Incidental Mutation 'R3625:Thy1'
ID 269380
Institutional Source Beutler Lab
Gene Symbol Thy1
Ensembl Gene ENSMUSG00000032011
Gene Name thymus cell antigen 1, theta
Synonyms Thy1.2, Thy1.1, Thy 1.2, Thy-1, Thy-1.2, T25, CD90
MMRRC Submission 040679-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R3625 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 43954681-43959876 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 43958028 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Glycine at position 52 (E52G)
Ref Sequence ENSEMBL: ENSMUSP00000150960 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114840] [ENSMUST00000214627] [ENSMUST00000215156] [ENSMUST00000215809]
AlphaFold P01831
Predicted Effect probably damaging
Transcript: ENSMUST00000114840
AA Change: E52G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110489
Gene: ENSMUSG00000032011
AA Change: E52G

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
IGv 33 107 2.13e-7 SMART
low complexity region 145 154 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213632
Predicted Effect noncoding transcript
Transcript: ENSMUST00000213733
Predicted Effect probably benign
Transcript: ENSMUST00000214627
Predicted Effect probably benign
Transcript: ENSMUST00000215156
Predicted Effect probably damaging
Transcript: ENSMUST00000215809
AA Change: E52G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.6705 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.1%
Validation Efficiency 100% (40/40)
MGI Phenotype FUNCTION: This gene encodes a glycoprotein that is anchored to the cell surface of thymocytes, neuronal and other cells through a glycosyl-phosphatidylinositol moiety. A soluble form of the encoded protein has also been detected in serum and cerebrospinal fluid. The encoded protein undergoes further processing to generate the mature protein which mediates cell-cell interactions to trigger downstream signaling pathways. [provided by RefSeq, Jul 2015]
PHENOTYPE: Homozygous null mice are viable, fertile, and display no abnormalities in the brain and spinal cord, have normal axonal development and regeneration and no behavioral abnormalities. Long term potentiation is inhibited in the dentate gyrus. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acte1 T C 7: 143,425,591 (GRCm39) V80A possibly damaging Het
Arsi G A 18: 61,049,723 (GRCm39) G202E probably benign Het
Atg3 T A 16: 44,995,624 (GRCm39) I119N probably benign Het
Cdh12 G C 15: 21,358,842 (GRCm39) V89L probably damaging Het
Cdh3 C A 8: 107,270,310 (GRCm39) H396N probably damaging Het
Crygs C T 16: 22,624,301 (GRCm39) G102D possibly damaging Het
Dab2ip C A 2: 35,533,903 (GRCm39) S43* probably null Het
Dmxl2 A G 9: 54,300,927 (GRCm39) S2394P probably benign Het
F13a1 T G 13: 37,082,067 (GRCm39) N546H probably benign Het
Fbn2 T C 18: 58,194,814 (GRCm39) N1449S probably damaging Het
Flywch1 T C 17: 23,979,175 (GRCm39) probably benign Het
Grxcr2 T A 18: 42,131,883 (GRCm39) D62V probably damaging Het
H2bc8 T C 13: 23,755,625 (GRCm39) probably benign Het
Ifnab A T 4: 88,609,016 (GRCm39) I150N probably damaging Het
Igsf8 T C 1: 172,145,336 (GRCm39) V284A probably benign Het
Kdm1a T C 4: 136,288,419 (GRCm39) E388G possibly damaging Het
Map3k8 G A 18: 4,333,965 (GRCm39) R376C probably damaging Het
Map6 A T 7: 98,918,402 (GRCm39) T189S possibly damaging Het
Mms22l T A 4: 24,505,357 (GRCm39) S206T probably damaging Het
N4bp1 A G 8: 87,578,337 (GRCm39) L676S probably damaging Het
Nkx6-2 A G 7: 139,162,106 (GRCm39) F117S possibly damaging Het
Ociad2 C T 5: 73,481,173 (GRCm39) C72Y probably damaging Het
Or10w1 T A 19: 13,632,346 (GRCm39) C184* probably null Het
Or52e15 A T 7: 104,645,191 (GRCm39) F307I probably benign Het
Pcdhb6 G T 18: 37,469,193 (GRCm39) V21L probably damaging Het
Pogk G A 1: 166,231,081 (GRCm39) T82I probably damaging Het
Pramel51 T C 12: 88,142,731 (GRCm39) S296G probably benign Het
Prkcsh A G 9: 21,922,548 (GRCm39) E283G probably null Het
Prkd3 C T 17: 79,292,733 (GRCm39) R113H probably damaging Het
Rabgef1 T C 5: 130,240,961 (GRCm39) probably null Het
Rec8 T C 14: 55,859,954 (GRCm39) I234T possibly damaging Het
Sim1 A T 10: 50,857,432 (GRCm39) H394L probably benign Het
Trav14n-3 A T 14: 53,607,543 (GRCm39) I4F probably damaging Het
Trim15 T C 17: 37,177,768 (GRCm39) T76A possibly damaging Het
Ttn A G 2: 76,599,145 (GRCm39) I19288T probably damaging Het
Vmn1r6 C T 6: 56,979,920 (GRCm39) T172I probably damaging Het
Vmn2r52 A T 7: 9,893,105 (GRCm39) L678Q probably damaging Het
Vpreb1a T C 16: 16,686,668 (GRCm39) H74R probably benign Het
Yeats4 T C 10: 117,056,273 (GRCm39) I100V probably benign Het
Zfp36 C A 7: 28,077,681 (GRCm39) A76S probably benign Het
Other mutations in Thy1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02832:Thy1 APN 9 43,958,111 (GRCm39) missense probably benign 0.00
R0551:Thy1 UTSW 9 43,958,645 (GRCm39) missense probably damaging 1.00
R0621:Thy1 UTSW 9 43,958,030 (GRCm39) missense probably damaging 1.00
R1774:Thy1 UTSW 9 43,958,636 (GRCm39) missense probably benign 0.07
R4724:Thy1 UTSW 9 43,958,645 (GRCm39) missense probably damaging 1.00
R7190:Thy1 UTSW 9 43,958,222 (GRCm39) missense possibly damaging 0.84
R7667:Thy1 UTSW 9 43,958,732 (GRCm39) missense probably damaging 1.00
R7684:Thy1 UTSW 9 43,957,855 (GRCm39) missense unknown
R9022:Thy1 UTSW 9 43,957,947 (GRCm39) missense probably damaging 1.00
R9227:Thy1 UTSW 9 43,958,004 (GRCm39) missense probably damaging 0.99
R9326:Thy1 UTSW 9 43,957,983 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CAATACCTCAAGGGCGAGTG -3'
(R):5'- GAAGCTCACAAAAGTAGTCGC -3'

Sequencing Primer
(F):5'- CAAGTCTACTTTTCCTGCAGGTGG -3'
(R):5'- AAAAGTAGTCGCCCTCATCCTTGG -3'
Posted On 2015-02-19