Incidental Mutation 'R3552:Zfp352'
ID 268979
Institutional Source Beutler Lab
Gene Symbol Zfp352
Ensembl Gene ENSMUSG00000070902
Gene Name zinc finger protein 352
Synonyms 2czf48
MMRRC Submission 040669-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3552 (G1)
Quality Score 225
Status Validated
Chromosome 4
Chromosomal Location 90107057-90113924 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 90113339 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 493 (E493G)
Ref Sequence ENSEMBL: ENSMUSP00000102746 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080541] [ENSMUST00000107129]
AlphaFold A2AML7
Predicted Effect probably benign
Transcript: ENSMUST00000080541
AA Change: E493G

PolyPhen 2 Score 0.329 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000079383
Gene: ENSMUSG00000070902
AA Change: E493G

DomainStartEndE-ValueType
ZnF_C2H2 459 483 3.34e-2 SMART
ZnF_C2H2 489 513 8.22e-2 SMART
ZnF_C2H2 519 542 1.76e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000107129
AA Change: E493G

PolyPhen 2 Score 0.329 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000102746
Gene: ENSMUSG00000070902
AA Change: E493G

DomainStartEndE-ValueType
ZnF_C2H2 459 483 3.34e-2 SMART
ZnF_C2H2 489 513 8.22e-2 SMART
ZnF_C2H2 519 542 1.76e-1 SMART
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.4%
Validation Efficiency 100% (66/66)
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acaca T A 11: 84,152,450 (GRCm39) Y866N probably damaging Het
Agk A G 6: 40,371,615 (GRCm39) T371A probably benign Het
Akna T C 4: 63,316,361 (GRCm39) M1V probably null Het
Aldh7a1 T C 18: 56,683,364 (GRCm39) probably null Het
Ankrd26 A T 6: 118,484,737 (GRCm39) L1500H probably damaging Het
Atp13a5 T A 16: 29,129,584 (GRCm39) D452V probably damaging Het
Bahcc1 C T 11: 120,167,598 (GRCm39) T1333M possibly damaging Het
Carmil3 G T 14: 55,744,859 (GRCm39) R1276L possibly damaging Het
Ccni T C 5: 93,335,620 (GRCm39) S173G probably benign Het
Chrm2 A T 6: 36,500,745 (GRCm39) I201F probably damaging Het
Col16a1 A G 4: 129,970,834 (GRCm39) T618A probably benign Het
Dele1 A G 18: 38,391,418 (GRCm39) probably benign Het
Dock2 T C 11: 34,611,787 (GRCm39) Y192C probably benign Het
Ep400 T A 5: 110,877,153 (GRCm39) E821V unknown Het
Esrrg G A 1: 187,882,387 (GRCm39) V215I probably benign Het
Evx1 A T 6: 52,293,908 (GRCm39) S359C probably damaging Het
Fcrl2 A G 3: 87,166,717 (GRCm39) I92T possibly damaging Het
Gal3st1 T A 11: 3,948,110 (GRCm39) F106I possibly damaging Het
Gm9944 T C 4: 144,179,613 (GRCm39) probably benign Het
Hjurp GT GTT 1: 88,194,246 (GRCm39) probably null Het
Hrc G C 7: 44,985,757 (GRCm39) E303Q possibly damaging Het
Kcnh1 A G 1: 191,921,074 (GRCm39) N118D probably damaging Het
Khdrbs1 A G 4: 129,614,584 (GRCm39) I323T possibly damaging Het
Klhdc7b T C 15: 89,271,724 (GRCm39) Y869H probably benign Het
