Incidental Mutation 'R3698:Btg3'
ID 269899
Institutional Source Beutler Lab
Gene Symbol Btg3
Ensembl Gene ENSMUSG00000022863
Gene Name BTG anti-proliferation factor 3
Synonyms tob5, ANA
Accession Numbers
Essential gene? Probably non essential (E-score: 0.139) question?
Stock # R3698 (G1)
Quality Score 204
Status Not validated
Chromosome 16
Chromosomal Location 78156748-78174069 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 78161722 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 136 (S136P)
Ref Sequence ENSEMBL: ENSMUSP00000156138 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023570] [ENSMUST00000148124] [ENSMUST00000231353]
AlphaFold P50615
Predicted Effect probably benign
Transcript: ENSMUST00000023570
AA Change: S163P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000023570
Gene: ENSMUSG00000022863
AA Change: S163P

DomainStartEndE-ValueType
btg1 1 108 1.28e-81 SMART
low complexity region 140 154 N/A INTRINSIC
low complexity region 206 216 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000148124
SMART Domains Protein: ENSMUSP00000119706
Gene: ENSMUSG00000022863

DomainStartEndE-ValueType
btg1 1 108 1.28e-81 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000231353
AA Change: S136P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.2%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes B cell translocation gene 3, a member of the BTG gene family. This family is defined by a conserved N-terminal domain, known to bind transcription factors, and a less conserved C-terminal domain. This protein is thought to have anti-proliferative properties, and may be involved in regulating the G1-S transition to suppress cell cycle progression. Mice deficient for this gene display an increased incidence of lung cancers, and many human lung cancer cells exhibit decreased levels of B cell translocation gene 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 17. [provided by RefSeq, Jul 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased incidence of lung tumors. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Afap1l2 C A 19: 56,904,955 (GRCm39) S549I possibly damaging Het
Aldh4a1 A G 4: 139,369,562 (GRCm39) H371R possibly damaging Het
Arpc1a G T 5: 145,033,001 (GRCm39) K103N probably damaging Het
Ckap5 C A 2: 91,450,511 (GRCm39) T2014K probably benign Het
Dennd10 A G 19: 60,821,054 (GRCm39) probably null Het
Emc1 T G 4: 139,092,697 (GRCm39) S546A possibly damaging Het
G3bp2 T C 5: 92,204,139 (GRCm39) E316G possibly damaging Het
Il12a TCAC TC 3: 68,605,320 (GRCm39) probably null Het
Il6st T G 13: 112,640,916 (GRCm39) D897E probably benign Het
Ipo13 A G 4: 117,757,890 (GRCm39) L767P probably damaging Het
Kcnd3 C T 3: 105,566,082 (GRCm39) A421V probably damaging Het
Klhl13 G A X: 23,114,422 (GRCm39) T94I probably benign Het
Morc2a A T 11: 3,629,672 (GRCm39) K364* probably null Het
Nat8f2 T A 6: 85,844,778 (GRCm39) T195S probably benign Het
Nckipsd G A 9: 108,688,320 (GRCm39) G83S probably damaging Het
Nfu1 A G 6: 86,992,634 (GRCm39) T83A probably damaging Het
Nid1 G A 13: 13,661,344 (GRCm39) C748Y probably damaging Het
Or1af1 C T 2: 37,110,188 (GRCm39) P229L probably damaging Het
Or5w15 T C 2: 87,568,360 (GRCm39) T103A probably benign Het
Rgs22 C T 15: 36,100,038 (GRCm39) V226I probably benign Het
Slc13a4 T A 6: 35,251,892 (GRCm39) I467F probably benign Het
Stat2 T A 10: 128,114,662 (GRCm39) L253Q probably benign Het
Tnxb G T 17: 34,909,407 (GRCm39) probably null Het
Ttn C T 2: 76,564,595 (GRCm39) R28514H probably damaging Het
Usp15 T C 10: 123,017,643 (GRCm39) D51G probably damaging Het
Uvrag T C 7: 98,589,150 (GRCm39) E417G probably damaging Het
Other mutations in Btg3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0578:Btg3 UTSW 16 78,161,834 (GRCm39) missense probably benign 0.24
R1467:Btg3 UTSW 16 78,161,688 (GRCm39) critical splice donor site probably null
R1467:Btg3 UTSW 16 78,161,688 (GRCm39) critical splice donor site probably null
R2860:Btg3 UTSW 16 78,161,868 (GRCm39) missense probably damaging 1.00
R2861:Btg3 UTSW 16 78,161,868 (GRCm39) missense probably damaging 1.00
R2862:Btg3 UTSW 16 78,161,868 (GRCm39) missense probably damaging 1.00
R6938:Btg3 UTSW 16 78,157,216 (GRCm39) missense probably benign 0.01
R7336:Btg3 UTSW 16 78,161,695 (GRCm39) missense probably benign 0.15
R8930:Btg3 UTSW 16 78,170,298 (GRCm39) missense probably benign 0.01
R8932:Btg3 UTSW 16 78,170,298 (GRCm39) missense probably benign 0.01
RF007:Btg3 UTSW 16 78,129,836 (GRCm39) makesense probably null
Predicted Primers PCR Primer
(F):5'- CCAGTTGCATCTCTGATAAGCAG -3'
(R):5'- TCATGTCCACCTAGGTATGGAG -3'

Sequencing Primer
(F):5'- AAGCAGCTTTCCACTAGTGTG -3'
(R):5'- TCCACCTAGGTATGGAGAGAAAAAC -3'
Posted On 2015-03-18