Incidental Mutation 'R3691:Or10ag2'
ID 268767
Institutional Source Beutler Lab
Gene Symbol Or10ag2
Ensembl Gene ENSMUSG00000043274
Gene Name olfactory receptor family 10 subfamily AG member 2
Synonyms Olfr1123, MOR264-17, GA_x6K02T2Q125-48917235-48918206
MMRRC Submission 040686-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.244) question?
Stock # R3691 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87248394-87249365 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 87248514 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 39 (F39L)
Ref Sequence ENSEMBL: ENSMUSP00000154459 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054974] [ENSMUST00000216208]
AlphaFold A2AT85
Predicted Effect probably benign
Transcript: ENSMUST00000054974
AA Change: F41L

PolyPhen 2 Score 0.126 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000058786
Gene: ENSMUSG00000043274
AA Change: F41L

DomainStartEndE-ValueType
Pfam:7tm_4 44 321 4.4e-52 PFAM
Pfam:7tm_1 54 303 2.6e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213950
Predicted Effect noncoding transcript
Transcript: ENSMUST00000214663
Predicted Effect probably benign
Transcript: ENSMUST00000216208
AA Change: F39L

PolyPhen 2 Score 0.199 (Sensitivity: 0.92; Specificity: 0.88)
Meta Mutation Damage Score 0.3410 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.2%
  • 20x: 95.0%
Validation Efficiency 100% (34/34)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afdn A G 17: 14,108,671 (GRCm39) E1398G probably damaging Het
Avl9 C T 6: 56,713,812 (GRCm39) H357Y probably benign Het
Best2 A G 8: 85,737,883 (GRCm39) F171L probably benign Het
Btbd19 A T 4: 116,977,789 (GRCm39) probably benign Het
Cap1 A G 4: 122,758,419 (GRCm39) S254P probably damaging Het
Cfap43 G A 19: 47,885,512 (GRCm39) L368F probably benign Het
Clasrp C A 7: 19,319,165 (GRCm39) probably benign Het
Cog3 T C 14: 75,991,878 (GRCm39) M1V probably null Het
Drosha G A 15: 12,834,724 (GRCm39) R276H unknown Het
Efr3b T A 12: 4,032,059 (GRCm39) D183V possibly damaging Het
Epha1 T C 6: 42,338,064 (GRCm39) T794A probably damaging Het
Fbxo17 G A 7: 28,436,887 (GRCm39) V281I probably damaging Het
Flii T C 11: 60,610,583 (GRCm39) Y571C probably benign Het
Flywch1 G A 17: 23,982,186 (GRCm39) P6L probably damaging Het
Foxj3 T C 4: 119,473,839 (GRCm39) probably benign Het
Fras1 C T 5: 96,929,371 (GRCm39) T3925I probably benign Het
Gk5 T C 9: 96,011,149 (GRCm39) probably null Het
Gm12588 T G 11: 121,796,751 (GRCm39) Q366P possibly damaging Het
Gm3248 A G 14: 5,943,068 (GRCm38) I161T probably damaging Het
Gzmg T A 14: 56,395,134 (GRCm39) probably benign Het
Lrrc69 A T 4: 14,795,980 (GRCm39) N22K possibly damaging Het
Med13l A G 5: 118,859,562 (GRCm39) R250G probably benign Het
Mideas C T 12: 84,203,245 (GRCm39) G886S probably benign Het
Mxi1 T C 19: 53,358,062 (GRCm39) L73P probably damaging Het
Myo9b G A 8: 71,786,981 (GRCm39) R721Q probably benign Het
Napb T C 2: 148,544,977 (GRCm39) probably null Het
Nsun2 A G 13: 69,760,456 (GRCm39) N45D probably damaging Het
Oxct1 A G 15: 4,076,999 (GRCm39) M111V probably benign Het
Pcnx4 A G 12: 72,620,493 (GRCm39) D771G probably damaging Het
Serpina6 T C 12: 103,620,668 (GRCm39) D27G probably benign Het
Tecpr1 A G 5: 144,146,797 (GRCm39) F523S probably benign Het
Zan A G 5: 137,418,281 (GRCm39) I2939T unknown Het
Zfc3h1 A G 10: 115,256,595 (GRCm39) T1522A probably benign Het
Other mutations in Or10ag2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00231:Or10ag2 APN 2 87,248,910 (GRCm39) missense possibly damaging 0.75
IGL01067:Or10ag2 APN 2 87,248,714 (GRCm39) missense probably benign 0.00
IGL01526:Or10ag2 APN 2 87,249,319 (GRCm39) missense probably damaging 0.99
IGL01580:Or10ag2 APN 2 87,248,880 (GRCm39) missense probably benign 0.06
IGL01986:Or10ag2 APN 2 87,248,880 (GRCm39) missense probably benign 0.00
IGL02503:Or10ag2 APN 2 87,248,636 (GRCm39) missense probably benign 0.03
IGL02527:Or10ag2 APN 2 87,249,181 (GRCm39) missense probably damaging 1.00
IGL02731:Or10ag2 APN 2 87,249,051 (GRCm39) missense probably benign 0.00
IGL03215:Or10ag2 APN 2 87,248,412 (GRCm39) missense probably benign 0.05
IGL03366:Or10ag2 APN 2 87,248,587 (GRCm39) missense possibly damaging 0.88
R0645:Or10ag2 UTSW 2 87,248,612 (GRCm39) nonsense probably null
R1857:Or10ag2 UTSW 2 87,248,992 (GRCm39) missense probably damaging 1.00
R2175:Or10ag2 UTSW 2 87,248,500 (GRCm39) missense probably damaging 1.00
R4082:Or10ag2 UTSW 2 87,248,801 (GRCm39) nonsense probably null
R4635:Or10ag2 UTSW 2 87,249,043 (GRCm39) missense probably benign 0.05
R4877:Or10ag2 UTSW 2 87,248,907 (GRCm39) nonsense probably null
R5190:Or10ag2 UTSW 2 87,249,187 (GRCm39) missense probably damaging 1.00
R5253:Or10ag2 UTSW 2 87,249,012 (GRCm39) missense possibly damaging 0.64
R6266:Or10ag2 UTSW 2 87,249,350 (GRCm39) missense probably benign 0.01
R6784:Or10ag2 UTSW 2 87,248,796 (GRCm39) missense probably benign 0.20
R6909:Or10ag2 UTSW 2 87,248,959 (GRCm39) missense probably damaging 1.00
R7255:Or10ag2 UTSW 2 87,249,286 (GRCm39) missense probably damaging 0.96
R8076:Or10ag2 UTSW 2 87,248,889 (GRCm39) missense probably benign 0.00
R8116:Or10ag2 UTSW 2 87,249,081 (GRCm39) missense probably damaging 1.00
R8315:Or10ag2 UTSW 2 87,248,995 (GRCm39) missense probably damaging 1.00
R8888:Or10ag2 UTSW 2 87,248,659 (GRCm39) missense probably benign 0.00
R8895:Or10ag2 UTSW 2 87,248,659 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCATTCAAGTCCAGGAACATGG -3'
(R):5'- AACACATTTGAGTGGCACAGG -3'

Sequencing Primer
(F):5'- TTCAAGTCCAGGAACATGGCAATG -3'
(R):5'- TTTCTGAGTACACAGGTCCACAAG -3'
Posted On 2015-02-19