Incidental Mutation 'R3623:Greb1l'
ID 268759
Institutional Source Beutler Lab
Gene Symbol Greb1l
Ensembl Gene ENSMUSG00000042942
Gene Name growth regulation by estrogen in breast cancer-like
Synonyms AK220484, mKIAA4095
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R3623 (G1)
Quality Score 225
Status Validated
Chromosome 18
Chromosomal Location 10325177-10562934 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 10542380 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 1325 (I1325N)
Ref Sequence ENSEMBL: ENSMUSP00000049003 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048977] [ENSMUST00000172532] [ENSMUST00000172680]
AlphaFold B9EJV3
Predicted Effect probably damaging
Transcript: ENSMUST00000048977
AA Change: I1325N

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000049003
Gene: ENSMUSG00000042942
AA Change: I1325N

DomainStartEndE-ValueType
Pfam:GREB1 1 1172 N/A PFAM
Pfam:GREB1 1154 1913 N/A PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000172532
SMART Domains Protein: ENSMUSP00000134090
Gene: ENSMUSG00000042942

DomainStartEndE-ValueType
low complexity region 83 100 N/A INTRINSIC
low complexity region 282 301 N/A INTRINSIC
low complexity region 606 617 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000172680
SMART Domains Protein: ENSMUSP00000134314
Gene: ENSMUSG00000042942

DomainStartEndE-ValueType
low complexity region 116 129 N/A INTRINSIC
Meta Mutation Damage Score 0.7808 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.6%
Validation Efficiency 100% (69/69)
Allele List at MGI

All alleles(5) : Targeted, other(2) Gene trapped(3)

Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy1 A G 11: 7,130,348 (GRCm38) T364A probably benign Het
Adpgk G A 9: 59,313,753 (GRCm38) V281I probably benign Het
Akap9 C A 5: 3,976,235 (GRCm38) Q1297K possibly damaging Het
Ankrd13d T C 19: 4,281,940 (GRCm38) E110G probably damaging Het
Ankrd53 A G 6: 83,763,262 (GRCm38) E104G possibly damaging Het
Bscl2 T A 19: 8,841,150 (GRCm38) C40S probably benign Het
Btaf1 A G 19: 36,981,086 (GRCm38) T668A probably benign Het
Camk2g G A 14: 20,755,707 (GRCm38) probably benign Het
Cd109 A T 9: 78,667,357 (GRCm38) D541V probably damaging Het
Cep135 G A 5: 76,624,739 (GRCm38) G657D probably benign Het
Coch A G 12: 51,602,826 (GRCm38) I307V probably benign Het
D17H6S53E A G 17: 35,127,536 (GRCm38) E141G probably benign Het
Ddias T C 7: 92,859,592 (GRCm38) T372A probably benign Het
Dffb T C 4: 153,965,519 (GRCm38) T296A probably damaging Het
Dock8 A G 19: 25,079,877 (GRCm38) Q216R probably benign Het
Ep400 T C 5: 110,719,236 (GRCm38) Y1014C unknown Het
Ephx1 A G 1: 180,989,933 (GRCm38) I391T probably benign Het
Fam208b T C 13: 3,595,556 (GRCm38) T98A probably benign Het
Fcgbp A G 7: 28,101,276 (GRCm38) Y1249C probably damaging Het
Gm38100 T C 1: 175,920,631 (GRCm38) C88R possibly damaging Het
Gm5592 T C 7: 41,157,628 (GRCm38) probably benign Het
Gm7964 A G 7: 83,756,421 (GRCm38) N149S probably benign Het
H2-T3 T C 17: 36,190,065 (GRCm38) T20A possibly damaging Het
