Incidental Mutation 'R3694:Vmn2r18'
ID 268902
Institutional Source Beutler Lab
Gene Symbol Vmn2r18
Ensembl Gene ENSMUSG00000091794
Gene Name vomeronasal 2, receptor 18
Synonyms EG632671
MMRRC Submission 040689-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R3694 (G1)
Quality Score 225
Status Not validated
Chromosome 5
Chromosomal Location 151485126-151529232 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 151508033 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 364 (F364L)
Ref Sequence ENSEMBL: ENSMUSP00000127506 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165928]
AlphaFold A0A3B2WB67
Predicted Effect probably benign
Transcript: ENSMUST00000165928
AA Change: F364L

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000127506
Gene: ENSMUSG00000091794
AA Change: F364L

DomainStartEndE-ValueType
Pfam:ANF_receptor 1 403 5.7e-39 PFAM
Pfam:NCD3G 446 499 5.5e-20 PFAM
Pfam:7tm_3 531 767 5e-53 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2900092C05Rik A G 7: 12,284,443 (GRCm39) I97V possibly damaging Het
AI182371 A G 2: 34,975,764 (GRCm39) C267R probably benign Het
Ankrd29 G A 18: 12,387,757 (GRCm39) A275V possibly damaging Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Atp8b1 G A 18: 64,666,792 (GRCm39) T1135I possibly damaging Het
Avil T C 10: 126,844,199 (GRCm39) Y253H probably damaging Het
Bcas3 G T 11: 85,692,628 (GRCm39) V338L probably benign Het
Cabp2 A G 19: 4,133,593 (GRCm39) T12A probably benign Het
Ccdc158 T C 5: 92,757,904 (GRCm39) E1056G probably damaging Het
Clcn7 T A 17: 25,378,681 (GRCm39) I722N probably damaging Het
Cnga3 T C 1: 37,300,821 (GRCm39) Y552H probably damaging Het
Crygs C T 16: 22,624,301 (GRCm39) G102D possibly damaging Het
Cyp3a25 A T 5: 145,926,786 (GRCm39) probably null Het
Dmrta1 T A 4: 89,580,415 (GRCm39) Y458* probably null Het
Eya1 A G 1: 14,299,725 (GRCm39) Y343H probably damaging Het
Fads2b T G 2: 85,324,454 (GRCm39) I291L probably benign Het
Fbln5 T C 12: 101,731,511 (GRCm39) N228D probably benign Het
Fmo5 T C 3: 97,553,230 (GRCm39) F393L probably damaging Het
Gpr63 A G 4: 25,007,993 (GRCm39) Y239C probably damaging Het
Ints2 T C 11: 86,133,827 (GRCm39) M408V probably benign Het
Lztr1 G A 16: 17,326,925 (GRCm39) A12T possibly damaging Het
Magi2 A AG 5: 20,807,459 (GRCm39) probably null Het
Mutyh T A 4: 116,673,651 (GRCm39) S146T possibly damaging Het
Obscn T C 11: 58,969,221 (GRCm39) K2460E probably damaging Het
Or4p18 A T 2: 88,232,540 (GRCm39) I246N possibly damaging Het
Or5b112 T C 19: 13,319,893 (GRCm39) I257T possibly damaging Het
Ppfia4 G T 1: 134,240,305 (GRCm39) T896K probably damaging Het
Ppp2r2a C A 14: 67,257,199 (GRCm39) D344Y probably damaging Het
Rbm4 A G 19: 4,837,411 (GRCm39) Y358H probably damaging Het
