Incidental Mutation 'IGL00919:Olfr1226'
ID26872
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1226
Ensembl Gene ENSMUSG00000075097
Gene Nameolfactory receptor 1226
SynonymsGA_x6K02T2Q125-50672630-50671698, MOR233-2
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.066) question?
Stock #IGL00919
Quality Score
Status
Chromosome2
Chromosomal Location89188839-89200048 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to G at 89193504 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Leucine at position 177 (M177L)
Ref Sequence ENSEMBL: ENSMUSP00000151855 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099790] [ENSMUST00000214709] [ENSMUST00000215562] [ENSMUST00000215987] [ENSMUST00000216445] [ENSMUST00000217601] [ENSMUST00000220416]
Predicted Effect probably benign
Transcript: ENSMUST00000099790
AA Change: M177L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000097378
Gene: ENSMUSG00000075097
AA Change: M177L

DomainStartEndE-ValueType
Pfam:7tm_4 29 302 6.5e-47 PFAM
Pfam:7tm_1 39 285 3.4e-15 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214709
AA Change: M177L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000215562
AA Change: M177L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000215987
AA Change: M177L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000216445
AA Change: M177L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000217601
AA Change: M177L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Predicted Effect probably benign
Transcript: ENSMUST00000220416
AA Change: M177L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arfgef1 A G 1: 10,173,237 V1029A probably damaging Het
Arhgap9 T C 10: 127,327,893 probably benign Het
Ccdc63 T C 5: 122,124,919 probably benign Het
Cfap206 C T 4: 34,721,562 S162N probably damaging Het
Coa7 G T 4: 108,338,308 G145C possibly damaging Het
Ctps A G 4: 120,567,348 V23A probably benign Het
Ehd4 T C 2: 120,097,054 E333G possibly damaging Het
Espl1 T C 15: 102,298,629 V176A probably benign Het
Fbxo41 A G 6: 85,478,570 I544T probably damaging Het
Fut9 A G 4: 25,620,316 V166A possibly damaging Het
Kirrel3 A G 9: 35,015,253 probably null Het
Nell2 T A 15: 95,383,727 D366V possibly damaging Het
Neurod4 A T 10: 130,270,814 I197N probably damaging Het
Nlrp9c A T 7: 26,394,056 Y61* probably null Het
Pcdh1 T A 18: 38,202,812 K118* probably null Het
Phf12 T A 11: 77,983,340 I10N probably damaging Het
Ptprc A T 1: 138,113,642 C250S probably damaging Het
Rtl8c A G X: 53,608,220 T59A possibly damaging Het
Serpine1 A G 5: 137,063,522 I377T probably benign Het
Shank2 A T 7: 144,411,271 D865V probably damaging Het
Ski A T 4: 155,222,342 V60E possibly damaging Het
St7l T A 3: 104,926,466 L481H probably damaging Het
Tmpo A G 10: 91,162,800 I375T probably damaging Het
Ubr5 T C 15: 38,040,842 D266G probably damaging Het
Other mutations in Olfr1226
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01073:Olfr1226 APN 2 89193137 missense possibly damaging 0.78
IGL01539:Olfr1226 APN 2 89193492 missense possibly damaging 0.81
IGL01549:Olfr1226 APN 2 89193789 missense probably benign 0.01
IGL02040:Olfr1226 APN 2 89193563 missense probably benign 0.16
IGL02174:Olfr1226 APN 2 89193368 missense probably benign 0.01
IGL02322:Olfr1226 APN 2 89193462 missense probably damaging 0.99
IGL02881:Olfr1226 APN 2 89193641 missense probably damaging 1.00
IGL03336:Olfr1226 APN 2 89193897 missense probably benign 0.16
R1565:Olfr1226 UTSW 2 89193883 missense probably damaging 0.99
R3429:Olfr1226 UTSW 2 89193273 missense probably benign 0.04
R5668:Olfr1226 UTSW 2 89193826 missense possibly damaging 0.60
R6404:Olfr1226 UTSW 2 89193562 missense probably damaging 1.00
R6418:Olfr1226 UTSW 2 89193479 missense probably damaging 0.97
R7039:Olfr1226 UTSW 2 89193446 missense probably damaging 0.96
R7863:Olfr1226 UTSW 2 89193951 missense probably benign
R8097:Olfr1226 UTSW 2 89193632 missense probably damaging 1.00
R8544:Olfr1226 UTSW 2 89193968 missense possibly damaging 0.68
R8792:Olfr1226 UTSW 2 89193887 missense probably benign 0.00
Posted On2013-04-17