Htr1d T C 4: 136,443,504 (GRCm38) I348T probably damaging Het
Hyal4 A T 6: 24,765,738 (GRCm38) S364C probably damaging Het
Igkv1-133 A T 6: 67,724,960 (GRCm38) Q16L probably benign Het
Irs2 C T 8: 11,007,643 (GRCm38) G263D probably damaging Het
Itga10 C T 3: 96,651,738 (GRCm38) probably benign Het
Kmt2a A G 9: 44,848,966 (GRCm38) Y529H probably damaging Het
Mdfic T A 6: 15,770,320 (GRCm38) N108K probably damaging Het
Met A T 6: 17,549,086 (GRCm38) D979V probably damaging Het
Mettl21e T A 1: 44,206,697 (GRCm38) I130F probably damaging Het
Mlh3 C T 12: 85,268,395 (GRCm38) C339Y probably damaging Het
Mog T C 17: 37,012,446 (GRCm38) H200R possibly damaging Het
Msrb3 C T 10: 120,784,198 (GRCm38) R72H probably damaging Het
Mtmr11 A G 3: 96,165,266 (GRCm38) H324R probably damaging Het
Myh7 T C 14: 54,973,381 (GRCm38) E1693G probably damaging Het
Nadk2 T A 15: 9,084,223 (GRCm38) W139R probably damaging Het
Ndufa9 A T 6: 126,844,399 (GRCm38) M76K possibly damaging Het
Nr1i2 A G 16: 38,265,907 (GRCm38) probably benign Het
Nsd3 A G 8: 25,662,819 (GRCm38) T392A probably damaging Het
Olfr305 A G 7: 86,364,100 (GRCm38) F79S probably benign Het
Olfr653 T C 7: 104,579,942 (GRCm38) S99P probably damaging Het
P2ry2 A T 7: 100,998,499 (GRCm38) S200T probably benign Het
Pcnt T A 10: 76,433,750 (GRCm38) E228V probably benign Het
Phka2 T A X: 160,544,295 (GRCm38) Y334* probably null Het
Pkhd1l1 A T 15: 44,526,869 (GRCm38) K1460N probably damaging Het
Rpl7a-ps3 G A 15: 36,308,283 (GRCm38) noncoding transcript Het
Rspry1 A G 8: 94,649,777 (GRCm38) D309G probably damaging Het
Scap A G 9: 110,380,203 (GRCm38) Y648C probably damaging Het
Sgcz T C 8: 37,953,047 (GRCm38) E17G probably damaging Het
Slc17a5 A T 9: 78,538,274 (GRCm38) V433D probably damaging Het
Smad9 C T 3: 54,789,284 (GRCm38) R257W probably damaging Het
Srcap T C 7: 127,542,147 (GRCm38) S1639P probably damaging Het
Strn3 T C 12: 51,661,216 (GRCm38) Y132C possibly damaging Het
Tas2r110 A T 6: 132,868,470 (GRCm38) M155L probably benign Het
Thbd A G 2: 148,406,973 (GRCm38) V325A probably damaging Het
Trpd52l3 T A 19: 30,003,933 (GRCm38) C29* probably null Het
Trpm1 A G 7: 64,244,853 (GRCm38) Y951C probably damaging Het
Ube3a T A 7: 59,272,112 (GRCm38) N77K probably damaging Het
Upp2 G A 2: 58,790,116 (GRCm38) R300Q possibly damaging Het
Usp35 T C 7: 97,312,620 (GRCm38) H533R probably damaging Het
Veph1 C T 3: 66,215,437 (GRCm38) V224I probably benign Het
Vmn1r30 A T 6: 58,435,452 (GRCm38) F132I probably benign Het
Vmn2r24 A G 6: 123,816,038 (GRCm38) R775G probably damaging Het
Vps13c T A 9: 67,975,907 (GRCm38) probably null Het
Vps37c T A 19: 10,706,205 (GRCm38) probably null Het
Zap70 C T 1: 36,779,135 (GRCm38) T301I probably benign Het
Zfp341 A G 2: 154,624,881 (GRCm38) K57E probably damaging Het
Zfp60 T A 7: 27,749,328 (GRCm38) F474I probably benign Het
Zfp786 T C 6: 47,821,423 (GRCm38) N194D probably benign Het
Other mutations in Greb1l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00485:Greb1l APN 18 10,555,962 (GRCm38) missense possibly damaging 0.90
