Incidental Mutation 'R3605:Or5k3'
ID 269068
Institutional Source Beutler Lab
Gene Symbol Or5k3
Ensembl Gene ENSMUSG00000062608
Gene Name olfactory receptor family 5 subfamily K member 3
Synonyms MOR184-5, GA_x54KRFPKG5P-55369823-55370749, Olfr195
MMRRC Submission 040670-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R3605 (G1)
Quality Score 225
Status Validated
Chromosome 16
Chromosomal Location 58969215-58970141 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 58969846 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 211 (I211T)
Ref Sequence ENSEMBL: ENSMUSP00000150249 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075381] [ENSMUST00000216957]
AlphaFold Q8VGQ6
Predicted Effect probably damaging
Transcript: ENSMUST00000075381
AA Change: I211T

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000073737
Gene: ENSMUSG00000062608
AA Change: I211T

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 4.1e-53 PFAM
Pfam:7TM_GPCR_Srsx 35 161 2.7e-8 PFAM
Pfam:7tm_1 41 307 9.4e-17 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000208239
Predicted Effect probably damaging
Transcript: ENSMUST00000216957
AA Change: I211T

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 93.3%
Validation Efficiency 95% (40/42)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankrd35 C T 3: 96,589,497 (GRCm39) Q239* probably null Het
Arid4b T C 13: 14,294,826 (GRCm39) V36A probably damaging Het
Art2b T A 7: 101,229,152 (GRCm39) N249I probably benign Het
Bpifb1 T A 2: 154,053,485 (GRCm39) N242K possibly damaging Het
Cd200r1 A G 16: 44,609,939 (GRCm39) T53A possibly damaging Het
Cracr2b C T 7: 141,046,059 (GRCm39) P370S possibly damaging Het
Crb1 T A 1: 139,165,077 (GRCm39) T1016S probably damaging Het
Esrrg A G 1: 187,943,299 (GRCm39) H424R possibly damaging Het
Fgfrl1 C A 5: 108,853,289 (GRCm39) T213K probably damaging Het
Flrt3 T A 2: 140,503,287 (GRCm39) N114Y probably damaging Het
Fsip2 T C 2: 82,815,253 (GRCm39) V3662A probably benign Het
Gabra6 T A 11: 42,205,777 (GRCm39) I359F probably benign Het
Gal A G 19: 3,464,026 (GRCm39) probably null Het
Gm10801 G C 2: 98,494,352 (GRCm39) R143T possibly damaging Het
Gm5814 G T 17: 47,721,430 (GRCm39) R48L probably damaging Het
Hcn1 G A 13: 118,111,788 (GRCm39) G584D unknown Het
Iqgap1 T C 7: 80,373,537 (GRCm39) D1484G probably benign Het
Kmt2a G A 9: 44,760,493 (GRCm39) T485M probably damaging Het
Kprp C A 3: 92,731,588 (GRCm39) Q487H unknown Het
Lctl T C 9: 64,040,475 (GRCm39) Y473H probably damaging Het
Lrrc8d G A 5: 105,974,873 (GRCm39) C93Y unknown Het
Mnt T A 11: 74,727,746 (GRCm39) S211T possibly damaging Het
Mtdh T A 15: 34,114,258 (GRCm39) probably benign Het
Nxt1 T C 2: 148,517,399 (GRCm39) W47R probably damaging Het
Or4f59 T A 2: 111,873,168 (GRCm39) I70F probably benign Het
Plekha7 T C 7: 115,763,477 (GRCm39) D313G possibly damaging Het