Lrrc4c T A 2: 97,460,306 (GRCm39) W311R probably damaging Het
Megf11 A G 9: 64,602,745 (GRCm39) D862G possibly damaging Het
Muc5b A G 7: 141,415,072 (GRCm39) T2673A possibly damaging Het
Muc5b A G 7: 141,421,442 (GRCm39) S4311G probably benign Het
Myo15a C T 11: 60,400,489 (GRCm39) A1767V possibly damaging Het
Neo1 T A 9: 58,801,161 (GRCm39) K1140M probably damaging Het
Oc90 T C 15: 65,750,650 (GRCm39) Q365R possibly damaging Het
Oplah C T 15: 76,186,294 (GRCm39) D734N possibly damaging Het
Or1e19 T C 11: 73,316,678 (GRCm39) I44V probably benign Het
Or4c58 A C 2: 89,674,687 (GRCm39) M210R possibly damaging Het
Or9g3 T C 2: 85,590,237 (GRCm39) N161S possibly damaging Het
Pbx1 G A 1: 167,986,362 (GRCm39) P411L possibly damaging Het
Pcdhga6 G T 18: 37,841,270 (GRCm39) R330L probably benign Het
Phox2b C A 5: 67,254,999 (GRCm39) R150L probably damaging Het
Plscr2 A G 9: 92,172,848 (GRCm39) E169G probably damaging Het
Ptprn2 A T 12: 116,852,497 (GRCm39) Q518L probably benign Het
Rbl1 A T 2: 157,037,505 (GRCm39) I214K probably benign Het
Ryr1 T A 7: 28,756,422 (GRCm39) Q3464L probably damaging Het
Ryr3 T A 2: 112,582,132 (GRCm39) I2854F probably damaging Het
Shtn1 T C 19: 58,963,470 (GRCm39) Y615C probably benign Het
Sirt5 A T 13: 43,536,643 (GRCm39) N226Y probably damaging Het
Slc30a3 G A 5: 31,252,422 (GRCm39) probably benign Het
Slc5a4b A G 10: 75,917,358 (GRCm39) V226A probably damaging Het
Slf2 C A 19: 44,923,390 (GRCm39) S68* probably null Het
Smyd5 G A 6: 85,419,193 (GRCm39) E292K probably damaging Het
Spns1 A G 7: 125,969,543 (GRCm39) V512A possibly damaging Het
Sry T A Y: 2,663,141 (GRCm39) Q173L unknown Het
Ssrp1 C A 2: 84,874,736 (GRCm39) Q519K probably benign Het
Tgfbr3 T C 5: 107,287,705 (GRCm39) E498G probably damaging Het
Tnrc6b T G 15: 80,764,448 (GRCm39) L650W probably damaging Het
Tnxb A T 17: 34,937,695 (GRCm39) E3861D probably damaging Het
Trbc1 G T 6: 41,516,579 (GRCm39) probably benign Het
Trpm7 T A 2: 126,668,630 (GRCm39) probably benign Het
Usp39 G A 6: 72,314,815 (GRCm39) T197I possibly damaging Het
Vmn1r38 T C 6: 66,753,477 (GRCm39) H213R possibly damaging Het
Washc2 A G 6: 116,197,529 (GRCm39) D168G probably damaging Het
Washc4 A G 10: 83,382,720 (GRCm39) I45V probably benign Het
Zfp692 C T 11: 58,200,254 (GRCm39) T170I possibly damaging Het
Zfp735 C A 11: 73,602,067 (GRCm39) S337* probably null Het
Other mutations in Zfp352
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01963:Zfp352 APN 4 90,112,391 (GRCm39) missense possibly damaging 0.95
IGL02252:Zfp352 APN 4 90,112,367 (GRCm39) missense probably benign 0.02
IGL03156:Zfp352 APN 4 90,112,324 (GRCm39) missense possibly damaging 0.57
IGL03167:Zfp352 APN 4 90,112,939 (GRCm39) missense probably damaging 0.99
IGL03190:Zfp352 APN 4 90,111,994 (GRCm39) missense possibly damaging 0.94
IGL03335:Zfp352 APN 4 90,112,583 (GRCm39) missense probably damaging 0.99