IGL01554:Greb1l APN 18 10,522,144 (GRCm38) missense probably benign 0.01
IGL01563:Greb1l APN 18 10,469,399 (GRCm38) missense probably damaging 0.99
IGL01944:Greb1l APN 18 10,557,280 (GRCm38) missense possibly damaging 0.91
IGL02110:Greb1l APN 18 10,515,271 (GRCm38) missense probably damaging 1.00
IGL02249:Greb1l APN 18 10,532,961 (GRCm38) missense probably damaging 1.00
IGL02318:Greb1l APN 18 10,469,388 (GRCm38) missense possibly damaging 0.91
IGL02340:Greb1l APN 18 10,515,200 (GRCm38) missense probably damaging 0.99
IGL02516:Greb1l APN 18 10,537,064 (GRCm38) missense probably benign 0.31
IGL02566:Greb1l APN 18 10,503,299 (GRCm38) missense probably damaging 0.99
IGL02583:Greb1l APN 18 10,542,362 (GRCm38) missense probably damaging 1.00
IGL02838:Greb1l APN 18 10,560,430 (GRCm38) missense probably damaging 1.00
A4554:Greb1l UTSW 18 10,532,862 (GRCm38) missense possibly damaging 0.58
PIT4453001:Greb1l UTSW 18 10,533,032 (GRCm38) missense probably benign 0.08
PIT4453001:Greb1l UTSW 18 10,533,031 (GRCm38) missense probably damaging 0.98
R0099:Greb1l UTSW 18 10,509,158 (GRCm38) missense probably damaging 1.00
R0226:Greb1l UTSW 18 10,522,076 (GRCm38) intron probably benign
R0234:Greb1l UTSW 18 10,560,331 (GRCm38) missense probably damaging 1.00
R0234:Greb1l UTSW 18 10,560,331 (GRCm38) missense probably damaging 1.00
R0239:Greb1l UTSW 18 10,458,567 (GRCm38) splice site probably benign
R0316:Greb1l UTSW 18 10,547,420 (GRCm38) missense probably damaging 1.00
R0369:Greb1l UTSW 18 10,469,375 (GRCm38) missense possibly damaging 0.80
R0394:Greb1l UTSW 18 10,523,374 (GRCm38) missense probably damaging 0.99
R0478:Greb1l UTSW 18 10,509,281 (GRCm38) missense probably damaging 1.00
R0555:Greb1l UTSW 18 10,458,781 (GRCm38) splice site probably benign
R0671:Greb1l UTSW 18 10,474,303 (GRCm38) missense probably damaging 1.00
R1282:Greb1l UTSW 18 10,547,289 (GRCm38) missense probably benign 0.13
R1574:Greb1l UTSW 18 10,554,997 (GRCm38) missense possibly damaging 0.95
R1574:Greb1l UTSW 18 10,554,997 (GRCm38) missense possibly damaging 0.95
R1607:Greb1l UTSW 18 10,529,703 (GRCm38) missense possibly damaging 0.85
R1666:Greb1l UTSW 18 10,529,708 (GRCm38) critical splice donor site probably null
R1666:Greb1l UTSW 18 10,501,080 (GRCm38) critical splice donor site probably null
R1720:Greb1l UTSW 18 10,553,848 (GRCm38) missense probably benign 0.19
R1808:Greb1l UTSW 18 10,542,143 (GRCm38) missense probably benign
R1829:Greb1l UTSW 18 10,509,314 (GRCm38) missense probably damaging 1.00
R1897:Greb1l UTSW 18 10,498,992 (GRCm38) missense probably benign 0.00
R1967:Greb1l UTSW 18 10,501,049 (GRCm38) missense possibly damaging 0.91
R2025:Greb1l UTSW 18 10,515,221 (GRCm38) missense possibly damaging 0.71
R2086:Greb1l UTSW 18 10,523,281 (GRCm38) missense probably damaging 1.00
R2125:Greb1l UTSW 18 10,511,422 (GRCm38) missense probably damaging 0.98
R2139:Greb1l UTSW 18 10,555,011 (GRCm38) missense probably damaging 1.00
R2255:Greb1l UTSW 18 10,554,857 (GRCm38) missense probably damaging 1.00
