Incidental Mutation 'IGL00955:Meig1'
ID26959
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Meig1
Ensembl Gene ENSMUSG00000026650
Gene Namemeiosis expressed gene 1
SynonymsMeg1
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.160) question?
Stock #IGL00955
Quality Score
Status
Chromosome2
Chromosomal Location3409043-3422648 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 3409274 bp
ZygosityHeterozygous
Amino Acid Change Aspartic acid to Glycine at position 63 (D63G)
Ref Sequence ENSEMBL: ENSMUSP00000123118 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000064685] [ENSMUST00000115081] [ENSMUST00000115082] [ENSMUST00000115083] [ENSMUST00000115084] [ENSMUST00000144584]
Predicted Effect probably damaging
Transcript: ENSMUST00000064685
AA Change: D63G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000070310
Gene: ENSMUSG00000026650
AA Change: D63G

DomainStartEndE-ValueType
Pfam:Meiosis_expr 11 87 1.4e-42 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000115081
AA Change: D63G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110733
Gene: ENSMUSG00000026650
AA Change: D63G

DomainStartEndE-ValueType
Pfam:Meiosis_expr 11 86 6.3e-43 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000115082
AA Change: D63G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110734
Gene: ENSMUSG00000026650
AA Change: D63G

DomainStartEndE-ValueType
Pfam:Meiosis_expr 11 87 1.4e-42 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000115083
AA Change: D63G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110735
Gene: ENSMUSG00000026650
AA Change: D63G

DomainStartEndE-ValueType
Pfam:Meiosis_expr 11 87 1.4e-42 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000115084
AA Change: D63G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000110736
Gene: ENSMUSG00000026650
AA Change: D63G

DomainStartEndE-ValueType
Pfam:Meiosis_expr 11 87 1.4e-42 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000144584
AA Change: D63G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000123118
Gene: ENSMUSG00000026650
AA Change: D63G

DomainStartEndE-ValueType
Pfam:Meiosis_expr 11 65 6.1e-29 PFAM
Meta Mutation Damage Score 0.2459 question?
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit male sterility with arrested spermatogenesis, absent sperm flagellum, and deformed sperm heads. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arl11 A T 14: 61,311,242 Q167L probably benign Het
Ces3a T A 8: 105,050,570 V175E probably damaging Het
Cherp C T 8: 72,470,194 E140K probably damaging Het
Clpx A T 9: 65,324,270 T546S probably damaging Het
Csgalnact2 A G 6: 118,129,264 L31P probably damaging Het
Cxcr1 A T 1: 74,192,220 F214L probably benign Het
Cyp2c67 T A 19: 39,643,385 T123S possibly damaging Het
Dbt G A 3: 116,546,114 G384S probably benign Het
Dzank1 G A 2: 144,490,174 T414I probably benign Het
Erich3 A G 3: 154,748,519 I641V probably benign Het
Gtf2e1 A T 16: 37,535,920 D83E possibly damaging Het
Hars2 T C 18: 36,789,357 probably benign Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Kcnh2 T C 5: 24,324,966 D372G probably damaging Het
Kcnk2 A T 1: 189,243,014 I264N probably damaging Het
Kctd4 A G 14: 75,963,228 D213G probably damaging Het
Lhx9 T C 1: 138,828,680 T323A possibly damaging Het
Lilra6 C A 7: 3,911,404 probably benign Het
Mov10l1 A G 15: 88,994,989 Y184C probably damaging Het
Mrpl24 T A 3: 87,922,219 L91* probably null Het
Mup11 C T 4: 60,659,550 R175H probably benign Het
Nbea T C 3: 56,005,472 K965E possibly damaging Het
Olfr598 C A 7: 103,329,321 H278Q probably damaging Het
Papss1 G A 3: 131,599,949 E252K probably benign Het
Robo2 A T 16: 74,015,972 L278Q probably damaging Het
Sned1 A T 1: 93,274,403 I638F probably damaging Het
Spin1 T C 13: 51,144,541 probably null Het
Taar9 T C 10: 24,109,531 T2A probably benign Het
Tbc1d8b T C X: 139,725,880 probably null Het
Other mutations in Meig1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01311:Meig1 APN 2 3409208 missense possibly damaging 0.78
IGL02329:Meig1 APN 2 3409251 missense probably damaging 0.97
IGL02730:Meig1 APN 2 3411910 missense probably damaging 1.00
R1119:Meig1 UTSW 2 3409274 missense probably damaging 1.00
R1681:Meig1 UTSW 2 3409274 missense probably damaging 1.00
R2155:Meig1 UTSW 2 3409253 missense probably benign 0.08
R4387:Meig1 UTSW 2 3409241 missense probably damaging 1.00
R4787:Meig1 UTSW 2 3409214 missense possibly damaging 0.95
R4814:Meig1 UTSW 2 3411922 missense probably benign 0.14
R5145:Meig1 UTSW 2 3409226 missense probably damaging 0.98
R5694:Meig1 UTSW 2 3411962 missense probably damaging 0.99
R7843:Meig1 UTSW 2 3409211 missense probably damaging 1.00
R7926:Meig1 UTSW 2 3409211 missense probably damaging 1.00
R8061:Meig1 UTSW 2 3409203 missense not run
Posted On2013-04-17