Incidental Mutation 'IGL00969:Olfr1008'
ID 26995
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr1008
Ensembl Gene ENSMUSG00000050603
Gene Name olfactory receptor 1008
Synonyms MOR187-3, GA_x6K02T2Q125-47170431-47171372
Accession Numbers
Essential gene? Probably non essential (E-score: 0.090) question?
Stock # IGL00969
Quality Score
Chromosome 2
Chromosomal Location 85689431-85690372 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 85689663 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 78 (C78Y)
Ref Sequence ENSEMBL: ENSMUSP00000061191 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000054868]
AlphaFold Q8VGC7
Predicted Effect probably benign
Transcript: ENSMUST00000054868
AA Change: C78Y

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000061191
Gene: ENSMUSG00000050603
AA Change: C78Y

Pfam:7tm_4 31 308 1.9e-46 PFAM
Pfam:7tm_1 41 290 2.4e-14 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 34 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Akap9 G A 5: 4,001,550 (GRCm38) S1439N probably benign Het
Bcl9l A G 9: 44,508,242 (GRCm38) T1069A possibly damaging Het
Btaf1 T G 19: 37,011,252 (GRCm38) probably benign Het
Cdc40 A T 10: 40,843,128 (GRCm38) V335E probably damaging Het
Cenpj A T 14: 56,564,963 (GRCm38) N48K possibly damaging Het
Cfh A G 1: 140,088,682 (GRCm38) W635R probably damaging Het
Clca1 A G 3: 145,008,958 (GRCm38) S633P possibly damaging Het
Cnot6 T C 11: 49,685,120 (GRCm38) M176V probably benign Het
Cryz G T 3: 154,618,526 (GRCm38) E51* probably null Het
Dcc A G 18: 71,456,883 (GRCm38) Y681H probably benign Het
Dmxl1 T A 18: 49,912,725 (GRCm38) N2412K probably benign Het
Gpr137b C T 13: 13,365,065 (GRCm38) W258* probably null Het
Hnf1b A G 11: 83,882,700 (GRCm38) T242A probably benign Het
Hsd11b1 A T 1: 193,223,644 (GRCm38) C213* probably null Het
Igsf11 A T 16: 39,008,917 (GRCm38) T117S probably damaging Het
Inpp5b T C 4: 124,783,994 (GRCm38) Y416H probably damaging Het
Kcnq3 C A 15: 66,004,726 (GRCm38) V523F probably damaging Het
Krtap9-5 T C 11: 99,948,465 (GRCm38) probably benign Het
Lrig3 T C 10: 125,997,115 (GRCm38) L286S probably damaging Het
Myo18b C T 5: 112,875,007 (GRCm38) probably benign Het
Nupl1 A G 14: 60,228,916 (GRCm38) probably benign Het
Olfr1442 T C 19: 12,674,241 (GRCm38) L12P probably damaging Het
Olfr186 A G 16: 59,027,631 (GRCm38) I92T possibly damaging Het
Olfr623 T A 7: 103,661,067 (GRCm38) Y61F probably damaging Het
Pyroxd2 T C 19: 42,731,438 (GRCm38) D443G possibly damaging Het
Ttc28 A G 5: 111,225,740 (GRCm38) D1014G probably benign Het
Tubgcp5 T A 7: 55,806,595 (GRCm38) S312T possibly damaging Het
Uckl1 T C 2: 181,569,617 (GRCm38) D473G probably benign Het
Vmn2r76 G T 7: 86,228,717 (GRCm38) H491N probably benign Het
Wwc2 G A 8: 47,846,158 (GRCm38) R1039W unknown Het
Zc3h14 T A 12: 98,758,843 (GRCm38) S255T probably benign Het
Zfp369 T C 13: 65,297,260 (GRCm38) V739A probably benign Het
Zfyve21 A G 12: 111,824,934 (GRCm38) probably benign Het
Znhit6 A G 3: 145,594,596 (GRCm38) probably benign Het
Other mutations in Olfr1008
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02192:Olfr1008 APN 2 85,690,128 (GRCm38) missense possibly damaging 0.80
IGL02560:Olfr1008 APN 2 85,689,519 (GRCm38) missense possibly damaging 0.79
IGL02726:Olfr1008 APN 2 85,690,210 (GRCm38) missense possibly damaging 0.94
IGL02756:Olfr1008 APN 2 85,690,058 (GRCm38) missense probably damaging 0.99
R0463:Olfr1008 UTSW 2 85,689,839 (GRCm38) missense possibly damaging 0.94
R0961:Olfr1008 UTSW 2 85,689,446 (GRCm38) missense probably benign 0.00
R0964:Olfr1008 UTSW 2 85,690,365 (GRCm38) missense probably benign
R1259:Olfr1008 UTSW 2 85,689,531 (GRCm38) missense probably damaging 0.98
R1756:Olfr1008 UTSW 2 85,690,083 (GRCm38) missense probably damaging 1.00
R1871:Olfr1008 UTSW 2 85,690,311 (GRCm38) missense probably damaging 1.00
R1882:Olfr1008 UTSW 2 85,689,606 (GRCm38) missense probably damaging 1.00
R6573:Olfr1008 UTSW 2 85,689,999 (GRCm38) missense probably damaging 0.99
R6640:Olfr1008 UTSW 2 85,689,935 (GRCm38) missense probably damaging 1.00
R6746:Olfr1008 UTSW 2 85,689,608 (GRCm38) missense probably damaging 1.00
R7045:Olfr1008 UTSW 2 85,689,911 (GRCm38) missense possibly damaging 0.49
R7347:Olfr1008 UTSW 2 85,689,837 (GRCm38) missense probably damaging 0.99
R7875:Olfr1008 UTSW 2 85,689,494 (GRCm38) missense probably benign 0.14
R8030:Olfr1008 UTSW 2 85,689,719 (GRCm38) missense probably damaging 1.00
R9161:Olfr1008 UTSW 2 85,689,887 (GRCm38) missense probably benign 0.01
R9193:Olfr1008 UTSW 2 85,690,300 (GRCm38) nonsense probably null
R9399:Olfr1008 UTSW 2 85,690,051 (GRCm38) missense probably damaging 0.97
R9460:Olfr1008 UTSW 2 85,690,015 (GRCm38) missense probably benign 0.02
R9467:Olfr1008 UTSW 2 85,690,282 (GRCm38) missense
R9685:Olfr1008 UTSW 2 85,689,522 (GRCm38) missense probably damaging 1.00
Z1177:Olfr1008 UTSW 2 85,689,680 (GRCm38) missense possibly damaging 0.93
Posted On 2013-04-17