R2256:Greb1l UTSW 18 10,503,307 (GRCm38) missense possibly damaging 0.91
R2257:Greb1l UTSW 18 10,503,307 (GRCm38) missense possibly damaging 0.91
R2880:Greb1l UTSW 18 10,547,288 (GRCm38) missense possibly damaging 0.93
R3778:Greb1l UTSW 18 10,469,444 (GRCm38) missense possibly damaging 0.60
R3975:Greb1l UTSW 18 10,522,247 (GRCm38) missense possibly damaging 0.71
R4038:Greb1l UTSW 18 10,515,209 (GRCm38) missense possibly damaging 0.93
R4062:Greb1l UTSW 18 10,522,150 (GRCm38) missense probably damaging 0.99
R4134:Greb1l UTSW 18 10,529,708 (GRCm38) critical splice donor site probably null
R4342:Greb1l UTSW 18 10,544,561 (GRCm38) missense probably benign 0.12
R4409:Greb1l UTSW 18 10,503,182 (GRCm38) missense possibly damaging 0.70
R4600:Greb1l UTSW 18 10,553,705 (GRCm38) missense probably damaging 1.00
R4618:Greb1l UTSW 18 10,498,965 (GRCm38) missense probably benign 0.00
R4683:Greb1l UTSW 18 10,529,563 (GRCm38) splice site probably null
R4686:Greb1l UTSW 18 10,522,112 (GRCm38) missense probably damaging 0.98
R4707:Greb1l UTSW 18 10,532,922 (GRCm38) missense probably benign 0.02
R4780:Greb1l UTSW 18 10,541,792 (GRCm38) missense probably benign 0.00
R4819:Greb1l UTSW 18 10,458,358 (GRCm38) missense probably damaging 1.00
R4925:Greb1l UTSW 18 10,547,447 (GRCm38) missense possibly damaging 0.79
R4960:Greb1l UTSW 18 10,547,306 (GRCm38) missense probably damaging 0.99
R5150:Greb1l UTSW 18 10,555,950 (GRCm38) frame shift probably null
R5154:Greb1l UTSW 18 10,458,312 (GRCm38) missense probably benign 0.02
R5269:Greb1l UTSW 18 10,511,409 (GRCm38) missense probably benign
R5290:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5310:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5328:Greb1l UTSW 18 10,553,720 (GRCm38) missense probably damaging 1.00
R5337:Greb1l UTSW 18 10,509,143 (GRCm38) missense probably damaging 1.00
R5393:Greb1l UTSW 18 10,458,312 (GRCm38) missense probably benign 0.02
R5402:Greb1l UTSW 18 10,537,169 (GRCm38) missense probably benign 0.26
R5718:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5719:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5720:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5721:Greb1l UTSW 18 10,542,427 (GRCm38) missense probably damaging 1.00
R5902:Greb1l UTSW 18 10,538,302 (GRCm38) missense probably benign 0.00
R5993:Greb1l UTSW 18 10,544,455 (GRCm38) missense probably benign 0.10
R6035:Greb1l UTSW 18 10,501,025 (GRCm38) missense possibly damaging 0.91
R6035:Greb1l UTSW 18 10,501,025 (GRCm38) missense possibly damaging 0.91
R6045:Greb1l UTSW 18 10,547,068 (GRCm38) missense probably damaging 1.00
R6063:Greb1l UTSW 18 10,557,340 (GRCm38) missense probably damaging 1.00
R6297:Greb1l UTSW 18 10,469,494 (GRCm38) missense probably damaging 1.00
R6405:Greb1l UTSW 18 10,501,076 (GRCm38) missense probably benign 0.30
R6552:Greb1l UTSW 18 10,541,814 (GRCm38) missense probably benign 0.00
R6572:Greb1l UTSW 18 10,522,131 (GRCm38) missense probably benign 0.07
R6575:Greb1l UTSW 18 10,547,347 (GRCm38) missense possibly damaging 0.88