Ranbp10 A G 8: 106,502,667 (GRCm39) S300P probably benign Het
Rbl1 A T 2: 157,019,153 (GRCm39) F531I probably damaging Het
Rpap2 A G 5: 107,768,395 (GRCm39) D411G probably damaging Het
Sapcd1 A G 17: 35,246,781 (GRCm39) F36L probably damaging Het
Svep1 A T 4: 58,066,542 (GRCm39) S3181T probably benign Het
Tgfbr2 G A 9: 115,938,960 (GRCm39) T314I probably benign Het
Thbs4 G T 13: 92,894,467 (GRCm39) C685* probably null Het
Tk2 A G 8: 104,957,803 (GRCm39) V181A possibly damaging Het
Traf2 T C 2: 25,420,427 (GRCm39) T141A probably benign Het
Ttn C T 2: 76,661,788 (GRCm39) probably null Het
Ube3c A G 5: 29,803,936 (GRCm39) T180A possibly damaging Het
Yif1b C T 7: 28,937,835 (GRCm39) A7V possibly damaging Het
Zfp738 A T 13: 67,819,508 (GRCm39) L151* probably null Het
Other mutations in Or5k3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01937:Or5k3 APN 16 58,969,827 (GRCm39) missense probably benign 0.01
IGL01945:Or5k3 APN 16 58,969,827 (GRCm39) missense probably benign 0.01
R0071:Or5k3 UTSW 16 58,969,578 (GRCm39) missense probably benign 0.23
R0390:Or5k3 UTSW 16 58,969,662 (GRCm39) missense probably benign 0.01
R0601:Or5k3 UTSW 16 58,970,117 (GRCm39) missense probably benign 0.00
R1499:Or5k3 UTSW 16 58,969,287 (GRCm39) missense probably benign
R1612:Or5k3 UTSW 16 58,969,987 (GRCm39) missense probably benign 0.00
R1785:Or5k3 UTSW 16 58,969,660 (GRCm39) missense probably damaging 1.00
R2082:Or5k3 UTSW 16 58,969,248 (GRCm39) missense probably damaging 0.99
R4168:Or5k3 UTSW 16 58,969,363 (GRCm39) missense probably benign 0.00
R4839:Or5k3 UTSW 16 58,969,393 (GRCm39) missense probably damaging 1.00
R4989:Or5k3 UTSW 16 58,969,981 (GRCm39) missense probably damaging 1.00
R5285:Or5k3 UTSW 16 58,969,633 (GRCm39) missense probably damaging 1.00
R7107:Or5k3 UTSW 16 58,969,279 (GRCm39) missense probably benign 0.10
R7136:Or5k3 UTSW 16 58,969,327 (GRCm39) missense probably damaging 1.00
R7317:Or5k3 UTSW 16 58,969,684 (GRCm39) missense possibly damaging 0.80
R7601:Or5k3 UTSW 16 58,969,597 (GRCm39) missense probably benign 0.01
R7729:Or5k3 UTSW 16 58,969,570 (GRCm39) missense probably damaging 1.00
R8004:Or5k3 UTSW 16 58,969,351 (GRCm39) missense probably damaging 1.00
R8208:Or5k3 UTSW 16 58,969,382 (GRCm39) missense probably benign 0.41
R8282:Or5k3 UTSW 16 58,969,529 (GRCm39) nonsense probably null
R8954:Or5k3 UTSW 16 58,969,319 (GRCm39) nonsense probably null
R9137:Or5k3 UTSW 16 58,969,635 (GRCm39) missense probably benign 0.30
R9197:Or5k3 UTSW 16 58,969,489 (GRCm39) missense probably damaging 0.99
R9396:Or5k3 UTSW 16 58,969,302 (GRCm39) missense probably damaging 0.97
R9547:Or5k3 UTSW 16 58,970,107 (GRCm39) missense possibly damaging 0.89
Predicted Primers PCR Primer
(F):5'- TGATGTCCAAGAAGCTCTGC -3'
(R):5'- CTCCTTCATTGGCTGAATGTG -3'

Sequencing Primer
(F):5'- TGCCTTCAAATGACCATGGG -3'
(R):5'- CTGAATGTGGTTGAGCATACATG -3'
Posted On 2015-02-19