Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00972:Or4f61'

27007

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or4f61

Ensembl Gene

ENSMUSG00000074945

Gene Name

olfactory receptor family 4 subfamily F member 61

Synonyms

MOR245-2, Olfr1314, GA_x6K02T2Q125-73139026-73138088

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.059) question?

Stock #

IGL00972

Quality Score

Status

Chromosome

Chromosomal Location

111922106-111923044 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 111922439 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 202 (N202K)

Ref Sequence

ENSEMBL: ENSMUSP00000146418 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099598] [ENSMUST00000207976]

AlphaFold

A2AVL6

Predicted Effect

probably damaging
Transcript: ENSMUST00000099598
AA Change: N202K

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000097193
Gene: ENSMUSG00000074945
AA Change: N202K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	30	305	9.2e-42	PFAM
Pfam:7tm_1	41	287	1.6e-23	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000207976
AA Change: N202K

PolyPhen 2 Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3100002H09Rik	A	G	4: 124,504,484 (GRCm39)	F23L	probably damaging	Het
Abcf3	A	T	16: 20,370,434 (GRCm39)	M320L	probably damaging	Het
Adam4	A	T	12: 81,467,423 (GRCm39)	H399Q	probably damaging	Het
Ank1	A	G	8: 23,631,660 (GRCm39)	K140E	probably damaging	Het
Atg2a	G	A	19: 6,304,629 (GRCm39)	C1162Y	probably damaging	Het
Atp2b1	T	A	10: 98,850,906 (GRCm39)	I34N	probably damaging	Het
Bin1	A	T	18: 32,557,887 (GRCm39)	E260V	probably benign	Het
Birc2	G	A	9: 7,833,716 (GRCm39)	S255L	probably benign	Het
Cdc42bpa	A	G	1: 179,902,249 (GRCm39)	Q502R	probably benign	Het
Cep170	A	G	1: 176,563,262 (GRCm39)	V1584A	probably benign	Het
Commd3	A	T	2: 18,679,476 (GRCm39)	R120S	probably benign	Het
Cyp39a1	A	T	17: 44,012,434 (GRCm39)	I304L	probably benign	Het
Cyp3a44	A	T	5: 145,716,534 (GRCm39)	M352K	possibly damaging	Het
Dna2	T	C	10: 62,786,602 (GRCm39)	Y117H	probably benign	Het
Dnah6	A	G	6: 73,060,140 (GRCm39)		probably benign	Het
Dsc1	G	A	18: 20,221,420 (GRCm39)	P685L	probably benign	Het
Efna5	T	A	17: 62,920,374 (GRCm39)	I168L	possibly damaging	Het
Ephx1	A	G	1: 180,827,365 (GRCm39)	F96S	probably benign	Het
Fig4	A	T	10: 41,127,784 (GRCm39)	I560K	probably damaging	Het
Fktn	T	A	4: 53,734,992 (GRCm39)	I210N	probably damaging	Het
Fmnl1	T	C	11: 103,071,781 (GRCm39)	V96A	probably damaging	Het
Gabra1	T	G	11: 42,024,453 (GRCm39)	E407D	probably benign	Het
Gm5277	A	T	3: 78,799,593 (GRCm39)		noncoding transcript	Het
H2-M10.5	A	T	17: 37,084,227 (GRCm39)	E63V	possibly damaging	Het
Icam5	T	A	9: 20,945,993 (GRCm39)	V275E	probably damaging	Het
Kel	G	A	6: 41,665,000 (GRCm39)	A588V	possibly damaging	Het
Klra5	T	A	6: 129,883,568 (GRCm39)	E96D	probably damaging	Het
Limd1	C	T	9: 123,309,141 (GRCm39)	T280I	probably benign	Het
Mul1	C	A	4: 138,165,628 (GRCm39)	S95*	probably null	Het
Nlrp4a	T	C	7: 26,156,473 (GRCm39)	S733P	probably benign	Het
Ntn1	T	A	11: 68,104,098 (GRCm39)	I517F	possibly damaging	Het
Ntrk3	T	A	7: 77,897,070 (GRCm39)	M656L	possibly damaging	Het
Oacyl	T	G	18: 65,858,572 (GRCm39)	L226R	possibly damaging	Het
Or1ad6	A	T	11: 50,859,946 (GRCm39)	M34L	probably benign	Het
Or5ac17	A	G	16: 59,036,829 (GRCm39)	I49T	probably damaging	Het
Pibf1	T	A	14: 99,416,885 (GRCm39)	L486*	probably null	Het
Pla2g4c	A	G	7: 13,074,583 (GRCm39)	Y253C	probably benign	Het
Rims3	C	A	4: 120,748,583 (GRCm39)	A268E	probably benign	Het
Rpl12	T	C	2: 32,853,759 (GRCm39)	I129T	probably benign	Het
Rsl1	A	T	13: 67,329,862 (GRCm39)	K103N	probably benign	Het
Scn11a	A	T	9: 119,623,004 (GRCm39)	W612R	probably benign	Het
Sdk2	G	A	11: 113,745,210 (GRCm39)	T695M	possibly damaging	Het
Slc17a1	T	A	13: 24,062,437 (GRCm39)		probably benign	Het
Stam	A	T	2: 14,120,779 (GRCm39)		probably benign	Het
Tacr3	T	G	3: 134,638,116 (GRCm39)	N424K	probably benign	Het
Tas1r2	C	T	4: 139,387,347 (GRCm39)	R240W	probably damaging	Het
Tle1	T	C	4: 72,040,637 (GRCm39)	R648G	probably damaging	Het
Tmem92	T	C	11: 94,673,254 (GRCm39)	D3G	possibly damaging	Het
Trip11	T	C	12: 101,860,596 (GRCm39)	I250V	probably null	Het
Tspan8	C	T	10: 115,680,044 (GRCm39)		probably benign	Het
Vmn1r128	A	G	7: 21,084,001 (GRCm39)	E235G	probably benign	Het
Vmn1r220	A	G	13: 23,368,558 (GRCm39)	L46P	probably damaging	Het
Vmn2r9	T	C	5: 108,996,903 (GRCm39)	E122G	probably benign	Het
Zfp27	A	T	7: 29,594,383 (GRCm39)	N527K	probably damaging	Het

