Incidental Mutation 'R3738:Or4l15'
ID 270257
Institutional Source Beutler Lab
Gene Symbol Or4l15
Ensembl Gene ENSMUSG00000096254
Gene Name olfactory receptor family 4 subfamily L member 15
Synonyms MOR247-2, Olfr724, GA_x6K02T2PMLR-5645801-5644872
Accession Numbers
Essential gene? Probably non essential (E-score: 0.230) question?
Stock # R3738 (G1)
Quality Score 208
Status Not validated
Chromosome 14
Chromosomal Location 50197548-50198553 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 50198013 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 172 (N172S)
Ref Sequence ENSEMBL: ENSMUSP00000149110 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075030] [ENSMUST00000213390]
AlphaFold K7N5X7
Predicted Effect possibly damaging
Transcript: ENSMUST00000075030
AA Change: N172S

PolyPhen 2 Score 0.600 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000074546
Gene: ENSMUSG00000096254
AA Change: N172S

DomainStartEndE-ValueType
Pfam:7tm_4 31 305 1.3e-42 PFAM
Pfam:7TM_GPCR_Srsx 34 302 3e-11 PFAM
Pfam:7tm_1 41 287 5.3e-23 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213390
AA Change: N172S

PolyPhen 2 Score 0.600 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 94.6%
Validation Efficiency 98% (47/48)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik2 A T 11: 48,910,108 (GRCm39) L775* probably null Het
Abcb8 A G 5: 24,605,619 (GRCm39) S168G probably benign Het
Ankrd11 A G 8: 123,623,454 (GRCm39) probably benign Het
Api5 C T 2: 94,255,958 (GRCm39) R243Q possibly damaging Het
Atp8b1 A G 18: 64,666,800 (GRCm39) probably benign Het
Camk2d A G 3: 126,565,488 (GRCm39) D136G probably damaging Het
Capn3 G A 2: 120,315,768 (GRCm39) D227N possibly damaging Het
Ccdc168 A G 1: 44,098,026 (GRCm39) V1024A probably benign Het
Cwf19l2 A T 9: 3,456,803 (GRCm39) H712L probably benign Het
Dlgap3 A G 4: 127,089,399 (GRCm39) T332A probably damaging Het
Eml6 C A 11: 29,753,137 (GRCm39) V925L probably benign Het
Fbll1 G A 11: 35,688,505 (GRCm39) H253Y possibly damaging Het
Fbxw18 T A 9: 109,517,981 (GRCm39) Y335F possibly damaging Het
Gbp10 T A 5: 105,372,324 (GRCm39) E145D possibly damaging Het
Ifi203 T A 1: 173,757,040 (GRCm39) probably benign Het
Insig1 T A 5: 28,276,701 (GRCm39) I89N probably damaging Het
Itpkc T A 7: 26,927,029 (GRCm39) D295V possibly damaging Het
Jak1 T C 4: 101,048,665 (GRCm39) probably benign Het
Kctd9 G A 14: 67,971,737 (GRCm39) D157N possibly damaging Het
Kmt2c A C 5: 25,610,381 (GRCm39) F242V probably benign Het
Lcorl A T 5: 45,891,383 (GRCm39) N323K possibly damaging Het
Lin54 T C 5: 100,607,665 (GRCm39) probably benign Het
Ltbp2 A T 12: 84,851,248 (GRCm39) C836S probably damaging Het
Mfsd2b A G 12: 4,920,578 (GRCm39) S80P probably damaging Het
Myh9 G A 15: 77,651,012 (GRCm39) R1612C probably damaging Het
Nr1d2 T A 14: 18,211,804 (GRCm38) N433I possibly damaging Het
Or2y1 A G 11: 49,386,287 (GRCm39) D309G possibly damaging Het
Or4c112 T C 2: 88,853,954 (GRCm39) Y131C probably damaging Het
Pld4 T C 12: 112,734,469 (GRCm39) I410T probably benign Het
Pnma8b C T 7: 16,680,521 (GRCm39) H502Y probably benign Het
Pramel12 T C 4: 143,143,212 (GRCm39) probably benign Het
Rbbp8nl G T 2: 179,923,041 (GRCm39) T184K probably benign Het
Saa4 T A 7: 46,379,053 (GRCm39) N96Y possibly damaging Het
Serpinb6d T A 13: 33,851,663 (GRCm39) V140E probably damaging Het
Ska3 A T 14: 58,049,053 (GRCm39) M306K probably benign Het
Slfn4 T C 11: 83,076,137 (GRCm39) M1T probably null Het
Sorcs1 T C 19: 50,139,659 (GRCm39) I1168V probably benign Het
Srsf4 C T 4: 131,627,413 (GRCm39) probably benign Het
St18 G A 1: 6,925,697 (GRCm39) probably null Het
Trim9 T C 12: 70,297,969 (GRCm39) T579A probably damaging Het
Trpc2 G A 7: 101,733,711 (GRCm39) S220N probably damaging Het
Ube2j1 A T 4: 33,036,723 (GRCm39) M16L probably benign Het
Usp42 C T 5: 143,701,194 (GRCm39) S943N probably benign Het
Utp20 C T 10: 88,598,668 (GRCm39) V103I probably benign Het
Vmn2r62 G A 7: 42,437,311 (GRCm39) P391L probably benign Het
Zfa-ps T A 10: 52,420,636 (GRCm39) noncoding transcript Het
Zfp423 A G 8: 88,507,972 (GRCm39) C666R probably damaging Het
Other mutations in Or4l15
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02811:Or4l15 APN 14 50,197,590 (GRCm39) utr 3 prime probably benign
R0829:Or4l15 UTSW 14 50,198,503 (GRCm39) missense probably benign 0.03
R1513:Or4l15 UTSW 14 50,198,558 (GRCm39) critical splice acceptor site probably null
R2016:Or4l15 UTSW 14 50,197,959 (GRCm39) missense probably benign 0.00
R2936:Or4l15 UTSW 14 50,197,611 (GRCm39) missense probably benign 0.03
R3082:Or4l15 UTSW 14 50,198,161 (GRCm39) missense probably damaging 1.00
R4772:Or4l15 UTSW 14 50,198,452 (GRCm39) small deletion probably benign
R4830:Or4l15 UTSW 14 50,197,681 (GRCm39) missense probably damaging 1.00
R4839:Or4l15 UTSW 14 50,197,646 (GRCm39) missense probably benign 0.41
R5362:Or4l15 UTSW 14 50,197,986 (GRCm39) missense possibly damaging 0.95
R5695:Or4l15 UTSW 14 50,198,080 (GRCm39) missense probably benign 0.00
R6187:Or4l15 UTSW 14 50,198,526 (GRCm39) start codon destroyed probably null 0.99
R7371:Or4l15 UTSW 14 50,198,563 (GRCm39) splice site probably null
R7611:Or4l15 UTSW 14 50,198,368 (GRCm39) missense probably benign 0.03
R9243:Or4l15 UTSW 14 50,197,881 (GRCm39) missense probably benign 0.06
Predicted Primers PCR Primer
(F):5'- AGACTGCCAGGTGATTTGTGC -3'
(R):5'- TGGTCCAGATGTTCTTCAGC -3'

Sequencing Primer
(F):5'- TGCTTTACAATGAGCAGAATGACAG -3'
(R):5'- AATGACCCTTTTGATAGTCATGGCC -3'
Posted On 2015-03-18