Incidental Mutation 'IGL00960:Fastkd1'
ID26971
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fastkd1
Ensembl Gene ENSMUSG00000027086
Gene NameFAST kinase domains 1
Synonyms5330408N05Rik
Accession Numbers
Is this an essential gene? Possibly essential (E-score: 0.550) question?
Stock #IGL00960
Quality Score
Status
Chromosome2
Chromosomal Location69686815-69713516 bp(-) (GRCm38)
Type of Mutationsplice site
DNA Base Change (assembly) A to T at 69694653 bp
ZygosityHeterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000099767 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000073152] [ENSMUST00000102706]
Predicted Effect probably benign
Transcript: ENSMUST00000073152
SMART Domains Protein: ENSMUSP00000072896
Gene: ENSMUSG00000027086

DomainStartEndE-ValueType
low complexity region 179 191 N/A INTRINSIC
low complexity region 316 324 N/A INTRINSIC
low complexity region 385 396 N/A INTRINSIC
low complexity region 461 472 N/A INTRINSIC
Pfam:FAST_1 560 628 6.6e-25 PFAM
Pfam:FAST_2 645 730 6.4e-26 PFAM
RAP 763 822 4.38e-25 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000102706
SMART Domains Protein: ENSMUSP00000099767
Gene: ENSMUSG00000027086

DomainStartEndE-ValueType
low complexity region 179 191 N/A INTRINSIC
low complexity region 316 324 N/A INTRINSIC
low complexity region 385 396 N/A INTRINSIC
low complexity region 461 472 N/A INTRINSIC
Pfam:FAST_1 530 600 2.2e-26 PFAM
Pfam:FAST_2 614 701 4.4e-31 PFAM
RAP 734 793 4.38e-25 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 29 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 C A 17: 46,323,745 R444L probably damaging Het
Baiap2 T A 11: 119,999,292 S460T possibly damaging Het
Cckar A G 5: 53,701,292 Y158H probably damaging Het
Cdk4 A G 10: 127,064,297 Y21C probably damaging Het
Entpd1 C T 19: 40,711,270 P42S probably benign Het
Epha8 A T 4: 136,951,839 probably null Het
Fmnl2 A G 2: 53,123,482 D951G probably damaging Het
Hnrnpm C A 17: 33,649,902 R517L probably damaging Het
Kcnj5 T A 9: 32,322,423 T199S probably damaging Het
Med13 T C 11: 86,291,040 probably benign Het
Mycbp2 G T 14: 103,229,384 H1314Q possibly damaging Het
Ncapd2 A T 6: 125,173,848 S795T probably benign Het
Nf1 T C 11: 79,445,121 S1042P probably damaging Het
Nlgn1 C A 3: 25,912,697 L197F probably damaging Het
Nsun7 A G 5: 66,289,503 Y428C probably benign Het
Olfr976 A G 9: 39,956,159 Y259H probably damaging Het
Parp14 T C 16: 35,841,219 D1453G probably benign Het
Pcdhb8 A T 18: 37,355,973 I235F probably benign Het
Pclo T C 5: 14,675,220 V1364A unknown Het
Polq T C 16: 37,060,512 S734P probably damaging Het
Sco1 T C 11: 67,064,038 *290Q probably null Het
Slc22a3 A T 17: 12,425,610 I496N probably damaging Het
Slc5a8 T G 10: 88,921,765 I539S probably benign Het
Tecta A G 9: 42,359,080 F1311L possibly damaging Het
Tex261 A T 6: 83,775,668 I19N possibly damaging Het
Tfr2 T C 5: 137,571,692 V120A probably benign Het
Vmn2r71 A T 7: 85,624,374 S799C probably damaging Het
Zar1 G A 5: 72,577,285 T197I probably damaging Het
Zfa-ps A G 10: 52,543,947 noncoding transcript Het
Other mutations in Fastkd1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00163:Fastkd1 APN 2 69707549 missense probably benign 0.02
IGL00702:Fastkd1 APN 2 69708545 missense probably damaging 0.99
IGL01154:Fastkd1 APN 2 69690060 splice site probably null
IGL01463:Fastkd1 APN 2 69690061 critical splice donor site probably null
IGL01913:Fastkd1 APN 2 69708501 splice site probably benign
IGL01977:Fastkd1 APN 2 69694588 missense possibly damaging 0.64
IGL02408:Fastkd1 APN 2 69702601 missense probably benign
IGL02715:Fastkd1 APN 2 69712125 critical splice donor site probably null
IGL03411:Fastkd1 APN 2 69707359 missense probably damaging 0.99
PIT4519001:Fastkd1 UTSW 2 69690157 missense probably damaging 0.97
R0541:Fastkd1 UTSW 2 69702406 missense probably damaging 1.00
R0612:Fastkd1 UTSW 2 69712383 missense probably benign 0.03
R1170:Fastkd1 UTSW 2 69708649 splice site probably benign
R1499:Fastkd1 UTSW 2 69708638 critical splice acceptor site probably null
R1586:Fastkd1 UTSW 2 69712148 missense probably benign 0.43
R1698:Fastkd1 UTSW 2 69702469 missense probably benign 0.22
R2172:Fastkd1 UTSW 2 69700133 missense probably damaging 1.00
R2240:Fastkd1 UTSW 2 69696953 missense probably benign 0.01
R2327:Fastkd1 UTSW 2 69705528 nonsense probably null
R2897:Fastkd1 UTSW 2 69702616 missense probably damaging 1.00
R4120:Fastkd1 UTSW 2 69707310 missense probably damaging 0.98
R4544:Fastkd1 UTSW 2 69712311 missense probably damaging 1.00
R4546:Fastkd1 UTSW 2 69712311 missense probably damaging 1.00
R4798:Fastkd1 UTSW 2 69691307 missense probably benign 0.38
R4993:Fastkd1 UTSW 2 69702740 missense probably damaging 0.99
R5284:Fastkd1 UTSW 2 69712188 missense probably benign 0.01
R5668:Fastkd1 UTSW 2 69707381 missense possibly damaging 0.92
R6869:Fastkd1 UTSW 2 69702760 missense probably benign 0.02
R6870:Fastkd1 UTSW 2 69708614 missense probably benign 0.05
R7062:Fastkd1 UTSW 2 69704322 missense possibly damaging 0.74
R7576:Fastkd1 UTSW 2 69694644 missense probably damaging 1.00
Posted On2013-04-17