmn1r159	UTSW	7	22,542,912 (GRCm39)	missense	probably benign	0.00
R9467:Vmn1r159	UTSW	7	22,542,141 (GRCm39)	missense	possibly damaging	0.90
R9525:Vmn1r159	UTSW	7	22,542,417 (GRCm39)	missense	probably damaging	0.96
R9601:Vmn1r159	UTSW	7	22,542,616 (GRCm39)	missense	probably damaging	1.00
R9699:Vmn1r159	UTSW	7	22,542,675 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- AGTGAAACTGTCTTCTGGATTTGGC -3'
(R):5'- TTGCAGTTTGCCTATGATGCC -3'

Sequencing Primer
(F):5'- CAGTTGAAGAGCACAGAAC -3'
(R):5'- GCCTATGATGCCACATTCATGAG -3'

Posted On

2015-02-19