R0051:Zfp352 UTSW 4 90,112,522 (GRCm39) missense probably damaging 0.99
R0403:Zfp352 UTSW 4 90,113,246 (GRCm39) missense possibly damaging 0.60
R0550:Zfp352 UTSW 4 90,112,927 (GRCm39) missense probably damaging 0.99
R0671:Zfp352 UTSW 4 90,112,156 (GRCm39) missense probably benign
R1034:Zfp352 UTSW 4 90,112,393 (GRCm39) missense possibly damaging 0.94
R1754:Zfp352 UTSW 4 90,112,046 (GRCm39) missense probably benign 0.23
R2016:Zfp352 UTSW 4 90,113,408 (GRCm39) missense probably benign 0.42
R2064:Zfp352 UTSW 4 90,113,357 (GRCm39) missense probably benign 0.08
R2308:Zfp352 UTSW 4 90,113,480 (GRCm39) missense probably benign 0.00
R3794:Zfp352 UTSW 4 90,113,386 (GRCm39) missense probably damaging 1.00
R3795:Zfp352 UTSW 4 90,113,386 (GRCm39) missense probably damaging 1.00
R4135:Zfp352 UTSW 4 90,113,261 (GRCm39) missense probably damaging 0.96
R4356:Zfp352 UTSW 4 90,112,071 (GRCm39) missense possibly damaging 0.91
R4409:Zfp352 UTSW 4 90,113,401 (GRCm39) missense probably benign 0.00
R4590:Zfp352 UTSW 4 90,112,772 (GRCm39) missense probably damaging 0.98
R4614:Zfp352 UTSW 4 90,113,318 (GRCm39) missense probably benign 0.00
R4617:Zfp352 UTSW 4 90,113,318 (GRCm39) missense probably benign 0.00
R4618:Zfp352 UTSW 4 90,113,318 (GRCm39) missense probably benign 0.00
R4741:Zfp352 UTSW 4 90,113,177 (GRCm39) missense possibly damaging 0.94
R4931:Zfp352 UTSW 4 90,112,541 (GRCm39) missense probably damaging 0.98
R4959:Zfp352 UTSW 4 90,112,376 (GRCm39) missense probably benign 0.01
R4973:Zfp352 UTSW 4 90,112,376 (GRCm39) missense probably benign 0.01
R5167:Zfp352 UTSW 4 90,112,453 (GRCm39) missense possibly damaging 0.94
R5260:Zfp352 UTSW 4 90,112,697 (GRCm39) missense probably damaging 0.99
R5524:Zfp352 UTSW 4 90,113,341 (GRCm39) missense possibly damaging 0.95
R5942:Zfp352 UTSW 4 90,113,307 (GRCm39) missense probably damaging 0.98
R6802:Zfp352 UTSW 4 90,113,437 (GRCm39) missense probably benign 0.33
R6819:Zfp352 UTSW 4 90,112,936 (GRCm39) missense probably benign
R7072:Zfp352 UTSW 4 90,112,661 (GRCm39) missense probably benign 0.00
R7099:Zfp352 UTSW 4 90,113,117 (GRCm39) missense probably benign 0.00
R7569:Zfp352 UTSW 4 90,111,896 (GRCm39) missense possibly damaging 0.77
R7645:Zfp352 UTSW 4 90,113,014 (GRCm39) missense probably benign 0.13
R7705:Zfp352 UTSW 4 90,113,512 (GRCm39) missense possibly damaging 0.94
R8424:Zfp352 UTSW 4 90,112,480 (GRCm39) missense possibly damaging 0.87
R9180:Zfp352 UTSW 4 90,113,118 (GRCm39) missense probably benign 0.38
R9378:Zfp352 UTSW 4 90,112,575 (GRCm39) missense probably benign 0.13
R9509:Zfp352 UTSW 4 90,112,943 (GRCm39) missense probably damaging 0.99
R9623:Zfp352 UTSW 4 90,113,128 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TGGGTGAATCCTCATACCCTTC -3'
(R):5'- ACAGTCAGGTTGCAGTGGTG -3'

Sequencing Primer
(F):5'- GCTTCCAGTTTAGTCCAGAGACAG -3'
(R):5'- CAGGTTGCAGTGGTGGGTTG -3'
Posted On 2015-02-19