Scn9a T G 2: 66,392,749 (GRCm39) E281A probably benign Het
Strn T C 17: 78,964,421 (GRCm39) N515D probably damaging Het
Stxbp5l A T 16: 37,061,708 (GRCm39) Y367* probably null Het
Syt7 G T 19: 10,413,000 (GRCm39) R265L possibly damaging Het
Tub A G 7: 108,627,039 (GRCm39) S313G probably benign Het
Vmn2r77 A G 7: 86,450,044 (GRCm39) N97D probably damaging Het
Vmn2r85 A G 10: 130,254,171 (GRCm39) S838P probably damaging Het
Vmn2r92 T A 17: 18,372,205 (GRCm39) L5* probably null Het
Zfyve28 A G 5: 34,374,812 (GRCm39) F401L probably damaging Het
Other mutations in Vmn2r18
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01098:Vmn2r18 APN 5 151,496,296 (GRCm39) missense probably damaging 0.99
IGL01564:Vmn2r18 APN 5 151,508,633 (GRCm39) missense possibly damaging 0.69
IGL01602:Vmn2r18 APN 5 151,510,106 (GRCm39) missense possibly damaging 0.64
IGL01605:Vmn2r18 APN 5 151,510,106 (GRCm39) missense possibly damaging 0.64
IGL01619:Vmn2r18 APN 5 151,510,229 (GRCm39) missense probably benign 0.25
IGL02177:Vmn2r18 APN 5 151,510,274 (GRCm39) missense possibly damaging 0.76
IGL02682:Vmn2r18 APN 5 151,508,102 (GRCm39) missense probably damaging 0.99
IGL02751:Vmn2r18 APN 5 151,508,072 (GRCm39) missense probably benign 0.09
IGL02977:Vmn2r18 APN 5 151,510,149 (GRCm39) missense probably damaging 1.00
R0089:Vmn2r18 UTSW 5 151,508,269 (GRCm39) missense probably benign 0.00
R0282:Vmn2r18 UTSW 5 151,508,668 (GRCm39) missense probably benign 0.02
R0529:Vmn2r18 UTSW 5 151,485,988 (GRCm39) missense probably damaging 0.99
R0812:Vmn2r18 UTSW 5 151,496,395 (GRCm39) splice site probably benign
R1467:Vmn2r18 UTSW 5 151,510,301 (GRCm39) missense possibly damaging 0.48
R1467:Vmn2r18 UTSW 5 151,510,301 (GRCm39) missense possibly damaging 0.48
R1506:Vmn2r18 UTSW 5 151,499,099 (GRCm39) splice site probably null
R1562:Vmn2r18 UTSW 5 151,510,301 (GRCm39) missense probably benign 0.12
R1637:Vmn2r18 UTSW 5 151,508,222 (GRCm39) missense probably damaging 1.00
R1651:Vmn2r18 UTSW 5 151,485,464 (GRCm39) missense probably damaging 1.00
R1883:Vmn2r18 UTSW 5 151,499,190 (GRCm39) missense probably benign 0.37
R1884:Vmn2r18 UTSW 5 151,499,190 (GRCm39) missense probably benign 0.37
R1914:Vmn2r18 UTSW 5 151,499,286 (GRCm39) missense probably benign 0.02
R2051:Vmn2r18 UTSW 5 151,486,016 (GRCm39) missense possibly damaging 0.90
R2056:Vmn2r18 UTSW 5 151,508,160 (GRCm39) missense probably damaging 0.98
R2252:Vmn2r18 UTSW 5 151,508,441 (GRCm39) missense possibly damaging 0.59
R2265:Vmn2r18 UTSW 5 151,510,127 (GRCm39) missense probably damaging 1.00
R2266:Vmn2r18 UTSW 5 151,510,127 (GRCm39) missense probably damaging 1.00
R2267:Vmn2r18 UTSW 5 151,510,127 (GRCm39) missense probably damaging 1.00
R2843:Vmn2r18 UTSW 5 151,485,749 (GRCm39) missense probably damaging 1.00