R6922:Greb1l UTSW 18 10,547,482 (GRCm38) missense possibly damaging 0.88
R6957:Greb1l UTSW 18 10,558,786 (GRCm38) missense probably benign 0.23
R6962:Greb1l UTSW 18 10,547,327 (GRCm38) missense probably damaging 1.00
R7012:Greb1l UTSW 18 10,529,707 (GRCm38) critical splice donor site probably null
R7179:Greb1l UTSW 18 10,544,576 (GRCm38) missense probably benign 0.00
R7251:Greb1l UTSW 18 10,515,319 (GRCm38) missense probably damaging 1.00
R7275:Greb1l UTSW 18 10,544,561 (GRCm38) missense probably benign 0.12
R7301:Greb1l UTSW 18 10,544,970 (GRCm38) missense probably damaging 1.00
R7307:Greb1l UTSW 18 10,538,142 (GRCm38) missense probably damaging 0.99
R7455:Greb1l UTSW 18 10,554,915 (GRCm38) missense probably damaging 1.00
R7832:Greb1l UTSW 18 10,542,056 (GRCm38) missense probably benign 0.38
R7934:Greb1l UTSW 18 10,474,371 (GRCm38) nonsense probably null
R8137:Greb1l UTSW 18 10,474,357 (GRCm38) missense possibly damaging 0.77
R8138:Greb1l UTSW 18 10,533,060 (GRCm38) missense probably benign 0.13
R8208:Greb1l UTSW 18 10,510,703 (GRCm38) missense probably damaging 1.00
R8227:Greb1l UTSW 18 10,515,371 (GRCm38) missense probably damaging 1.00
R8312:Greb1l UTSW 18 10,511,587 (GRCm38) intron probably benign
R8331:Greb1l UTSW 18 10,458,706 (GRCm38) missense possibly damaging 0.96
R8364:Greb1l UTSW 18 10,529,687 (GRCm38) missense possibly damaging 0.85
R8389:Greb1l UTSW 18 10,529,613 (GRCm38) missense probably benign 0.00
R8695:Greb1l UTSW 18 10,544,450 (GRCm38) missense probably benign 0.01
R8795:Greb1l UTSW 18 10,553,739 (GRCm38) missense probably damaging 0.98
R8836:Greb1l UTSW 18 10,509,257 (GRCm38) missense probably benign 0.30
R8862:Greb1l UTSW 18 10,555,042 (GRCm38) missense possibly damaging 0.90
R8872:Greb1l UTSW 18 10,529,684 (GRCm38) missense probably benign 0.18
R8874:Greb1l UTSW 18 10,544,896 (GRCm38) missense probably benign 0.01
R8886:Greb1l UTSW 18 10,553,843 (GRCm38) missense probably benign 0.21
R8921:Greb1l UTSW 18 10,541,825 (GRCm38) missense probably benign 0.01
R8997:Greb1l UTSW 18 10,510,747 (GRCm38) missense probably damaging 1.00
R9015:Greb1l UTSW 18 10,541,675 (GRCm38) missense probably benign 0.00
R9018:Greb1l UTSW 18 10,542,004 (GRCm38) missense possibly damaging 0.76
R9074:Greb1l UTSW 18 10,558,795 (GRCm38) missense probably damaging 1.00
R9074:Greb1l UTSW 18 10,532,797 (GRCm38) missense probably damaging 1.00
R9117:Greb1l UTSW 18 10,542,422 (GRCm38) missense probably benign 0.31
R9189:Greb1l UTSW 18 10,499,983 (GRCm38) missense probably benign
R9332:Greb1l UTSW 18 10,532,796 (GRCm38) missense possibly damaging 0.92
R9367:Greb1l UTSW 18 10,522,130 (GRCm38) missense probably benign 0.00
R9497:Greb1l UTSW 18 10,458,600 (GRCm38) missense probably benign 0.00
R9796:Greb1l UTSW 18 10,538,233 (GRCm38) missense possibly damaging 0.69
Z1176:Greb1l UTSW 18 10,515,305 (GRCm38) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TACAGATAGTGCAGGGTGGACC -3'
(R):5'- TGAGAGCCACAGTTCAGTTG -3'

Sequencing Primer
(F):5'- CCTGTCTTGGCTGTAAGGGACATC -3'
(R):5'- GAGCCACAGTTCAGTTGGAATTAC -3'
Posted On 2015-02-19