Incidental Mutation 'R3607:Gmfg'
Institutional Source Beutler Lab
Gene Symbol Gmfg
Ensembl Gene ENSMUSG00000060791
Gene Nameglia maturation factor, gamma
Synonyms2310057N07Rik, 0610039G16Rik
MMRRC Submission 040671-MU
Accession Numbers
Is this an essential gene? Not available question?
Stock #R3607 (G1)
Quality Score173
Status Not validated
Chromosomal Location28437447-28448233 bp(+) (GRCm38)
Type of Mutationsplice site (6 bp from exon)
DNA Base Change (assembly) T to A at 28441536 bp
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000119321 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000040531] [ENSMUST00000078845] [ENSMUST00000108289] [ENSMUST00000108292] [ENSMUST00000135686]
Predicted Effect probably benign
Transcript: ENSMUST00000040531
SMART Domains Protein: ENSMUSP00000040486
Gene: ENSMUSG00000109336

low complexity region 81 90 N/A INTRINSIC
low complexity region 174 190 N/A INTRINSIC
low complexity region 200 211 N/A INTRINSIC
low complexity region 278 290 N/A INTRINSIC
SAM 296 359 1.02e-9 SMART
low complexity region 406 420 N/A INTRINSIC
low complexity region 433 461 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000078845
SMART Domains Protein: ENSMUSP00000077889
Gene: ENSMUSG00000060791

ADF 12 139 2.54e-35 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000108289
SMART Domains Protein: ENSMUSP00000103924
Gene: ENSMUSG00000060791

ADF 2 98 1.56e-12 SMART
Predicted Effect probably null
Transcript: ENSMUST00000108292
SMART Domains Protein: ENSMUSP00000103927
Gene: ENSMUSG00000060791

ADF 12 139 2.54e-35 SMART
Predicted Effect probably null
Transcript: ENSMUST00000135686
SMART Domains Protein: ENSMUSP00000119321
Gene: ENSMUSG00000060791

Pfam:Cofilin_ADF 1 87 2.2e-20 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000138741
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 93.3%
Validation Efficiency 98% (48/49)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930510E17Rik C A 9: 53,279,783 noncoding transcript Het
Adnp2 A T 18: 80,129,069 N708K probably damaging Het
Arhgef17 C A 7: 100,931,172 G190W probably damaging Het
Aspm T A 1: 139,480,668 M2431K probably benign Het
Aurkc A G 7: 7,002,860 Y157C probably damaging Het
Bpifb1 T A 2: 154,211,565 N242K possibly damaging Het
Cracr2b C T 7: 141,466,146 P370S possibly damaging Het
Etv1 A G 12: 38,831,086 Y66C probably damaging Het
F830016B08Rik A T 18: 60,300,708 K288* probably null Het
Fam131a C T 16: 20,701,595 P181L probably damaging Het
Fat2 T A 11: 55,281,685 E2734V probably damaging Het
Fgfrl1 C A 5: 108,705,423 T213K probably damaging Het
Gtpbp8 T C 16: 44,743,756 Y184C probably damaging Het
Heatr5b T C 17: 78,834,217 E2G probably damaging Het
Itpr2 T G 6: 146,227,601 T2005P probably damaging Het
Kmt2a G A 9: 44,849,196 T485M probably damaging Het
Kng1 T C 16: 23,067,802 F112L probably damaging Het
Kprp C A 3: 92,824,281 Q487H unknown Het
Lctl T C 9: 64,133,193 Y473H probably damaging Het
Lpin2 T A 17: 71,229,392 D225E probably damaging Het
Myom2 T C 8: 15,069,775 V177A probably damaging Het
Nkrf T G X: 36,890,077 N184T probably benign Het
Nt5c1b A G 12: 10,377,236 N329D probably damaging Het
Ogdhl T A 14: 32,335,361 V308E probably damaging Het
Olfr304 A G 7: 86,385,695 C322R probably benign Het
Pcnx T A 12: 81,928,292 F791I probably damaging Het
Prkg2 G T 5: 98,947,377 T616K probably damaging Het
Psmd3 C T 11: 98,690,954 R302W probably damaging Het
Ptpn1 A G 2: 167,975,507 S355G probably benign Het
Pxdn A G 12: 29,990,918 N398D probably benign Het
Ranbp10 A G 8: 105,776,035 S300P probably benign Het
Rbl1 A T 2: 157,177,233 F531I probably damaging Het
Rgl3 A G 9: 21,987,691 S151P probably damaging Het
Rnf213 C A 11: 119,441,976 C2670* probably null Het
Tex16 T A X: 112,093,970 S159T probably damaging Het
Tnfaip3 A G 10: 19,005,602 I312T probably damaging Het
Traf2 T C 2: 25,530,415 T141A probably benign Het
Trpm7 T C 2: 126,796,428 probably benign Het
Usp11 T G X: 20,714,632 F426L probably damaging Het
Vcan G T 13: 89,703,301 T1180K probably damaging Het
Wasf1 G C 10: 40,936,384 A390P unknown Het
Yif1b C T 7: 29,238,410 A7V possibly damaging Het
Other mutations in Gmfg
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00498:Gmfg APN 7 28446385 missense possibly damaging 0.76
IGL01581:Gmfg APN 7 28443221 missense probably benign 0.03
IGL02691:Gmfg APN 7 28444870 missense probably damaging 0.98
R0670:Gmfg UTSW 7 28441528 missense probably damaging 0.98
R4332:Gmfg UTSW 7 28437572 start codon destroyed probably benign 0.00
R4583:Gmfg UTSW 7 28445944 missense probably damaging 1.00
R5348:Gmfg UTSW 7 28446394 missense probably benign 0.18
X0021:Gmfg UTSW 7 28445940 missense probably benign 0.03
Predicted Primers PCR Primer

Sequencing Primer
Posted On2015-02-19