R3023:Vmn2r18 UTSW 5 151,485,148 (GRCm39) missense probably benign 0.13
R3763:Vmn2r18 UTSW 5 151,508,644 (GRCm39) missense probably damaging 1.00
R3816:Vmn2r18 UTSW 5 151,485,148 (GRCm39) missense probably benign 0.13
R4007:Vmn2r18 UTSW 5 151,508,711 (GRCm39) missense probably damaging 0.99
R4152:Vmn2r18 UTSW 5 151,485,730 (GRCm39) missense probably damaging 1.00
R4308:Vmn2r18 UTSW 5 151,508,268 (GRCm39) nonsense probably null
R4362:Vmn2r18 UTSW 5 151,496,368 (GRCm39) missense probably damaging 1.00
R4618:Vmn2r18 UTSW 5 151,508,424 (GRCm39) missense possibly damaging 0.64
R4716:Vmn2r18 UTSW 5 151,485,602 (GRCm39) missense possibly damaging 0.87
R4817:Vmn2r18 UTSW 5 151,508,897 (GRCm39) splice site probably null
R5111:Vmn2r18 UTSW 5 151,485,913 (GRCm39) missense possibly damaging 0.85
R5692:Vmn2r18 UTSW 5 151,485,724 (GRCm39) missense possibly damaging 0.65
R6115:Vmn2r18 UTSW 5 151,508,462 (GRCm39) missense possibly damaging 0.81
R6244:Vmn2r18 UTSW 5 151,508,116 (GRCm39) missense probably damaging 1.00
R6595:Vmn2r18 UTSW 5 151,485,889 (GRCm39) missense probably damaging 1.00
R6997:Vmn2r18 UTSW 5 151,485,338 (GRCm39) missense possibly damaging 0.95
R7227:Vmn2r18 UTSW 5 151,496,264 (GRCm39) missense probably damaging 1.00
R7349:Vmn2r18 UTSW 5 151,485,682 (GRCm39) nonsense probably null
R7506:Vmn2r18 UTSW 5 151,508,485 (GRCm39) missense possibly damaging 0.51
R7590:Vmn2r18 UTSW 5 151,485,194 (GRCm39) missense probably damaging 1.00
R7721:Vmn2r18 UTSW 5 151,510,158 (GRCm39) missense possibly damaging 0.53
R7877:Vmn2r18 UTSW 5 151,508,437 (GRCm39) missense probably damaging 1.00
R7882:Vmn2r18 UTSW 5 151,485,329 (GRCm39) missense probably damaging 1.00
R7984:Vmn2r18 UTSW 5 151,485,526 (GRCm39) missense probably damaging 1.00
R8295:Vmn2r18 UTSW 5 151,508,621 (GRCm39) missense probably damaging 0.97
R8353:Vmn2r18 UTSW 5 151,485,373 (GRCm39) missense probably damaging 1.00
R8453:Vmn2r18 UTSW 5 151,485,373 (GRCm39) missense probably damaging 1.00
R8670:Vmn2r18 UTSW 5 151,485,854 (GRCm39) missense probably damaging 1.00
R8725:Vmn2r18 UTSW 5 151,508,462 (GRCm39) missense probably damaging 0.99
R8727:Vmn2r18 UTSW 5 151,508,462 (GRCm39) missense probably damaging 0.99
R8895:Vmn2r18 UTSW 5 151,485,140 (GRCm39) missense possibly damaging 0.46
R9286:Vmn2r18 UTSW 5 151,499,175 (GRCm39) missense probably benign 0.00
R9339:Vmn2r18 UTSW 5 151,485,132 (GRCm39) missense probably damaging 0.99
Z1176:Vmn2r18 UTSW 5 151,508,498 (GRCm39) missense probably damaging 0.99
Z1187:Vmn2r18 UTSW 5 151,508,497 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GCACCATTATTTCAGGCACATACAC -3'
(R):5'- GACAAGTTTGATTGCGCACCTC -3'

Sequencing Primer
(F):5'- TATTTCAGGCACATACACACCCATTG -3'
(R):5'- CTATGTGGAAGGAATAAACCCTGTCC -3'
Posted On 2015-02-19