Other mutations in Or4f61

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01701:Or4f61	APN	2	111,922,851 (GRCm39)	missense	possibly damaging	0.69
IGL02085:Or4f61	APN	2	111,922,869 (GRCm39)	missense	probably damaging	1.00
IGL02156:Or4f61	APN	2	111,922,361 (GRCm39)	missense	probably benign	0.12
IGL02266:Or4f61	APN	2	111,922,588 (GRCm39)	missense	probably benign	0.05
IGL02396:Or4f61	APN	2	111,922,812 (GRCm39)	missense	probably benign	0.20
IGL02602:Or4f61	APN	2	111,922,906 (GRCm39)	missense	probably benign	0.00
IGL03130:Or4f61	APN	2	111,922,166 (GRCm39)	missense	probably benign
R0452:Or4f61	UTSW	2	111,922,981 (GRCm39)	nonsense	probably null
R1498:Or4f61	UTSW	2	111,922,938 (GRCm39)	missense	probably benign	0.40
R1514:Or4f61	UTSW	2	111,922,381 (GRCm39)	missense	probably benign	0.01
R1852:Or4f61	UTSW	2	111,922,192 (GRCm39)	missense	probably benign	0.03
R2118:Or4f61	UTSW	2	111,922,675 (GRCm39)	missense	probably benign	0.02
R2219:Or4f61	UTSW	2	111,922,752 (GRCm39)	missense	probably damaging	0.99
R2357:Or4f61	UTSW	2	111,922,743 (GRCm39)	missense	possibly damaging	0.69
R3743:Or4f61	UTSW	2	111,922,965 (GRCm39)	missense	probably benign	0.33
R4692:Or4f61	UTSW	2	111,923,026 (GRCm39)	missense	probably damaging	1.00
R5092:Or4f61	UTSW	2	111,922,452 (GRCm39)	missense	possibly damaging	0.94
R5150:Or4f61	UTSW	2	111,922,880 (GRCm39)	missense	possibly damaging	0.95
R5230:Or4f61	UTSW	2	111,922,734 (GRCm39)	missense	probably benign	0.12
R5991:Or4f61	UTSW	2	111,922,960 (GRCm39)	missense	probably benign	0.30
R7894:Or4f61	UTSW	2	111,922,822 (GRCm39)	missense	probably benign
R8991:Or4f61	UTSW	2	111,922,682 (GRCm39)	missense	probably damaging	1.00
R9206:Or4f61	UTSW	2	111,922,410 (GRCm39)	missense	probably benign	0.12
R9595:Or4f61	UTSW	2	111,922,375 (GRCm39)	missense	probably damaging	0.96
Z1177:Or4f61	UTSW	2	111,922,929 (GRCm39)	missense	possibly damaging	0.88

Posted On

2013-04-17