Incidental Mutation 'R3613:Or6c5c'
ID 269289
Institutional Source Beutler Lab
Gene Symbol Or6c5c
Ensembl Gene ENSMUSG00000096497
Gene Name olfactory receptor family 6 subfamily C member 5C
Synonyms MOR111-10, GA_x6K02T2PULF-11141498-11142436, Olfr787
Accession Numbers
Essential gene? Probably non essential (E-score: 0.063) question?
Stock # R3613 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 129297809-129299485 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 129298937 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 131 (T131S)
Ref Sequence ENSEMBL: ENSMUSP00000149391 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000077836] [ENSMUST00000213329]
AlphaFold Q7TRI1
Predicted Effect probably benign
Transcript: ENSMUST00000077836
AA Change: T131S

PolyPhen 2 Score 0.288 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000077005
Gene: ENSMUSG00000096497
AA Change: T131S

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 4e-49 PFAM
Pfam:7tm_1 39 288 2.1e-20 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213329
AA Change: T131S

PolyPhen 2 Score 0.288 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.1%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 17 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc4 C T 14: 118,864,863 (GRCm39) probably null Het
Ccdc110 T A 8: 46,395,843 (GRCm39) M578K possibly damaging Het
Ctsh A C 9: 89,957,763 (GRCm39) M281L probably damaging Het
Fabp3 C T 4: 130,206,180 (GRCm39) T57I probably benign Het
Hinfp T C 9: 44,209,041 (GRCm39) H359R probably damaging Het
Hps5 A G 7: 46,426,298 (GRCm39) probably null Het
Lsamp T C 16: 41,775,686 (GRCm39) V179A probably benign Het
Nr1i3 T A 1: 171,042,564 (GRCm39) C63* probably null Het
Pdk2 T C 11: 94,918,072 (GRCm39) E387G probably benign Het
Pelp1 T C 11: 70,286,261 (GRCm39) N572S probably benign Het
Rdh16f2 A T 10: 127,710,808 (GRCm39) I142F probably benign Het
Sdk1 A T 5: 142,105,441 (GRCm39) H1515L probably damaging Het
Sema5b C T 16: 35,480,520 (GRCm39) T729I probably benign Het
Tgfbi G A 13: 56,773,539 (GRCm39) R179Q probably damaging Het
Vmn1r27 A T 6: 58,192,787 (GRCm39) N72K probably damaging Het
Vps13a G A 19: 16,662,766 (GRCm39) T1573M probably damaging Het
Vrk3 C T 7: 44,424,866 (GRCm39) T427M probably benign Het
Other mutations in Or6c5c
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0384:Or6c5c UTSW 10 129,298,909 (GRCm39) nonsense probably null
R1851:Or6c5c UTSW 10 129,299,370 (GRCm39) missense probably damaging 1.00
R2211:Or6c5c UTSW 10 129,298,809 (GRCm39) missense probably damaging 1.00
R3701:Or6c5c UTSW 10 129,298,821 (GRCm39) missense probably damaging 1.00
R3702:Or6c5c UTSW 10 129,298,821 (GRCm39) missense probably damaging 1.00
R4496:Or6c5c UTSW 10 129,299,430 (GRCm39) missense possibly damaging 0.93
R5745:Or6c5c UTSW 10 129,299,307 (GRCm39) missense probably damaging 1.00
R6791:Or6c5c UTSW 10 129,299,023 (GRCm39) missense probably benign 0.00
R7190:Or6c5c UTSW 10 129,298,626 (GRCm39) missense probably benign 0.00
R7278:Or6c5c UTSW 10 129,298,620 (GRCm39) missense probably damaging 1.00
R7313:Or6c5c UTSW 10 129,298,856 (GRCm39) missense probably damaging 0.98
R7369:Or6c5c UTSW 10 129,299,390 (GRCm39) missense probably benign
R7824:Or6c5c UTSW 10 129,298,665 (GRCm39) missense probably damaging 1.00
R7851:Or6c5c UTSW 10 129,299,429 (GRCm39) missense probably benign 0.36
R8961:Or6c5c UTSW 10 129,299,225 (GRCm39) missense probably damaging 1.00
R9635:Or6c5c UTSW 10 129,299,463 (GRCm39) missense probably benign 0.00
R9775:Or6c5c UTSW 10 129,298,677 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- GTGTCACTGGAAACCTAACCATC -3'
(R):5'- TCTGAGCAGGAGAGCTGTAG -3'

Sequencing Primer
(F):5'- TGCTAGACTCTCAGTTAAAGACTCC -3'
(R):5'- CTGTAGAATGGGGAAGTAGTCAC -3'
Posted On 2015-02-19