Incidental Mutation 'R3620:Ccng1'
ID 268606
Institutional Source Beutler Lab
Gene Symbol Ccng1
Ensembl Gene ENSMUSG00000020326
Gene Name cyclin G1
Synonyms cyclin G
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.340) question?
Stock # R3620 (G1)
Quality Score 225
Status Validated
Chromosome 11
Chromosomal Location 40639379-40646044 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 40642992 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 152 (T152A)
Ref Sequence ENSEMBL: ENSMUSP00000020576 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000020576]
AlphaFold P51945
Predicted Effect probably benign
Transcript: ENSMUST00000020576
AA Change: T152A

PolyPhen 2 Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000020576
Gene: ENSMUSG00000020326
AA Change: T152A

DomainStartEndE-ValueType
CYCLIN 56 142 3.63e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151359
Meta Mutation Damage Score 0.7176 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Depending on the allele, homozygous mutants exhibit increased cellular sensitivity to gamma-irradiation or decreased incidence of induced hepatic tumors. [provided by MGI curators]
Allele List at MGI

All alleles(7) : Targeted, knock-out(2) Targeted, other(1) Gene trapped(4)

Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010I14Rik T C 17: 9,226,864 (GRCm39) M473T probably benign Het
Asxl1 C A 2: 153,199,075 (GRCm39) R76S probably damaging Het
Bhlhe41 C A 6: 145,808,733 (GRCm39) G360C possibly damaging Het
Ccdc88a T C 11: 29,380,227 (GRCm39) I201T probably benign Het
Cep192 T C 18: 67,962,928 (GRCm39) V648A probably benign Het
Cldn16 T A 16: 26,296,302 (GRCm39) F93I possibly damaging Het
Csmd1 T C 8: 16,042,684 (GRCm39) S2350G probably benign Het
Enpp6 T C 8: 47,518,540 (GRCm39) W223R probably benign Het
Fah T C 7: 84,238,159 (GRCm39) probably null Het
Fat2 A T 11: 55,147,521 (GRCm39) V3907D probably damaging Het
Fsip2 C A 2: 82,810,602 (GRCm39) T2307K probably benign Het
Gcg T C 2: 62,307,279 (GRCm39) E94G probably damaging Het
Gramd1b C A 9: 40,366,842 (GRCm39) R42L probably benign Het
H2bc9 C A 13: 23,727,324 (GRCm39) V67L probably benign Het
Hdc T A 2: 126,458,187 (GRCm39) Y45F possibly damaging Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Igsf10 T G 3: 59,243,752 (GRCm39) D194A probably damaging Het
Jarid2 T A 13: 45,059,752 (GRCm39) N661K probably damaging Het
Lrpprc A T 17: 85,077,452 (GRCm39) C412S probably benign Het
Mga T A 2: 119,747,149 (GRCm39) D433E probably damaging Het
Myo15a A T 11: 60,369,468 (GRCm39) S743C possibly damaging Het
Myo15b T G 11: 115,762,013 (GRCm39) L1176R possibly damaging Het
Ndor1 T C 2: 25,138,047 (GRCm39) Q526R probably damaging Het
Nipbl A G 15: 8,362,508 (GRCm39) I1429T probably damaging Het
Or1d2 T A 11: 74,256,050 (GRCm39) L185Q probably damaging Het
Or4c126 T C 2: 89,824,196 (GRCm39) I153T probably damaging Het
Or4k38 T A 2: 111,165,689 (GRCm39) I245L probably benign Het
Otogl T C 10: 107,710,232 (GRCm39) D619G probably damaging Het
Pa2g4 C G 10: 128,399,464 (GRCm39) E67Q probably damaging Het
Pnpla1 C T 17: 29,096,362 (GRCm39) A147V probably damaging Het
Prdm13 A G 4: 21,683,532 (GRCm39) Y143H unknown Het
Rad23a A G 8: 85,567,193 (GRCm39) M1T probably null Het
Rpl31-ps17 C T 12: 54,748,397 (GRCm39) noncoding transcript Het
Slc10a2 A T 8: 5,154,909 (GRCm39) I92N probably damaging Het
Slc24a4 T C 12: 102,185,222 (GRCm39) F111L probably damaging Het
Sox11 T C 12: 27,391,735 (GRCm39) T225A probably benign Het
Thbs1 T C 2: 117,951,640 (GRCm39) V820A probably benign Het
Unc45a G T 7: 79,983,799 (GRCm39) N332K possibly damaging Het
Vmn1r159 A C 7: 22,542,258 (GRCm39) I258S possibly damaging Het
Wdr31 A T 4: 62,375,701 (GRCm39) F251L possibly damaging Het
Wdr43 C T 17: 71,957,601 (GRCm39) T530M probably benign Het
Zfp445 C T 9: 122,681,833 (GRCm39) A703T probably benign Het
Other mutations in Ccng1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00693:Ccng1 APN 11 40,644,885 (GRCm39) missense probably benign 0.00
IGL01875:Ccng1 APN 11 40,643,183 (GRCm39) missense probably benign 0.09
IGL02986:Ccng1 APN 11 40,641,690 (GRCm39) utr 3 prime probably benign
G5030:Ccng1 UTSW 11 40,644,629 (GRCm39) splice site probably benign
R1375:Ccng1 UTSW 11 40,642,941 (GRCm39) missense probably benign 0.02
R1377:Ccng1 UTSW 11 40,642,941 (GRCm39) missense probably benign 0.02
R1715:Ccng1 UTSW 11 40,642,941 (GRCm39) missense probably benign 0.02
R3857:Ccng1 UTSW 11 40,644,660 (GRCm39) missense probably damaging 0.99
R3858:Ccng1 UTSW 11 40,644,660 (GRCm39) missense probably damaging 0.99
R5082:Ccng1 UTSW 11 40,643,015 (GRCm39) missense possibly damaging 0.77
R5172:Ccng1 UTSW 11 40,642,113 (GRCm39) missense probably benign
R5521:Ccng1 UTSW 11 40,643,093 (GRCm39) missense possibly damaging 0.87
R7431:Ccng1 UTSW 11 40,644,745 (GRCm39) missense possibly damaging 0.74
R7961:Ccng1 UTSW 11 40,642,096 (GRCm39) missense probably benign 0.00
R8009:Ccng1 UTSW 11 40,642,096 (GRCm39) missense probably benign 0.00
R8794:Ccng1 UTSW 11 40,644,826 (GRCm39) missense probably benign
R9036:Ccng1 UTSW 11 40,643,078 (GRCm39) missense possibly damaging 0.55
R9530:Ccng1 UTSW 11 40,644,885 (GRCm39) missense probably benign 0.00
T0975:Ccng1 UTSW 11 40,644,871 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- ACTGGCAGGCATCTTTTCAC -3'
(R):5'- GCACTGTAAAGACACTGGTGTG -3'

Sequencing Primer
(F):5'- CACTTCTGTTAGGCAGCAAAG -3'
(R):5'- TGTTTGTAGGTACAGGCGAAG -3'
Posted On 2015-02-19